AR113224A1 - Conjugados de anticuerpo que comprenden un agonista de sting - Google Patents

Conjugados de anticuerpo que comprenden un agonista de sting

Info

Publication number
AR113224A1
AR113224A1 ARP180101063A ARP180101063A AR113224A1 AR 113224 A1 AR113224 A1 AR 113224A1 AR P180101063 A ARP180101063 A AR P180101063A AR P180101063 A ARP180101063 A AR P180101063A AR 113224 A1 AR113224 A1 AR 113224A1
Authority
AR
Argentina
Prior art keywords
antibody conjugates
sting agonist
conjugates including
immunoconjugates
methods
Prior art date
Application number
ARP180101063A
Other languages
English (en)
Inventor
Yongqin Wan
Tom Yao Wu
- Uno Tetsuo Hsiang
George Scott Tria
Leonard Sung
Weijia Ou
Chudiobioma Ndubaku
Sarah Mwhirter
Jeffrey Mkenna
Justin Leong
Thanh Ngoc Lan Le
George Edwin Katibah
Shailaja Kasibhatla
David Kanne
Xueshi Hao
Laura Glickman
Kelsey Gauthier
Thomas W Dubensky
Charles Y Cho
Stephen Canham
Jacob Robert Bruml
Original Assignee
Novartis Ag
Aduro Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Aduro Biotech Inc filed Critical Novartis Ag
Publication of AR113224A1 publication Critical patent/AR113224A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin

Abstract

Se proporcionan en la presente inmunoconjugados que comprenden agonistas de STING. También se dan a conocer métodos para producir los inmunoconjugados y métodos de tratamiento del cáncer usando los inmunoconjugados.
ARP180101063A 2017-04-28 2018-04-25 Conjugados de anticuerpo que comprenden un agonista de sting AR113224A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762491879P 2017-04-28 2017-04-28

Publications (1)

Publication Number Publication Date
AR113224A1 true AR113224A1 (es) 2020-02-19

Family

ID=62165655

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101063A AR113224A1 (es) 2017-04-28 2018-04-25 Conjugados de anticuerpo que comprenden un agonista de sting

Country Status (5)

