SG11202100023XA - Engineered immunostimulatory bacterial strains and uses thereof - Google Patents

Engineered immunostimulatory bacterial strains and uses thereof

Info

Publication number
SG11202100023XA
SG11202100023XA SG11202100023XA SG11202100023XA SG11202100023XA SG 11202100023X A SG11202100023X A SG 11202100023XA SG 11202100023X A SG11202100023X A SG 11202100023XA SG 11202100023X A SG11202100023X A SG 11202100023XA SG 11202100023X A SG11202100023X A SG 11202100023XA
Authority
SG
Singapore
Prior art keywords
bacterial strains
immunostimulatory bacterial
engineered immunostimulatory
engineered
strains
Prior art date
Application number
SG11202100023XA
Inventor
Christopher Thanos
Laura Glickman
Justin Skoble
Alexandre Iannello
Original Assignee
Actym Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/033,187 external-priority patent/US11168326B2/en
Application filed by Actym Therapeutics Inc filed Critical Actym Therapeutics Inc
Publication of SG11202100023XA publication Critical patent/SG11202100023XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4614—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4648—Bacterial antigens
    • A61K39/464832—Salmonella; Shigella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/50—Colon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/095—Fusion polypeptide containing a localisation/targetting motif containing a nuclear export signal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11202100023XA 2018-07-11 2019-07-11 Engineered immunostimulatory bacterial strains and uses thereof SG11202100023XA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16/033,187 US11168326B2 (en) 2017-07-11 2018-07-11 Engineered immunostimulatory bacterial strains and uses thereof
PCT/US2018/041713 WO2019014398A1 (en) 2017-07-11 2018-07-11 Engineered immunostimulatory bacterial strains and uses thereof
US201962789983P 2019-01-08 2019-01-08
US201962828990P 2019-04-03 2019-04-03
PCT/US2019/041489 WO2020014543A2 (en) 2018-07-11 2019-07-11 Engineered immunostimulatory bacterial strains and uses thereof

Publications (1)

Publication Number Publication Date
SG11202100023XA true SG11202100023XA (en) 2021-01-28

Family

ID=69142524

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202100023XA SG11202100023XA (en) 2018-07-11 2019-07-11 Engineered immunostimulatory bacterial strains and uses thereof

Country Status (12)

Country Link
US (4) US11779612B2 (en)
EP (1) EP3820992A2 (en)
JP (2) JP7340591B2 (en)
KR (1) KR20210030973A (en)
CN (1) CN112673092B (en)
AU (2) AU2019301699B2 (en)
BR (1) BR112021000315A2 (en)
CA (2) CA3106143A1 (en)
IL (1) IL279981A (en)
MX (1) MX2021000165A (en)
SG (1) SG11202100023XA (en)
WO (1) WO2020014543A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811530B1 (en) 2007-05-14 2019-01-02 Research Foundation Of State Univ Of New York composition comprising inducer (s) of physiological response to decanoic acid dispersion, surface, solution, ex vivo method of treating or inhibiting the formation of a biofilm on a surface
US9765117B2 (en) * 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
CA3011283A1 (en) 2016-01-11 2017-07-20 Synlogic Operating Company, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
MX2019008196A (en) 2017-01-06 2019-12-16 Synlogic Operating Co Inc Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells.
CN108359667B (en) * 2018-01-06 2021-01-05 武汉泽智生物医药有限公司 siRNA sequence expressed by silent programmed death receptor-ligand and application thereof
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3820992A2 (en) * 2018-07-11 2021-05-19 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
CN110859951A (en) * 2019-09-23 2020-03-06 中国药科大学 Application of CD200 protein and CD200 fusion protein in preparation of psoriasis treatment drugs
WO2021097144A2 (en) 2019-11-12 2021-05-20 Actym Therapeutics, Inc. Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products
CN111471646B (en) * 2020-04-20 2022-07-05 安徽中盛溯源生物科技有限公司 Method for preparing iPSC by using free plasmid vector screened by non-antibiotics
MX2023001782A (en) 2020-08-12 2023-05-22 Actym Therapeutics Inc Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms.
WO2022094847A1 (en) * 2020-11-05 2022-05-12 中国科学院深圳先进技术研究院 Cell lysis solution of engineering bacterium and use thereof in tumor therapy
CN112746117B (en) * 2020-12-25 2022-10-28 上海国际旅行卫生保健中心(上海海关口岸门诊部) Primer group for enterohemorrhagic escherichia coli detection, application thereof and kit
WO2022150779A1 (en) * 2021-01-11 2022-07-14 Synlogic Operating Company, Inc. Methods of treating cancer using recombinant microorganisms expressing a sting agonist
CN112852698B (en) * 2021-01-30 2022-11-29 军事科学院军事医学研究院军事兽医研究所 Construction method and application of Brucella A19 strain asd gene deletion strain
CA3210760A1 (en) * 2021-02-09 2022-08-18 University Of Massachusetts Intracellular delivery of therapeutic proteins designed to invade and autonomously lyse and methods of use thereof
KR20220132444A (en) * 2021-03-22 2022-09-30 클립스비엔씨 주식회사 Novel Recombinant Mycobacterium smegmatis and Use Thereof
CN113583928A (en) * 2021-07-09 2021-11-02 长江大学 Salmonella typhimurium green fluorescent strain and construction method thereof
CA3235418A1 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment
WO2023105076A1 (en) * 2021-12-09 2023-06-15 Prokarium Limited Combination cancer therapy
CN114349950A (en) * 2021-12-15 2022-04-15 深圳先进技术研究院 Antibody synthetic bacterium-nano stimulant hybrid system and application thereof
CN114344463B (en) * 2022-01-10 2023-07-28 南方医科大学南方医院 Use of angiogenesis inhibitors to enhance distant effects in patients with malignant tumor metastasis
WO2023246840A1 (en) * 2022-06-22 2023-12-28 Wuhan Houxian Biopharmaceutical Co. Ltd. Combination of il-12 and ox40l for cancer immunotherapy
CN115678841A (en) * 2022-11-18 2023-02-03 广东医科大学附属医院 Composition for enhancing immune suppression function of human umbilical cord mesenchymal stem cells and application

