HK1248762A1 - 高功能性血小板的製造方法 - Google Patents

高功能性血小板的製造方法

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Publication number
HK1248762A1
HK1248762A1 HK18108449.0A HK18108449A HK1248762A1 HK 1248762 A1 HK1248762 A1 HK 1248762A1 HK 18108449 A HK18108449 A HK 18108449A HK 1248762 A1 HK1248762 A1 HK 1248762A1
Authority
HK
Hong Kong
Prior art keywords
performance
platelet manufacturing
platelet
manufacturing
performance platelet
Prior art date
Application number
HK18108449.0A
Other languages
English (en)
Inventor
江藤浩之
中村壯
伊東幸敬
重盛智大
堂田丈明
Original Assignee
國立大學法人京都大學
株式會社美加細胞
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 國立大學法人京都大學, 株式會社美加細胞 filed Critical 國立大學法人京都大學
Publication of HK1248762A1 publication Critical patent/HK1248762A1/zh

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0644Platelets; Megakaryocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/19Platelets; Megacaryocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0669Bone marrow stromal cells; Whole bone marrow
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60Transcription factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65MicroRNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes
    • C12N2501/72Transferases (EC 2.)
    • C12N2501/727Kinases (EC 2.7.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18108449.0A 2015-06-16 2018-06-29 高功能性血小板的製造方法 HK1248762A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015121456 2015-06-16
PCT/JP2016/068015 WO2016204256A1 (ja) 2015-06-16 2016-06-16 高機能性血小板の製造方法

Publications (1)

Publication Number Publication Date
HK1248762A1 true HK1248762A1 (zh) 2018-10-19

Family

ID=57545938

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18108449.0A HK1248762A1 (zh) 2015-06-16 2018-06-29 高功能性血小板的製造方法

Country Status (13)

Country Link
US (1) US10947504B2 (zh)
EP (1) EP3312270B1 (zh)
JP (1) JP6814507B2 (zh)
KR (1) KR102600772B1 (zh)
CN (1) CN107709546B (zh)
AU (1) AU2016278335B2 (zh)
CA (1) CA2989755A1 (zh)
DK (1) DK3312270T3 (zh)
ES (1) ES2839220T3 (zh)
HK (1) HK1248762A1 (zh)
RU (1) RU2724533C2 (zh)
SG (1) SG11201710342TA (zh)
WO (1) WO2016204256A1 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017011550A1 (en) 2015-07-13 2017-01-19 University Of Utah Research Foundation Methods of making red blood cells and platelets in vitro and uses thereof
SG11201802159UA (en) * 2015-10-14 2018-04-27 Megakaryon Corp Method for producing purified platelets
US11952587B2 (en) 2017-03-06 2024-04-09 Kyoto University Method for producing platelets
JP7002720B2 (ja) * 2017-07-28 2022-01-20 国立大学法人京都大学 AhRアンタゴニストを含む血小板産生促進剤及びそれを用いた血小板の製造方法
CA3073956A1 (en) 2017-09-03 2019-03-07 Angion Biomedica Corp. Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors
CN112654627A (zh) 2018-09-07 2021-04-13 大塚制药株式会社 杂环化合物
JPWO2020184685A1 (zh) * 2019-03-13 2020-09-17
WO2021067378A1 (en) * 2019-10-01 2021-04-08 University Of Utah Research Foundation Methods of engineering platelets for targeting circulating tumor cells
WO2021117733A1 (en) * 2019-12-09 2021-06-17 Otsuka Pharmaceutical Co., Ltd. Acrylamide compounds
EP4074321A4 (en) 2019-12-12 2024-01-03 Univ Chiba Nat Univ Corp FREEZE DRIED PREPARATION CONTAINING MEGAKARYOCYTES AND PLATELETS
JP2021180620A (ja) 2020-05-18 2021-11-25 株式会社マイオリッジ 目的細胞の生産方法、目的細胞による生産物の生産方法、および無血清培地
WO2024085650A1 (ko) * 2022-10-18 2024-04-25 의료법인 성광의료재단 줄기세포에서 혈소판 전구세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1542714E (pt) * 2002-09-18 2014-06-23 Janssen Pharmaceuticals Inc Métodos para aumentar a produção de células estaminais plaquetárias e hematopoiéticas
US8933071B2 (en) * 2008-11-07 2015-01-13 Northwestern University Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders
PL2352815T3 (pl) * 2008-12-04 2016-07-29 Inst Nat Sante Rech Med Sposób wytwarzania płytek krwi
US9574178B2 (en) 2011-03-18 2017-02-21 New York Blood Center, Inc. Megakaryocyte and platelet production from stem cells
US9803164B2 (en) * 2011-03-18 2017-10-31 New York Blood Center, Inc. Megakaryocyte and platelet production from stem cells
DK2708597T3 (en) 2011-05-13 2018-02-05 Univ Tokyo POLYNUCLEAR MEGACARYOCYTIC CELL AND METHOD FOR PRODUCING BLADETS
US9074186B2 (en) * 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
ES2896354T3 (es) * 2012-12-21 2022-02-24 Astellas Inst For Regenerative Medicine Métodos para la producción de plaquetas a partir de células madre pluripotentes
WO2014138485A1 (en) * 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
EP2970881A4 (en) * 2013-03-14 2017-01-25 Children's Medical Center Corporation Compositions and methods for reprogramming hematopoietic stem cell lineages

Also Published As

Publication number Publication date
CN107709546B (zh) 2022-04-22
RU2018101211A (ru) 2019-07-16
JP6814507B2 (ja) 2021-01-20
KR20180017154A (ko) 2018-02-20
EP3312270A4 (en) 2018-12-12
KR102600772B1 (ko) 2023-11-13
RU2724533C2 (ru) 2020-06-23
WO2016204256A1 (ja) 2016-12-22
EP3312270B1 (en) 2020-09-30
CA2989755A1 (en) 2016-12-22
AU2016278335A1 (en) 2018-01-18
EP3312270A1 (en) 2018-04-25
ES2839220T3 (es) 2021-07-05
AU2016278335B2 (en) 2021-10-28
DK3312270T3 (da) 2020-10-12
RU2018101211A3 (zh) 2019-11-27
US10947504B2 (en) 2021-03-16
JPWO2016204256A1 (ja) 2018-05-31
CN107709546A (zh) 2018-02-16
US20190048317A1 (en) 2019-02-14
SG11201710342TA (en) 2018-01-30

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