FR2891273B1 - NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet - Google Patents
NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMetInfo
- Publication number
- FR2891273B1 FR2891273B1 FR0509850A FR0509850A FR2891273B1 FR 2891273 B1 FR2891273 B1 FR 2891273B1 FR 0509850 A FR0509850 A FR 0509850A FR 0509850 A FR0509850 A FR 0509850A FR 2891273 B1 FR2891273 B1 FR 2891273B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- pharmaceutical use
- benzothiazole derivatives
- novel benzimidazole
- cmet inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0509850A FR2891273B1 (fr) | 2005-09-27 | 2005-09-27 | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet |
KR1020087007348A KR20080050438A (ko) | 2005-09-27 | 2006-09-25 | 신규 벤즈이미다졸 및 벤조티아졸 유도체, 이들의 제조방법, 약물로서의 이들의 용도, 제약 조성물, 및 특히c-met 억제제로서의 신규 용도 |
PCT/FR2006/002183 WO2007036630A1 (fr) | 2005-09-27 | 2006-09-25 | Derives de benzimidazoles et benzothiazoles et leur utilisation en tant qu'inhibiteurs de kinases notamment de met |
CNA2006800355055A CN101273019A (zh) | 2005-09-27 | 2006-09-25 | 新的苯并咪唑和苯并噻唑衍生物,它们的制备方法,作为药物的应用,药物组合物和特别地作为C-Met抑制剂的新用途 |
JP2008532821A JP2009510033A (ja) | 2005-09-27 | 2006-09-25 | 新規ベンゾイミダゾール及びベンゾチアゾール誘導体、その調製方法、薬物としてのその使用、薬剤組成物、並びに特にc−met阻害剤としての新規使用 |
EP06808199A EP1934187A1 (fr) | 2005-09-27 | 2006-09-25 | Derives de benzimidazoles et benzothiazoles et leur utilisation en tant qu'inhibiteurs de kinases notamment de met |
SG201006691-8A SG165381A1 (en) | 2005-09-27 | 2006-09-25 | Novel benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use in particular as c-met inhibitors |
ZA200802447A ZA200802447B (en) | 2005-09-27 | 2006-09-25 | Novel benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use in particular as C-MET inhibitors |
NZ566568A NZ566568A (en) | 2005-09-27 | 2006-09-25 | Novel benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use especially as C-Met inhibitors |
ARP060104155A AR056528A1 (es) | 2005-09-27 | 2006-09-25 | Derivados de bencimidazoles y benzotiazoles su proceso de preparacion su aplicacion como medicamentos composiciones farmaceuticas y utilizacion principalmente como inhibidores de cmet |
AU2006296468A AU2006296468B2 (en) | 2005-09-27 | 2006-09-25 | Novel benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use in particular as C-Met inhibitors |
CA002620857A CA2620857A1 (fr) | 2005-09-27 | 2006-09-25 | Derives de benzimidazoles et benzothiazoles et leur utilisation en tant qu'inhibiteurs de kinases notamment de met |
EA200800947A EA014315B1 (ru) | 2005-09-27 | 2006-09-25 | НОВЫЕ ПРОИЗВОДНЫЕ БЕНЗИМИДАЗОЛОВ И БЕНЗОТИАЗОЛОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И НОВОЕ ПРИМЕНЕНИЕ, В ЧАСТНОСТИ, В КАЧЕСТВЕ ИНГИБИТОРОВ Cmet |
BRPI0616754-3A BRPI0616754A2 (pt) | 2005-09-27 | 2006-09-25 | derivados de benzimidazóis e benzotiazóis, o respectivo processo de preparo, respectivos medicamentos, composições farmacêuticas e utilização |
TW095135816A TW200745048A (en) | 2005-09-27 | 2006-09-27 | Novel benzimidazole and benzothiazole derivatives, preparation process therefor, application thereof as medicaments, pharmaceutical compositions and novel use especially as CMET inhibitors |
UY29814A UY29814A1 (es) | 2005-09-27 | 2006-09-27 | Derivados nuevos de bencimidazoles y benzotiazoles, su proceso de preparación, su aplicación como medicamentos, composiciones farmacéuticas y utilización nueva principalmente como inhibidores de cmet |
IL189961A IL189961A0 (en) | 2005-09-27 | 2008-03-05 | Novel benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use in particular as c-met inhibitors |
US12/054,719 US8110571B2 (en) | 2005-09-27 | 2008-03-25 | Benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use especially as c-MET inhibitors |
NO20081944A NO20081944L (no) | 2005-09-27 | 2008-04-23 | Nye benzimidazol- og benzothiazolderivater, fremgangsmate for fremstilling, anvendelse derav som legemiddel, samt farmasoytiske sammensetninger og ny anvendelse spesielt som C-Met inhibitorer |
