HRP20170197T1 - 2' -fluoro supstituirani karba-nukleozidni analozi za antiviralno liječenje - Google Patents
2' -fluoro supstituirani karba-nukleozidni analozi za antiviralno liječenjeInfo
- Publication number
- HRP20170197T1 HRP20170197T1 HRP20170197TT HRP20170197T HRP20170197T1 HR P20170197 T1 HRP20170197 T1 HR P20170197T1 HR P20170197T T HRP20170197T T HR P20170197TT HR P20170197 T HRP20170197 T HR P20170197T HR P20170197 T1 HRP20170197 T1 HR P20170197T1
- Authority
- HR
- Croatia
- Prior art keywords
- nucleoside analogs
- fluoro substituted
- antiviral treatment
- substituted carba
- carba
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C7/00—Multicolour photographic processes or agents therefor; Regeneration of such processing agents; Photosensitive materials for multicolour processes
- G03C7/30—Colour processes using colour-coupling substances; Materials therefor; Preparing or processing such materials
- G03C7/32—Colour coupling substances
- G03C7/36—Couplers containing compounds with active methylene groups
- G03C7/38—Couplers containing compounds with active methylene groups in rings
- G03C7/381—Heterocyclic compounds
- G03C7/382—Heterocyclic compounds with two heterocyclic rings
- G03C7/3825—Heterocyclic compounds with two heterocyclic rings the nuclei containing only nitrogen as hetero atoms
- G03C7/3835—Heterocyclic compounds with two heterocyclic rings the nuclei containing only nitrogen as hetero atoms four nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24429709P | 2009-09-21 | 2009-09-21 | |
PCT/US2010/049471 WO2011035231A1 (en) | 2009-09-21 | 2010-09-20 | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
EP10763083.2A EP2480552B1 (en) | 2009-09-21 | 2010-09-20 | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20170197T1 true HRP20170197T1 (hr) | 2017-04-07 |
Family
ID=43031517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170197TT HRP20170197T1 (hr) | 2009-09-21 | 2017-02-07 | 2' -fluoro supstituirani karba-nukleozidni analozi za antiviralno liječenje |
Country Status (32)
Country | Link |
---|---|
EP (2) | EP3150608B1 (hr) |
JP (3) | JP5795766B2 (hr) |
KR (2) | KR20180006499A (hr) |
CN (1) | CN102596958A (hr) |
AP (1) | AP2012006189A0 (hr) |
AU (4) | AU2010295373B2 (hr) |
BR (3) | BR112012006261B1 (hr) |
CA (1) | CA2773772C (hr) |
CL (1) | CL2012000707A1 (hr) |
CR (2) | CR20190103A (hr) |
CY (1) | CY1118605T1 (hr) |
DK (1) | DK2480552T3 (hr) |
EA (1) | EA201200525A1 (hr) |
EC (1) | ECSP12011817A (hr) |
ES (2) | ES2730805T3 (hr) |
HR (1) | HRP20170197T1 (hr) |
HU (1) | HUE032252T2 (hr) |
IL (2) | IL218599A (hr) |
LT (1) | LT2480552T (hr) |
ME (1) | ME02656B (hr) |
MX (1) | MX352646B (hr) |
NZ (1) | NZ599402A (hr) |
PE (3) | PE20120995A1 (hr) |
PL (1) | PL2480552T3 (hr) |
PT (1) | PT2480552T (hr) |
RS (1) | RS55699B1 (hr) |
SG (1) | SG179194A1 (hr) |
SI (1) | SI2480552T1 (hr) |
SM (1) | SMT201700091B (hr) |
UA (1) | UA110466C2 (hr) |
WO (1) | WO2011035231A1 (hr) |
ZA (1) | ZA201202175B (hr) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ588400A (en) | 2008-04-23 | 2012-08-31 | Gilead Sciences Inc | 1'-substituted carba-nucleoside analogs for antiviral treatment |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
NZ593648A (en) | 2008-12-23 | 2013-09-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
