HK1243076A1 - 作為布羅莫結構域抑制劑的取代的吡咯並吡啶 - Google Patents
作為布羅莫結構域抑制劑的取代的吡咯並吡啶Info
- Publication number
- HK1243076A1 HK1243076A1 HK18102678.5A HK18102678A HK1243076A1 HK 1243076 A1 HK1243076 A1 HK 1243076A1 HK 18102678 A HK18102678 A HK 18102678A HK 1243076 A1 HK1243076 A1 HK 1243076A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bromodomain
- inhibitors
- substituted pyrrolopyridines
- pyrrolopyridines
- substituted
- Prior art date
Links
- 102000001805 Bromodomains Human genes 0.000 title 1
- 108050009021 Bromodomains Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000005255 pyrrolopyridines Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462077707P | 2014-11-10 | 2014-11-10 | |
PCT/US2015/060007 WO2016077380A1 (en) | 2014-11-10 | 2015-11-10 | Substituted pyrrolopyridines as inhibitors of bromodomain |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1243076A1 true HK1243076A1 (zh) | 2018-07-06 |
Family
ID=54602075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18102678.5A HK1243076A1 (zh) | 2014-11-10 | 2018-02-26 | 作為布羅莫結構域抑制劑的取代的吡咯並吡啶 |
Country Status (7)
Country | Link |
---|---|
US (1) | US10150767B2 (zh) |
EP (1) | EP3218374B1 (zh) |
JP (1) | JP6669745B2 (zh) |
CN (1) | CN107108614B (zh) |
HK (1) | HK1243076A1 (zh) |
MA (1) | MA40940A (zh) |
WO (1) | WO2016077380A1 (zh) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA40943A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
EP3218376B1 (en) | 2014-11-10 | 2019-12-25 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
JP6709792B2 (ja) | 2015-01-29 | 2020-06-17 | ジェネンテック, インコーポレイテッド | 治療用化合物およびその使用 |
JP6857606B2 (ja) * | 2015-03-05 | 2021-04-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ブロモドメインbrd9の阻害剤としての新規ピリジノンおよびイソキノリノン |
AR104259A1 (es) * | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
CN109071534B (zh) | 2016-04-15 | 2021-11-23 | 艾伯维公司 | 布罗莫结构域抑制剂 |
CN109475528B (zh) | 2016-04-22 | 2022-01-11 | 达纳-法伯癌症研究所股份有限公司 | 用于egfr降解的双功能分子和使用方法 |
CN110167939B (zh) * | 2017-01-11 | 2021-12-31 | 江苏豪森药业集团有限公司 | 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用 |
WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
US20210130346A1 (en) * | 2017-04-14 | 2021-05-06 | Abbvie Inc. | Bromodomain Inhibitors |
WO2018223909A1 (zh) * | 2017-06-05 | 2018-12-13 | 成都海创药业有限公司 | 一种嵌合分子及其制备和应用 |
MX2020006612A (es) | 2017-12-20 | 2020-11-09 | Betta Pharmaceuticals Co Ltd | Compuesto que funciona como inhibidor de proteína de bromodominio y composición. |
EP3750885A4 (en) * | 2018-02-06 | 2021-10-27 | Shanghai Haihe Pharmaceutical Co., Ltd. | COMPOUND PRESENTING AN INHIBITORING ACTIVITY OF BET, ITS PREPARATION PROCESS AND ITS USE |
CN108465108B (zh) * | 2018-03-12 | 2020-07-07 | 上海宇玫博生物科技有限公司 | 一种预防或治疗脑胶质瘤的特异性基因靶点 |
US10442799B1 (en) | 2018-04-07 | 2019-10-15 | Fuqiang Ruan | Heterocyclic compounds and uses thereof |
CN110372693B (zh) * | 2018-07-04 | 2022-05-03 | 清华大学 | 一种靶向降解bet蛋白的化合物及其应用 |
CN110776508B (zh) * | 2018-07-27 | 2021-07-16 | 海创药业股份有限公司 | 一种brd4抑制剂及其制备方法和用途 |
CN110818609A (zh) * | 2018-08-11 | 2020-02-21 | 中国药科大学 | 3-乙酰基吲哚类brpf1抑制剂的制备方法及其用途 |
EP3841115A4 (en) * | 2018-08-20 | 2022-08-24 | University of Georgia Research Foundation, Inc. | COMPOSITIONS AND METHODS FOR ENHANCING WHITE FAT TISSUE BROWNING |
CN109125729A (zh) * | 2018-09-06 | 2019-01-04 | 苏州吉玛基因股份有限公司 | 与非小细胞肺癌诊疗相关的基因BRD9及其siRNAs和应用 |
GB201905721D0 (en) * | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
US11171132B2 (en) * | 2019-10-03 | 2021-11-09 | Globalfoundries U.S. Inc. | Bi-directional breakdown silicon controlled rectifiers |
CN112625036A (zh) * | 2019-10-08 | 2021-04-09 | 上海海和药物研究开发股份有限公司 | 一类具有brd4抑制活性的化合物、其制备方法及用途 |
WO2022012456A1 (en) * | 2020-07-17 | 2022-01-20 | Chengdu Easton Biopharmaceuticals Co., Ltd. | Novel heterocyclic compounds as bet inhibitors |
TW202237095A (zh) | 2020-12-03 | 2022-10-01 | 德商艾斯巴赫生物有限公司 | Alc1抑制劑及與parpi之協同性 |
EP4363417A1 (en) * | 2021-06-29 | 2024-05-08 | Tay Therapeutics Limited | Pyrrolopyridone derivatives useful in the treatment of cancer |
CN115611890B (zh) * | 2021-07-15 | 2024-05-31 | 成都硕德药业有限公司 | 一种新型噻吩类bet溴结构域抑制剂、其制备方法及医药用途 |
WO2023213833A1 (en) | 2022-05-02 | 2023-11-09 | Eisbach Bio Gmbh | Use of alc1 inhibitors and synergy with parpi |
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-
2015
- 2015-11-09 MA MA040940A patent/MA40940A/fr unknown
- 2015-11-10 WO PCT/US2015/060007 patent/WO2016077380A1/en active Application Filing
- 2015-11-10 CN CN201580072518.9A patent/CN107108614B/zh active Active
- 2015-11-10 JP JP2017525078A patent/JP6669745B2/ja active Active
- 2015-11-10 EP EP15797572.3A patent/EP3218374B1/en active Active
-
2017
- 2017-05-10 US US15/592,017 patent/US10150767B2/en active Active
-
2018
- 2018-02-26 HK HK18102678.5A patent/HK1243076A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP3218374A1 (en) | 2017-09-20 |
US20170342067A1 (en) | 2017-11-30 |
MA40940A (fr) | 2017-09-19 |
CN107108614B (zh) | 2021-06-01 |
EP3218374B1 (en) | 2021-12-29 |
US10150767B2 (en) | 2018-12-11 |
CN107108614A (zh) | 2017-08-29 |
WO2016077380A1 (en) | 2016-05-19 |
JP6669745B2 (ja) | 2020-03-18 |
JP2017533249A (ja) | 2017-11-09 |
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