MA30876A MA29922B1 (fr) | 2005-09-27 | 2008-04-24 | NOUVEAUX DERIVES DE BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE CMet |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0509850A FR2891273B1 (fr) | 2005-09-27 | 2005-09-27 | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2891273A1 FR2891273A1 (fr) | 2007-03-30 |
FR2891273B1 true FR2891273B1 (fr) | 2007-11-23 |
Family
ID=35911217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0509850A Expired - Fee Related FR2891273B1 (fr) | 2005-09-27 | 2005-09-27 | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet |
Country Status (20)
Country | Link |
---|---|
US (1) | US8110571B2 (fr) |
EP (1) | EP1934187A1 (fr) |
JP (1) | JP2009510033A (fr) |
KR (1) | KR20080050438A (fr) |
CN (1) | CN101273019A (fr) |
AR (1) | AR056528A1 (fr) |
AU (1) | AU2006296468B2 (fr) |
BR (1) | BRPI0616754A2 (fr) |
CA (1) | CA2620857A1 (fr) |
EA (1) | EA014315B1 (fr) |
FR (1) | FR2891273B1 (fr) |
IL (1) | IL189961A0 (fr) |
MA (1) | MA29922B1 (fr) |
NO (1) | NO20081944L (fr) |
NZ (1) | NZ566568A (fr) |
SG (1) | SG165381A1 (fr) |
TW (1) | TW200745048A (fr) |
UY (1) | UY29814A1 (fr) |
WO (1) | WO2007036630A1 (fr) |
ZA (1) | ZA200802447B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2868421B1 (fr) | 2004-04-01 | 2008-08-01 | Aventis Pharma Sa | Nouveaux benzothiazoles et leur utilisation comme medicaments |
FR2922550B1 (fr) * | 2007-10-19 | 2009-11-27 | Sanofi Aventis | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
EP2483407A2 (fr) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Procédés de modulation de l'autophagie par la modulation de produits géniques renforçant l'autophagie |
KR20160024639A (ko) | 2014-08-26 | 2016-03-07 | 삼성전자주식회사 | c-Met 표적 치료제의 저항성 또는 효능 예측을 위한 바이오마커 PDGF |
WO2020188015A1 (fr) | 2019-03-21 | 2020-09-24 | Onxeo | Molécule dbait associée à un inhibiteur de kinase pour le traitement du cancer |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2541752A1 (de) * | 1975-09-19 | 1977-03-24 | Hoechst Ag | Anthelminthisch wirksame 2-carbalkoxyamino-5(6)-phenyl-sulfonyloxy- benzimidazole und verfahren zu ihrer herstellung |
JPS5914027B2 (ja) * | 1976-02-27 | 1984-04-02 | ヘキスト・アクチ−エンゲゼルシヤフト | 2−カルボアルコキシアミノ−5(6)−フエニルスルホニルオキシ−ベンズイミダゾ−ル化合物 |
DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
FR2751649B1 (fr) * | 1996-07-26 | 1998-08-28 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GB9900752D0 (en) * | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
WO2001057008A1 (fr) * | 2000-02-07 | 2001-08-09 | Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft | Derives de 2-benzothiazolyle uree et leur utilisation en tant qu'inhibiteurs de proteine kinase |
US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
US20050038022A1 (en) * | 2001-03-26 | 2005-02-17 | Unisearch Limited | Method for treatment of cancer and compositions for use therein |
EP1298125A1 (fr) * | 2001-09-26 | 2003-04-02 | Aventis Pharma S.A. | Benzimidazoles substitués et leur usage comme traitement du cancer |
FR2868421B1 (fr) * | 2004-04-01 | 2008-08-01 | Aventis Pharma Sa | Nouveaux benzothiazoles et leur utilisation comme medicaments |
-
2005
- 2005-09-27 FR FR0509850A patent/FR2891273B1/fr not_active Expired - Fee Related
-
2006
- 2006-09-25 ZA ZA200802447A patent/ZA200802447B/xx unknown
- 2006-09-25 KR KR1020087007348A patent/KR20080050438A/ko not_active Application Discontinuation
- 2006-09-25 SG SG201006691-8A patent/SG165381A1/en unknown
- 2006-09-25 CN CNA2006800355055A patent/CN101273019A/zh active Pending
- 2006-09-25 AU AU2006296468A patent/AU2006296468B2/en not_active Ceased
- 2006-09-25 CA CA002620857A patent/CA2620857A1/fr not_active Abandoned
- 2006-09-25 BR BRPI0616754-3A patent/BRPI0616754A2/pt not_active IP Right Cessation
