DK2347775T3
(da)
|
2005-12-13 |
2020-07-13 |
Harvard College |
Skabeloner til celletransplantation
|
EP2624873B1
(en)
|
2010-10-06 |
2019-12-04 |
President and Fellows of Harvard College |
Injectable, pore-forming hydrogels for materials-based cell therapies
|
LT2838515T
(lt)
|
2012-04-16 |
2020-03-10 |
President And Fellows Of Harvard College |
Mezoporinės silico dioksido kompozicijos, skirtos imuninio atsako moduliavimui
|
IN2014MN02492A
(zh)
|
2012-06-08 |
2015-07-17 |
Aduro Biotech |
|
AU2013358892B2
(en)
|
2012-12-13 |
2018-06-21 |
Aduro Biotech, Inc. |
Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
|
SG10201708821RA
(en)
|
2013-04-29 |
2017-12-28 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for altering second messenger signaling
|
WO2014179760A1
(en)
|
2013-05-03 |
2014-11-06 |
The Regents Of The University Of California |
Cyclic di-nucleotide induction of type i interferon
|
US9549944B2
(en)
|
2013-05-18 |
2017-01-24 |
Aduro Biotech, Inc. |
Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
|
AP2015008700A0
(en)
|
2013-05-18 |
2015-08-31 |
Univ California |
Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
|
EP3027227A4
(en)
*
|
2013-07-31 |
2018-05-23 |
Memorial Sloan Kettering Cancer Center |
Sting crystals and modulators
|
US10570204B2
(en)
|
2013-09-26 |
2020-02-25 |
The Medical College Of Wisconsin, Inc. |
Methods for treating hematologic cancers
|
EP3071209A4
(en)
*
|
2013-11-19 |
2017-08-16 |
The University of Chicago |
Use of sting agonist as cancer treatment
|
US10441654B2
(en)
|
2014-01-24 |
2019-10-15 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
SMC combination therapy for the treatment of cancer
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
CN107073090A
(zh)
|
2014-04-30 |
2017-08-18 |
哈佛学院董事会 |
结合的疫苗装置和杀死癌细胞的方法
|
JP6462006B2
(ja)
|
2014-06-04 |
2019-01-30 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
Stingのモジュレーターとしての環式ジヌクレオチド
|
EP3925622A1
(en)
|
2014-09-13 |
2021-12-22 |
Novartis AG |
Combination therapies
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
EP4245376A3
(en)
|
2014-10-14 |
2023-12-13 |
Novartis AG |
Antibody molecules to pd-l1 and uses thereof
|
JP6762030B2
(ja)
*
|
2014-11-20 |
2020-09-30 |
国立研究開発法人医薬基盤・健康・栄養研究所 |
異なる核酸アジュバントの組み合わせによる、新規Th1誘導性アジュバントおよびその用途
|
CN107148424B
(zh)
*
|
2014-12-16 |
2021-01-08 |
凯拉治疗股份公司 |
用于诱导细胞因子的环状二核苷酸
|
GB201501462D0
(en)
*
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
CA3012602A1
(en)
|
2015-01-30 |
2016-08-04 |
President And Fellows Of Harvard College |
Peritumoral and intratumoral materials for cancer therapy
|
US10130663B2
(en)
|
2015-02-11 |
2018-11-20 |
The John Hopkins University |
Bacteria over-expressing c-di-AMP and therapeutic methods
|
JO3746B1
(ar)
|
2015-03-10 |
2021-01-31 |
Aduro Biotech Inc |
تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون"
|
WO2016164705A1
(en)
|
2015-04-10 |
2016-10-13 |
Omar Abdel-Rahman Ali |
Immune cell trapping devices and methods for making and using the same
|
MX2017013321A
(es)
|
2015-04-22 |
2018-07-06 |
Curevac Ag |
Composicion que contiene arn para tratamiento de enfermedades tumorales.