PA8855801A1 (es) | 2008-12-23 | 2010-07-27 | Sintesis de nucleosidos de purina | |
WO2010075517A2 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Nucleoside analogs |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
JP5767643B2 (ja) * | 2009-09-21 | 2015-08-19 | ギリード・サイエンシズ・インコーポレーテッド | 1’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体 |
RS55699B1 (sr) * | 2009-09-21 | 2017-07-31 | Gilead Sciences | 2' -fluoro supstituisani karba-nukleozidni analozi zaantiviralno lečenje |
US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
US7973013B2 (en) * | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
ES2551944T3 (es) * | 2010-03-31 | 2015-11-24 | Gilead Pharmasset Llc | (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2H)-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato de isopropilo cristalino |
TW201201815A (en) * | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
US9090642B2 (en) | 2010-07-19 | 2015-07-28 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
BR122020020745B8 (pt) | 2010-07-22 | 2023-10-31 | Gilead Sciences Inc | Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende |
TW201305185A (zh) * | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之2’-氟取代之碳-核苷類似物 |
KR101879887B1 (ko) * | 2010-09-20 | 2018-07-18 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료용 2'-플루오로 치환된 카바-누클레오시드 유사체 |
UA114075C2 (xx) | 2010-11-19 | 2017-04-25 | БАГАТОШАРОВА ТАБЛЕТКА, ЩО МІСТИТЬ РИЛПІВІРИН HCl, ЕМТРИЦИТАБІН І ТЕНОФОВІРУ ДИЗОПРОКСИЛФУМАРАТ | |
CA2822037A1 (en) | 2010-12-20 | 2012-06-28 | Gilead Sciences, Inc. | Methods for treating hcv |
TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
DE202012013074U1 (de) | 2011-09-16 | 2014-10-29 | Gilead Pharmasset Lcc | Zusammensetzungen zur Behandlung von HCV |
EP2768838A1 (en) | 2011-10-14 | 2014-08-27 | IDENIX Pharmaceuticals, Inc. | Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
US9481704B2 (en) | 2012-03-13 | 2016-11-01 | Gilead Sciences, Inc. | 2′-substituted carba-nucleoside analogs for antiviral treatment |
EP2909209B1 (en) * | 2012-10-17 | 2022-08-03 | Merck Sharp & Dohme LLC | 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases |
US9457039B2 (en) | 2012-10-17 | 2016-10-04 | Merck Sharp & Dohme Corp. | 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
CA2891125A1 (en) | 2012-11-19 | 2014-05-22 | Merck Sharp & Dohme Corp. | 2 -alkynyl substituted nucleoside derivatives for treating viral diseases |
CN104144682A (zh) | 2013-01-31 | 2014-11-12 | 吉利德法莫赛特有限责任公司 | 两个抗病毒化合物的联用制剂 |
EP3010512B1 (en) | 2013-06-18 | 2017-12-27 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
WO2015095419A1 (en) * | 2013-12-18 | 2015-06-25 | Idenix Pharmaceuticals, Inc. | 4'-or nucleosides for the treatment of hcv |
TWI678369B (zh) | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並[3,2-d]嘧啶、呋喃並[3,2-d]嘧啶及吡咯並[3,2-d]嘧啶化合物類 |
WO2016023522A2 (en) | 2014-08-15 | 2016-02-18 | Merck Sharp & Dohme Corp. | Substituted phosphoramidate compounds and uses thereof |
TWI673283B (zh) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2’-氯胺基嘧啶酮及嘧啶二酮核苷類 |
TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
BR112017013858A2 (pt) | 2014-12-26 | 2018-02-27 | Univ Emory | n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos |
WO2016160646A1 (en) | 2015-04-02 | 2016-10-06 | Merck Sharp & Dohme Corp. | Process for making phosphoramidate protected nucleoside compounds |
CN104945437B (zh) * | 2015-05-19 | 2017-03-01 | 广州诺威生物技术有限公司 | 一种嘧啶类新化合物 |
LT3785717T (lt) | 2015-09-16 | 2022-04-11 | Gilead Sciences, Inc. | Coronaviridae infekcijų gydymo būdai |
TWI740910B (zh) * | 2016-03-09 | 2021-10-01 | 美商艾洛斯生物製藥公司 | 非環抗病毒劑 |
SG10202009423QA (en) | 2016-03-28 | 2020-11-27 | Incyte Corp | Pyrrolotriazine compounds as tam inhibitors |
CN106083962B (zh) * | 2016-06-08 | 2018-12-18 | 成都倍特药业有限公司 | 一种具有环磷酰胺结构的化合物及其制备方法 |
US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
EP3484886B1 (en) * | 2016-07-14 | 2020-03-04 | Hoffmann-La Roche AG | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine and 6,7-dihydro-4h-triazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases |
MA45925A (fr) * | 2016-08-12 | 2019-06-19 | Janssen Biopharma Inc | Nucléosides et nucléotides substitués et leurs analogues |
JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
ES2961460T3 (es) | 2017-03-14 | 2024-03-12 | Gilead Sciences Inc | Métodos para tratar las infecciones por coronavirus felinas |
AU2018262501B2 (en) | 2017-05-01 | 2020-12-10 | Gilead Sciences, Inc. | Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
CN111093627B (zh) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物 |
MX2020005392A (es) | 2017-12-07 | 2020-12-07 | Univ Emory | N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos. |
CN111788204B (zh) | 2018-02-26 | 2023-05-05 | 吉利德科学公司 | 作为hbv复制抑制剂的取代吡咯嗪化合物 |
CA3129178A1 (en) * | 2019-02-07 | 2020-08-13 | Beigene, Ltd. | Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as tlr7 agonist |
CN114127082A (zh) | 2019-05-09 | 2022-03-01 | 阿里戈斯治疗公司 | 作为sting调节剂的经修饰的环状二核苷化合物 |
CA3163424A1 (en) | 2020-01-27 | 2021-08-05 | Gilead Sciences, Inc. | Methods for treating sars cov-2 infections |
JP7429799B2 (ja) | 2020-02-18 | 2024-02-08 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス化合物 |
TW202322824A (zh) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
TW202315607A (zh) | 2020-02-18 | 2023-04-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
JP2023516087A (ja) | 2020-03-12 | 2023-04-17 | ギリアード サイエンシーズ, インコーポレイテッド | 1’-シアノヌクレオシドを調製する方法 |
AU2021251689A1 (en) | 2020-04-06 | 2022-11-17 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
US11975012B2 (en) | 2020-05-29 | 2024-05-07 | Gilead Sciences, Inc. | Remdesivir treatment methods |
WO2021262826A2 (en) | 2020-06-24 | 2021-12-30 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
TW202228722A (zh) | 2020-08-27 | 2022-08-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之化合物及方法 |
WO2022219636A1 (en) * | 2021-04-14 | 2022-10-20 | Yeda Research And Development Co. Ltd. | Anti-viral and anti-tumoral compounds, and uses thereof |
WO2022221514A1 (en) | 2021-04-16 | 2022-10-20 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
JP2024518530A (ja) * | 2021-05-14 | 2024-05-01 | ビーエム ファーマ コンサルティング ピーティーワイ リミテッド | ウイルス感染の予防及び治療のための二環式複素環化合物 |
TW202400185A (zh) | 2022-03-02 | 2024-01-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
WO1991019721A1 (en) | 1990-06-13 | 1991-12-26 | Arnold Glazier | Phosphorous produgs |
DE69129650T2 (de) | 1990-09-14 | 1999-03-25 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
