HK1251939A1 - 作為組蛋白脫乙酰酶6抑制劑的1,3,4-噁二唑酰胺衍生物化合物及含有其的藥物組合物 - Google Patents
作為組蛋白脫乙酰酶6抑制劑的1,3,4-噁二唑酰胺衍生物化合物及含有其的藥物組合物Info
- Publication number
- HK1251939A1 HK1251939A1 HK18111268.2A HK18111268A HK1251939A1 HK 1251939 A1 HK1251939 A1 HK 1251939A1 HK 18111268 A HK18111268 A HK 18111268A HK 1251939 A1 HK1251939 A1 HK 1251939A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitor
- pharmaceutical composition
- composition containing
- histone deacetylase
- derivative compound
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20150106007 | 2015-07-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1251939A1 true HK1251939A1 (zh) | 2019-05-03 |
Family
ID=57886896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18111268.2A HK1251939A1 (zh) | 2015-07-27 | 2018-09-03 | 作為組蛋白脫乙酰酶6抑制劑的1,3,4-噁二唑酰胺衍生物化合物及含有其的藥物組合物 |
Country Status (20)
Country | Link |
---|---|
US (1) | US10584117B2 (zh) |
EP (1) | EP3330259B1 (zh) |
JP (1) | JP6559325B2 (zh) |
KR (1) | KR101799009B1 (zh) |
CN (1) | CN108026056B (zh) |
AU (1) | AU2016299485B2 (zh) |
CA (1) | CA2993918C (zh) |
DK (1) | DK3330259T3 (zh) |
ES (1) | ES2814229T3 (zh) |
HK (1) | HK1251939A1 (zh) |
HR (1) | HRP20201304T1 (zh) |
HU (1) | HUE051537T2 (zh) |
MX (1) | MX2018001196A (zh) |
MY (1) | MY190301A (zh) |
NZ (1) | NZ739211A (zh) |
PH (1) | PH12018500162A1 (zh) |
PL (1) | PL3330259T3 (zh) |
PT (1) | PT3330259T (zh) |
RU (1) | RU2700696C2 (zh) |
WO (1) | WO2017018804A1 (zh) |
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TWI639587B (zh) | 2015-07-27 | 2018-11-01 | 鐘根堂股份有限公司 | 作為組蛋白去乙醯酶6抑制劑之1,3,4-二唑磺胺衍生物及含彼之醫藥組合物 |
NZ739211A (en) | 2015-07-27 | 2019-05-31 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same |
RU2695227C9 (ru) * | 2015-07-27 | 2020-03-04 | Чонг Кун Данг Фармасьютикал Корп. | Производные 1,3,4-оксадиазолсульфамида в качестве ингибитора гистондеацетилазы 6 и содержащая их фармацевтическая композиция |
KR101799010B1 (ko) | 2015-08-04 | 2017-11-17 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
PL3362445T3 (pl) | 2015-10-12 | 2023-08-07 | Chong Kun Dang Pharmaceutical Corp. | Związki będące pochodnymi oksadiazoloamin jako inhibitor deacetylazy histonowej 6 oraz kompozycja farmaceutyczna obejmujące takie związki |
US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
JP7135007B2 (ja) * | 2017-07-31 | 2022-09-12 | 武田薬品工業株式会社 | 複素環化合物 |
WO2019040105A2 (en) * | 2017-08-21 | 2019-02-28 | Acadia Pharmaceuticals Inc. | COMPOUNDS, SALTS THEREOF AND METHODS FOR THE TREATMENT OF DISEASES |
KR102316234B1 (ko) * | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
US20220098180A1 (en) | 2019-01-30 | 2022-03-31 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
BR112021020682A2 (pt) | 2019-04-17 | 2021-12-07 | Fund Kertor | Derivados de 1,3,4-oxadiazol como inibidores de histona deacetilase |
TWI748491B (zh) * | 2019-05-31 | 2021-12-01 | 韓商鐘根堂股份有限公司 | 作為組蛋白去乙醯酶6抑制劑之1,3,4-㗁二唑高鄰苯二甲醯亞胺衍生化合物及包含彼之醫藥組合物 |
CA3139026A1 (en) * | 2019-05-31 | 2020-12-03 | Chang Sik Lee | 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
KR20220070465A (ko) | 2019-09-27 | 2022-05-31 | 다케다 야쿠힌 고교 가부시키가이샤 | Hdac6 억제제로서 유용한 2-이소인돌-1,3,4-옥사디아졸 유도체 |
KR102576148B1 (ko) * | 2020-04-13 | 2023-09-07 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
KR20220139752A (ko) * | 2021-04-08 | 2022-10-17 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 싸이오카보닐 화합물 및 이를 포함하는 약제학적 조성물 |
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KR20240035172A (ko) * | 2022-09-08 | 2024-03-15 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
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2016
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- 2016-07-27 DK DK16830837.7T patent/DK3330259T3/da active
- 2016-07-27 PL PL16830837T patent/PL3330259T3/pl unknown
- 2016-07-27 HU HUE16830837A patent/HUE051537T2/hu unknown
- 2016-07-27 JP JP2018504720A patent/JP6559325B2/ja active Active
- 2016-07-27 MY MYPI2018700206A patent/MY190301A/en unknown
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- 2016-07-27 WO PCT/KR2016/008216 patent/WO2017018804A1/ko active Application Filing
- 2016-07-27 CN CN201680053218.0A patent/CN108026056B/zh active Active
- 2016-07-27 RU RU2018106914A patent/RU2700696C2/ru active
- 2016-07-27 KR KR1020160095334A patent/KR101799009B1/ko active IP Right Grant
- 2016-07-27 CA CA2993918A patent/CA2993918C/en active Active
- 2016-07-27 AU AU2016299485A patent/AU2016299485B2/en active Active
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- 2016-07-27 ES ES16830837T patent/ES2814229T3/es active Active
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CN108026056B (zh) | 2021-08-03 |
JP6559325B2 (ja) | 2019-08-14 |
AU2016299485B2 (en) | 2019-02-07 |
RU2018106914A3 (zh) | 2019-08-27 |
CA2993918C (en) | 2020-09-29 |
JP2018521110A (ja) | 2018-08-02 |
KR101799009B1 (ko) | 2017-11-17 |
KR20170013187A (ko) | 2017-02-06 |
PT3330259T (pt) | 2020-09-03 |
DK3330259T3 (da) | 2020-08-10 |
MX2018001196A (es) | 2018-05-22 |
MY190301A (en) | 2022-04-13 |
CN108026056A (zh) | 2018-05-11 |
BR112018001716A2 (pt) | 2018-11-06 |
HRP20201304T1 (hr) | 2020-11-27 |
EP3330259B1 (en) | 2020-06-10 |
AU2016299485A1 (en) | 2018-02-08 |
WO2017018804A1 (ko) | 2017-02-02 |
RU2018106914A (ru) | 2019-08-27 |
NZ739211A (en) | 2019-05-31 |
PL3330259T3 (pl) | 2021-02-08 |
PH12018500162B1 (en) | 2018-07-30 |
CA2993918A1 (en) | 2017-02-02 |
EP3330259A1 (en) | 2018-06-06 |
RU2700696C2 (ru) | 2019-09-19 |
HUE051537T2 (hu) | 2021-03-01 |
US20180215743A1 (en) | 2018-08-02 |
US10584117B2 (en) | 2020-03-10 |
EP3330259A4 (en) | 2019-01-16 |
PH12018500162A1 (en) | 2018-07-30 |
ES2814229T3 (es) | 2021-03-26 |
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