HRP20020264B1 - 2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preparations containing said compounds - Google Patents

2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preparations containing said compounds

Info

Publication number: HRP20020264B1
Authority: HR; Croatia
Prior art keywords: carbon atoms; alkyl; phenyl; substituted; conh2
Prior art date: 1999-10-02

Application number

HR20020264A

Other languages

English (en)

Croatian (hr)

Inventor

Brendel Joachim

Schmidt Wolfgang

Below Peter

Original Assignee

Sanofi-Aventis Deutschland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-02

Filing date

2002-03-28

Publication date

2010-08-31

2002-03-28 Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh

2004-02-29 Publication of HRP20020264A2 publication Critical patent/HRP20020264A2/hr

2010-08-31 Publication of HRP20020264B1 publication Critical patent/HRP20020264B1/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 22
-1 OR (15) Chemical group 0.000 abstract 12
125000000217 alkyl group Chemical group 0.000 abstract 12
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 12
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 5
125000001424 substituent group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
125000002541 furyl group Chemical group 0.000 abstract 4
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
125000001624 naphthyl group Chemical group 0.000 abstract 4
125000001544 thienyl group Chemical group 0.000 abstract 4
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 4
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 2
JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 2
108010081348 HRT1 protein Hairy Proteins 0.000 abstract 2
102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 2
VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 2
125000005009 perfluoropropyl group Chemical group FC(C(C(F)(F)F)(F)F)(F)* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)

HR20020264A 1999-10-02 2002-03-28 2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preparations containing said compounds HRP20020264B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19947457A DE19947457A1 (de)	1999-10-02	1999-10-02	2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
PCT/EP2000/009151 WO2001025189A1 (de)	1999-10-02	2000-09-19	2'-substituierte 1,1'-biphenyl-2-carbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen

Publications (2)

Publication Number	Publication Date
HRP20020264A2 HRP20020264A2 (en)	2004-02-29
HRP20020264B1 true HRP20020264B1 (en)	2010-08-31

Family

ID=7924254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020264A HRP20020264B1 (en)	1999-10-02	2002-03-28	2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preparations containing said compounds

Country Status (32)

Country	Link
EP (1)	EP1222163B1 (no)
JP (1)	JP4713800B2 (no)
KR (1)	KR100722178B1 (no)
CN (1)	CN1195738C (no)
AR (1)	AR031226A1 (no)
AT (1)	ATE332890T1 (no)
AU (1)	AU766365B2 (no)
BR (1)	BR0014465B1 (no)
CA (1)	CA2385859C (no)
CY (1)	CY1106178T1 (no)
CZ (1)	CZ302591B6 (no)
DE (2)	DE19947457A1 (no)
DK (1)	DK1222163T3 (no)
EE (1)	EE05000B1 (no)
ES (1)	ES2265985T3 (no)
HK (1)	HK1048986B (no)
HR (1)	HRP20020264B1 (no)
HU (1)	HU229046B1 (no)
IL (2)	IL148870A0 (no)
ME (1)	MEP60908A (no)
MX (1)	MXPA02002691A (no)
NO (1)	NO327709B1 (no)
NZ (1)	NZ518065A (no)
PL (1)	PL204034B1 (no)
PT (1)	PT1222163E (no)
RS (1)	RS50387B (no)
RU (1)	RU2252214C2 (no)
SK (1)	SK286756B6 (no)
TR (1)	TR200200883T2 (no)
TW (1)	TWI270541B (no)
WO (1)	WO2001025189A1 (no)
ZA (1)	ZA200202521B (no)

