HRPK20040293B3 - Substituted benzimidazole compounds and their use for the treatment of cancer - Google Patents

Substituted benzimidazole compounds and their use for the treatment of cancer

Info

Publication number: HRPK20040293B3
Authority: HR; Croatia
Prior art keywords: optionally substituted; group; aryl; alkoxy; alkyl
Prior art date: 2001-09-26

Application number

HR20040293A

Other languages

English (en)

Croatian (hr)

Inventor

Clerc Fran�ois

Hamy Fran�ois

Depaty Isabelle

Angouillant-Boniface Odile

Deprets St�phanie

Carrez Chantal

Roesner Manfred

Original Assignee

Aventis Pharma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-26

Filing date

2004-03-25

Publication date

2007-06-30

2004-03-25 Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.

2005-06-30 Publication of HRP20040293A2 publication Critical patent/HRP20040293A2/hr

2007-06-30 Publication of HRPK20040293B3 publication Critical patent/HRPK20040293B3/xx

Links

206010028980 Neoplasm Diseases 0.000 title 1
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 6
125000002252 acyl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 5
239000002253 acid Chemical class 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000004404 heteroalkyl group Chemical group 0.000 abstract 3
-1 heteroaryl compound Chemical class 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 3
229920001774 Perfluoroether Polymers 0.000 abstract 2
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004438 haloalkoxy group Chemical group 0.000 abstract 1
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HR20040293A 2001-09-26 2004-03-25 Substituted benzimidazole compounds and their use for the treatment of cancer HRPK20040293B3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01402460A EP1298125A1 (en)	2001-09-26	2001-09-26	Substituted benzimidazole compounds and their use for the treatment of cancer
PCT/EP2002/011353 WO2003028721A2 (en)	2001-09-26	2002-09-26	Substituted benzimidazole compounds and their use for the treatment of cancer

Publications (2)

Publication Number	Publication Date
HRP20040293A2 HRP20040293A2 (en)	2005-06-30
HRPK20040293B3 true HRPK20040293B3 (en)	2007-06-30

Family

ID=8182891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20040293A HRPK20040293B3 (en)	2001-09-26	2004-03-25	Substituted benzimidazole compounds and their use for the treatment of cancer

Country Status (35)