Country Link
EP (1) EP3615080A1 (es)
JP (1) JP2020517700A (es)
CN (1) CN110799218A (es)
AR (1) AR113224A1 (es)
WO (1) WO2018200812A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20170192A1 (ar) 2016-12-01 2019-01-30 Takeda Pharmaceuticals Co داي نوكليوتيد حلقي
US11707531B2 (en) 2017-09-11 2023-07-25 F-star Therapeutics, Inc. Compounds, compositions, and methods for the treatment of disease
WO2019051488A1 (en) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
MX2020004858A (es) 2017-11-10 2020-10-01 Takeda Pharmaceuticals Co Compuestos moduladores de sting y metodos de elaboracion y uso.
EP3505188A1 (en) * 2017-12-29 2019-07-03 Invivogen Pro-cyclic dinucleotide conjugates for cytokine induction
BR112020022299A2 (pt) 2018-05-09 2021-02-23 Legochem Biosciences, Inc. composições e métodos relacionados a conjugados de anticorpo-fármaco anti-cd19
CA3101623A1 (en) * 2018-06-01 2019-12-05 Eisai R&D Management Co., Ltd. Methods for the treatment of bladder cancer
WO2020014127A1 (en) 2018-07-10 2020-01-16 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
CN113348181A (zh) * 2018-10-31 2021-09-03 诺华股份有限公司 包含sting激动剂的dc-sign抗体缀合物
WO2020089815A1 (en) * 2018-10-31 2020-05-07 Novartis Ag Antibody conjugates comprising sting agonist
PE20211296A1 (es) * 2018-12-21 2021-07-20 Novartis Ag Anticuerpos anti-pmel17 y conjugados de los mismos
MA55805A (fr) * 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
AU2020267486A1 (en) 2019-05-09 2021-11-11 Aligos Therapeutics, Inc. Modified cyclic dinucleoside compounds as STING modulators
SG11202112223XA (en) 2019-05-10 2021-12-30 Takeda Pharmaceuticals Co Antibody drug conjugates
PE20220218A1 (es) 2019-05-20 2022-02-02 Novartis Ag Conjugados de anticuerpo-farmaco inhibidores de mcl-1 y sus metodos de uso
AU2020315802A1 (en) 2019-07-19 2022-02-24 ImmuneSensor Therapeutics Inc. Antibody-sting agonist conjugates and their use in immunotherapy
CN114585623A (zh) 2019-08-02 2022-06-03 梅尔莎纳医疗公司 双[N-((5-氨基甲酰基)-1H-苯并[d]咪唑-2-基)吡唑-5-甲酰胺]衍生物和相关化合物作为STING（干扰素基因刺激物）激动剂用于治疗癌症
MX2022002152A (es) * 2019-08-21 2022-05-18 Scripps Research Inst Agonistas biciclicos del estimulador de genes de interferon sting.
KR20210028544A (ko) * 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
WO2021046426A1 (en) * 2019-09-06 2021-03-11 Sperovie Biosciences, Inc. Cyclic dinucleotide sting agonists tethered to a pd-1 or ctla-4 antibodies
US20230074385A1 (en) * 2019-12-23 2023-03-09 Eisai R&D Management Co., Ltd. Method for producing eribulin-based antibody-drug conjugate
US20230330248A1 (en) * 2020-03-06 2023-10-19 Daiichi Sankyo Company, Limited Antibody-drug conjugate including novel cyclic dinucleotide derivative
MX2022012304A (es) * 2020-04-02 2022-11-30 Mersana Therapeutics Inc Conjugados de anticuerpo-farmaco que comprenden agonistas de sting.
EP4134098A1 (en) 2020-04-10 2023-02-15 ONO Pharmaceutical Co., Ltd. Method of cancer therapy
WO2021216572A1 (en) 2020-04-20 2021-10-28 Massachusetts Institute Of Technology Lipid compositions for delivery of sting agonist compounds and uses thereof
CA3178464A1 (en) 2020-05-15 2021-11-18 Immunesensor Therapeutics, Inc. Sting agonist combination treatments with immune checkpoint inhibitors
CN111592570B (zh) * 2020-05-15 2022-04-29 清华大学 新型sting激动剂及其制备方法和应用
PE20231947A1 (es) 2020-11-09 2023-12-05 Takeda Pharmaceuticals Co Conjugados de anticuerpo y farmaco
EP4319820A1 (en) 2021-04-10 2024-02-14 Profoundbio Us Co. Folr1 binding agents, conjugates thereof and methods of using the same
JP2024514707A (ja) 2021-04-20 2024-04-02 アンスティテュ・クリー 免疫療法における使用のための組成物及び方法
CA3216459A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
WO2023004440A2 (en) 2021-07-23 2023-01-26 Immunesensor Therapeutics, Inc. Sting agonist combination treatments with cytokines
WO2023109942A1 (en) * 2021-12-17 2023-06-22 Jacobio Pharmaceuticals Co., Ltd. Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof
WO2024020164A2 (en) 2022-07-21 2024-01-25 Firefly Bio, Inc. Glucocorticoid receptor agonists and conjugates thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3614866B2 (ja) 1997-06-12 2005-01-26 リサーチ コーポレイション テクノロジーズ，インコーポレイティド 人工抗体ポリペプチド
US8076303B2 (en) 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs
JP5769616B2 (ja) 2008-04-30 2015-08-26 イミュノジェン・インコーポレーテッド クロスリンカーおよびそれらの使用
US10022256B2 (en) 2012-11-30 2018-07-17 Novartis Ag Methods for making conjugates from disulfide-containing proteins
ES2718910T3 (es) 2012-12-13 2019-07-05 Aduro Biotech Inc Composiciones que comprenden dinucleótidos cíclicos de purina que tienen estereoquímicas definidas y métodos para su preparación y uso
AU2014214751B2 (en) * 2013-02-08 2017-06-01 Novartis Ag Specific sites for modifying antibodies to make immunoconjugates
CA2908154C (en) 2013-04-29 2023-11-28 Memorial Sloan Kettering Cancer Center Compositions and methods for altering second messenger signaling
DK2996473T3 (da) 2013-05-18 2019-11-04 Aduro Biotech Inc Sammensætninger og fremgangsmåder til aktivering af "stimulator af interferon-gen"-afhængig signalering
US10092644B2 (en) 2013-11-22 2018-10-09 Brock University Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants
US9315523B2 (en) 2013-12-06 2016-04-19 Rutgers, The State University Of New Jersey Cyclic dinucleosides
SG11201609021QA (en) 2014-06-04 2016-11-29 Glaxosmithkline Ip Dev Ltd Cyclic di-nucleotides as modulators of sting
DK3233882T3 (da) 2014-12-16 2020-01-27 Kayla Therapeutics Fluorinerede cykliske dinukleotider til cytokininduktion
SG11201706756VA (en) * 2015-03-10 2017-09-28 Aduro Biotech Inc Compositions and methods for activating "stimulator of interferon gene" -dependent signalling
WO2016161372A1 (en) * 2015-04-01 2016-10-06 President And Fellows Of Harvard College Immunoconjugates for programming or reprogramming of cells
CN107922455A (zh) 2015-07-02 2018-04-17 春季银行制药股份有限公司 用于治疗病毒感染的组合物和方法
TW201717968A (zh) 2015-07-14 2017-06-01 春季銀行製藥公司 誘導ｒｉｇ－ｉ和其他模式辨識受體之化合物及組成物
EP3328418A1 (en) * 2015-07-29 2018-06-06 Novartis AG Combination therapies comprising antibody molecules to pd-1
BR112018002757A8 (pt) 2015-08-13 2023-04-11 Merck Sharp & Dohme Composto, composição farmacêutica, e, métodos para induzir uma resposta imune, para induzir uma produção de interferon tipo i e para tratamento de um distúrbio
EP3386536A4 (en) * 2015-12-07 2019-07-31 Opi Vi- IP Holdco LLC COMPOSITION OF ANTIBODY CONSTRUCT AGONIST CONJUGATES AND METHOD FOR USE THEREOF
CN106540256A (zh) * 2016-03-27 2017-03-29 聊城市奥润生物医药科技有限公司 环二核苷酸-脂质体偶联单克隆抗体在抗肿瘤中的应用
TW201803886A (zh) 2016-07-06 2018-02-01 史貝羅威生物科學有限公司 化合物、組合物及用於治療疾病之方法
JP7100227B2 (ja) 2016-07-06 2022-07-13 エフ－スター・セラピューティクス・インコーポレイテッド 疾患の治療のための化合物、組成物、および方法
CR20190071A (es) 2016-07-15 2019-10-29 Sperovie Biosciences Inc Compuestos, composiciones y métodos para el tratamiento de enfermedades
WO2018013887A1 (en) 2016-07-15 2018-01-18 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease

