HRP20221255T1 - Postupak za pripremu biljnih ekstrakata - Google Patents

Postupak za pripremu biljnih ekstrakata Download PDF

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HRP20221255T1
HRP20221255T1 HRP20221255TT HRP20221255T HRP20221255T1 HR P20221255 T1 HRP20221255 T1 HR P20221255T1 HR P20221255T T HRP20221255T T HR P20221255TT HR P20221255 T HRP20221255 T HR P20221255T HR P20221255 T1 HRP20221255 T1 HR P20221255T1
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process according
mixture
extractor
added
root
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HRP20221255TT
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Kirti S. LADDHA
Shreeram N Agharkar
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Moleac Pte Ltd.
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Publication of HRP20221255T1 publication Critical patent/HRP20221255T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/882—Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
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  • Zoology (AREA)
  • Insects & Arthropods (AREA)
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  • Urology & Nephrology (AREA)
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Claims (14)

1. Postupak za pripremu mješavine biljnih ekstrakata, pri čemu se postupak sastoji od dodavanja: (i) Radix Astragali (korijen od membranskog kozlinca ili Huang Qi); (ii) Rhizome od Ligusticum Chuanxiong (Chuan Xiong); (iii) Radix Angelicae sinensis (korijen kineske anđelike ili Dang Gui); (iv) Radix Polygalae (korijen tankolisne mlječike, Polygala tenuifolia Willd., Polygala sibirica L. ili Yuanzhi) u ekstraktor kao sušene biljke u težinskom omjeru sušenih biljaka 5:1:1:1 od (i):(ii):(iii):(iv) i zagrijavanje mješavine sušenih biljaka u hidro-alkoholnom otapalu, za proizvodnju otopine koja sadrži mješavinu biljnih ekstrakata.
2. Postupak prema patentnom zahtjevu 1, pri čemu se sljedeće bilje također dodaje u ekstraktor prije zagrijavanja mješavine u hidro-alkoholnom otapalu: a) Radix et Rhizoma Salviae Miltiorrhizae (korijen crvene kadulje ili Dan Shen); b) Radix Paeoniae rubra (korijen crvenog božura); c) cvijet Carthamus Tinctorius (šafranika ili HongHua); d) sjeme Persicae (sjemenke Prunus Persica ili Taoren); e) Rhizoma Acori tatarinowii (rizom močvarnog ljiljana ili Shichangpu).
3. Postupak prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, pri čemu je alkohol u hidro-alkoholnom otapalu etanol.
4. Postupak prema bilo kojem patentnom zahtjevu 1 do 3, pri čemu je koncentracija alkohola ekstrakcijske mješavine u rasponu od 69% v/v do 75% v/v.
5. Postupak prema bilo kojem od patentnih zahtjeva 1 do 3, pri čemu je koncentracija alkohola ekstrakcijske mješavine 72% v/v.
6. Postupak prema bilo kojem od patentnih zahtjeva 2 do 5, pri čemu je svaka biljka dodana u ekstraktor kao sušena biljka.
7. Postupak prema bilo kojem od patentnih zahtjeva 2 do 5, pri čemu su jedna ili više biljaka prethodno tretirane kako bi se uklonilo hlapljivo ulje i dodane u ekstraktor kao biljni ostatak i dekokt.
8. Postupak prema bilo kojem od patentnih zahtjeva 2 do 5, pri čemu je Rhizoma Acori tatarinowii dodan u ekstraktor u obliku biljnih ostataka i dekokta, dok su preostale biljke dodane u ekstraktor kao sušene biljke.
9. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu se mješavina zagrijava i održava na temperaturi u rasponu od 50°C do 90°C.
10. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu se mješavina zagrijava i povišena temperatura održava 60 minuta do 240 minuta.,
11. Postupak prema bilo kojem od patentnih zahtjeva 2 do 10, pri čemu se Rhizoma acori Tatarinowii dodaje u ekstraktor nakon obrade kako bi se smanjila razina beta azarona u Rhizoma acori Tatarinowii.
12. Postupak prema patentnom zahtjevu 11, pri čemu se razina beta azarona smanjuje putem hidro-destilacije ili parne destilacije.
13. Postupak prema bilo kojem prethodnom patentnom zahtjevu, pri čemu se biljke, prije dodavanja u ekstraktor, podvrgavaju jednom ili više od sljedećih koraka prethodne obrade: (1) čišćenje; (2) sušenje; (3) povećanje površinskog područja.
14. Postupak prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu se otopina koja sadrži mješavinu biljnog ekstrakta podvrgava sljedećim koracima: (1) odvajanje čestičnog materijala od ekstrakcijske otopine i zatim (2) koncentriranje ekstrakcijske otopine uklanjanjem otapala da bi se dobio koncentrirani ekstrakt u obliku paste ili sirupa.
HRP20221255TT 2015-09-14 2016-09-13 Postupak za pripremu biljnih ekstrakata HRP20221255T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG10201507607RA SG10201507607RA (en) 2015-09-14 2015-09-14 Process For Producing Traditional Chinese Medicine Compositions, And Compositions Obtainable By The Process
PCT/SG2016/050444 WO2017048191A1 (en) 2015-09-14 2016-09-13 Process for preparing herbal extracts
EP16846968.2A EP3349772B1 (en) 2015-09-14 2016-09-13 Process for preparing herbal extracts

