HRP20201847T1 - Postupak za pripremu spoja diariltiohidantoina - Google Patents

Postupak za pripremu spoja diariltiohidantoina

Info

Publication number
HRP20201847T1
HRP20201847T1 HRP20201847TT HRP20201847T HRP20201847T1 HR P20201847 T1 HRP20201847 T1 HR P20201847T1 HR P20201847T T HRP20201847T T HR P20201847TT HR P20201847 T HRP20201847 T HR P20201847T HR P20201847 T1 HRP20201847 T1 HR P20201847T1
Authority
HR
Croatia
Prior art keywords
preparation
diarylthiohydantoin compound
diarylthiohydantoin
compound
Prior art date
Application number
HRP20201847TT
Other languages
English (en)
Inventor
Cyril BEN HAIM
Andras Horvath
Johan Erwin Edmond Weerts
Original Assignee
Aragon Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aragon Pharmaceuticals, Inc. filed Critical Aragon Pharmaceuticals, Inc.
Publication of HRP20201847T1 publication Critical patent/HRP20201847T1/hr
Publication of HRP20201847T2 publication Critical patent/HRP20201847T2/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J27/00Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
    • B01J27/14Phosphorus; Compounds thereof
    • B01J27/186Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
    • B01J27/195Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium with vanadium, niobium or tantalum
    • B01J27/198Vanadium
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J37/00Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
    • B01J37/04Mixing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HRP20201847TT 2014-12-19 2020-11-20 Postupak za pripremu spoja diariltiohidantoina HRP20201847T2 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462094436P 2014-12-19 2014-12-19
EP18169756.6A EP3372584B9 (en) 2014-12-19 2015-12-17 Process for the preparation of a diarylthiohydantoin compound

Publications (2)

Publication Number Publication Date
HRP20201847T1 true HRP20201847T1 (hr) 2021-03-19
HRP20201847T2 HRP20201847T2 (hr) 2021-05-28

Family

ID=55168400

Family Applications (3)

Application Number Title Priority Date Filing Date
HRP20220750TT HRP20220750T1 (hr) 2014-12-19 2015-12-17 Postupak za proizvodnju spoja diariltiohidantoina
HRP20190540TT HRP20190540T1 (hr) 2014-12-19 2019-03-19 Postupak za pripremu spoja diariltiohidantoina
HRP20201847TT HRP20201847T2 (hr) 2014-12-19 2020-11-20 Postupak za pripremu spoja diariltiohidantoina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HRP20220750TT HRP20220750T1 (hr) 2014-12-19 2015-12-17 Postupak za proizvodnju spoja diariltiohidantoina
HRP20190540TT HRP20190540T1 (hr) 2014-12-19 2019-03-19 Postupak za pripremu spoja diariltiohidantoina

Country Status (33)

Country Link
US (1) US9688655B2 (hr)
EP (4) EP3233803B1 (hr)
JP (2) JP6681902B2 (hr)
KR (1) KR102586059B1 (hr)
CN (1) CN107108507A (hr)
AR (1) AR103228A1 (hr)
AU (1) AU2015364537B2 (hr)
BR (1) BR112017013113B1 (hr)
CA (1) CA2970937A1 (hr)
CY (2) CY1121684T1 (hr)
DK (3) DK3233803T3 (hr)
EA (4) EA201892487A1 (hr)
ES (3) ES2718539T3 (hr)
HR (3) HRP20220750T1 (hr)
HU (2) HUE042409T2 (hr)
IL (1) IL252843A0 (hr)
LT (3) LT3372585T (hr)
MA (1) MA41200B1 (hr)
MD (1) MD3233803T2 (hr)
ME (1) ME03420B (hr)
MX (1) MX2017008179A (hr)
NZ (1) NZ732766A (hr)
PH (1) PH12017501152A1 (hr)
PL (3) PL3233803T3 (hr)
PT (3) PT3233803T (hr)
RS (3) RS61060B9 (hr)
SG (4) SG10201912802XA (hr)
SI (3) SI3372584T1 (hr)
TR (1) TR201904739T4 (hr)
TW (4) TWI753336B (hr)
UA (1) UA123201C2 (hr)
WO (1) WO2016100652A2 (hr)
ZA (1) ZA201704877B (hr)