DE19912636A1 (de) | 1999-03-20 | 2000-09-21 | Aventis Cropscience Gmbh | Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel |
US6566365B1 (en) | 1999-11-04 | 2003-05-20 | Biochem Pharma Inc. | Method for the treatment of Flaviviridea viral infection using nucleoside analogues |
WO2001060315A2 (en) | 2000-02-18 | 2001-08-23 | Shire Biochem Inc. | Method for the treatment or prevention of flavivirus infections using nucleoside analogues |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
KR101005299B1 (ko) | 2000-10-18 | 2011-01-04 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
CZ20032005A3 (en) * | 2001-01-22 | 2004-04-14 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
WO2003026675A1 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
CN1849142A (zh) | 2002-11-15 | 2006-10-18 | 埃迪尼克斯(开曼)有限公司 | 2′-支链核苷和黄病毒突变 |
ES2769377T3 (es) | 2004-09-14 | 2020-06-25 | Gilead Pharmasset Llc | Intermedios de D-ribonolactona con sustitución de 2-fluoro-2-alquilo |
CN101043893A (zh) * | 2004-10-21 | 2007-09-26 | 默克公司 | 治疗RNA-依赖性RNA病毒感染的氟化吡咯并[2,3-d]嘧啶核苷 |
EP1804812A4 (en) * | 2004-10-21 | 2009-09-02 | Merck & Co Inc | FLUORINATED PYRROLO [2,3-D] PYRIMIDIN NUCLEOSIDES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRUS INFECTIONS |
AR056327A1 (es) * | 2005-04-25 | 2007-10-03 | Genelabs Tech Inc | Compuestos de nucleosidos para el tratamiento de infecciones virales |
WO2006121820A1 (en) | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Phosphoramidate prodrugs for treatment of viral infection |
WO2007027248A2 (en) | 2005-05-16 | 2007-03-08 | Valeant Research & Development | 3', 5' - cyclic nucleoside analogues for treatment of hcv |
US8431695B2 (en) | 2005-11-02 | 2013-04-30 | Bayer Intellectual Property Gmbh | Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
WO2008005542A2 (en) * | 2006-07-07 | 2008-01-10 | Gilead Sciences, Inc., | Antiviral phosphinate compounds |
US20080261913A1 (en) * | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
CA2673649A1 (en) | 2007-01-05 | 2008-07-17 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
SG177974A1 (en) | 2007-01-12 | 2012-02-28 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
WO2008116064A2 (en) | 2007-03-21 | 2008-09-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases |
DK2155758T3 (da) | 2007-05-10 | 2012-11-05 | Biocryst Pharm Inc | Tetrahydrofuro[3,4-d]dioxolanforbindelser til anvendelse i behandlingen af virusinfektioner og cancer |
US8227431B2 (en) * | 2008-03-17 | 2012-07-24 | Hetero Drugs Limited | Nucleoside derivatives |
NZ588400A (en) | 2008-04-23 | 2012-08-31 | Gilead Sciences Inc | 1'-substituted carba-nucleoside analogs for antiviral treatment |
EP2313102A2 (en) * | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
RS55699B1 (sr) * | 2009-09-21 | 2017-07-31 | Gilead Sciences | 2' -fluoro supstituisani karba-nukleozidni analozi zaantiviralno lečenje |
JP5767643B2 (ja) * | 2009-09-21 | 2015-08-19 | ギリード・サイエンシズ・インコーポレーテッド | 1’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体 |
-
2010
- 2010-09-20 RS RS20170152A patent/RS55699B1/sr unknown
- 2010-09-20 PT PT107630832T patent/PT2480552T/pt unknown
- 2010-09-20 PE PE2012000359A patent/PE20120995A1/es not_active Application Discontinuation
- 2010-09-20 CR CR20190103A patent/CR20190103A/es unknown
