HRP20200415T1 - Anti-ceacam5 protutijela i njihova uporaba - Google Patents

Anti-ceacam5 protutijela i njihova uporaba Download PDF

Info

Publication number
HRP20200415T1
HRP20200415T1 HRP20200415TT HRP20200415T HRP20200415T1 HR P20200415 T1 HRP20200415 T1 HR P20200415T1 HR P20200415T T HRP20200415T T HR P20200415TT HR P20200415 T HRP20200415 T HR P20200415T HR P20200415 T1 HRP20200415 T1 HR P20200415T1
Authority
HR
Croatia
Prior art keywords
sequence
antibody
immunoconjugate
seq
cancer
Prior art date
Application number
HRP20200415TT
Other languages
English (en)
Inventor
Pierre-François BERNE
Francis Blanche
Hervé Bouchard
Béatrice Cameron
Tarik Dabdoubi
Stéphanie DECARY
Paul Ferrari
Alexey RAK
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of HRP20200415T1 publication Critical patent/HRP20200415T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6853—Carcino-embryonic antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57473—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen, i.e. CEA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

Claims (22)

1. Protutijelo koje sadrži teški lanac i laki lanac naznačeno time što varijabilna domena teškog lanca sadrži sekvencu SEQ ID NO: 5, ili sekvencu koja je najmanje 85% identična s njom, CDR1-H od sekvence SEQ ID NO:7, CDR2-H od sekvence SEQ ID NO:8, i CDR3-H od sekvence SEQ ID NO:9, te varijabilna domena lakog lanca sadrži sekvencu SEQ ID NO: 29, ili sekvencu koja je najmanje 85% identična s njom, CDR1-L od sekvence SEQ ID NO:10, CDR2-L od sekvence NTR i CDR3-L od sekvence SEQ ID NO:12.
2. Protutijelo prema patentnom zahtjevu 1 naznačeno time što varijabilna domena teškog lanca sadrži sekvencu SEQ ID NO: 5, ili sekvencu koja je najmanje 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% ili 99% identična s njom.
3. Protutijelo prema patentnom zahtjevu 1 naznačeno time što varijabilna domena lakog lanca sadrži sekvencu SEQ ID NO: 29, ili sekvencu koja je najmanje 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% ili 99% identična s njom.
4. Protutijelo prema patentnom zahtjevu 1 naznačeno time što protutijelo sadrži teški lanac koji sadrži sekvencu SEQ ID NO:87, ili sekvencu koja je najmanje 85% identična s njom, te laki lanac koji sadrži sekvencu SEQ ID NO:88, ili sekvencu koja je najmanje 85% identična s njom.
5. Izolirana nukleinska kiselina naznačena time što sadrži sekvencu koja kodira protutijelo prema bilo kojem od patentnih zahtjeva 1 do 4.
6. Stanica domaćin naznačena time što je transformirana nukleinskom kiselinom prema patentnom zahtjevu 5.
7. Imunokonjugat naznačen time što sadrži protutijelo prema bilo kojem od patentnih zahtjeva 1 do 4 konjugirano ili vezano na najmanje jedno sredstvo za inhibiciju rasta.
8. Imunokonjugat prema patentnom zahtjevu 7, naznačen time što je navedeno sredstvo za inhibiciju rasta citotoksično sredstvo ili radioaktivni izotop.
9. Imunokonjugat prema patentnom zahtjevu 7 ili 8, naznačen time što je navedeno sredstvo za inhibiciju rasta odabrano iz skupine koju čine kemoterapeutska sredstva, enzimi, antibiotici, i toksini kao što su toksini malih molekula ili enzimatski aktivni toksini, taksoidi, vinka, taksani, majtanzinoid ili analozi majtanzinoida, tomamicin ili derivati pirolobenzodiazepina, derivati kriptoficina, derivati leptomicina, analozi auristatina ili dolastatina, predlijekovi, inhibitori topoizomeraze II, DNA alkilirajuća sredstva, anti-tubulinska sredstva, te analozi CC-1065 ili CC-1065.
10. Imunokonjugat prema bilo kojem od patentnih zahtjeva 7 do 9, naznačen time što je navedeno sredstvo za inhibiciju rasta (N2'-deacetil-N2'-(3-merkapto-1-oksopropil)-majtanzin) DM1 ili N2'-deacetil-N-2'(4-metil-4-merkapto-1-oksopentil)-majtanzin (DM4).