Country	Link
US (1)	US7041668B2 (es)
EP (2)	EP1298125A1 (es)
JP (1)	JP4510450B2 (es)
KR (1)	KR100891439B1 (es)
CN (1)	CN100346786C (es)
AR (1)	AR037096A1 (es)
AT (1)	ATE386517T1 (es)
AU (1)	AU2002337151B2 (es)
BR (1)	BR0212856A (es)
CA (1)	CA2461622C (es)
CO (1)	CO5570675A2 (es)
CY (1)	CY1107953T1 (es)
DE (1)	DE60225159T2 (es)
DK (1)	DK1432417T3 (es)
EA (1)	EA006802B1 (es)
ES (1)	ES2301682T3 (es)
GT (1)	GT200200190A (es)
HK (1)	HK1068551A1 (es)
HR (1)	HRPK20040293B3 (es)
HU (1)	HUP0401756A3 (es)
IL (1)	IL161059A0 (es)
ME (1)	MEP16808A (es)
MX (1)	MXPA04002042A (es)
MY (1)	MY135339A (es)
NO (1)	NO327008B1 (es)
NZ (1)	NZ531246A (es)
PA (1)	PA8555501A1 (es)
PE (1)	PE20030427A1 (es)
PL (1)	PL369527A1 (es)
PT (1)	PT1432417E (es)
RS (1)	RS50896B (es)
SI (1)	SI1432417T1 (es)
UY (1)	UY27452A1 (es)
WO (1)	WO2003028721A2 (es)
ZA (1)	ZA200401887B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2011250847B2 (en) *	2003-06-23	2013-06-20	Bhi Limited Partnership	Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en)	2003-06-23	2007-01-11	Xianqi Kong	Methods and compositions for treating amyloid-related diseases
WO2005040355A2 (en) *	2003-10-24	2005-05-06	Exelixis, Inc.	Tao kinase modulators and methods of use
DE102004010207A1 (de)	2004-03-02	2005-09-15	Aventis Pharma S.A.	Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
FR2868421B1 (fr) *	2004-04-01	2008-08-01	Aventis Pharma Sa	Nouveaux benzothiazoles et leur utilisation comme medicaments
EP1598348A1 (en)	2004-05-18	2005-11-23	Aventis Pharma Deutschland GmbH	Novel pyridazinone derivatives as inhibitors of CDK2
AU2005326962A1 (en)	2004-12-22	2006-08-17	Bellus Health (International) Limited	Methods and compositions for treating amyloid-related diseases
CN101300251B (zh) *	2005-09-06	2011-08-03	史密丝克莱恩比彻姆公司	作为plk抑制剂的苯并咪唑噻吩化合物
FR2891273B1 (fr) *	2005-09-27	2007-11-23	Aventis Pharma Sa	NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet
SI2089417T1 (sl)	2006-10-12	2015-04-30	Bhi Limited Partnership	Metode, spojine, sestavki in vektorji za dostavo 3-amino-1-propansulfonske kisline
PA8792501A1 (es)	2007-08-09	2009-04-23	Sanofi Aventis	Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.
MY156691A (en) *	2007-10-12	2016-03-15	Abbvie Bahamas Ltd	2-(r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide crystalline from 1
FR2922550B1 (fr)	2007-10-19	2009-11-27	Sanofi Aventis	Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet
FR2941949B1 (fr)	2009-02-06	2011-04-01	Sanofi Aventis	Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941952B1 (fr)	2009-02-06	2011-04-01	Sanofi Aventis	Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941950B1 (fr)	2009-02-06	2011-04-01	Sanofi Aventis	Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941951B1 (fr)	2009-02-06	2011-04-01	Sanofi Aventis	Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
WO2011091152A1 (en) *	2010-01-22	2011-07-28	Pablo Gastaminza	Inhibitors of hepatitis c virus infection
CN114469984A (zh)	2015-08-25	2022-05-13	阿尔尼拉姆医药品有限公司	用于治疗前蛋白转化酶枯草杆菌蛋白酶kexin(pcsk9)基因相关障碍的方法和组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2441201C2 (de) *	1974-08-28	1986-08-07	Hoechst Ag, 6230 Frankfurt	Anthelminthisch wirksame 2-Carbalkoxyamino-5(6)-phenyl-sulfonyloxy-benzimidazole und Verfahren zu ihrer Herstellung
DE2541752A1 (de)	1975-09-19	1977-03-24	Hoechst Ag	Anthelminthisch wirksame 2-carbalkoxyamino-5(6)-phenyl-sulfonyloxy- benzimidazole und verfahren zu ihrer herstellung
DE3247615A1 (de) *	1982-12-23	1984-07-05	Hoechst Ag, 6230 Frankfurt	Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9900752D0 (en) *	1999-01-15	1999-03-03	Angiogene Pharm Ltd	Benzimidazole vascular damaging agents
US6693125B2 (en) *	2001-01-24	2004-02-17	Combinatorx Incorporated	Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders