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LT3233823T (lt) * 2014-12-19 2019-04-10 Aragon Pharmaceuticals, Inc. Diariltiohidantoino junginio gamybos būdai
BR112017013113B1 (pt) * 2014-12-19 2023-11-21 Aragon Pharmaceuticals, Inc. Processo para a preparação de um composto de diaril tio-hidantoína
CN108069869B (zh) * 2016-11-09 2022-03-01 上海医药工业研究院 一种Apalutamide的制备方法及其中间体
TW201831461A (zh) * 2017-01-18 2018-09-01 台灣神隆股份有限公司 製備阿帕魯醯胺的方法
US10364245B2 (en) 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
CN107501237B (zh) * 2017-08-17 2022-03-22 上海西浦医药科技有限公司 一种Apalutamide的合成方法
CN108383749B (zh) * 2018-01-30 2021-03-09 杭州科巢生物科技有限公司 阿帕鲁胺的合成方法及其中间体
US10513504B2 (en) 2018-03-08 2019-12-24 Apotex Inc. Processes for the preparation of apalutamide and intermediates thereof
CN108314646B (zh) * 2018-04-11 2021-03-19 武汉慧敏科技中心 一种高分散双金属纳米材料制备泌尿生殖***用药物中间体的方法
CN109651256A (zh) * 2018-11-20 2019-04-19 上海健康医学院 一种式(viii)的恩杂鲁胺的制备方法
CN110511206A (zh) * 2019-06-17 2019-11-29 扬子江药业集团江苏海慈生物药业有限公司 芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN110511207A (zh) * 2019-06-17 2019-11-29 扬子江药业集团江苏海慈生物药业有限公司 芳基-2-硫代海因类化合物中间体、其制备方法及应用
EP4208451A1 (en) 2020-09-04 2023-07-12 Synthon B.V. Improved process for preparation of apalutamide
CN113292535B (zh) * 2021-06-18 2022-07-01 南京方生和医药科技有限公司 一种制备阿帕鲁胺中间体及阿帕鲁胺的方法
CN113402466B (zh) * 2021-06-18 2022-08-16 南京方生和医药科技有限公司 一种阿帕鲁胺中间体及制备阿帕鲁胺的方法
CN115850233A (zh) * 2021-09-24 2023-03-28 南京方生和医药科技有限公司 一种阿帕鲁胺的合成方法
CN115536634A (zh) * 2022-10-17 2022-12-30 上海博悦生物科技有限公司 一种阿帕他胺的合成方法

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US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
TWI263640B (en) * 2001-12-19 2006-10-11 Bristol Myers Squibb Co Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
LT3412290T (lt) * 2006-03-27 2021-04-26 The Regents Of The University Of California Androgeno receptorių moduliatorius, skirtas prostatos vėžio bei su androgeno receptoriais susijusių ligų gydymui
US8461343B2 (en) 2007-03-27 2013-06-11 Sloan-Kettering Institute For Cancer Research Synthesis of thiohydantoins
AR071811A1 (es) 2008-05-16 2010-07-14 Takeda Pharmaceutical Derivados de diazol como activadores de glucoquinasa
BR112012015868A2 (pt) * 2009-12-11 2017-06-20 Autifony Therapeutics Ltd derivados de imidazolidinadiona
EA028869B1 (ru) * 2010-02-16 2018-01-31 Арагон Фармасьютикалс, Инк. Модуляторы рецептора андрогенов и их применение
ES2671343T3 (es) * 2010-02-24 2018-06-06 Medivation Prostate Therapeutics Llc Procesos para la síntesis de compuestos de diariltiohidantoína y diarilhidantoína
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WO2013029338A1 (en) * 2011-09-01 2013-03-07 Glaxo Group Limited Novel compounds
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BR112017013113B1 (pt) * 2014-12-19 2023-11-21 Aragon Pharmaceuticals, Inc. Processo para a preparação de um composto de diaril tio-hidantoína