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3630200A (en) 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3847770A (en) 1972-04-10 1974-11-12 Continental Can Co Photopolymerizable compositions prepared from beta hydroxy esters and polyitaconates
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3936354A (en) 1974-04-29 1976-02-03 Lapointe Jean Rock Anti-tumour product of bacterial origin
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
US4769027A (en) 1984-08-15 1988-09-06 Burroughs Wellcome Co. Delivery system
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (en) 1989-03-22 1991-07-25 Bioresearch Spa USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
ATE452207T1 (en) 1992-08-21 2010-01-15 Univ Bruxelles IMMUNOGLOBULINS WITHOUT LIGHT CHAINS
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
IT1270594B (en) 1994-07-07 1997-05-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
US6190657B1 (en) 1995-06-07 2001-02-20 Yale University Vectors for the diagnosis and treatment of solid tumors including melanoma
US5997881A (en) 1995-11-22 1999-12-07 University Of Maryland, Baltimore Method of making non-pyrogenic lipopolysaccharide or A
JP2002513287A (en) * 1997-04-18 2002-05-08 ゲゼルシャフト フュア バイオテクノロギッシェ フォーシュンク エム ベー ハー（ゲー ベー エフ） Salmonella strain
CA2302866C (en) 1997-09-10 2012-02-21 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
US6080849A (en) 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
US6024961A (en) 1997-11-14 2000-02-15 Washington University Recombinant avirulent immunogenic S typhi having rpos positive phenotype
EE05627B1 (en) 1998-12-23 2013-02-15 Pfizer Inc. Human monoclonal antibodies to CTLA-4
AP1590A (en) 1998-12-23 2006-03-14 Pfizer Human monoclonal antibodies to CTLA-4.
JP2001010973A (en) 1999-06-29 2001-01-16 Dnavec Research Inc Cancer vaccine
CN1371416B (en) 1999-08-24 2012-10-10 梅达里克斯公司 Human CTLA-4 antibodies and their uses
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
US6962696B1 (en) 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
AU7993600A (en) 1999-10-04 2001-05-10 Sloan-Kettering Institute For Cancer Research Non-invasive tumor imaging by tumor-targeted bacteria
DE60131430T2 (en) 2000-01-14 2008-10-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services OLIGODE OXYNUCLEOTIDES AND THEIR USE FOR INDUCING AN IMMUNE REACTION
CA2403397A1 (en) 2000-03-16 2001-09-20 Genetica, Inc. Methods and compositions for rna interference
US8202846B2 (en) 2000-03-16 2012-06-19 Cold Spring Harbor Laboratory Methods and compositions for RNA interference
US6872547B1 (en) 2000-10-11 2005-03-29 Washington University Functional balanced-lethal host-vector systems
IL149701A0 (en) 2001-05-23 2002-11-10 Pfizer Prod Inc Use of anti-ctla-4 antibodies
AU2002350235A1 (en) 2001-11-21 2003-06-10 The Johns Hopkins University Combination bacteriolytic therapy for the treatment of tumors
US20060051380A1 (en) 2002-02-06 2006-03-09 The Johns Hopkins University Methods and compositions for the targeting of a systemic immune response to specific organs or tissues
US7195757B2 (en) * 2002-04-15 2007-03-27 Washington University Modulation of immune responses to foreign antigens expressed by recombinant attenuated bacterial vectors
EP1499191B1 (en) * 2002-04-15 2012-05-09 Washington University in St. Louis Regulated attenuation of live vaccines to enhance cross protective immunogenicity
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
US7390646B2 (en) 2003-09-17 2008-06-24 The Regents Of The University Of California Bacterial vectors and methods of use thereof
US20070298012A1 (en) 2003-12-16 2007-12-27 Ivan King Compositions and Methods for Tumor-Targeted Delivery of Effector Molecules
JP2005299711A (en) 2004-04-07 2005-10-27 Shonan Plastic Mfg Co Ltd Regenerating pipe and its laying method
US8221739B2 (en) 2004-04-29 2012-07-17 Botanic Oil Innovations, Inc. Method of cancer treatment
US20050244375A1 (en) 2004-04-29 2005-11-03 Leonard Arnold S Composition and method of cancer treatment