|
LT3317301T
(lt)
|
2015-07-29 |
2021-07-26 |
Novartis Ag |
Kombinuotos terapijos, apimančios antikūno molekules prieš lag-3
|
US20180207273A1
(en)
|
2015-07-29 |
2018-07-26 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
EP3328418A1
(en)
|
2015-07-29 |
2018-06-06 |
Novartis AG |
Combination therapies comprising antibody molecules to pd-1
|
CN106692967A
(zh)
*
|
2015-08-12 |
2017-05-24 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸cGAMP联合PD1的抗体(Nivolumab)在制备抗肿瘤药物中的应用
|
AU2016304899B2
(en)
*
|
2015-08-13 |
2018-11-08 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
CN106540255A
(zh)
*
|
2015-09-18 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸cGAMP联合贝伐珠单抗在抗肿瘤中的应用
|
BR112018008339A2
(pt)
|
2015-10-28 |
2018-10-30 |
Aduro Biotech Inc |
composições e métodos para ativar estimulador de sinalização dependente do gene de interferon
|
MA44334A
(fr)
|
2015-10-29 |
2018-09-05 |
Novartis Ag |
Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
|
AU2016362697B2
(en)
*
|
2015-12-03 |
2018-07-12 |
Glaxosmithkline Intellectual Property Development Limited |
Cyclic purine dinucleotides as modulators of STING
|
RU2729116C2
(ru)
|
2015-12-16 |
2020-08-04 |
Гритстоун Онколоджи, Инк. |
Идентификация, производство и применение неоантигенов
|
WO2017106740A1
(en)
*
|
2015-12-16 |
2017-06-22 |
Aduro Biotech, Inc. |
Methods for identifying inhibitors of "stimulator of interferon gene"-dependent interferon production
|
MX2018007423A
(es)
|
2015-12-17 |
2018-11-09 |
Novartis Ag |
Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas.
|
WO2017123657A1
(en)
|
2016-01-11 |
2017-07-20 |
Gary Glick |
Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
|
BR112018013808A2
(pt)
|
2016-01-11 |
2018-12-11 |
Innate Tumor Immunity, Inc. |
dinucleotídeos cíclicos para o tratamento de condições associadas à atividade de sting, tal como câncer
|
IL260218B2
(en)
|
2016-01-11 |
2023-04-01 |
Novartis Ag |
Humanized monoclonal antibodies that elicit an immune response against interleukin-2, and their fusion proteins
|
CN106544319A
(zh)
*
|
2016-01-24 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法
|
CN109072197A
(zh)
|
2016-02-06 |
2018-12-21 |
哈佛学院校长同事会 |
重塑造血巢以重建免疫
|
NZ746112A
(en)
*
|
2016-03-18 |
2023-01-27 |
Immune Sensor Llc |
Cyclic di-nucleotide compounds and methods of use
|
CN106540256A
(zh)
*
|
2016-03-27 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸-脂质体偶联单克隆抗体在抗肿瘤中的应用
|
JP2019510802A
(ja)
|
2016-04-07 |
2019-04-18 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
タンパク質調節物質として有用な複素環アミド
|
SI3440076T1
(sl)
|
2016-04-07 |
2022-09-30 |
Glaxosmithkline Intellectual Property Development Limited |
Heterociklični amidi uporabni kot proteinski modulatorji
|
WO2017184735A1
(en)
|
2016-04-19 |
2017-10-26 |
Ifm Therapeutics, Inc |
Nlrp3 modulators
|
EP3445761A1
(en)
|
2016-04-19 |
2019-02-27 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
US10696985B1
(en)
|
2016-06-06 |
2020-06-30 |
Vanderbilt University |
Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
|
EP3507367A4
(en)
*
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
IL264049B2
(en)
*
|
2016-07-06 |
2023-11-01 |
Sperovie Biosciences Inc |
Compounds, preparations and methods for treating the disease
|
WO2018009652A1
(en)
*