11. Imunokonjugat prema bilo kojem od patentnih zahtjeva 7 do 10, naznačen time što je protutijelo kovalentno vezano preko cijepajućeg ili ne-cijepajućeg linkera na najmanje jedno sredstvo za inhibiciju rasta.
12. Imunokonjugat prema patentnom zahtjevu 11, naznačen time što je navedeni linker odabran iz skupine koju čine N-sukcinimidil piridilditiobutirat (SPDB), 4-(piridin-2-ildisulfanil)-2-sulfo-maslačna kiselina (sulfo-SPDB), i sukcinimidil (N-maleimidometil) cikloheksan-1-karboksilat (SMCC).
13. Imunokonjugat prema bilo kojem od patentnih zahtjeva 7 do 11 naznačen time što je protutijelo kovalentno vezano putem N-sukcinimidil piridilditiobutirata (SPDB) na N2'-deacetil-N-2'(4-metil-4-merkapto-1-oksopentil)-majtanzin (DM4).
14. Imunokonjugat prema bilo kojem od patentnih zahtjeva 7 do 13 naznačen time što protutijelo sadrži teški lanac koji sadrži sekvencu SEQ ID NO:87 i laki lanac koji sadrži sekvencu SEQ ID NO:88 i kovalentno je vezano putem N-sukcinimidil piridilditiobutirata (SPDB) na N2'-deacetil-N-2'(4-metil-4-merkapto-1-oksopentil)-majtanzin (DM4).
15. Farmaceutski pripravak naznačen time što sadrži protutijelo prema bilo kojem od patentnih zahtjeva 1 do 4 ili imunokonjugat prema bilo kojem od patentnih zahtjeva 7 do 14, te farmaceutski prihvatljiv nosač.
16. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 4, ili imunokonjugat prema bilo kojem od patentnih zahtjeva 7 do 14, ili farmaceutski pripravak prema patentnom zahtjevu 15, naznačen time što je za uporabu za liječenje raka.
17. Protutijelo ili imunokonjugat prema patentnom zahtjevu 16 naznačen time što rak je rak debelog crijeva, želuca, gastrični rak ili rak pluća.
18. Postupak za proizvodnju protutijela prema bilo kojem od patentnih zahtjeva 1 do 4, koji postupak obuhvaća korake koji se sastoje od: (i) kultiviranja transformirane stanice domaćina prema patentnom zahtjevu 6; (ii) eksprimiranje navedenog protutijela ili polipeptida; i (iii) izdvajanje eksprimiranog protutijela ili polipeptida.
19. Postupak prema patentnom zahtjevu 18 naznačen time što je navedeno protutijelo prikladno odvojeno iz medija za kultiviranje konvencionalnim postupcima pročišćavanja imunoglobulina.
20. Postupak za proizvodnju imunokonjugata ili imunokonjugat prema bilo kojem od patentnih zahtjeva 7 do 14 naznačen time što sadrži korake (i) dovođenje u kontakt po izboru puferirane vodene otopine protutijela prema bilo kojem od patentnih zahtjeva 1 do 4 s otopinama poveznice i citotoksičnog spoja, i (ii) zatim izborno odvajanje konjugata koji je nastao u (i) iz nereagiranog protutijela.
21. Postupak za proizvodnju imunokonjugata ili imunokonjugat prema patentnom zahtjevu 20 naznačen time što se nakon koraka (i) ili (ii), otopina koja sadrži konjugat može podvrgnuti dodatnom koraku (iii) kromatografije, ultrafiltracije i/ili diafiltracije.
22. Postupak za pripremu farmaceutskog pripravka koji sadrži protutijelo prema bilo kojem od patentnih zahtjeva 1 do 4 ili dobivenog postupkom prema patentnim zahtjevima 18 ili 19, ili imunokonjugat prema bilo kojem od patentnih zahtjeva 7 do 14 ili dobivenog postupkom prema patentnim zahtjevima 20 ili 21, naznačen time što je učinkovita količina navedenog protutijela ili navedenog imunokonjugata otopljena ili dispergirana u farmaceutski prihvatljivom nosaču ili vodenom mediju.
HRP20200415TT 2012-11-20 2020-03-13 Anti-ceacam5 protutijela i njihova uporaba HRP20200415T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12306444 2012-11-20
EP17157890.9A EP3199552B1 (en) 2012-11-20 2013-11-20 Anti-ceacam5 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
HRP20200415T1 true HRP20200415T1 (hr) 2020-06-26

