HRP20191805T1 - Postupci za liječenje netuberkuloznih mikobakterijskih infekcija pluća - Google Patents
Postupci za liječenje netuberkuloznih mikobakterijskih infekcija pluća Download PDFInfo
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- HRP20191805T1 HRP20191805T1 HRP20191805TT HRP20191805T HRP20191805T1 HR P20191805 T1 HRP20191805 T1 HR P20191805T1 HR P20191805T T HRP20191805T T HR P20191805TT HR P20191805 T HRP20191805 T HR P20191805T HR P20191805 T1 HRP20191805 T1 HR P20191805T1
- Authority
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- Croatia
- Prior art keywords
- pharmaceutical preparation
- patient
- use according
- amikacin
- period
- Prior art date
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- 238000000034 method Methods 0.000 title claims 2
- 208000019839 Pulmonary non-tuberculous mycobacterial infection Diseases 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 16
- 229960004821 amikacin Drugs 0.000 claims 6
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 238000011282 treatment Methods 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000002502 liposome Substances 0.000 claims 3
- 238000011321 prophylaxis Methods 0.000 claims 3
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- YWMSSKBMOFPBDM-UHFFFAOYSA-N 4-carbamoylbenzenesulfonyl chloride Chemical group NC(=O)C1=CC=C(S(Cl)(=O)=O)C=C1 YWMSSKBMOFPBDM-UHFFFAOYSA-N 0.000 claims 1
- 208000033126 Colobomatous microphthalmia Diseases 0.000 claims 1
- 208000032376 Lung infection Diseases 0.000 claims 1
- 241000513886 Mycobacterium avium complex (MAC) Species 0.000 claims 1
- 241001502334 Mycobacterium avium complex bacterium Species 0.000 claims 1
- 238000012387 aerosolization Methods 0.000 claims 1
- 229960001656 amikacin sulfate Drugs 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 208000034367 isolated with coloboma microphthalmia Diseases 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000002691 unilamellar liposome Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Claims (14)
1. Farmaceutski pripravak koji sadrži od 450 mg do 650 mg amikacina, ili njegove farmaceutski prihvatljive soli, ugrađenog u mnoštvu liposoma, gdje se lipidna komponenta mnoštva liposoma sastoji od dipalmitoilfosfatidilholina (DPPC) i kolesterola, namijenjena liječenju ili osiguravanju profilakse protiv infekcije pluća izazvane Mycobacterium avium kompleksom (MAC) kod pacijenta kome je potrebno liječenje ili profilaksa,
pri čemu se pripravak primjenjuje jednom dnevno u jednom doziranju, tokom perioda primijene od najmanje tri mjeseca, na pluća pacijenta aerosolizacijom farmaceutskog pripravka putem raspršivača da bi se osigurao aerosolizirani farmaceutski pripravak koji sadrži mješavinu slobodnog amikacina, ili njegove farmaceutski prihvatljive soli i liposomalno kompleksnog amikacina, ili njegove farmaceutski prihvatljive soli,
pri čemu tokom perioda primijene ili nakon perioda primijene, kod pacijenta dolazi do konverzije kulture MAC u negativnu.
2. Farmaceutski pripravak za uporabu prema patentnom zahtjevu 1, naznačen time, što tokom perioda primijene ili nakon perioda primijene, pacijent ostvaruje povećani broj prijeđenih metara u 6-minutnom testu hodanja (6MWT), u usporedbi sa brojem metara koje je pacijent prešao prije podvrgavanja postupku liječenja.
3. Farmaceutski pripravak za uporabu prema patentnom zahtjevu 1 ili 2, naznačen time, što kod pacijenta dolazi do poboljšanja volumena prisilnog izdisanja u jednoj sekundi (FEV1) tokom najmanje 15 dana nakon završetka perioda primijene, u usporedbi sa FEV1 pacijenta prije liječenja.
4. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-3, naznačen time, što je amikacin ili njegova farmaceutski prihvatljiva sol amikacin sulfat.
5. Farmaceutski pripravak za uporabu prema patentnom zahtjevu 4, naznačen time, što liposom sadrži jednolamelarne vezikule, višelamelarne vezikule, ili njihovu mješavinu.
6. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-5, naznačen time, što je volumen farmaceutskog pripravka koji je primijenjen kod pacijenta od oko 8 mL do oko 10 mL.
7. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-6, naznačen time, što se tokom jednog doziranja, aerosolizirani farmaceutski pripravak primjenjuje za manje od oko 15 minuta, manje od oko 14 minuta, manje od oko 13 minuta, manje od oko 12 minuta, ili manje od oko 11 minuta.
8. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-7, naznačen time, što pacijent kome je potrebno liječenje ili profilaksa prethodno nije odgovarao na terapiju protiv MAC.
9. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-8, naznačen time, što je povećani broj uspoređenih metara u testu 6MWT najmanje oko 5 metara.
10. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 3-9, naznačen time, što poboljšanje FEV1 pacijenta iznosi najmanje 5% u odnosu na FEV1 pacijenta prije liječenja.
11. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-10, naznačen time, što farmaceutski pripravak sadrži od oko 550 mg do oko 625 mg amikacina, ili njegove farmaceutski prihvatljive soli.
12. Farmaceutski pripravak za uporabu prema patentnom zahtjevu 11, naznačen time, što farmaceutski pripravak sadrži od oko 550 mg do oko 600 mg amikacina, ili njegove farmaceutski prihvatljive soli.
13. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-12, naznačen time, što kod pacijenta dolazi do poboljšanja zasićenosti krvi kisikom tokom najmanje 15 dana nakon završetka perioda primijene, u usporedbi sa zasićenošću krvi kisikom kod pacijenta prije perioda primijene.
14. Farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-13, naznačen time, što je period primijene najmanje oko 6 mjeseci.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993439P | 2014-05-15 | 2014-05-15 | |
| US201462042126P | 2014-08-26 | 2014-08-26 | |
| US201462048068P | 2014-09-09 | 2014-09-09 | |
| US201462056296P | 2014-09-26 | 2014-09-26 | |
| EP15791964.8A EP3142643B1 (en) | 2014-05-15 | 2015-05-15 | Methods for treating pulmonary non-tuberculous mycobacterial infections |
| PCT/US2015/031079 WO2015175939A1 (en) | 2014-05-15 | 2015-05-15 | Methods for treating pulmonary non-tuberculous mycobacterial infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191805T1 true HRP20191805T1 (hr) | 2019-12-27 |
Family
ID=54480776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191805TT HRP20191805T1 (hr) | 2014-05-15 | 2019-10-03 | Postupci za liječenje netuberkuloznih mikobakterijskih infekcija pluća |
Country Status (22)
| Country | Link |
|---|---|
| US (13) | US9895385B2 (hr) |
| EP (4) | EP3466432B1 (hr) |
| JP (4) | JP6646653B2 (hr) |
| KR (4) | KR102657132B1 (hr) |
| CN (1) | CN106535877A (hr) |
| AU (2) | AU2015258947B2 (hr) |
| BR (1) | BR112016026699B1 (hr) |
| CA (1) | CA2949078C (hr) |
| CY (2) | CY1122129T1 (hr) |
| DK (2) | DK3142643T3 (hr) |
| ES (3) | ES2755941T3 (hr) |
| HR (1) | HRP20191805T1 (hr) |
| HU (1) | HUE051440T2 (hr) |
| LT (2) | LT3466432T (hr) |
| ME (1) | ME03536B (hr) |
| MX (2) | MX2016014921A (hr) |
| NZ (1) | NZ726256A (hr) |
| PL (2) | PL3142643T3 (hr) |
| PT (2) | PT3142643T (hr) |
| RS (1) | RS60827B1 (hr) |
| SI (2) | SI3466432T1 (hr) |
| WO (1) | WO2015175939A1 (hr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1962805T (pt) | 2005-12-08 | 2016-10-05 | Insmed Inc | Composições de anti-infeciosos baseadas em lípidos para tratamento de infeções pulmonares |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| BR112015012351A8 (pt) | 2012-11-29 | 2019-10-01 | Insmed Inc | composição de antibiótico de glicopeptídeo à base de lipídeo estabilizado e uso de um componente lipídico, um componente de antibiótico de glicopeptídeo e um aminoácido ou derivado do mesmo |
| NO2699580T3 (hr) | 2014-01-24 | 2018-02-24 | ||
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