|
2016-07-06 |
2018-01-11 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
CN109789092A
(zh)
|
2016-07-13 |
2019-05-21 |
哈佛学院院长等 |
抗原呈递细胞模拟支架及其制备和使用方法
|
NL2017267B1
(en)
|
2016-07-29 |
2018-02-01 |
Aduro Biotech Holdings Europe B V |
Anti-pd-1 antibodies
|
NL2017270B1
(en)
|
2016-08-02 |
2018-02-09 |
Aduro Biotech Holdings Europe B V |
New anti-hCTLA-4 antibodies
|
EP3497119A1
(en)
|
2016-08-09 |
2019-06-19 |
Aarhus Universitet |
Modulation of ifi16 and sting activity
|
DK3506884T3
(da)
|
2016-08-30 |
2021-07-26 |
Dana Farber Cancer Inst Inc |
Sammensætninger til indgivelse af medicin og anvendelser af disse
|
US11052149B2
(en)
|
2016-09-19 |
2021-07-06 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for inducing an immune response
|
US10537590B2
(en)
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
AR109788A1
(es)
|
2016-10-04 |
2019-01-23 |
Merck Sharp & Dohme |
Compuestos de benzo[b]tiofeno como agonistas de sting
|
WO2018065360A1
(de)
|
2016-10-07 |
2018-04-12 |
Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb Gmbh |
Benzimidazolhaltige cyclische dinukleotide, verfahren zu deren herstellung und ihre verwendung zur aktivierung von stimulator von interferongenen (sting)-abhängigen signalwegen
|
EP3525817A4
(en)
|
2016-10-11 |
2020-09-16 |
The Governors of the University of Alberta |
IMMUNOGENIC HEPATITIS C VIRUS COMPOSITIONS WITH A CYCLIC DINUCLEOTIDE OR ARCHAEOSOME AS ADJUVANS AND METHOD OF USE THEREOF
|
JOP20170188A1
(ar)
*
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
JOP20170192A1
(ar)
*
|
2016-12-01 |
2019-01-30 |
Takeda Pharmaceuticals Co |
داي نوكليوتيد حلقي
|
JP2018090562A
(ja)
*
|
2016-12-01 |
2018-06-14 |
武田薬品工業株式会社 |
環状ジヌクレオチド
|
RU2019122598A
(ru)
*
|
2016-12-20 |
2021-01-22 |
Мерк Шарп И Доум Корп. |
Циклические динуклеотидные агонисты sting для лечения рака
|
RU2019122602A
(ru)
*
|
2016-12-20 |
2021-01-22 |
Мерк Шарп И Доум Корп. |
Комбинации антагонистов pd-1 и циклических динуклеотидных агонистов sting для лечения рака
|
ES2891326T3
(es)
|
2017-01-27 |
2022-01-27 |
Janssen Biotech Inc |
Dinucleótidos cíclicos como agonistas de la STING
|
AU2018212788A1
(en)
*
|
2017-01-27 |
2019-07-25 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as STING agonists
|
CA3051252A1
(en)
|
2017-02-01 |
2018-08-09 |
Modernatx, Inc. |
Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
JP2018131427A
(ja)
*
|
2017-02-17 |
2018-08-23 |
国立研究開発法人理化学研究所 |
免疫細胞の制御技術
|
TWI674261B
(zh)
|
2017-02-17 |
2019-10-11 |
美商英能腫瘤免疫股份有限公司 |
Nlrp3 調節劑
|
JP2020508310A
(ja)
|
2017-02-21 |
2020-03-19 |
ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System |
インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド
|
CN106727331B
(zh)
*
|
2017-03-13 |
2022-02-01 |
杭州星鳌生物科技有限公司 |
免疫脂质体-环二核苷酸的组成、制备方法及其在抗肿瘤中的应用
|
JP2020514378A
(ja)
|
2017-03-20 |
2020-05-21 |
ジェノセア バイオサイエンシーズ, インコーポレイテッド |
処置方法
|
JOP20190218A1
(ar)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
EP3609922A2
(en)
|
2017-04-13 |
2020-02-19 |
Aduro Biotech Holdings, Europe B.V. |
Anti-sirp alpha antibodies
|
WO2018189382A1
(en)
|
2017-04-14 |
2018-10-18 |
Solstice Biologics, Ltd. |
Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
|
AR111651A1
(es)
|
2017-04-28 |
2019-08-07 |
Novartis Ag |
Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
