HU196959B - Process for producing merkapto-acyl-proline derivatives - Google Patents

Process for producing merkapto-acyl-proline derivatives Download PDF

Info

Publication number
HU196959B
HU196959B HU862689A HU268986A HU196959B HU 196959 B HU196959 B HU 196959B HU 862689 A HU862689 A HU 862689A HU 268986 A HU268986 A HU 268986A HU 196959 B HU196959 B HU 196959B
Authority
HU
Hungary
Prior art keywords
formula
thiourea
proline
solvent
iii
Prior art date
Application number
HU862689A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT44490A (en
Inventor
Janos Fischer
Tamas Fodor
Bela Stefko
Laszlo Dobay
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT0091186A priority Critical patent/AT395012B/de
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to HU862689A priority patent/HU196959B/hu
Priority to CH2372/87A priority patent/CH673279A5/de
Priority to YU118187A priority patent/YU46319B/sh
Priority to CN198787104388A priority patent/CN87104388A/zh
Priority to JP62159491A priority patent/JPS6327475A/ja
Priority to PL1987266478A priority patent/PL153449B1/pl
Priority to AT0162087A priority patent/AT387381B/de
Priority to PT85190A priority patent/PT85190B/pt
Priority to KR1019870006546A priority patent/KR900007217B1/ko
Priority to IT8721085A priority patent/IT1206792B/it
Priority to DD87304203A priority patent/DD263757A5/de
Priority to SU874202836A priority patent/SU1650007A3/ru
Priority to CS874794A priority patent/CS276394B6/cs
Priority to SE8702654A priority patent/SE462751B/sv
Priority to DK329787A priority patent/DK329787A/da
Priority to AR87307987A priority patent/AR243159A1/es
Priority to GR871012A priority patent/GR871012B/el
Priority to ES8702024A priority patent/ES2004451A6/es
Priority to NO872690A priority patent/NO168941C/no
Priority to FI872859A priority patent/FI87770C/fi
Priority to DE19873721430 priority patent/DE3721430A1/de
Publication of HUT44490A publication Critical patent/HUT44490A/hu
Publication of HU196959B publication Critical patent/HU196959B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU862689A 1986-06-27 1986-06-27 Process for producing merkapto-acyl-proline derivatives HU196959B (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
AT0091186A AT395012B (de) 1986-06-27 1986-04-07 Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen
HU862689A HU196959B (en) 1986-06-27 1986-06-27 Process for producing merkapto-acyl-proline derivatives
CH2372/87A CH673279A5 (da) 1986-06-27 1987-06-24
YU118187A YU46319B (sh) 1986-06-27 1987-06-24 Postupak za dobijanje 1-/3-merkapto-/2s/-metilpropionil/-pirolidin-/2s/-karboksilne kiseline
CN198787104388A CN87104388A (zh) 1986-06-27 1987-06-24 制备硫基酰基脯氨酸的方法
DD87304203A DD263757A5 (de) 1986-06-27 1987-06-26 Verfahren zur herstellung von 1-[3-mercapto-(2s)-methyl-propionyl]-pyrrolidin-(2s)-carbonsaeure
SE8702654A SE462751B (sv) 1986-06-27 1987-06-26 Saett foer framstaellning av en merkaptoacylprolin
AT0162087A AT387381B (de) 1986-06-27 1987-06-26 Verfahren zur herstellung von einem mercapto-acylprolin
PT85190A PT85190B (pt) 1986-06-27 1987-06-26 Processo para a preparacao de uma mercaptoacilprolina
KR1019870006546A KR900007217B1 (ko) 1986-06-27 1987-06-26 메르캅토아실프롤린의 제조방법
IT8721085A IT1206792B (it) 1986-06-27 1987-06-26 Procedimento per preparare una mercaptoacilprolina.
JP62159491A JPS6327475A (ja) 1986-06-27 1987-06-26 メルカプトアシルプロリンの製造法
SU874202836A SU1650007A3 (ru) 1986-06-27 1987-06-26 Способ получени 1-[3-меркапто-(2S)-метилпропионил]-пирролидин-(2S)-карбоновой кислоты
CS874794A CS276394B6 (en) 1986-06-27 1987-06-26 Process for preparing 1-/3-mercapto-(2s)-methylpropionyl/-pyrrolidine-(2s)-carboxylic acid
PL1987266478A PL153449B1 (en) 1986-06-27 1987-06-26 Procedure for the production of mercaptoacyloproline
DK329787A DK329787A (da) 1986-06-27 1987-06-26 Fremgangsmaade til fremstilling af mercaptoacylprolinderivater
AR87307987A AR243159A1 (es) 1986-06-27 1987-06-26 Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico o sus sales farmaceuticamente aceptables.
GR871012A GR871012B (en) 1986-06-27 1987-06-26 Process for preparing a mercaptoacylproline
ES8702024A ES2004451A6 (es) 1986-06-27 1987-06-26 Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil-pirrolidin-(2s)-carboxilico
NO872690A NO168941C (no) 1986-06-27 1987-06-26 Fremgangsmaate for fremstilling av mercaptoacylprolin.
FI872859A FI87770C (fi) 1986-06-27 1987-06-26 Foerfarande foer framstaellning av merkaptoacylprolin
DE19873721430 DE3721430A1 (de) 1986-06-27 1987-06-29 Verfahren zur herstellung von 1-(3'-(mercapto)-(2's)-(methyl)-propionyl)-pyrrolidin-(2s)-carbonsaeure oder ihren salzen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862689A HU196959B (en) 1986-06-27 1986-06-27 Process for producing merkapto-acyl-proline derivatives