Family

ID=47257727

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20170743TT HRP20170743T1 (hr) 2012-11-20 2017-05-17 Anti-ceacam5 protutijela i njihova uporaba
HRP20200415TT HRP20200415T1 (hr) 2012-11-20 2020-03-13 Anti-ceacam5 protutijela i njihova uporaba

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20170743TT HRP20170743T1 (hr) 2012-11-20 2017-05-17 Anti-ceacam5 protutijela i njihova uporaba

Country Status (39)

Country Link
US (4) US9617345B2 (hr)
EP (3) EP3594243A1 (hr)
JP (1) JP6324399B2 (hr)
KR (3) KR102661801B1 (hr)
CN (2) CN109180815B (hr)
AR (1) AR093557A1 (hr)
AU (2) AU2013349733C1 (hr)
BR (1) BR112015010993B1 (hr)
CA (2) CA3207769A1 (hr)
CL (1) CL2015001321A1 (hr)
CR (1) CR20150258A (hr)
CY (1) CY1119219T1 (hr)
DK (2) DK2922875T3 (hr)
DO (1) DOP2015000110A (hr)
EA (1) EA039377B1 (hr)
EC (1) ECSP15025845A (hr)
ES (2) ES2778823T3 (hr)
HK (1) HK1215444A1 (hr)
HR (2) HRP20170743T1 (hr)
HU (1) HUE033369T2 (hr)
IL (1) IL238559B (hr)
LT (2) LT2922875T (hr)
MA (1) MA38194B1 (hr)
MX (1) MX358321B (hr)
MY (1) MY171100A (hr)
NZ (1) NZ708528A (hr)
PE (1) PE20151180A1 (hr)
PH (1) PH12015501092B1 (hr)
PL (2) PL2922875T3 (hr)
PT (2) PT3199552T (hr)
RS (2) RS60043B1 (hr)
SG (1) SG11201503285TA (hr)
SI (2) SI3199552T1 (hr)
TN (1) TN2015000177A1 (hr)
TW (2) TWI664192B (hr)
UA (1) UA120247C2 (hr)
UY (1) UY35147A (hr)
WO (1) WO2014079886A1 (hr)
ZA (1) ZA201502959B (hr)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI664192B (zh) 2012-11-20 2019-07-01 法商賽諾菲公司 抗ｃｅａｃａｍ５抗體及其用途
US9753036B2 (en) 2014-04-29 2017-09-05 Edp Biotech Corporation Methods and compositions for screening and detecting biomarkers
CN113842468A (zh) * 2014-09-02 2021-12-28 伊缪诺金公司 用于配制抗体药物缀合物组合物的方法
AU2016329111A1 (en) 2015-10-02 2018-02-08 F. Hoffmann-La Roche Ag Bispecific anti-CEAXCD3 T cell activating antigen binding molecules
EP3400246B1 (en) 2016-01-08 2020-10-21 H. Hoffnabb-La Roche Ag Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies
AU2017343377A1 (en) * 2016-10-10 2019-05-02 Agency For Science, Technology And Research Anti-CEACAM6 antibodies and methods of use
AU2017360168B2 (en) 2016-11-18 2023-10-12 Astellas Pharma Inc. Novel anti-human MUC1 antibody Fab fragment
CN106749667B (zh) * 2016-12-04 2020-07-14 深圳市国创纳米抗体技术有限公司 一种抗癌胚抗原的纳米抗体及其应用
CN108341876B (zh) * 2017-01-22 2021-06-04 中国人民解放军第四军医大学 抗人ceacam5单克隆抗体及其制备方法和应用
CN106946989B (zh) * 2017-03-02 2020-02-18 深圳市国创纳米抗体技术有限公司 抗cea抗原vhh结构域及含有其的双特异性抗体
TWI795415B (zh) * 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
JP7028953B2 (ja) * 2017-07-11 2022-03-02 ファイザー・インク Ｃｅａ、ｍｕｃ１およびｔｅｒｔを含む免疫原性組成物
EP3502140A1 (en) 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules
CA3093477A1 (en) 2018-03-13 2019-09-19 Zymeworks Inc. Anti-her2 biparatopic antibody-drug conjugates and methods of use
EP3781592A4 (en) * 2018-04-20 2023-01-11 The Regents of the University of California TREATMENT OF PROSTATE CANCER WITH CHIMERIC ANTIGEN RECEPTORS