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HRP20221255T1 true HRP20221255T1 (hr) 2022-12-23

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US (1) US10463707B2 (hr)
EP (1) EP3349772B1 (hr)
JP (2) JP2018531915A (hr)
KR (1) KR102323567B1 (hr)
CN (2) CN113893278A (hr)
AU (1) AU2016322351B2 (hr)
BR (1) BR112018004939B1 (hr)
CA (1) CA2998577A1 (hr)
DK (1) DK3349772T3 (hr)
ES (1) ES2928369T3 (hr)
HK (1) HK1252102A1 (hr)
HR (1) HRP20221255T1 (hr)
HU (1) HUE060248T2 (hr)
LT (1) LT3349772T (hr)
MX (1) MX2018003135A (hr)
MY (1) MY191037A (hr)
PL (1) PL3349772T3 (hr)
PT (1) PT3349772T (hr)
RS (1) RS63678B1 (hr)
RU (1) RU2723945C2 (hr)
SG (1) SG10201507607RA (hr)
SI (1) SI3349772T1 (hr)
WO (1) WO2017048191A1 (hr)

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JP7137225B2 (ja) * 2017-08-21 2022-09-14 国立大学法人三重大学 非ヒト哺乳類の脳梗塞モデルによる観察方法及び非ヒト哺乳類の脳梗塞モデルによる観察装置
CN108404450B (zh) * 2018-05-18 2023-06-20 河南莱帕克化工设备制造有限公司 通用型天然产物提取综合生产线
CN109394826B (zh) * 2018-09-29 2021-07-13 兰州大学 一种蜜炙红芪饮片的制备方法
CN110013519A (zh) * 2019-04-22 2019-07-16 沈阳国和医疗科技有限公司 一种治疗高血压的药物配方
CN110893225A (zh) * 2019-11-15 2020-03-20 朱海真 一种用于治疗帕金森病的组合中药配方
CN112972638B (zh) * 2021-04-20 2022-02-15 南方医科大学 治疗银屑病中药在制备防治心肌缺血再灌注损伤药物中的应用
CN113759062B (zh) * 2021-06-30 2023-03-21 北京康仁堂药业有限公司 一种快速筛查石菖蒲不同产地的方法
CN114432391A (zh) * 2022-02-17 2022-05-06 刘红亮 一种用于治疗脑病的外用膏剂及其制备方法
CN115004897A (zh) * 2022-04-06 2022-09-06 西南民族大学 川赤芍种子的萌发方法
WO2023250515A1 (en) * 2022-06-24 2023-12-28 Moleac Pte. Ltd. Spinal cord regeneration therapy
WO2024058722A1 (en) 2022-09-15 2024-03-21 Moleac Pte Ltd. Treating inflammation