AR113224A1
(es)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
EP3621624B1
(en)
|
2017-05-12 |
2023-08-30 |
Merck Sharp & Dohme LLC |
Cyclic di-nucleotide compounds as sting agonists
|
CN108853144A
(zh)
*
|
2017-05-16 |
2018-11-23 |
科济生物医药(上海)有限公司 |
Toll样受体激动剂与免疫效应细胞的联用
|
WO2018229715A1
(en)
|
2017-06-16 |
2018-12-20 |
Novartis Ag |
Compositions comprising anti-cd32b antibodies and methods of use thereof
|
EP3642240A1
(en)
|
2017-06-22 |
2020-04-29 |
Novartis AG |
Antibody molecules to cd73 and uses thereof
|
PE20200717A1
(es)
|
2017-06-22 |
2020-07-21 |
Novartis Ag |
Moleculas de anticuerpo que se unen a cd73 y usos de las mismas
|
NZ761519A
(en)
|
2017-07-14 |
2023-07-28 |
Innate Tumor Immunity Inc |
Nlrp3 modulators
|
EP3431484A1
(en)
*
|
2017-07-21 |
2019-01-23 |
Ludwig-Maximilians-Universität München |
A fluorescent cyclic dinucleotide and its use in methods of identifying substances having an ability to modulate the cgas/sting pathway
|
KR20200032180A
(ko)
*
|
2017-07-28 |
2020-03-25 |
브리스톨-마이어스 스큅 컴퍼니 |
항암제로서의 시클릭 디뉴클레오티드
|
US11312772B2
(en)
|
2017-08-04 |
2022-04-26 |
Merck Sharp & Dohme Corp. |
Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment
|
EP3661498A4
(en)
|
2017-08-04 |
2021-04-21 |
Merck Sharp & Dohme Corp. |
BENZO [B] THIOPHEN STING ANTAGONISTS FOR CANCER TREATMENT
|
KR20200058411A
(ko)
|
2017-08-30 |
2020-05-27 |
베이징 슈안이 파마사이언시스 컴퍼니, 리미티드 |
인터페론 유전자 조절인자의 자극제로서의 환식 다이-뉴클레오타이드
|
WO2019046511A1
(en)
|
2017-08-31 |
2019-03-07 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
|
US10953032B2
(en)
*
|
2017-08-31 |
2021-03-23 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
US10947263B2
(en)
*
|
2017-08-31 |
2021-03-16 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
JP7292740B2
(ja)
|
2017-09-08 |
2023-06-19 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
Enpp1阻害剤及びがんの治療のためのそれらの使用
|
WO2019051488A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
US11707531B2
(en)
|
2017-09-11 |
2023-07-25 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
CA3077337A1
(en)
|
2017-10-05 |
2019-04-11 |
Glaxosmithkline Intellectual Property Development Limited |
Modulators of stimulator of interferon genes (sting)
|
EP3692033A1
(en)
|
2017-10-05 |
2020-08-12 |
GlaxoSmithKline Intellectual Property Development Limited |
Modulators of stimulator of interferon genes (sting) useful in treating hiv
|
KR20200087143A
(ko)
|
2017-10-10 |
2020-07-20 |
그릿스톤 온콜로지, 인코포레이티드 |
핫스팟을 이용한 신생항원 동정
|
WO2019081983A1
(en)
|
2017-10-25 |
2019-05-02 |
Novartis Ag |
CD32B TARGETING ANTIBODIES AND METHODS OF USE
|
CN111566119A
(zh)
|
2017-11-10 |
2020-08-21 |
武田药品工业有限公司 |
Sting调节剂化合物以及制备和使用方法
|
EA038805B1
(ru)
*
|
2017-11-21 |
2021-10-21 |
Такеда Фармасьютикал Компани Лимитед |
Циклические динуклеотиды в качестве агонистов sting (стимулятор генов интерферона)
|
JP2021503897A
(ja)
|
2017-11-22 |
2021-02-15 |
グリットストーン オンコロジー インコーポレイテッド |
新生抗原のためのジャンクションエピトープ提示の低減
|
WO2019104353A1
(en)
*
|
2017-11-27 |
2019-05-31 |
Children's Medical Center Corporation |
Stimulator of interferon genes (sting) ligands and uses thereof
|
EP3728283B1
(en)
|
2017-12-20 |
2023-11-22 |
Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. |
3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