KR20210029158A (ko) 2018-06-03 2021-03-15 람카프 바이오 베타 엘티디. Ceacam5 및 cd47에 대한 이중특이성 항체
CN110684107B (zh) * 2018-07-06 2021-03-23 中国人民解放军第四军医大学 抗MG7-Ag的单克隆抗体(MGd1)及其用途
CN110684108B (zh) * 2018-07-06 2021-06-04 中国人民解放军第四军医大学 抗MG7-Ag的单克隆抗体(CEA37)及其用途
CA3109139A1 (en) 2018-08-30 2020-03-05 HCW Biologics, Inc. Methods of treating aging-related disorders
CN112996805A (zh) 2018-08-30 2021-06-18 Hcw生物科技公司 多链嵌合多肽和其用途
JP7407822B2 (ja) 2018-08-30 2024-01-04 エイチシーダブリュー バイオロジックス インコーポレイテッド 単鎖キメラポリペプチドおよびその使用
US20210355233A1 (en) * 2018-10-10 2021-11-18 Astellas Pharma Inc. Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
CN111487411B (zh) * 2019-01-29 2023-05-09 瑞博奥(广州)生物科技股份有限公司 Ceacam1多肽的新应用
EP3693023A1 (en) 2019-02-11 2020-08-12 Sanofi Use of anti-ceacam5 immunoconjugates for treating lung cancer
KR20210124260A (ko) 2019-02-07 2021-10-14 사노피 폐암을 치료하기 위한 항-ceacam5 면역접합체의 용도
WO2020216847A1 (en) * 2019-04-23 2020-10-29 Sanofi Stable, low-viscosity antibody formulations and uses thereof
US20220242968A1 (en) * 2019-06-04 2022-08-04 Biotheus Inc. Anti-CEACAM5 monoclonal antibody and preparation method thereof and use thereof
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
EP3983082A1 (en) 2019-06-13 2022-04-20 Bolt Biotherapeutics, Inc. Aminobenzazepine compounds, immunoconjugates, and uses thereof
AU2020294797A1 (en) 2019-06-21 2021-12-23 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
WO2020260326A1 (en) 2019-06-27 2020-12-30 F. Hoffmann-La Roche Ag Novel icos antibodies and tumor-targeted antigen binding molecules comprising them
EP4025254A1 (en) 2019-09-03 2022-07-13 Bolt Biotherapeutics, Inc. Aminoquinoline compounds, immunoconjugates, and uses thereof
WO2021053587A1 (en) 2019-09-18 2021-03-25 Klaus Strein Bispecific antibodies against ceacam5 and cd3
US20220347310A1 (en) 2019-09-30 2022-11-03 Bolt Biotherapeutics, Inc. Amide-linked, aminobenzazepine immunoconjugates, and uses thereof
BR112022007719A2 (pt) 2019-10-25 2022-07-12 Bolt Biotherapeutics Inc Imunoconjugados, composto ligante, composição farmacêutica, método para tratar câncer, uso de um imunoconjugado e método de preparação de um imunoconjugado
EP3831849A1 (en) 2019-12-02 2021-06-09 LamKap Bio beta AG Bispecific antibodies against ceacam5 and cd47
WO2021163298A1 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of activating regulatory t cells
AU2021219720A1 (en) 2020-02-11 2022-08-04 HCW Biologics, Inc. Chromatography resin and uses thereof
WO2021163369A2 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of treating age-related and inflammatory diseases
CN115427083A (zh) 2020-04-24 2022-12-02 赛诺菲 含有抗ceacam5抗体缀合物和西妥昔单抗的抗肿瘤组合
AU2021260823A1 (en) 2020-04-24 2023-01-05 Sanofi Antitumor combinations containing anti-CEACAM5 antibody conjugates and FOLFOX