US8501198B2 (en) 2004-06-07 2013-08-06 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
US8822194B2 (en) 2004-06-29 2014-09-02 Anticancer, Inc. Cancer selective auxotrophs
US20070166281A1 (en) 2004-08-21 2007-07-19 Kosak Kenneth M Chloroquine coupled antibodies and other proteins with methods for their synthesis
EP1655370A1 (en) 2004-11-05 2006-05-10 Gesellschaft für Biotechnologische Forschung Bacterial vector
DE602005023345D1 (en) 2004-12-17 2010-10-14 Beth Israel Hospital COMPOSITIONS FOR BACTERIALLY MEDIATED GENE SILENCING AND METHOD OF USE THEREOF
AU2006213610B2 (en) 2005-02-10 2012-04-05 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnosing and treating cancer using beta-catenin splice variants
MX2007011767A (en) 2005-03-23 2007-10-18 Pfizer Prod Inc Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer.
EP2418278A3 (en) 2005-05-09 2012-07-04 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
WO2007053184A2 (en) 2005-05-31 2007-05-10 Cold Spring Harbor Laboratory Methods for producing micrornas
AU2006265108C1 (en) 2005-07-01 2013-01-17 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
US8426375B2 (en) 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US7892740B2 (en) 2006-01-19 2011-02-22 The University Of Chicago Prognosis and therapy predictive markers and methods of use
US20070207171A1 (en) * 2006-03-01 2007-09-06 Cerus Corporation Engineered listeria and methods of use thereof
EP2007872A1 (en) 2006-03-20 2008-12-31 Vrije Universiteit Brussel VUB Live attenuated salmonella vaccine
WO2007130604A2 (en) 2006-05-04 2007-11-15 Baylor Research Institute Anti-tumor activity of an oncolytic adenovirus-delivered oncogene sirna
CN1974759B (en) 2006-07-26 2010-06-09 吉林大学 Attenuated salmonella transporting recombinant plasmid and its application in treating tumor
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
US7421354B2 (en) 2006-10-13 2008-09-02 General Electric Company Systems and methods for reducing an effect of a disturbance
EP3222634A1 (en) 2007-06-18 2017-09-27 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor pd-1
US20110111481A1 (en) 2007-06-29 2011-05-12 Chiang Li ENABLING THE USE OF LONG dsRNA FOR GENE TARGETING IN MAMMALIAN AND OTHER SELECTED ANIMAL CELLS
WO2009023525A2 (en) 2007-08-09 2009-02-19 Dharmacon, Inc. Methods of modulating mesenchymal stem cell differentiation
US7998461B2 (en) 2007-11-15 2011-08-16 University Of Massachusetts Salmonella cancer therapeutics and related therapeutic methods
EP2085466A1 (en) 2008-01-29 2009-08-05 AEterna Zentaris GmbH Non-pathogenic and/or attenuated bacteria capable of inducing apoptosis in macrophages, process of manufacturing and uses thereof
KR101042541B1 (en) 2008-07-25 2011-06-17 한국생명공학연구원 Recombinant Gram-negative Bacteria Producing Outer Membrane Vesicles and Method for Preparing Outer Membrane Vesicles Tagged with Foreign Epitopes Using the Same
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US8241844B2 (en) 2008-10-03 2012-08-14 Ralph Clark, legal representative Methods and compositions for modulating an immune response with immunogenic oligonucleotides
WO2010045620A1 (en) 2008-10-17 2010-04-22 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae
CN102317457A (en) 2008-11-14 2012-01-11 玛瑞纳生物技术有限公司 E. coli mediated gene silencing of beta-catenin
PE20120341A1 (en) 2008-12-09 2012-04-24 Genentech Inc ANTI-PD-L1 ANTIBODIES AND ITS USE TO IMPROVE T-CELL FUNCTION
US20120009153A1 (en) 2009-08-13 2012-01-12 Hongnian Guo Compositions for bacterial mediated gene silencing and methods of using the same
KR101934071B1 (en) 2009-11-24 2019-01-02 메디뮨 리미티드 Targeted binding agents against b7-h1
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US20130017218A1 (en) 2010-02-12 2013-01-17 The Brigham And Women's Hospital, Inc. Live bacterial vaccine safety
CA2795815C (en) 2010-04-23 2018-06-26 Cold Spring Harbor Laboratory Novel structurally designed shrnas