2001
- 2001-09-26 EP EP01402460A patent/EP1298125A1/en not_active Withdrawn
2002
- 2002-09-17 PE PE2002000913A patent/PE20030427A1/es not_active Application Discontinuation
- 2002-09-24 UY UY27452A patent/UY27452A1/es unknown
- 2002-09-25 GT GT200200190A patent/GT200200190A/es unknown
- 2002-09-25 MY MYPI20023586A patent/MY135339A/en unknown
- 2002-09-26 JP JP2003532053A patent/JP4510450B2/ja not_active Expired - Fee Related
- 2002-09-26 DE DE60225159T patent/DE60225159T2/de not_active Expired - Lifetime
- 2002-09-26 CN CNB028187458A patent/CN100346786C/zh not_active Expired - Fee Related
- 2002-09-26 IL IL16105902A patent/IL161059A0/xx unknown
- 2002-09-26 AU AU2002337151A patent/AU2002337151B2/en not_active Ceased
- 2002-09-26 MX MXPA04002042A patent/MXPA04002042A/es active IP Right Grant
- 2002-09-26 PT PT02772370T patent/PT1432417E/pt unknown
- 2002-09-26 KR KR1020047004365A patent/KR100891439B1/ko not_active IP Right Cessation
- 2002-09-26 AR ARP020103629A patent/AR037096A1/es unknown
- 2002-09-26 ME MEP-168/08A patent/MEP16808A/xx unknown
- 2002-09-26 HU HU0401756A patent/HUP0401756A3/hu unknown
- 2002-09-26 AT AT02772370T patent/ATE386517T1/de active
- 2002-09-26 DK DK02772370T patent/DK1432417T3/da active
- 2002-09-26 CA CA002461622A patent/CA2461622C/en not_active Expired - Fee Related
- 2002-09-26 PL PL02369527A patent/PL369527A1/xx not_active Application Discontinuation
- 2002-09-26 WO PCT/EP2002/011353 patent/WO2003028721A2/en active IP Right Grant
- 2002-09-26 SI SI200230686T patent/SI1432417T1/sl unknown
- 2002-09-26 ES ES02772370T patent/ES2301682T3/es not_active Expired - Lifetime
- 2002-09-26 PA PA20028555501A patent/PA8555501A1/es unknown
- 2002-09-26 EP EP02772370A patent/EP1432417B1/en not_active Expired - Lifetime
- 2002-09-26 EA EA200400475A patent/EA006802B1/ru not_active IP Right Cessation
- 2002-09-26 BR BR0212856-0A patent/BR0212856A/pt not_active IP Right Cessation
- 2002-09-26 NZ NZ531246A patent/NZ531246A/en not_active IP Right Cessation
- 2002-09-26 RS YUP-214/04A patent/RS50896B/sr unknown
2004
- 2004-03-08 ZA ZA200401887A patent/ZA200401887B/en unknown
- 2004-03-23 NO NO20041214A patent/NO327008B1/no not_active IP Right Cessation
- 2004-03-25 CO CO04028337A patent/CO5570675A2/es not_active Application Discontinuation
- 2004-03-25 HR HR20040293A patent/HRPK20040293B3/xx not_active IP Right Cessation
- 2004-03-25 US US10/808,889 patent/US7041668B2/en not_active Expired - Fee Related
2005
- 2005-02-07 HK HK05101028A patent/HK1068551A1/xx not_active IP Right Cessation
2008
- 2008-05-20 CY CY20081100526T patent/CY1107953T1/el unknown

Also Published As

Publication number	Publication date
US20050014811A1 (en)	2005-01-20
CA2461622A1 (en)	2003-04-10
JP4510450B2 (ja)	2010-07-21
CN100346786C (zh)	2007-11-07
HUP0401756A3 (en)	2005-06-28
EP1432417A2 (en)	2004-06-30
EA200400475A1 (ru)	2004-08-26
EA006802B1 (ru)	2006-04-28
JP2005504112A (ja)	2005-02-10
WO2003028721A3 (en)	2003-12-11
MXPA04002042A (es)	2004-06-07
BR0212856A (pt)	2004-09-14
ZA200401887B (en)	2005-05-31
DE60225159T2 (de)	2009-02-19
HRP20040293A2 (en)	2005-06-30
PE20030427A1 (es)	2003-06-20
EP1432417B1 (en)	2008-02-20
CO5570675A2 (es)	2005-10-31
DK1432417T3 (da)	2008-06-16
CY1107953T1 (el)	2013-09-04
GT200200190A (es)	2003-11-11
KR20040048904A (ko)	2004-06-10
NO327008B1 (no)	2009-04-06
PT1432417E (pt)	2008-05-23
IL161059A0 (en)	2004-08-31
PA8555501A1 (es)	2003-06-30
HK1068551A1 (en)	2005-04-29
AR037096A1 (es)	2004-10-20
ATE386517T1 (de)	2008-03-15
RS50896B (sr)	2010-08-31
US7041668B2 (en)	2006-05-09
YU21404A (sh)	2006-08-17
SI1432417T1 (sl)	2008-08-31
PL369527A1 (en)	2005-05-02
KR100891439B1 (ko)	2009-04-03
HUP0401756A2 (hu)	2005-01-28
CN1558761A (zh)	2004-12-29
DE60225159D1 (de)	2008-04-03
UY27452A1 (es)	2003-02-28
NZ531246A (en)	2006-06-30
WO2003028721A2 (en)	2003-04-10
EP1298125A1 (en)	2003-04-02
MY135339A (en)	2008-03-31
NO20041214L (no)	2004-06-24
AU2002337151B2 (en)	2007-04-26
ES2301682T3 (es)	2008-07-01
MEP16808A (en)	2010-06-10
CA2461622C (en)	2008-12-02