IL297221A (en) 2020-04-24 2022-12-01 Sanofi Sa Antitumor combinations containing conjugates of antibodies to ceacam5 and folfiri
MX2022013404A (es) 2020-04-24 2022-11-14 Sanofi Sa Combinaciones antitumorales que contienen productos conjugados de anticuerpos anti-ceacam5, trifluridina y tipirazilo.
WO2021222587A1 (en) 2020-04-29 2021-11-04 HCW Biologics, Inc. Anti-cd26 proteins and uses thereof
JP2023524271A (ja) 2020-05-08 2023-06-09 ボルト バイオセラピューティクス、インコーポレーテッド エラスターゼ－基質ペプチドリンカーイムノコンジュゲート、及びそれらの使用
WO2021247003A1 (en) 2020-06-01 2021-12-09 HCW Biologics, Inc. Methods of treating aging-related disorders
EP4157460A1 (en) 2020-06-01 2023-04-05 HCW Biologics, Inc. Methods of treating aging-related disorders
CN111690061B (zh) * 2020-06-28 2022-08-23 中国人民解放军东部战区疾病预防控制中心 人源化抗鼠疫耶尔森菌抗原f1的抗体及应用
CN113201070B (zh) * 2020-08-04 2022-04-01 中山大学附属第五医院 抗ceacam5纳米抗体
KR20230051189A (ko) 2020-08-13 2023-04-17 볼트 바이오테라퓨틱스 인코퍼레이티드 피라졸로아제핀 면역접합체, 및 그의 용도
IL300497A (en) 2020-08-20 2023-04-01 A2 Biotherapeutics Inc Compositions and methods for treating CEACAM-positive cancer
WO2022040454A1 (en) 2020-08-20 2022-02-24 A2 Biotherapeutics, Inc. Compositions and methods for treating mesothelin positive cancers
US20220202946A1 (en) * 2020-11-10 2022-06-30 Sanofi Ceacam5 antibody-drug conjugate formulation
WO2022116079A1 (zh) * 2020-12-03 2022-06-09 上海吉倍生物技术有限公司 一种抗ceacam5的人源化抗体及其制备方法和用途
US20220195066A1 (en) 2020-12-11 2022-06-23 Bolt Biotherapeutics, Inc. Anti-cea immunoconjugates, and uses thereof
JP2024501453A (ja) 2020-12-11 2024-01-12 ボルト バイオセラピューティクス、インコーポレーテッド 抗ｃｅａイムノコンジュゲート、及びそれらの使用
CN112521509B (zh) * 2020-12-23 2022-07-08 姚雪英 一种抗ceacam5人源化抗体、其缀合物及其用途
IL306114A (en) 2021-03-26 2023-11-01 Bolt Biotherapeutics Inc 2-amino-4-carboxamide-benzazepine immunoconjugates and uses thereof
CN117769439A (zh) 2021-03-26 2024-03-26 博尔特生物治疗药物有限公司 2-氨基-4-甲酰胺-苯并氮杂卓免疫缀合物及其用途
CN117396516A (zh) * 2021-05-21 2024-01-12 百济神州有限公司 抗cea抗体和使用方法
WO2023057564A1 (en) 2021-10-07 2023-04-13 Sanofi IMIDAZO[4,5-c]QUINOLINE-4-AMINE COMPOUNDS AND CONJUGATES THEREOF, THEIR PREPARATION, AND THEIR THERAPEUTIC APPLICATIONS
CA3237142A1 (en) 2021-11-05 2023-05-11 Sanofi Antitumor combinations containing anti-ceacam5 antibody-drug conjugates and anti-vegfr-2 antibodies
WO2023099682A1 (en) 2021-12-02 2023-06-08 Sanofi Ceacam5 adc–anti-pd1/pd-l1 combination therapy
TW202339804A (zh) 2021-12-02 2023-10-16 法商賽諾菲公司 在癌症療法中用於患者選擇的ｃｅａ測定
WO2023164610A2 (en) * 2022-02-25 2023-08-31 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2b antibodies
WO2023168363A1 (en) 2022-03-02 2023-09-07 HCW Biologics, Inc. Method of treating pancreatic cancer
TW202346354A (zh) * 2022-03-09 2023-12-01 德商馬克專利公司 抗ceacam5抗體及其結合物及用途
WO2023180489A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen
US20240124607A1 (en) 2022-08-10 2024-04-18 Merck Sharp & Dohme Llc Proteins binding nkg2d, cd16, and ceacam5