Also Published As

Publication number Publication date
SG10201912802XA (en) 2020-02-27
JP6903785B2 (ja) 2021-07-14
LT3233803T (lt) 2019-04-10
RS61060B9 (sr) 2021-07-30
EA201892487A1 (ru) 2019-07-31
HRP20220750T1 (hr) 2022-09-02
IL252843A0 (en) 2017-08-31
EA201892486A1 (ru) 2019-07-31
KR20170095976A (ko) 2017-08-23
PH12017501152A1 (en) 2017-11-27
PL3372584T3 (pl) 2021-07-05
KR102586059B1 (ko) 2023-10-05
AU2015364537B2 (en) 2020-10-08
TW201945343A (zh) 2019-12-01
JP6681902B2 (ja) 2020-04-15
EP3372585B1 (en) 2022-03-30
PL3233803T3 (pl) 2019-07-31
MX2017008179A (es) 2017-09-18
EP3233803A2 (en) 2017-10-25
ME03420B (me) 2020-01-20
DK3233803T3 (en) 2019-04-08
ES2827549T3 (es) 2021-05-21
SI3372584T1 (sl) 2021-08-31
SG10201912805SA (en) 2020-02-27
MA41200A (fr) 2017-10-25
LT3372584T (lt) 2020-12-10
DK3372584T3 (da) 2021-01-04
RS61060B1 (sr) 2020-12-31
CY1121684T1 (el) 2020-07-31
ES2919951T3 (es) 2022-07-29
EP3372584A1 (en) 2018-09-12
EP3372585A1 (en) 2018-09-12
WO2016100652A3 (en) 2016-08-25
SI3233803T1 (sl) 2019-05-31
PT3372584T (pt) 2020-11-13
PT3372585T (pt) 2022-07-08
AU2015364537A1 (en) 2017-07-06
CN107108507A (zh) 2017-08-29
TW201945342A (zh) 2019-12-01
MD3233803T2 (ro) 2019-07-31
SI3372585T1 (sl) 2022-08-31
CY1123611T1 (el) 2022-03-24
AR103228A1 (es) 2017-04-26
US20160176845A1 (en) 2016-06-23
RS58454B1 (sr) 2019-04-30
ES2718539T3 (es) 2019-07-02
BR112017013113B1 (pt) 2023-11-21
BR112017013113A2 (pt) 2017-12-26
RS63455B1 (sr) 2022-08-31
PT3233803T (pt) 2019-05-20
DK3372585T3 (da) 2022-05-30
TR201904739T4 (tr) 2019-05-21
CA2970937A1 (en) 2016-06-23
HRP20190540T1 (hr) 2019-06-14
US9688655B2 (en) 2017-06-27
JP2020114842A (ja) 2020-07-30
TWI683810B (zh) 2020-02-01
WO2016100652A2 (en) 2016-06-23
EP3372584B9 (en) 2021-03-31
TW202031639A (zh) 2020-09-01
ES2827549T9 (es) 2021-07-02
MA41200B1 (fr) 2019-05-31
TWI753336B (zh) 2022-01-21
JP2018501237A (ja) 2018-01-18
DK3372584T5 (da) 2021-05-17
EA201791390A1 (ru) 2017-10-31
EP3372586A1 (en) 2018-09-12
EP3372584B1 (en) 2020-09-23
TW201639825A (zh) 2016-11-16
TWI689494B (zh) 2020-04-01
SG10201912811QA (en) 2020-02-27
TWI703132B (zh) 2020-09-01
SG11201704969QA (en) 2017-07-28
LT3372585T (lt) 2022-07-11
HUE052475T2 (hu) 2021-05-28
EP3233803B1 (en) 2019-01-30
HUE042409T2 (hu) 2019-06-28
NZ732766A (en) 2023-07-28
HRP20201847T2 (hr) 2021-05-28
PL3372585T3 (pl) 2022-10-10
EA201892485A1 (ru) 2019-07-31
ZA201704877B (en) 2019-02-27
UA123201C2 (uk) 2021-03-03

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