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US7091247B2 (en)	2000-06-28	2006-08-15	Takeda Pharmaceutical Company Limited	Biphenyl compound
DE10059418A1 (de) *	2000-11-30	2002-06-20	Aventis Pharma Gmbh	Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10060807A1 (de)	2000-12-07	2002-06-20	Aventis Pharma Gmbh	Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
TWI311133B (en)	2001-04-20	2009-06-21	Eisai R&D Man Co Ltd	Carboxylic acid derivativeand the salt thereof
DE10121003A1 (de)	2001-04-28	2002-12-19	Aventis Pharma Gmbh	Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US7687664B2 (en)	2001-06-04	2010-03-30	Eisai R&D Management Co., Ltd.	Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it
DE10128331A1 (de)	2001-06-12	2002-12-19	Aventis Pharma Gmbh	Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
WO2003057671A1 (fr)	2001-12-28	2003-07-17	Takeda Chemical Industries, Ltd.	Compose biaryle et son utilisation
MXPA05004206A (es)	2002-10-24	2005-06-08	Merck Patent Gmbh	Derivados de metilenurea.
DE10312061A1 (de) *	2003-03-18	2004-09-30	Aventis Pharma Deutschland Gmbh	Kombination von Phenylcarbonsäureamiden mit Blockern des IK-Kanals und deren Verwendung zur Behandlung von Vorhofarrhythmien
GB0315950D0 (en)	2003-06-11	2003-08-13	Xention Discovery Ltd	Compounds
WO2005020921A2 (en) *	2003-08-29	2005-03-10	Exelixis, Inc.	C-kit modulators and methods of use
DE10341233A1 (de) *	2003-09-08	2005-03-24	Aventis Pharma Deutschland Gmbh	Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
DE102004009931A1 (de) *	2004-02-26	2005-09-15	Aventis Pharma Deutschland Gmbh	Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz
JP2007528420A (ja) *	2004-03-11	2007-10-11	グラクソ　グループ　リミテッド	新規ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト
GB0412986D0 (en)	2004-06-10	2004-07-14	Xention Discovery Ltd	Compounds
US7569589B2 (en)	2004-07-29	2009-08-04	Merck & Co., Inc.	Potassium channel inhibitors
US7576212B2 (en)	2004-12-09	2009-08-18	Xention Limited	Thieno[2,3-B] pyridines as potassium channel inhibitors
GB0525164D0 (en)	2005-12-09	2006-01-18	Xention Discovery Ltd	Compounds
EP2012758A2 (en) *	2006-04-27	2009-01-14	Sanofi-Aventis Deutschland GmbH	Inhibitors of the task-1 and task-3 ion channel
GB0815781D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
GB0815784D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
GB0815782D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
CN102459181B (zh) *	2009-06-03	2014-05-07	赛诺菲-安万特德国有限公司	2′-{[2-(4-甲氧基-苯基)-乙酰基氨基]-甲基}-联苯基-2-甲酸(2-吡啶-3-基-乙基)-酰胺的晶相
GB201105659D0 (en)	2011-04-01	2011-05-18	Xention Ltd	Compounds
NO3175985T3 (no)	2011-07-01	2018-04-28
CA2862670A1 (en)	2012-01-27	2013-08-01	Gilead Sciences, Inc.	Combination therapies using late sodium ion channel blockers and potassium ion channel blockers

Citations (1)

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EP0620216A1 (en) *	1993-04-13	1994-10-19	Fujisawa Pharmaceutical Co., Ltd.	Benzamide derivatives and their use as vasopressin antagonists

Family Cites Families (1)

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DE4102024A1 (de) *	1991-01-24	1992-07-30	Thomae Gmbh Dr K	Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

1999
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2000
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2002
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2003
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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0620216A1 (en) *	1993-04-13	1994-10-19	Fujisawa Pharmaceutical Co., Ltd.	Benzamide derivatives and their use as vasopressin antagonists

Also Published As

Publication number	Publication date
DE19947457A1 (de)	2001-04-05
RU2002111561A (ru)	2004-01-20
PL354322A1 (en)	2004-01-12
RS50387B (sr)	2009-12-31
PL204034B1 (pl)	2009-12-31
NO20021398L (no)	2002-05-31
AU766365B2 (en)	2003-10-16
CY1106178T1 (el)	2011-06-08
MXPA02002691A (es)	2002-07-30
CZ20021144A3 (cs)	2002-06-12
MEP60908A (en)	2011-05-10
DK1222163T3 (da)	2006-11-13
IL148870A0 (en)	2002-09-12
AR031226A1 (es)	2003-09-17
BR0014465A (pt)	2002-06-11
CA2385859C (en)	2009-11-24
EP1222163A1 (de)	2002-07-17
EE200200160A (et)	2003-04-15
ZA200202521B (en)	2002-12-24
ES2265985T3 (es)	2007-03-01
DE50013167D1 (de)	2006-08-24
JP2003511363A (ja)	2003-03-25
JP4713800B2 (ja)	2011-06-29
NZ518065A (en)	2004-08-27
RU2252214C2 (ru)	2005-05-20
IL148870A (en)	2007-05-15
EE05000B1 (et)	2008-04-15
KR20020038791A (ko)	2002-05-23
WO2001025189A1 (de)	2001-04-12
HU229046B1 (hu)	2013-07-29
AU7777800A (en)	2001-05-10
YU24402A (sh)	2005-06-10
SK4382002A3 (en)	2002-08-06
TWI270541B (no)	2007-01-11
NO20021398D0 (no)	2002-03-20
ATE332890T1 (de)	2006-08-15
PT1222163E (pt)	2006-10-31
KR100722178B1 (ko)	2007-05-29
HUP0203505A2 (hu)	2003-03-28
BR0014465B1 (pt)	2011-12-27
HK1048986A1 (en)	2003-04-25
CZ302591B6 (cs)	2011-07-27
CA2385859A1 (en)	2001-04-12
HUP0203505A3 (en)	2004-01-28
HK1048986B (zh)	2005-07-29
CN1195738C (zh)	2005-04-06
CN1373750A (zh)	2002-10-09
HRP20020264A2 (en)	2004-02-29
EP1222163B1 (de)	2006-07-12
NO327709B1 (no)	2009-09-14
TR200200883T2 (tr)	2002-09-23
SK286756B6 (sk)	2009-05-07

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2004-02-29	A1OB	Publication of a patent application
2004-08-30	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2006-02-28	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE
2010-08-31	B1PR	Patent granted
2014-07-31	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20140731 Year of fee payment: 15
2016-03-21	PBON	Lapse due to non-payment of renewal fee	Effective date: 20150919

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