Legal Events

Date	Code	Title	Description
2005-06-30	A1OB	Publication of a patent application
2006-02-28	AKOB	Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent)
2007-06-30	PKB1	Consensual patent granted
2009-08-28	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20090828 Year of fee payment: 8
2011-03-27	PBKO	Lapse due to non-payment of renewal fee for consensual patent	Effective date: 20100927

Publication	Publication Date	Title
HRPK20040293B3 (en)	2007-06-30	Substituted benzimidazole compounds and their use for the treatment of cancer
ATE556058T1 (de)	2012-05-15	1-(2h)-isochinolonderivat
HRP20080113T3 (en)	2008-04-30	Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
RS52978B (en)	2014-02-28	FUSIONED AMINO PIRIDIN AS HSP90 INHIBITORS
MEP61208A (en)	2011-05-10	Novel compounds having inhibitory activity against sodium-dependant transporter
NO20052074L (no)	2005-06-01	Substituerte benzoksazinoner og anvendelser derav.
HRP20070529T3 (en)	2008-05-31	Imidazole derivatives as glutmate receptor antagonists
RS54260B1 (en)	2016-02-29	AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT
CO5231161A1 (es)	2002-12-27	4-aminopicolinatos y su uso como herbicidas
HRP20050213A2 (en)	2006-12-31	2,4-substituted indoles and their use as 5-ht6 modulators
CY1114932T1 (el)	2016-12-14	Αντιπαρασιτικοι παραγοντες
DE60329918D1 (de)	2009-12-17	Amidderivat
RS52451B (en)	2013-02-28	PHENYLPROPIONAMIDE COMPOUNDS AND THEIR USE
HRP20050775A2 (en)	2006-10-31	Quinolinone/benzoxazinone derivatives and uses thereof
DK0784054T3 (da)	2002-03-25	1,2,3,4-tetrahydroquinoxalinderivater og deres anvendelse som glutamatreceptorantagonister
ME00981B (me)	2012-06-20	1,2,4,5-tetrahidr0-3h-benzazepinska jedinjenja, postupak za njihovu izradu i smješe koje ih sadrže
MX344529B (es)	2016-12-19	Derivados antibioticos de 2 - oxo -oxazolidin - 3, 5 -diilo.
RS51085B (sr)	2010-10-31	Derivati dioksan-2-alkilkarbamata, postupak za njihovo dobijanje i primena istih u terapeuticima
PT1202957E (pt)	2005-01-31	Aminobenzofenonas como inibidoras de il-1beta e tnf-alpha
RS97004A (en)	2006-10-27	Benzoxazine derivatives as 5-ht6 modulators and uses thereof
ECSP066343A (es)	2006-08-30	6-(1,1-difluoroalquil)-4-aminopicolinatos y uso como herbicidas
MY129329A (en)	2007-03-30	6,7-DIHYDRO-5H-PYRAZOLO[1,2-a]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES
HRP20030610B1 (en)	2006-02-28	Process for the preparation of mesylates of piperazine derivatives
ATE546454T1 (de)	2012-03-15	Pyrrolin-2-on-derivate gegen tumornekrosefaktor freisetzende zellen, herstellungsverfahren und anwendungen davon
ATE332695T1 (de)	2006-08-15	Pyrimidin-derivate als selektive inhibitoren von cox-2