PL3789038T3 (en) 2010-05-14 2023-01-23 The Board Of Trustees Of The Leland Stanford Junior University Humanized and chimeric monoclonal antibodies to cd47
US9598697B2 (en) * 2010-05-28 2017-03-21 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium to decrease tumor growth
WO2012149364A1 (en) 2011-04-28 2012-11-01 Diamond Don J Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy
MX2013013054A (en) 2011-05-12 2014-02-20 Genentech Inc Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides.
ES2708669T3 (en) 2011-08-01 2019-04-10 Hoffmann La Roche Cancer treatment procedures using PD-1 axis-binding antagonists and MEK inhibitors
WO2013056352A1 (en) 2011-10-19 2013-04-25 University Health Network Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
EP2620159A1 (en) 2012-01-24 2013-07-31 Institut Pasteur Improved cancer treatment by immunotherapy with bcg or antigenically related non-pathogenic mycobacteria
US8829254B2 (en) 2012-02-14 2014-09-09 Honeywell International Inc. Process for making 1,3,3,3-tetrafluoropropene
CN108102945B (en) 2012-04-27 2021-08-24 山东新创生物科技有限公司 Compositions comprising derived bacterial strains of clostridium goeri and methods of use thereof
US9127284B2 (en) 2012-05-04 2015-09-08 The University Of Hong Kong Modified bacteria and their uses thereof for the treatment of cancer or tumor
ES2752141T3 (en) 2012-07-05 2020-04-03 Vaximm Ag DNA vaccine for use in patients with pancreatic cancer
ES2391108B1 (en) 2012-07-26 2013-10-07 Universitat Autonoma De Barcelona USE OF MYCOBACTERIUM BRUMAE FOR THE TREATMENT OF BLADDER CANCER
US10131712B2 (en) * 2012-08-14 2018-11-20 Ibc Pharmaceuticals, Inc. Combination therapy with T-cell redirecting bispecific antibodies and checkpoint inhibitors
US9242000B2 (en) 2012-10-18 2016-01-26 The Regents Of The University Of California Micro-RNAs and micro-RNA inhibitors to modulate blood vessel growth, patterning, tumor growth and malignant disease and method for making and using them
AU2013341242B2 (en) 2012-11-06 2018-06-28 Aduro Biotech, Inc. Facultatively attenuated bacterial species and methods of preparation and use thereof
SG11201504469XA (en) 2012-12-12 2015-07-30 Vasculox Inc Therapeutic cd47 antibodies
US9539290B2 (en) 2012-12-24 2017-01-10 Anticancer Inc. Individualized bacterial treatment of pancreatic cancer
DK2941258T3 (en) 2013-01-02 2019-12-16 Decoy Biosystems Inc COMPOSITIONS AND PROCEDURES FOR TREATING CANCER USING BACTERIA
KR20210084651A (en) 2013-04-18 2021-07-07 틸트 바이오세러퓨틱스 오이 Enhanced adoptive cell therapy
WO2014172631A2 (en) 2013-04-19 2014-10-23 Sutro Biopharma, Inc. Expression of biologically active proteins in a bacterial cell-free synthesis system using bacterial cells transformed to exhibit elevated levels of chaperone expression
JP6453855B2 (en) * 2013-05-18 2019-01-16 アドゥロ バイオテック，インク． Compositions and methods for activating "interferon gene stimulator" dependent signaling
WO2014189996A1 (en) 2013-05-24 2014-11-27 Nikolai Khodarev Anti-tumor therapy
WO2015002969A1 (en) 2013-07-03 2015-01-08 City Of Hope Anticancer combinations
US10987432B2 (en) * 2013-09-05 2021-04-27 The University Of Hong Kong Therapeutic delivery and expression system, methods and uses thereof
CN108715615B (en) 2013-09-13 2020-11-27 百济神州(广州)生物科技有限公司 anti-PD 1 antibodies and their use as therapeutic and diagnostic agents
CN103468626B (en) * 2013-09-27 2016-05-11 南开大学 Engineered strain and the construction method of preparation specificity salmonella H:6 diagnostic serum
SG11201602429QA (en) 2013-10-04 2016-04-28 Engeneic Molecular Delivery Pty Ltd Combination tumor treatment with drug-loaded, bispecific ligand-targeted minicells and interferon-gamma
MY175614A (en) 2013-10-25 2020-07-01 Akamis Bio Ltd Oncolytic adenoviruses armed with heterologous genes
US10487140B2 (en) 2014-01-14 2019-11-26 Integrated Biotherapeutics, Inc. Targeting immunological functions to the site of bacterial infections using cell wall targeting domains of bacteriolysins
US10421971B2 (en) 2014-01-15 2019-09-24 The University Of Chicago Anti-tumor therapy