WO2019125974A1
(en)
|
2017-12-20 |
2019-06-27 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
AU2018392212B9
(en)
|
2017-12-20 |
2021-03-18 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
|
JP7230035B2
(ja)
*
|
2018-01-04 |
2023-02-28 |
アカデミア シニカ |
治療を強化するための細胞会合免疫アジュバントならびに同アジュバントを含むキットおよび処方物
|
WO2019147509A1
(en)
*
|
2018-01-26 |
2019-08-01 |
The Regents Of The University Of California |
Intranasal delivery of a cyclic-di-nucleotide adjuvanted vaccine for tuberculosis
|
US20220211815A1
(en)
|
2018-02-02 |
2022-07-07 |
Novartis Ag |
Combination therapy for the treatment of cancer
|
CA3090659A1
(en)
*
|
2018-02-06 |
2019-08-15 |
Stipe Therapeutics Aps |
Modulation of p62 and sting activity
|
WO2019175145A1
(en)
|
2018-03-12 |
2019-09-19 |
Janssen Vaccines & Prevention B.V. |
Vaccines against urinary tract infections
|
CN110272462B
(zh)
*
|
2018-03-15 |
2023-03-10 |
南开大学 |
制备化合物的方法
|
CA3093849A1
(en)
|
2018-03-23 |
2019-09-26 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising sting-agonist
|
EP3774834A1
(en)
|
2018-03-27 |
2021-02-17 |
Boehringer Ingelheim International GmbH |
Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6h-pytazolo[1,5-d][1,2,4]triazin-7-one as sting agonists
|
CN111989338A
(zh)
|
2018-03-27 |
2020-11-24 |
勃林格殷格翰国际有限公司 |
修饰的环二核苷酸化合物
|
WO2019195063A1
(en)
|
2018-04-03 |
2019-10-10 |
Merck Sharp & Dohme Corp. |
Aza-benzothiophene compounds as sting agonists
|
TWI793294B
(zh)
|
2018-04-03 |
2023-02-21 |
美商默沙東有限責任公司 |
Sting促效劑化合物
|
US11874276B2
(en)
|
2018-04-05 |
2024-01-16 |
Dana-Farber Cancer Institute, Inc. |
STING levels as a biomarker for cancer immunotherapy
|
TWI833744B
(zh)
*
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
TW202005654A
(zh)
|
2018-04-06 |
2020-02-01 |
捷克科學院有機化學與生物化學研究所 |
2,2,─環二核苷酸
|
MX2020011234A
(es)
|
2018-04-25 |
2020-11-11 |
Innate Tumor Immunity Inc |
Moduladores de receptor similar al dominio de oligomerizacion de union a nucleotidos que contiene dominio de pirina 3 (nlrp3).
|
CN108310378A
(zh)
*
|
2018-04-28 |
2018-07-24 |
杭州星鳌生物科技有限公司 |
一类新型免疫联体抗肿瘤创新药物的制备及其应用
|
WO2019211799A1
(en)
|
2018-05-03 |
2019-11-07 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide
|
GB201807924D0
(en)
|
2018-05-16 |
2018-06-27 |
Ctxt Pty Ltd |
Compounds
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
JP7335277B2
(ja)
|
2018-06-01 |
2023-08-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
膀胱がんの治療のための方法
|
EP3810151A4
(en)
*
|
2018-06-20 |
2022-03-23 |
Yale University |
RIG-I AGONISTS AND TREATMENTS USING THEM
|
EP3818044A1
(en)
|
2018-07-03 |
2021-05-12 |
IFM Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
CN112823036A
(zh)
|
2018-07-03 |
2021-05-18 |
艾福姆德尤股份有限公司 |
用于治疗与sting活性有关的疾病的化合物和组合物
|
SG11202100023XA
(en)
*
|
2018-07-11 |
2021-01-28 |
Actym Therapeutics Inc |
Engineered immunostimulatory bacterial strains and uses thereof
|
US11572360B2
(en)
|
2018-08-16 |
2023-02-07 |
Innate Tumor Immunity, Inc. |
Substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
|
CN112041325B
(zh)
|
2018-08-16 |
2023-10-24 |
卫材R&D管理有限公司 |
化合物的盐及其晶体
|
CN112996567A
(zh)
|
2018-08-16 |
2021-06-18 |
先天肿瘤免疫公司 |
咪唑并[4,5-c]喹啉衍生的nlrp3-调节剂
|
KR20210046023A
(ko)
|
2018-08-16 |
2021-04-27 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