- 2010-09-20 ME MEP-2017-35A patent/ME02656B/me unknown
- 2010-09-20 NZ NZ599402A patent/NZ599402A/en unknown
- 2010-09-20 AP AP2012006189A patent/AP2012006189A0/xx unknown
- 2010-09-20 DK DK10763083.2T patent/DK2480552T3/en active
- 2010-09-20 AU AU2010295373A patent/AU2010295373B2/en active Active
- 2010-09-20 MX MX2012003391A patent/MX352646B/es active IP Right Grant
- 2010-09-20 CA CA2773772A patent/CA2773772C/en active Active
- 2010-09-20 BR BR112012006261-1A patent/BR112012006261B1/pt active IP Right Grant
- 2010-09-20 KR KR1020187000491A patent/KR20180006499A/ko not_active Application Discontinuation
- 2010-09-20 EP EP16196457.2A patent/EP3150608B1/en active Active
- 2010-09-20 KR KR1020127010076A patent/KR101818779B1/ko active IP Right Grant
- 2010-09-20 CN CN201080041902XA patent/CN102596958A/zh active Pending
- 2010-09-20 ES ES16196457T patent/ES2730805T3/es active Active
- 2010-09-20 WO PCT/US2010/049471 patent/WO2011035231A1/en active Application Filing
- 2010-09-20 UA UAA201204937A patent/UA110466C2/ru unknown
- 2010-09-20 SI SI201031372T patent/SI2480552T1/sl unknown
- 2010-09-20 BR BR122021021135-3A patent/BR122021021135B1/pt active IP Right Grant
- 2010-09-20 HU HUE10763083A patent/HUE032252T2/en unknown
- 2010-09-20 SG SG2012018883A patent/SG179194A1/en unknown
- 2010-09-20 EA EA201200525A patent/EA201200525A1/ru unknown
- 2010-09-20 PL PL10763083T patent/PL2480552T3/pl unknown
- 2010-09-20 ES ES10763083.2T patent/ES2614651T3/es active Active
- 2010-09-20 JP JP2012529958A patent/JP5795766B2/ja active Active
- 2010-09-20 LT LTEP10763083.2T patent/LT2480552T/lt unknown
- 2010-09-20 PE PE2016000070A patent/PE20160217A1/es unknown
- 2010-09-20 PE PE2020000354A patent/PE20210668A1/es unknown
- 2010-09-20 EP EP10763083.2A patent/EP2480552B1/en active Active
- 2010-09-20 BR BR122021012877A patent/BR122021012877B8/pt active IP Right Grant
-
2012
- 2012-03-13 IL IL218599A patent/IL218599A/en active IP Right Grant
- 2012-03-21 CL CL2012000707A patent/CL2012000707A1/es unknown
- 2012-03-23 ZA ZA2012/02175A patent/ZA201202175B/en unknown
- 2012-04-17 CR CR20120186A patent/CR20120186A/es unknown
- 2012-04-19 EC ECSP12011817 patent/ECSP12011817A/es unknown
-
2015
- 2015-05-14 JP JP2015098728A patent/JP6033362B2/ja active Active
-
2016
- 2016-09-28 IL IL248110A patent/IL248110A0/en unknown
- 2016-10-24 JP JP2016207475A patent/JP2017075146A/ja not_active Withdrawn
- 2016-11-23 AU AU2016262676A patent/AU2016262676B2/en active Active
-
2017
- 2017-02-07 CY CY20171100168T patent/CY1118605T1/el unknown
- 2017-02-07 HR HRP20170197TT patent/HRP20170197T1/hr unknown
- 2017-02-09 SM SM201700091T patent/SMT201700091B/it unknown
-
2018
- 2018-06-20 AU AU2018204449A patent/AU2018204449B2/en active Active
-
2020
- 2020-04-17 AU AU2020202600A patent/AU2020202600B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20170197T1 (hr) | 2' -fluoro supstituirani karba-nukleozidni analozi za antiviralno liječenje | |
HUS2000055I1 (hu) | 1'-szubsztituált carba-nukleozid analógok antivirális kezelésre | |
AP3699A (en) | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment | |
AP2922A (en) | Carbra-nucleoside analogs for antiviral treatment | |
ME01882B (me) | 1 '-supstituisani-karba-nukleozidni prolekovi za antivirusni tretman |