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4640A (en) 1846-07-14 Book-lock
US144A (en) 1837-03-11 Improvement in scythe-snaths
US5204A (en) 1847-07-24 james cantelo
US244A (en) 1837-06-30 Edward flint
US4301A (en) 1845-12-11 Ebenezbr barrows
US417A (en) 1837-09-28 Endless-ghain horse-power for driving iviaci-iii
US4670A (en) 1846-07-28 Improvement in fish-hooks
US835A (en) 1838-07-12 X i i i x
US689A (en) 1838-04-13 Julius austin
US4496A (en) 1846-05-02 Machinery for
US4791A (en) 1846-10-03 john g
US192A (en) 1837-05-15 Machine for cutting
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
EP0028683A1 (en) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
WO1981001145A1 (en) 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
WO1982001188A1 (en) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd 4,5-deoxymaytansinoide compounds and process for preparing same
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
EP0272253A4 (en) 1986-03-07 1990-02-05 Massachusetts Inst Technology METHOD FOR IMPROVING GLYCOPROTE INSTABILITY.
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5278056A (en) 1988-02-05 1994-01-11 The Trustees Of Columbia University In The City Of New York Retroviral packaging cell lines and process of using same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5670488A (en) 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
ATE255131T1 (de) 1991-06-14 2003-12-15 Genentech Inc Humanisierter heregulin antikörper
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5215534A (en) 1991-12-02 1993-06-01 Lawrence De Harde Safety syringe system
CA2076465C (en) 1992-03-25 2002-11-26 Ravi V. J. Chari Cell binding agent conjugates of analogues and derivatives of cc-1065
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
PL174494B1 (pl) 1992-11-13 1998-08-31 Idec Pharma Corp Kompozycja farmaceutyczna do leczenia chłoniaka z limfocytów B i sposób wytwarzania kompozycji farmaceutycznej do leczenia chłoniaka z limfocytów B
WO1994019478A1 (en) 1993-02-22 1994-09-01 The Rockefeller University Production of high titer helper-free retroviruses by transient transfection
FR2712812B1 (fr) 1993-11-23 1996-02-09 Centre Nat Rech Scient Composition pour la production de produits thérapeutiques in vivo.
WO1996002576A1 (fr) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Anticorps humain reconstitue contre l'interleukine-8 humaine
IL116816A (en) 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
ATE283926T1 (de) 1995-09-11 2004-12-15 Kyowa Hakko Kogyo Kk Antikörper gegen die alpha-kette von humanem interleukin 5 rezeptor
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
WO1998045322A2 (en) 1997-04-10 1998-10-15 Royal Netherlands Academy Of Arts And Sciences Diagnosis method and reagents
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
ATE499116T1 (de) 2002-08-16 2011-03-15 Immunogen Inc Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
GB0308731D0 (en) 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
EP1618181B1 (en) 2003-04-22 2014-10-15 IBC Pharmaceuticals Polyvalent protein complex
JP5399712B2 (ja) 2005-12-21 2014-01-29 アムゲン リサーチ （ミュンヘン） ゲーエムベーハー 可溶性ｃｅａに対する抵抗性を有する医薬組成物
ME00581B (me) 2006-07-18 2011-12-20 Sanofi Aventis Antagonisticna antitijela za tretman kancera polje pronalaska
MY150531A (en) 2007-07-16 2014-01-30 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
SG10201407388XA (en) 2007-08-29 2015-01-29 Sanofi Aventis Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
PT2281006T (pt) 2008-04-30 2017-12-06 Immunogen Inc Agentes de reticulação e as suas utilizações
IN2012DN01663A (hr) * 2009-09-16 2015-06-05 Immunomedics Inc
US9427531B2 (en) 2010-06-28 2016-08-30 Sanofi-Aventis Deutschland Gmbh Auto-injector
DK2681244T3 (da) * 2011-03-02 2018-01-29 Roche Glycart Ag Cea-antistoffer
US9248242B2 (en) 2012-04-20 2016-02-02 Safety Syringes, Inc. Anti-needle stick safety device for injection device
TWI664192B (zh) 2012-11-20 2019-07-01 法商賽諾菲公司 抗ｃｅａｃａｍ５抗體及其用途
US20140155827A1 (en) 2012-12-03 2014-06-05 Mylan, Inc. Medicament information system and method
TWI595006B (zh) * 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
CN104948958A (zh) * 2015-07-01 2015-09-30 上海顿格电子贸易有限公司 一种利用热敏电阻限流的led灯
CN108341876B (zh) * 2017-01-22 2021-06-04 中国人民解放军第四军医大学 抗人ceacam5单克隆抗体及其制备方法和应用
AU2019292580A1 (en) * 2018-06-29 2021-02-04 Krystal Biotech, Inc. Compositions and methods for antibody delivery