이미다조[4,5-c]퀴놀린 유래 NLRP3-조정제
|
MA53438A
(fr)
|
2018-08-24 |
2021-09-15 |
Codiak Biosciences Inc |
Vésicules extracellulaires ciblant des cellules dendritiques et utilisations associées
|
JP7254818B2
(ja)
|
2018-09-06 |
2023-04-10 |
第一三共株式会社 |
新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート
|
WO2020049534A1
(en)
|
2018-09-07 |
2020-03-12 |
Novartis Ag |
Sting agonist and combination therapy thereof for the treatment of cancer
|
US20220031825A1
(en)
*
|
2018-09-17 |
2022-02-03 |
Quratis Inc. |
Immunological adjuvant and vaccine composition including sting agonist
|
WO2020057546A1
(zh)
|
2018-09-21 |
2020-03-26 |
上海迪诺医药科技有限公司 |
环状二核苷酸类似物、其药物组合物及应用
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
WO2020092379A1
(en)
|
2018-10-29 |
2020-05-07 |
Genocea Biosciences, Inc. |
Treatment methods
|
US11161864B2
(en)
|
2018-10-29 |
2021-11-02 |
Venenum Biodesign, LLC |
Sting agonists
|
US20220008346A1
(en)
|
2018-10-30 |
2022-01-13 |
Vanderbilt University |
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
|
EP3873938A1
(en)
|
2018-10-31 |
2021-09-08 |
Novartis AG |
Dc-sign antibody conjugates comprising sting agonists
|
US11596692B1
(en)
|
2018-11-21 |
2023-03-07 |
Incyte Corporation |
PD-L1/STING conjugates and methods of use
|
US20220033435A1
(en)
*
|
2018-12-07 |
2022-02-03 |
Merck Sharp & Dohme Corp. |
Cyclic Di-Nucleotide Compounds as STING Agonists
|
EP3891165A4
(en)
*
|
2018-12-07 |
2022-08-24 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
EP3891164A4
(en)
*
|
2018-12-07 |
2022-08-24 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
US20220125821A1
(en)
*
|
2019-01-10 |
2022-04-28 |
Nankai University |
Cyclic dinucleotide prodrug molecule, preparation method therefor and application thereof
|
ES2930151T3
(es)
|
2019-01-14 |
2022-12-07 |
Innate Tumor Immunity Inc |
Moduladores heterocíclicos de NLRP3, para su uso en el tratamiento del cáncer
|
JP7335341B2
(ja)
|
2019-01-14 |
2023-08-29 |
イネイト・テューマー・イミュニティ・インコーポレイテッド |
Nlrp3モジュレーター
|
JP7373571B2
(ja)
|
2019-01-14 |
2023-11-02 |
イネイト・テューマー・イミュニティ・インコーポレイテッド |
がん治療に用いるためのnlrp3モジュレーターとしての置換キナゾリン
|
WO2020150116A1
(en)
|
2019-01-14 |
2020-07-23 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
TW202043198A
(zh)
|
2019-01-17 |
2020-12-01 |
美商Ifm Due有限公司 |
用於治療與sting活性相關之病況的化合物及組合物
|
US10998091B2
(en)
|
2019-02-07 |
2021-05-04 |
Sandeep Patil |
Systems for monitoring compliance with a patch dosage regimen and methods of using the same
|
EP3935065A1
(en)
|
2019-03-07 |
2022-01-12 |
Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. |
3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
|
EP3934757B1
(en)
*
|
2019-03-07 |
2023-02-22 |
Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. |
2'3'-cyclic dinucleotides and prodrugs thereof
|
AU2020231115A1
(en)
*
|
2019-03-07 |
2021-08-26 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotides and prodrugs thereof
|
AR118389A1
(es)
|
2019-03-18 |
2021-09-29 |
Janssen Pharmaceuticals Inc |
Métodos de producción de bioconjugados de polisacáridos de e. coli o-antígeno, sus composiciones y métodos de utilización
|
WO2020191082A1
(en)
|
2019-03-18 |
2020-09-24 |
Janssen Pharmaceuticals, Inc. |
Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof
|
US20220387906A1
(en)
|
2019-03-21 |