- 2006-09-25 AR ARP060104155A patent/AR056528A1/es unknown
- 2006-09-25 WO PCT/FR2006/002183 patent/WO2007036630A1/fr active Application Filing
- 2006-09-25 JP JP2008532821A patent/JP2009510033A/ja not_active Ceased
- 2006-09-25 NZ NZ566568A patent/NZ566568A/en not_active IP Right Cessation
- 2006-09-25 EA EA200800947A patent/EA014315B1/ru not_active IP Right Cessation
- 2006-09-25 EP EP06808199A patent/EP1934187A1/fr not_active Withdrawn
- 2006-09-27 UY UY29814A patent/UY29814A1/es not_active Application Discontinuation
- 2006-09-27 TW TW095135816A patent/TW200745048A/zh unknown
-
2008
- 2008-03-05 IL IL189961A patent/IL189961A0/en unknown
- 2008-03-25 US US12/054,719 patent/US8110571B2/en not_active Expired - Fee Related
- 2008-04-23 NO NO20081944A patent/NO20081944L/no not_active Application Discontinuation
- 2008-04-24 MA MA30876A patent/MA29922B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
WO2007036630A1 (fr) | 2007-04-05 |
TW200745048A (en) | 2007-12-16 |
US20080194555A1 (en) | 2008-08-14 |
AU2006296468A1 (en) | 2007-04-05 |
JP2009510033A (ja) | 2009-03-12 |
CN101273019A (zh) | 2008-09-24 |
NZ566568A (en) | 2012-05-25 |
BRPI0616754A2 (pt) | 2011-06-28 |
FR2891273A1 (fr) | 2007-03-30 |
ZA200802447B (en) | 2009-08-26 |
EP1934187A1 (fr) | 2008-06-25 |
KR20080050438A (ko) | 2008-06-05 |
EA014315B1 (ru) | 2010-10-29 |
NO20081944L (no) | 2008-06-19 |
EA200800947A1 (ru) | 2009-02-27 |
CA2620857A1 (fr) | 2007-04-05 |
UY29814A1 (es) | 2007-04-30 |
US8110571B2 (en) | 2012-02-07 |
SG165381A1 (en) | 2010-10-28 |
AR056528A1 (es) | 2007-10-10 |
MA29922B1 (fr) | 2008-11-03 |
AU2006296468B2 (en) | 2012-10-18 |
IL189961A0 (en) | 2008-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2922550B1 (fr) | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet | |
ES2439244T8 (es) | Inhibidores de serina proteasa tipo tripsina, su preparación y uso | |
HK1125368A1 (en) | Chromane substituted benzimidazoles and their use as acid pump inhibitors | |
BRPI0720124A2 (pt) | Composições farmacêuticas e seus métodos de uso. | |
DK3421471T3 (da) | Purin- og deazapurinderivater som farmaceutiske forbindelser | |
CR10743A (es) | Derivados de azaadamantano y metodos de uso de los mismos | |
BRPI0821499A2 (pt) | Artigos de filtração de fluído e métodos de preparo e uso dos mesmos | |
FR2891273B1 (fr) | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet | |
PL1861387T3 (pl) | Pochodne benzoimidazolu i ich kompozycje farmaceutyczne | |
FR2903985B1 (fr) | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique | |
CR10709A (es) | Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas | |
BRPI0808013A2 (pt) | Compostos de quinoxalina e uso dos mesmos | |
BRPI0812909A2 (pt) | Derivados de guanina policíclica e métodos de uso dos mesmos. | |
BRPI0808025A2 (pt) | Composto de benzimidazol e uso farmacêutico do mesmo | |
BRPI0821558A2 (pt) | virus da estomatite vesicular atenuado geneticamente modificado, ecomposições e métodos de uso dessas | |
FR2896504B1 (fr) | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases | |
BRPI0909954A2 (pt) | "diazacarbazóis e métodos de uso" | |
MA28941B1 (fr) | Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases | |
BRPI0907236A2 (pt) | inibidores de proteína quinase e uso dos mesmos | |
SMT201300080B (it) | Derivati di carbammati di alchiltiazoli, loro preparazione e loro utilizzo come inibitori dell'enzima faah | |
BRPI0808054A2 (pt) | análogos de indenoisoquinolinona e métodos de uso dos mesmos | |
BRPI0915527A2 (pt) | pepitídeos, composição farmacêutica e exossomos compreendendo os mesmos, métodos e usos | |
BRPI0907706A2 (pt) | Composto, uso do dito composto e composição farmacéutica compreendendo o dito composto | |
BRPI0720323A2 (pt) | composto, método de tratamento, composição farmacêutica e uso do composto | |
FR2907120B1 (fr) | Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20140530 |