Also Published As

Publication number Publication date
US20220340682A1 (en) 2022-10-27
HUE033369T2 (en) 2017-11-28
ECSP15025845A (es) 2016-01-29
JP6324399B2 (ja) 2018-05-16
RS60043B1 (sr) 2020-04-30
CN104918958A (zh) 2015-09-16
LT3199552T (lt) 2020-04-10
WO2014079886A1 (en) 2014-05-30
KR102408660B1 (ko) 2022-06-15
DK3199552T3 (da) 2020-03-30
EP3594243A1 (en) 2020-01-15
MA38194A1 (fr) 2018-02-28
MX358321B (es) 2018-08-14
AR093557A1 (es) 2015-06-10
EP2922875A1 (en) 2015-09-30
CA2889962C (en) 2023-10-24
HK1215444A1 (zh) 2016-08-26
US20160108131A1 (en) 2016-04-21
MY171100A (en) 2019-09-25
EP3199552A1 (en) 2017-08-02
BR112015010993B1 (pt) 2022-08-30
EA201590986A1 (ru) 2016-05-31
PH12015501092A1 (en) 2015-07-27
AU2018267636A1 (en) 2018-12-13
US9617345B2 (en) 2017-04-11
AU2013349733A1 (en) 2015-06-11
EA039377B1 (ru) 2022-01-20
MX2015006374A (es) 2015-10-09
PL3199552T3 (pl) 2020-06-01
JP2016506370A (ja) 2016-03-03
US11332542B2 (en) 2022-05-17
TWI664192B (zh) 2019-07-01
PL2922875T3 (pl) 2017-08-31
SG11201503285TA (en) 2015-05-28
SI2922875T1 (sl) 2017-06-30
LT2922875T (lt) 2017-06-12
UA120247C2 (uk) 2019-11-11
US20180022817A1 (en) 2018-01-25
DOP2015000110A (es) 2015-08-16
KR20150085828A (ko) 2015-07-24
NZ708528A (en) 2020-07-31
TW201427997A (zh) 2014-07-16
BR112015010993A2 (hr) 2017-08-22
US10457739B2 (en) 2019-10-29
RS55987B1 (sr) 2017-09-29
EP2922875B1 (en) 2017-03-15
DK2922875T3 (en) 2017-06-06
TW201940519A (zh) 2019-10-16
KR102194748B1 (ko) 2020-12-23
AU2013349733C1 (en) 2020-10-01
SI3199552T1 (sl) 2020-06-30
PH12015501092B1 (en) 2015-07-27
CA3207769A1 (en) 2014-05-30
KR20200143527A (ko) 2020-12-23
IL238559A0 (en) 2015-06-30
CN104918958B (zh) 2019-12-10
ZA201502959B (en) 2016-01-27
US20200102401A1 (en) 2020-04-02
CY1119219T1 (el) 2018-02-14
KR20220084193A (ko) 2022-06-21
ES2625742T3 (es) 2017-07-20
PT3199552T (pt) 2020-03-25
EP3199552B1 (en) 2019-12-25
CN109180815A (zh) 2019-01-11
