HRP20010559A2 - Ketolide antibiotics - Google Patents
Ketolide antibiotics Download PDFInfo
- Publication number
- HRP20010559A2 HRP20010559A2 HR20010559A HRP20010559A HRP20010559A2 HR P20010559 A2 HRP20010559 A2 HR P20010559A2 HR 20010559 A HR20010559 A HR 20010559A HR P20010559 A HRP20010559 A HR P20010559A HR P20010559 A2 HRP20010559 A2 HR P20010559A2
- Authority
- HR
- Croatia
- Prior art keywords
- cr4r5
- alkyl
- aryl
- groups
- halo
- Prior art date
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- 239000003242 anti bacterial agent Substances 0.000 title description 3
- 229940088710 antibiotic agent Drugs 0.000 title description 3
- 239000003835 ketolide antibiotic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 119
- -1 –NR4R5 Chemical group 0.000 claims description 41
- 125000000623 heterocyclic group Chemical group 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 24
- 208000010362 Protozoan Infections Diseases 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 208000035143 Bacterial infection Diseases 0.000 claims description 17
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 17
- 125000005843 halogen group Chemical group 0.000 claims description 17
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 12
- 241000251468 Actinopterygii Species 0.000 claims description 11
- 241000124008 Mammalia Species 0.000 claims description 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 10
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
- 239000012453 solvate Substances 0.000 claims description 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
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- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
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- HCUOEKSZWPGJIM-YBRHCDHNSA-N (e,2e)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical compound COCC([N+]([O-])=O)\C(C)=C\C(=N/O)\C(N)=O HCUOEKSZWPGJIM-YBRHCDHNSA-N 0.000 claims description 4
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- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 4
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- General Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Communicable Diseases (AREA)
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- Otolaryngology (AREA)
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- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11734299P | 1999-01-27 | 1999-01-27 | |
PCT/IB1999/002051 WO2000044761A2 (en) | 1999-01-27 | 1999-12-28 | Ketolide antibiotics |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20010559A2 true HRP20010559A2 (en) | 2002-08-31 |
Family
ID=22372371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20010559A HRP20010559A2 (en) | 1999-01-27 | 2001-07-25 | Ketolide antibiotics |
Country Status (39)
Country | Link |
---|---|
US (1) | US6833444B2 (cs) |
EP (1) | EP1147121B1 (cs) |
JP (1) | JP3947360B2 (cs) |
KR (1) | KR20020002380A (cs) |
CN (1) | CN1342163A (cs) |
AP (1) | AP2001002222A0 (cs) |
AT (1) | ATE256694T1 (cs) |
AU (1) | AU1675400A (cs) |
BG (1) | BG105730A (cs) |
BR (1) | BR9916969A (cs) |
CA (1) | CA2359708C (cs) |
CO (1) | CO5150229A1 (cs) |
CZ (1) | CZ20012675A3 (cs) |
DE (1) | DE69913738T2 (cs) |
DK (1) | DK1147121T3 (cs) |
DZ (1) | DZ3000A1 (cs) |
EA (1) | EA200100623A1 (cs) |
EE (1) | EE200100394A (cs) |
ES (1) | ES2212655T3 (cs) |
HK (1) | HK1042707A1 (cs) |
HN (1) | HN2000000003A (cs) |
HR (1) | HRP20010559A2 (cs) |
HU (1) | HUP0105190A3 (cs) |
ID (1) | ID30233A (cs) |
IL (1) | IL144178A0 (cs) |
IS (1) | IS5984A (cs) |
MA (1) | MA26717A1 (cs) |
NO (1) | NO20013680L (cs) |
OA (1) | OA11753A (cs) |
PA (1) | PA8489501A1 (cs) |
PE (1) | PE20001422A1 (cs) |
PT (1) | PT1147121E (cs) |
SI (1) | SI1147121T1 (cs) |
SK (1) | SK10172001A3 (cs) |
TN (1) | TNSN00007A1 (cs) |
TR (1) | TR200102128T2 (cs) |
UY (1) | UY25990A1 (cs) |
WO (1) | WO2000044761A2 (cs) |
ZA (1) | ZA200105580B (cs) |
Families Citing this family (30)
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AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
AU1675400A (en) | 1999-01-27 | 2000-08-18 | Pfizer Products Inc. | Ketolide antibiotics |
WO2000062783A2 (en) | 1999-04-16 | 2000-10-26 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