US20170080064A1 (en) * 2014-03-05 2017-03-23 Advaxis, Ins. Methods and compositions for increasing a t-effector cell to regulatory t cell ratio
WO2015142875A1 (en) * 2014-03-17 2015-09-24 The Trustees Of The University Of Pennsylvania Compositions and methods using modified salmonella
CA2944456C (en) 2014-03-31 2023-10-31 The Johns Hopkins University Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-ctla-4 and/or anti-pd-1 antibodies to treat solid tumor malignancies
US11103538B2 (en) 2014-08-12 2021-08-31 University Of Massachusetts Targeting epigenetic regulators using a bacterial delivery system
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
EP4071235A1 (en) 2015-04-09 2022-10-12 The Regents of the University of California Engineered bacteria for production and release of therapeutics
CA3018308A1 (en) 2015-04-28 2016-11-03 Albert Einstein College Of Medicine, Inc. Treatment of cancer using recall antigens delivered by attenuated bacteria
WO2017005773A1 (en) 2015-07-07 2017-01-12 Universite de Bordeaux Use of catenin- beta 1-targeting micrornas for treating liver cancer
JP6895968B2 (en) 2015-09-08 2021-06-30 シルラジェン インコーポレイテッド Oncolytic modified vaccinia virus expressing cytokines and carboxylesterase, and how to use it
CA2997912A1 (en) 2015-09-09 2017-03-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Genetic engineering of macrophages for immunotherapy
CA3011283A1 (en) 2016-01-11 2017-07-20 Synlogic Operating Company, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
EP3426271A4 (en) 2016-03-10 2019-10-16 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
CA3029426A1 (en) 2016-06-30 2018-01-04 Oncorus, Inc. Pseudotyped oncolytic viral delivery of therapeutic polypeptides
MX2019000415A (en) 2016-07-13 2019-03-28 Vaximm Ag Process for the production of a dna vaccine for cancer immunotherapy.
BR112019004042A2 (en) 2016-08-30 2019-05-28 Dana Farber Cancer Inst Inc drug release compositions and uses thereof
BR112019008369A2 (en) * 2016-10-26 2019-10-01 Modernatx Inc messenger ribonucleic acids to enhance immune responses and methods for using them
JP7249279B2 (en) 2016-12-07 2023-03-30 サルスペラ，リミティド ライアビリティ カンパニー Synergistic treatment methods for cancer
MX2019008196A (en) 2017-01-06 2019-12-16 Synlogic Operating Co Inc Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells.
CA3059634A1 (en) 2017-04-13 2018-10-18 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
EP3610026A4 (en) 2017-04-14 2021-03-24 Cold Genesys, Inc. Methods of treating bladder cancer
WO2018197621A1 (en) * 2017-04-27 2018-11-01 Helmholtz-Zentrum für Infektionsforschung GmbH Salmonella and immunogenic composition containing the same as well as its use
JP7097438B2 (en) * 2017-07-11 2022-07-07 アクティム・セラピューティクス・インコーポレイテッド Genetically engineered immunostimulatory bacterial strains and their use
JP2021502964A (en) * 2017-11-14 2021-02-04 エヴェロ バイオサイエンシズ，インコーポレーテッド Compositions and Methods for Treating Diseases Using the Blautia Strain
WO2019178057A1 (en) * 2018-03-12 2019-09-19 Evelo Biosciences, Inc. Methods of treating cancer using burkholderia
WO2019183117A1 (en) 2018-03-19 2019-09-26 Multivir Inc. Methods and compositions comprising genetically engineered vaccines for the treatment and prevention of cancer
EP3820992A2 (en) * 2018-07-11 2021-05-19 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
WO2020047161A2 (en) * 2018-08-28 2020-03-05 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
BR112021016728A2 (en) * 2019-02-27 2022-01-11 Actym Therapeutics Inc Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells and the tumor microenvironment
US20200270613A1 (en) * 2019-02-27 2020-08-27 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
WO2021091258A1 (en) * 2019-11-06 2021-05-14 엘지전자 주식회사 Method and apparatus for transmitting and receiving signal in wireless communication system
WO2021097144A2 (en) * 2019-11-12 2021-05-20 Actym Therapeutics, Inc. Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products