2022-12-08 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
CA3133314A1
(en)
|
2019-03-21 |
2020-09-24 |
Codiak Biosciences, Inc. |
Extracellular vesicle conjugates and uses thereof
|
WO2020191361A2
(en)
|
2019-03-21 |
2020-09-24 |
Codiak Biosciences, Inc. |
Extracellular vesicles for vaccine delivery
|
US20220177465A1
(en)
|
2019-04-04 |
2022-06-09 |
Merck Sharp & Dohme Corp. |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
TW202104214A
(zh)
|
2019-04-05 |
2021-02-01 |
英商葛蘭素史密斯克藍智慧財產發展有限公司 |
化合物
|
EP3962493A2
(en)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
|
US11787833B2
(en)
|
2019-05-09 |
2023-10-17 |
Aligos Therapeutics, Inc. |
Modified cyclic dinucleoside compounds as sting modulators
|
TW202108177A
(zh)
|
2019-05-10 |
2021-03-01 |
日商武田藥品工業股份有限公司 |
抗體藥物結合物
|
US20220227760A1
(en)
|
2019-05-29 |
2022-07-21 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
EP3994158A1
(en)
|
2019-07-03 |
2022-05-11 |
Codiak BioSciences, Inc. |
Extracellular vesicles targeting t cells and uses thereof
|
US20220259254A1
(en)
|
2019-07-05 |
2022-08-18 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
GB201910304D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
GB201910305D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
JP2022543086A
(ja)
|
2019-08-02 |
2022-10-07 |
メルサナ セラピューティクス インコーポレイテッド |
がんの処置用のSTING(インターフェロン遺伝子刺激因子)アゴニストとしてのビス-[N-((5-カルバモイル)-1H-ベンゾ[d]イミダゾール-2-イル)-ピラゾール-5-カルボキサミド]誘導体および関連化合物
|
MX2022001732A
(es)
|
2019-08-12 |
2022-05-06 |
Purinomia Biotech Inc |
Metodos y composiciones para promover y potenciar la respuesta inmunitaria mediada por linfocitos t dirigida a la adcc de las celulas con expresion de cd39.
|
WO2021041532A1
(en)
|
2019-08-26 |
2021-03-04 |
Dana-Farber Cancer Institute, Inc. |
Use of heparin to promote type 1 interferon signaling
|
EP3785719A1
(en)
*
|
2019-08-28 |
2021-03-03 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
New use of cyclic dinucleotides
|
WO2021062290A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
US20230241089A1
(en)
|
2019-09-25 |
2023-08-03 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
JP2022551420A
(ja)
|
2019-09-25 |
2022-12-09 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
腫瘍を治療するためのil-12提示エクソソームとstingアゴニスト含有エクソソームとの併用
|
JP2022549328A
(ja)
|
2019-09-25 |
2022-11-24 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
細胞外小胞組成物
|
KR20220107166A
(ko)
|
2019-10-02 |
2022-08-02 |
얀센 백신스 앤드 프리벤션 비.브이. |
스타필로코커스 펩티드 및 사용 방법
|
TW202128775A
(zh)
|
2019-10-16 |
2021-08-01 |
英商阿法克塔生命科學有限公司 |
PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分
|
EP4069683A1
(en)
|
2019-12-06 |
2022-10-12 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
WO2021142203A1
(en)
|
2020-01-10 |
2021-07-15 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
CN115038461A
(zh)
|
2020-01-16 |
2022-09-09 |
杨森制药公司 |
FimH突变体、其组合物及其用途
|
CN115427458A
(zh)
|
2020-02-28 |
2022-12-02 |
塔拉克治疗公司 |
转谷氨酰胺酶介导的缀合
|
EP4115909A1
(en)
|
2020-03-06 |
2023-01-11 |
Daiichi Sankyo Company, Limited |
Antibody-drug conjugate including novel cyclic dinucleotide derivative
|
US20230114434A1
(en)
|
2020-03-13 |
2023-04-13 |
Codiak Biosciences, Inc. |
Extracellular vesicles for treating neurological disorders
|
JP2023518414A
(ja)
|
2020-03-20 |