Also Published As

Publication number Publication date
JP2020517700A (ja) 2020-06-18
CN110799218A (zh) 2020-02-14
WO2018200812A1 (en) 2018-11-01
EP3615080A1 (en) 2020-03-04

Similar Documents

Publication Publication Date Title
AR113224A1 (es) Conjugados de anticuerpo que comprenden un agonista de sting
ECSP18038868A (es) Conjugados de anticuerpo que comprenden un agonista del receptor tipo toll
CL2018003406A1 (es) Agonista del receptor de glucocorticoides e inmunoconjugados del mismo.
CY1124131T1 (el) Συζευγματα αντι-ρτκ7 αντισωματος-φαρμακου
CL2019003050A1 (es) Conjugados de anticuerpos que comprenden agonista del receptor de tipo toll y terapias de combinación.
CO2017010618A2 (es) Anticuerpos contra icos
CL2018003758A1 (es) Conjugados anticuerpo anti-dll3-fármaco y métodos de uso. (divisional solicitud 201800458)
ECSP19072235A (es) Anticuerpos anti-ILT4 y fragmentos de unión a antígeno
CO2017004782A2 (es) Conjugados de anticuerpo- farmaco
CR20170131A (es) Anticuerpos anti-her2 e inmunoconjugados
CR20150482A (es) Anticuerpos e inmunoconjugados anti-b7-h4
CL2016002667A1 (es) Anticuerpos anti-rnf43 novedosos y métodos para su uso
NI201700016A (es) Conjugados de fármacos con anticuerpos anti-cdh6
CL2019003168A1 (es) Mejoras farmacocinéticas de quelatos bifuncionales y usos de los mismos.
CR20160500A (es) Anticuerpos anti-ox40 y métodos de uso
CY1124230T1 (el) Αγωνιστης υποδοχεα γλυκοκορτικοειδων και ανοσοσυζευγματα αυτου
CL2018001722A1 (es) Nuevos anticuerpos anti-mfi2 y métodos de uso (divisional solicitud 201700506)
UY38433A (es) Conjugados de anticuerpo dc–sign que comprenden agonistas de sting
BR112017026027A2 (pt) combinações de imunoconjugado anti-cd37 e anticorpo anti-cd20
BR112015027309A2 (pt) anticorpo, composição, método de tratamento e uso de um anticorpo
CO2018005393A2 (es) Anticuerpos anti-htra1 y métodos de uso de los mismos
CL2018002050A1 (es) Conjugados anticuerpo-fármaco dirigidos a gcc.
CO2022009696A2 (es) Anticuerpo anti-lilrb1 y usos del mismo
CL2021001593A1 (es) Tubulisinas y conjugados de proteína-tubulisina
CO2017010692A2 (es) Construcciones de calicheamicina y sus métodos de uso

Legal Events

Date Code Title Description
FB Suspension of granting procedure