HRP20170743T1 (hr) 2017-07-28
UY35147A (es) 2014-06-30
KR102661801B1 (ko) 2024-04-26
PT2922875T (pt) 2017-05-31
CA2889962A1 (en) 2014-05-30
ES2778823T3 (es) 2020-08-12
IL238559B (en) 2018-10-31
CN109180815B (zh) 2022-06-21
PE20151180A1 (es) 2015-08-12
MA38194B1 (fr) 2018-12-31
AU2013349733B2 (en) 2018-08-23
TN2015000177A1 (en) 2016-10-03
CL2015001321A1 (es) 2015-07-17
CR20150258A (es) 2015-06-11

Similar Documents

Publication Publication Date Title
HRP20200415T1 (hr) Anti-ceacam5 protutijela i njihova uporaba
HRP20191688T1 (hr) Cd37-vezujuće molekule i njihovi imunokonjugati
JP6870051B2 (ja) エリブリンをベースとする抗体−薬物コンジュゲート及び使用方法
JP2015510761A5 (hr)
RU2504553C2 (ru) Антитела к her
JP6328649B2 (ja) 薬物−タンパク質コンジュゲート
RU2012135395A (ru) Антитела против рецептора фолиевой кислоты 1, их иммуноконъюгаты и использование
JP2013519375A5 (hr)
HRP20210410T1 (hr) Konjugirana antitijela prema ly75 za liječenje raka
US20130137659A1 (en) Anticancer derivatives, preparation thereof and therapeutic use thereof
JP2016512832A5 (hr)
CN112218663A (zh) 剪接调节抗体-药物缀合物及其使用方法
JP2008532523A5 (hr)
MX2010005830A (es) Conjugado de anticuerpo monoclonal anti-b7h4 - farmaco y metodos de uso del mismo.
MX339927B (es) Preparacion de conjugados de maitansinoides y anticuerpos mediante un proceso de una etapa.
RU2009136946A (ru) Композиции и способы диагностики и лечения опухоли
EA027925B1 (ru) Ендиины, их конъюгаты и способы их получения и применения
WO2010009124A3 (en) Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
JPS58208238A (ja) 共有結合によつて酵素と抗体を結合させる新しい共役物とこの共役物を用いた医薬会合
MY171008A (en) Preparation of maytansinoid antibody conjugates by a one-step process
RU2008152431A (ru) Антитела и иммуноконъюгаты и их применения
JP2016503295A5 (hr)
WO2008091911A8 (en) Use of antibody conjugates
JP2021530436A (ja) Ａｘｌを標的とする抗体および抗体−薬物複合体ならびにその製造方法と使用
JP2022512401A (ja) ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法