JP2003523938A (ja) | 1999-04-16 | 2003-08-12 | コーサン バイオサイエンシーズ, インコーポレイテッド | マクロライド系抗感染剤 |
US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
PL352720A1 (en) | 1999-05-24 | 2003-09-08 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
TR200401847T4 (tr) | 2000-06-30 | 2004-09-21 | Pfizer Products Inc. | Makrolit antibiyotikler. |
US20020115621A1 (en) | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
AU1727702A (en) * | 2000-12-21 | 2002-07-01 | Glaxo Group Ltd | Macrolide antibiotics |
WO2003022289A1 (fr) * | 2001-09-05 | 2003-03-20 | Hokuriku Seiyaku Co., Ltd. | Medicament contenant de l'erythromycine pour traiter ou prevenir la tuberculose |
WO2004080391A2 (en) | 2003-03-10 | 2004-09-23 | Optimer Pharmaceuticals, Inc. | Novel antibacterial agents |
JP2008508322A (ja) * | 2004-07-28 | 2008-03-21 | ランバクシー ラボラトリーズ リミテッド | 抗菌剤としてのケトライド誘導体 |
PL1836211T3 (pl) | 2004-12-21 | 2010-07-30 | Pfizer Prod Inc | Makrolidy |
WO2007129646A1 (ja) * | 2006-05-01 | 2007-11-15 | Taisho Pharmaceutical Co., Ltd. | マクロライド誘導体 |
CN101917850B (zh) | 2007-10-25 | 2016-01-13 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
EP2358379B1 (en) | 2008-10-24 | 2015-12-16 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
AU2010292010B2 (en) | 2009-09-10 | 2016-01-07 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
KR20180101643A (ko) | 2010-03-22 | 2018-09-12 | 셈프라 파마슈티컬스, 인크. | 매크로라이드의 결정 형태들 및 그 용도들 |
BR112012029586A2 (pt) | 2010-05-20 | 2016-08-02 | Cempra Pharmaceuticals Inc | processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos |
JP6042334B2 (ja) | 2010-09-10 | 2016-12-14 | センプラ ファーマシューティカルズ,インコーポレイテッド | 疾患治療のための水素結合形成フルオロケトライド |
RU2658050C2 (ru) | 2012-03-27 | 2018-06-19 | Семпра Фармасьютикалз, Инк. | Парентеральные составы для введения макролидных антибиотиков |
CA2905975A1 (en) | 2013-03-14 | 2014-09-25 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
JP6675973B2 (ja) | 2013-03-15 | 2020-04-08 | センプラ ファーマシューティカルズ,インコーポレイテッド | マクロライド抗菌薬を調製するための集束的な方法 |
JP6332266B2 (ja) | 2013-03-28 | 2018-05-30 | 不二製油株式会社 | 緑豆蛋白ゲル状組成物及びチーズ様食品 |
CN106518939B (zh) * | 2015-09-14 | 2019-12-31 | 江苏奥赛康药业有限公司 | 一种制备Solithromycin化合物的方法 |
EP3522896A4 (en) * | 2016-10-04 | 2020-06-17 | Biopharmati SA | KETOLID WITH ANTIBACTERIAL EFFECT |
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SI8110592A8 (en) | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
US5141926A (en) | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
IL99995A (en) | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
FR2697524B1 (fr) | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
US5747466A (en) | 1995-11-08 | 1998-05-05 | Abbott Laboratories | 3-deoxy-3-descladinose derivatives of erythromycins A and B |
FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2745290B1 (fr) | 1996-02-28 | 1998-04-03 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2748746B1 (fr) | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
EP0910633B1 (en) | 1996-07-05 | 2009-12-09 | Biotica Technology Limited | Hybrid polyketide synthase I gene |
FR2751656B1 (fr) | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
FR2757168B1 (fr) | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2760017B1 (fr) | 1997-02-27 | 1999-04-30 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments |
AU4472897A (en) | 1997-03-10 | 1998-09-29 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
US20020025937A1 (en) | 2000-03-20 | 2002-02-28 | Yong-Jin Wu | 9-oxime erythromycin derivatives |
ZA987689B (en) | 1997-09-02 | 1999-02-24 | Abbott Lab | 3-descladinose 6-O substituted erythromycin derivatives |
HN1998000159A (es) | 1997-10-29 | 1999-02-09 | Monsanto Co | Derivados de 9- amino - 3 ceto eritromicina |
JP2003527301A (ja) | 1997-10-29 | 2003-09-16 | 大正製薬株式会社 | エリスロマイシンa誘導体 |
FR2771008B1 (fr) * | 1997-11-17 | 2000-04-28 | Hoechst Marion Roussel Inc | Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
WO1999025385A1 (en) | 1997-11-17 | 1999-05-27 | Imarx Pharmaceutical Corp. | A method of increasing nucleic acid synthesis with ultrasound |
AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
FR2777282B1 (fr) | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