Publications (2)

Publication Number Publication Date
HUT44490A HUT44490A (en) 1988-03-28
HU196959B true HU196959B (en) 1989-02-28

Family

ID=10960651

Family Applications (1)

Application Number Title Priority Date Filing Date
HU862689A HU196959B (en) 1986-06-27 1986-06-27 Process for producing merkapto-acyl-proline derivatives

Country Status (21)

Country Link
JP (1) JPS6327475A (da)
KR (1) KR900007217B1 (da)
CN (1) CN87104388A (da)
AR (1) AR243159A1 (da)
AT (2) AT395012B (da)
CH (1) CH673279A5 (da)
CS (1) CS276394B6 (da)
DD (1) DD263757A5 (da)
DE (1) DE3721430A1 (da)
DK (1) DK329787A (da)
ES (1) ES2004451A6 (da)
FI (1) FI87770C (da)
GR (1) GR871012B (da)
HU (1) HU196959B (da)
IT (1) IT1206792B (da)
NO (1) NO168941C (da)
PL (1) PL153449B1 (da)
PT (1) PT85190B (da)
SE (1) SE462751B (da)
SU (1) SU1650007A3 (da)
YU (1) YU46319B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE421551B (sv) * 1980-03-26 1982-01-04 Sandvik Ab Borrverktyg for rotations- och/eller slagborrning
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
JPS62125081A (ja) * 1985-11-21 1987-06-06 キングプリンテイング株式会社 捺染方法
PT928191E (pt) * 1996-09-26 2003-01-31 Meditor Pharmaceuticals Ltd Formulacoes farmaceuticas compreendendo derivados de s-alquilisotiouronio
CN103086939A (zh) * 2011-10-28 2013-05-08 华中药业股份有限公司 1-(3-溴-2-d-甲基丙酰基)吡咯烷-2-羧酸的重结晶方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
IE54551B1 (en) * 1982-01-22 1989-11-22 Ici Plc Amide derivatives
KR860001391B1 (ko) * 1984-07-23 1986-09-22 보령제약 주식회사 피롤리딘 유도체의 제조방법