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10324636A (ja) * 1997-03-28 1998-12-08 Toru Mihara 視覚障害の予防・改善剤
JP2002524419A (ja) * 1998-09-07 2002-08-06 パンディタ、マハライ・クリシェン 哺乳類において精神能力を改善するための組成物
CN1273156C (zh) * 2004-09-06 2006-09-06 青岛国风药业股份有限公司 一种治疗血管性痴呆的中药口服制剂
CN100443094C (zh) * 2004-09-06 2008-12-17 青岛国风药业股份有限公司 一种治疗中风病的口服中药组合物
KR100661132B1 (ko) * 2005-05-11 2006-12-26 한국과학기술연구원 숙취 해소용 조성물 및 이의 제조 방법
CN1709486A (zh) * 2005-06-24 2005-12-21 王衡新 补气安神的中药制剂及其制备方法
WO2007022710A1 (fr) 2005-08-24 2007-03-01 Tianjin Tasly Pharmaceutical Co. Ltd. Compositions a base de medecine chinoise pour le traitement de cephalees, formulations et procedes de preparation
WO2007106049A1 (en) 2006-03-16 2007-09-20 Moleac Pte Ltd Combination therapy for treatment of patients with neurological disorders and cerebral infarction
CN1883591A (zh) * 2006-05-18 2006-12-27 张江 一种治疗肩周炎的中药
CN100546615C (zh) * 2006-11-09 2009-10-07 天津市石天药业有限责任公司 用于治疗脑血管病的中药组合物及其制备方法
CN100473410C (zh) * 2006-11-15 2009-04-01 北京万寿通医药科技有限公司 一种治疗中风后遗症的中药制剂
CN101244208B (zh) * 2008-03-25 2010-05-12 中国人民解放军第三医院 一种治疗抑郁症及焦虑症的中药制剂的制备方法
HUE046494T2 (hu) 2008-11-10 2020-03-30 Moleac Pte Ltd Kombinációs kezelés neurológiai rendellenességekben és agyi infarktusban szenvedõ pácienseknek
TR201911199T4 (tr) 2009-03-27 2019-08-21 Moleac Pte Ltd Hücre büyümesini arttırmak için tedavi.
CN101524470B (zh) * 2009-04-17 2012-05-16 山东大学齐鲁医院 一种防治心血管疾病支架再狭窄的中药制剂及制备方法
CN102451126B (zh) * 2010-10-15 2013-05-01 台盐实业股份有限公司 育发化妆品组合物及其制造方法
CN102078520B (zh) 2011-01-10 2012-07-04 董春玲 一种治疗神经性头痛的中药制剂及其制备方法
SI2838545T1 (sl) * 2012-03-23 2020-04-30 Moleac Pte Ltd. Sestavek za zaščito živčevja, ki obsega polygalae, astragali, chuanxiong in angelico sinensis
CN102600321B (zh) * 2012-04-16 2013-12-11 山东省中医药研究院 一种用于治疗缺血性脑血管病中药复方制剂及其制备方法
CN102716459B (zh) * 2012-05-08 2014-06-18 四川中方制药有限公司 一种治疗老年轻度认知障碍的中药组合物及其制备方法
CN102847061B (zh) * 2012-08-22 2014-05-21 张萍 一种治疗小儿病毒性心肌炎的中药制剂及其制备方法
CN102846824B (zh) * 2012-08-28 2014-07-02 杨高林 一种治疗寒湿血瘀阻络型糖尿病足的中药组合物及其制备方法
CN102886026B (zh) * 2012-10-18 2013-10-23 邱中乔 草本黑发液
CN104645184A (zh) * 2013-11-20 2015-05-27 北大方正集团有限公司 一种治疗老年痴呆的中药组合物
CN103705845A (zh) * 2013-12-17 2014-04-09 吉林大学 一种防治老年痴呆中药组合制剂及其制备方法
CN103947888B (zh) 2014-05-09 2015-09-09 山东新希望六和集团有限公司 一种用于改善肉质风味的羔羊饲料及其制备方法
CN104225417A (zh) * 2014-08-19 2014-12-24 长春中医药大学 一种辅助改善记忆力功能的中药组合物及其制备方法
CN104258040A (zh) * 2014-09-13 2015-01-07 济南前程知识产权咨询有限公司 一种治疗神经衰弱的中药
CN104383464A (zh) * 2014-12-10 2015-03-04 高田田 一种治疗卵巢癌的中药组合物

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