Also Published As

Publication number Publication date
AU2024200578A1 (en) 2024-02-22
KR20210030973A (en) 2021-03-18
CN112673092B (en) 2024-03-29
CN112673092A (en) 2021-04-16
WO2020014543A3 (en) 2020-02-20
US20200215123A1 (en) 2020-07-09
JP7340591B2 (en) 2023-09-07
US20210030813A1 (en) 2021-02-04
US20230072505A1 (en) 2023-03-09
CA3176812A1 (en) 2020-01-16
MX2021000165A (en) 2021-05-28
BR112021000315A2 (en) 2021-08-03
US20220280577A1 (en) 2022-09-08
WO2020014543A2 (en) 2020-01-16
CA3106143A1 (en) 2020-01-16
JP2021530220A (en) 2021-11-11
IL279981A (en) 2021-03-01
US11779612B2 (en) 2023-10-10
JP2023179433A (en) 2023-12-19
AU2019301699B2 (en) 2023-11-02
EP3820992A2 (en) 2021-05-19
AU2019301699A1 (en) 2021-02-18

Similar Documents

Publication Publication Date Title
IL279981A (en) Engineered immunostimulatory bacterial strains and uses thereof
IL271319A (en) Compositions comprising bacterial strains
PL3412766T3 (en) Lactobacillus salivarius strain, composition comprising the same, and uses thereof
EP3722412A4 (en) Novel bifidobacterium bacteria and composition including novel bifidobacterium bacteria
IL283973A (en) Compositions comprising bacterial strains
LT3638271T (en) Compositions comprising bacterial strains
PL3630136T3 (en) Compositions comprising bacterial strains
GB201708182D0 (en) Compositions comprising bacterial strains
IL272491A (en) Compositions comprising bacterial strains
EP3722413A4 (en) Novel bifidobacterium bacteria and composition including novel bifidobacterium bacteria
GB201713622D0 (en) Microbial strains and uses thereof
EP3620513A4 (en) Composition comprising lactobacillus plantarum cjlp475 and lactobacillus plantarum cjlp243 strains, and use thereof
GB201919420D0 (en) Compositos comprising bacterial strains
GB201718551D0 (en) Compositions comprising bacterial strains
GB201714305D0 (en) Compositions comprising bacterial strains
GB201714298D0 (en) Compositions comprising bacterial strains
GB201714309D0 (en) Compositions comprising bacterial strains
GB201712851D0 (en) Compositions comprising bacterial strains
GB201712857D0 (en) Compositions comprising bacterial strains
GB201709534D0 (en) Compositions comprising bacterial strains
GB201709533D0 (en) Compositions comprising bacterial strains
GB201709526D0 (en) Compositions comprising bacterial strains
GB201709468D0 (en) Compositions comprising bacterial strains
GB201709465D0 (en) Compositions comprising bacterial strains
GB201709466D0 (en) Compositions comprising bacterial strains