2023-05-01 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
治療のための細胞外小胞
|
EP4134098A4
(en)
|
2020-04-10 |
2024-05-15 |
ONO Pharmaceutical Co., Ltd. |
CANCER THERAPY METHODS
|
US11857618B2
(en)
|
2020-04-17 |
2024-01-02 |
Emory University |
Boosting immunogenicity of vaccines using saponins and agonists of the intracellular stimulator of interferon genes pathway
|
CN115835856A
(zh)
|
2020-05-13 |
2023-03-21 |
麻省理工学院 |
聚合物微装置的组合物以及其在癌症免疫疗法中的用途
|
WO2021237100A1
(en)
|
2020-05-21 |
2021-11-25 |
Codiak Biosciences, Inc. |
Methods of targeting extracellular vesicles to lung
|
EP4192506A1
(en)
|
2020-08-07 |
2023-06-14 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
EP4209506A1
(en)
|
2020-09-02 |
2023-07-12 |
Daiichi Sankyo Company, Limited |
Novel endo-?-n-acetylglucosaminidase
|
IL301248B2
(en)
|
2020-09-17 |
2024-04-01 |
Janssen Pharmaceuticals Inc |
Multivalent vaccine compositions and their uses
|
WO2022066928A2
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
WO2022066883A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising kras antigens and uses thereof
|
WO2022066934A2
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
CA3192470A1
(en)
|
2020-09-23 |
2022-03-31 |
Tim SOOS |
Methods of producing extracellular vesicles
|
WO2022079175A1
(en)
|
2020-10-14 |
2022-04-21 |
Boehringer Ingelheim International Gmbh |
Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist
|
EP3984535A1
(en)
|
2020-10-16 |
2022-04-20 |
Albert-Ludwigs-Universität Freiburg |
Nlrp3 activators for use in the treatment of infectious diseases or cancer by activating nlrp3 inflammasome
|
JP2023546278A
(ja)
|
2020-10-20 |
2023-11-01 |
タイリガンド バイオサイエンス(シャンハイ)リミテッド |
多機能環状ジヌクレオチド及びその使用
|
US20230390409A1
(en)
|
2020-10-30 |
2023-12-07 |
Avacta Life Sciences Limited |
Fap-activated serum extended half-life therapeutic conjugates
|
US20220168330A1
(en)
|
2020-11-09 |
2022-06-02 |
Takeda Pharmaceutical Company Limited |
Antibody drug conjugates
|
CN116981479A
(zh)
|
2020-12-17 |
2023-10-31 |
塔夫茨大学信托人 |
Fap激活的放射治疗诊断法以及与之相关的用途
|
WO2022153166A1
(en)
|
2021-01-12 |
2022-07-21 |
Janssen Pharmaceuticals, Inc. |
Fimh mutants, compositions therewith and use thereof
|
TW202241454A
(zh)
|
2021-02-01 |
2022-11-01 |
日商第一三共股份有限公司 |
抗體-免疫賦活化劑共軛物之新穎製造方法
|
CA3215752A1
(en)
|
2021-04-01 |
2022-10-06 |
Janssen Pharmaceuticals, Inc. |
Production of e. coli o18 bioconjugates
|
WO2022223622A1
(en)
|
2021-04-20 |
2022-10-27 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
WO2022223619A1
(en)
|
2021-04-20 |
2022-10-27 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
US20220313724A1
(en)
*
|
2021-05-17 |
2022-10-06 |
Highlight Therapeutics, S.L. |
Compositions for intratumoral administration and related methods
|
WO2023056468A1
(en)
|
2021-09-30 |
2023-04-06 |
Codiak Biosciences, Inc. |
Extracellular vesicle comprising cholesterol tagged sting-agonist
|
WO2023057567A1
(en)
|
2021-10-07 |
2023-04-13 |
Avacta Life Sciences Limited |
Pd-l1 binding affimers
|
CN114106140A
(zh)
*
|
2021-11-23 |
2022-03-01 |
哈尔滨医科大学附属肿瘤医院 |
一种表达特定sting异构体、细胞系、制备方法、用途
|
WO2023154799A1
(en)
|
2022-02-14 |
2023-08-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Combination immunotherapy for treating cancer
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|