Also Published As

Publication number Publication date
SE8702654D0 (sv) 1987-06-26
YU118187A (en) 1988-04-30
AT395012B (de) 1992-08-25
NO872690D0 (no) 1987-06-26
SE462751B (sv) 1990-08-27
ATA91186A (de) 1992-01-15
NO872690L (no) 1987-12-28
IT8721085A0 (it) 1987-06-26
DK329787A (da) 1987-12-28
KR880000392A (ko) 1988-03-25
DD263757A5 (de) 1989-01-11
FI87770B (fi) 1992-11-13
DK329787D0 (da) 1987-06-26
YU46319B (sh) 1993-05-28
JPS6327475A (ja) 1988-02-05
NO168941B (no) 1992-01-13
ATA162087A (de) 1988-06-15
GR871012B (en) 1987-11-02
PT85190B (pt) 1990-03-30
PT85190A (en) 1987-07-01
SE8702654L (sv) 1987-12-28
AT387381B (de) 1989-01-10
DE3721430A1 (de) 1988-01-28
KR900007217B1 (ko) 1990-10-05
SU1650007A3 (ru) 1991-05-15
PL266478A1 (en) 1988-06-09
CN87104388A (zh) 1988-03-02
AR243159A1 (es) 1993-07-30
ES2004451A6 (es) 1989-01-01
CS479487A3 (en) 1992-01-15
PL153449B1 (en) 1991-04-30
IT1206792B (it) 1989-05-03
NO168941C (no) 1992-04-29
FI872859A (fi) 1987-12-28
CH673279A5 (da) 1990-02-28
FI87770C (fi) 1993-02-25
FI872859A0 (fi) 1987-06-26
HUT44490A (en) 1988-03-28
CS276394B6 (en) 1992-05-13

Similar Documents

Publication Publication Date Title
SU747422A3 (ru) Способ получени производных пролина
KR900001509B1 (ko) (트레오) - 1 - 아릴 - 2 - 아실아미도 - 3 - 플루오로 - 1 - 프로판올 및 그의 제조방법
US4154934A (en) Mercaptoacylamino derivatives of heterocyclic carboxylic acids
US4332725A (en) Process for the preparation of 1-[3-mercapto-(2S)-methylpropionyl]-pyrrolidine-(2S)-carboxylic acid
HU196959B (en) Process for producing merkapto-acyl-proline derivatives
EP0018546B1 (en) Process for the production of phenylglycyl chloride hydrochlorides
EP1440970B1 (en) Benzenesulfonic acid salt of 1-(6-halogeno-2-benzothiazolyl)ethylamine
US3983162A (en) Optical resolution of alkyl esters of DL-phenylalanine
US5473081A (en) Process for the preparation of l-proline derivatives
KR100317425B1 (ko) 할로겐화제 및 수산기의 할로겐화 방법
EP0967204A1 (en) Process for producing benzylsuccinic acid derivatives
PT863874E (pt) Processo para a preparacao de dioxoazabiciclo-hexanos
ITMI981478A1 (it) Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4- tetraidroisochinolin-3-carbossiammide
HU211101B (en) Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid
PT99022A (pt) Processo para a preparacao de 1-{(2s)-3-mercapto-metil-1-oxopropil}-l-prolina e de um intermediario
US4477677A (en) Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid
JPH05221966A (ja) Ｌ−プロリン誘導体の製造方法
KR840001751B1 (ko) 광학적 활성의 n-메르캅토 알카노일 아미노산의 제조법
KR860001312B1 (ko) 말론산 유도체의 제조방법
KR860000850B1 (ko) 인돌초산 유도체의 제조방법
KR0139260B1 (ko) 고리화된 이미다졸을 가지는 벤즈이미다졸 유도체
HU182778B (en) Process for preparing 4-/n-alkyl-carbamoyloxy/-l-proline
JPS61178947A (ja) アリ−ルアルキルケトンの製造方法
PL79142B1 (en) Novel cephalosporin derivatives, and processes for their preparation [gb1271013a]
CA1155443A (en) Processes for preparing proline derivatives and analogous compounds

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYRT., HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR, HU