AU5299499A (en) | 1998-09-22 | 2000-04-10 | Pfizer Products Inc. | Carbamate and carbazate ketolide antibiotics |
US6100240A (en) | 1998-10-09 | 2000-08-08 | Pfizer Inc | Macrolide derivatives |
FR2785612A1 (fr) | 1998-11-10 | 2000-05-12 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
AP2001002131A0 (en) | 1998-11-03 | 2001-06-30 | Pfizer Prod Inc | Novel macrolide antibiotics. |
FR2786188B1 (fr) | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
DE69933897T2 (de) | 1998-12-10 | 2007-03-15 | Pfizer Products Inc., Groton | Carbamat- und Carbazatketolid-Antibiotika |
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FR2789392B1 (fr) | 1999-02-04 | 2001-10-05 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
JP2003523938A (ja) | 1999-04-16 | 2003-08-12 | コーサン バイオサイエンシーズ, インコーポレイテッド | マクロライド系抗感染剤 |
WO2000062783A2 (en) | 1999-04-16 | 2000-10-26 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
US6355620B1 (en) | 1999-05-14 | 2002-03-12 | Abbott Laboratories | C-2 modified erythromycin derivatives |
PL352720A1 (en) | 1999-05-24 | 2003-09-08 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
EP1114826A3 (en) | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
EP1122261A3 (en) | 2000-01-31 | 2001-09-26 | Pfizer Products Inc. | 13 and 14-membered antibacterial macrolides |
US20020061856A1 (en) | 2000-04-24 | 2002-05-23 | Yong-Jin Wu | Novel tricyclic erythromycin derivatives |
TR200401847T4 (tr) | 2000-06-30 | 2004-09-21 | Pfizer Products Inc. | Makrolit antibiyotikler. |
-
1999
- 1999-12-28 AU AU16754/00A patent/AU1675400A/en not_active Abandoned
- 1999-12-28 EA EA200100623A patent/EA200100623A1/ru unknown
- 1999-12-28 BR BR9916969-0A patent/BR9916969A/pt not_active Application Discontinuation
- 1999-12-28 AP APAP/P/2001/002222A patent/AP2001002222A0/en unknown
- 1999-12-28 DK DK99959627T patent/DK1147121T3/da active
- 1999-12-28 DE DE69913738T patent/DE69913738T2/de not_active Expired - Lifetime
- 1999-12-28 EE EEP200100394A patent/EE200100394A/xx unknown
- 1999-12-28 TR TR2001/02128T patent/TR200102128T2/xx unknown
- 1999-12-28 WO PCT/IB1999/002051 patent/WO2000044761A2/en active IP Right Grant
- 1999-12-28 ES ES99959627T patent/ES2212655T3/es not_active Expired - Lifetime
- 1999-12-28 CA CA002359708A patent/CA2359708C/en not_active Expired - Fee Related
- 1999-12-28 AT AT99959627T patent/ATE256694T1/de not_active IP Right Cessation
- 1999-12-28 SK SK1017-2001A patent/SK10172001A3/sk unknown
- 1999-12-28 CN CN99815909A patent/CN1342163A/zh active Pending
- 1999-12-28 CZ CZ20012675A patent/CZ20012675A3/cs unknown
- 1999-12-28 IL IL14417899A patent/IL144178A0/xx unknown
- 1999-12-28 SI SI9930486T patent/SI1147121T1/xx unknown
- 1999-12-28 OA OA1200100191A patent/OA11753A/en unknown
- 1999-12-28 PT PT99959627T patent/PT1147121E/pt unknown
- 1999-12-28 HU HU0105190A patent/HUP0105190A3/hu unknown
- 1999-12-28 JP JP2000596017A patent/JP3947360B2/ja not_active Expired - Fee Related
- 1999-12-28 KR KR1020017009382A patent/KR20020002380A/ko not_active Application Discontinuation
- 1999-12-28 EP EP99959627A patent/EP1147121B1/en not_active Expired - Lifetime
- 1999-12-28 ID IDW00200101637A patent/ID30233A/id unknown
-
2000
- 2000-01-05 TN TNTNSN00007A patent/TNSN00007A1/fr unknown
- 2000-01-05 DZ DZ000002A patent/DZ3000A1/xx active
- 2000-01-06 PE PE2000000013A patent/PE20001422A1/es not_active Application Discontinuation
- 2000-01-06 MA MA25883A patent/MA26717A1/fr unknown
- 2000-01-06 HN HN2000000003A patent/HN2000000003A/es unknown
- 2000-01-06 PA PA20008489501A patent/PA8489501A1/es unknown
- 2000-01-21 CO CO00003460A patent/CO5150229A1/es unknown
- 2000-01-27 UY UY25990A patent/UY25990A1/es unknown
-
2001
- 2001-06-28 IS IS5984A patent/IS5984A/is unknown
- 2001-07-06 ZA ZA200105580A patent/ZA200105580B/en unknown
- 2001-07-25 HR HR20010559A patent/HRP20010559A2/hr not_active Application Discontinuation
- 2001-07-25 BG BG105730A patent/BG105730A/xx unknown
- 2001-07-26 NO NO20013680A patent/NO20013680L/no not_active Application Discontinuation
-
2002
- 2002-04-05 US US10/116,969 patent/US6833444B2/en not_active Expired - Fee Related
- 2002-05-31 HK HK02104131.0A patent/HK1042707A1/zh unknown
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