HK1215027A1 - 含磺亞胺基團的 吡啶- -基 嘧啶- -胺衍生物 - Google Patents
含磺亞胺基團的 吡啶- -基 嘧啶- -胺衍生物Info
- Publication number
- HK1215027A1 HK1215027A1 HK16103031.7A HK16103031A HK1215027A1 HK 1215027 A1 HK1215027 A1 HK 1215027A1 HK 16103031 A HK16103031 A HK 16103031A HK 1215027 A1 HK1215027 A1 HK 1215027A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyrimidin
- pyridin
- amine derivatives
- derivatives containing
- sulfoximine group
- Prior art date
Links
- KFHCTXQFMQPYRP-UHFFFAOYSA-N n-pyridin-2-ylpyrimidin-4-amine Chemical class C=1C=NC=NC=1NC1=CC=CC=N1 KFHCTXQFMQPYRP-UHFFFAOYSA-N 0.000 title 1
- 125000005555 sulfoximide group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12192855 | 2012-11-15 | ||
| PCT/EP2013/073683 WO2014076111A1 (en) | 2012-11-15 | 2013-11-13 | N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1215027A1 true HK1215027A1 (zh) | 2016-08-12 |
Family
ID=47148673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16103031.7A HK1215027A1 (zh) | 2012-11-15 | 2016-03-16 | 含磺亞胺基團的 吡啶- -基 嘧啶- -胺衍生物 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9650361B2 (zh) |
| EP (1) | EP2920164B1 (zh) |
| JP (1) | JP6263194B2 (zh) |
| KR (1) | KR20150082604A (zh) |
| CN (1) | CN104918932B (zh) |
| AP (1) | AP2015008436A0 (zh) |
| AR (1) | AR093503A1 (zh) |
| AU (1) | AU2013346866A1 (zh) |
| BR (1) | BR112015010484A2 (zh) |
| CA (1) | CA2891361C (zh) |
| CL (1) | CL2015001319A1 (zh) |
| CR (1) | CR20150257A (zh) |
| CU (1) | CU20150051A7 (zh) |
| DO (1) | DOP2015000117A (zh) |
| EA (1) | EA201590892A1 (zh) |
| ES (1) | ES2622566T3 (zh) |
| HK (1) | HK1215027A1 (zh) |
| IL (1) | IL238370A0 (zh) |
| MA (1) | MA38091B1 (zh) |
| MX (1) | MX2015006171A (zh) |
| PE (1) | PE20151142A1 (zh) |
| PH (1) | PH12015501076A1 (zh) |
| SG (1) | SG11201503274WA (zh) |
| TN (1) | TN2015000186A1 (zh) |
| TW (1) | TW201418243A (zh) |
| UY (1) | UY35138A (zh) |
| WO (1) | WO2014076111A1 (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI555737B (zh) | 2011-05-24 | 2016-11-01 | 拜耳知識產權公司 | 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺 |
| EP2909200B1 (en) * | 2012-10-18 | 2016-11-23 | Bayer Pharma Aktiengesellschaft | N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group |
| CA2964696C (en) * | 2014-10-16 | 2022-09-06 | Bayer Pharma Aktiengesellschaft | Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group |
| US9902716B2 (en) | 2014-10-16 | 2018-02-27 | Bayer Pharma Aktiengesellschaft | Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group |
| ES2786552T3 (es) | 2015-09-29 | 2020-10-13 | Bayer Pharma AG | Compuestos de sulfondiimina macrocíclicos nuevos |
| CA3001085A1 (en) | 2015-10-08 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Novel modified macrocyclic compounds |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| EP3601236A1 (en) | 2017-03-28 | 2020-02-05 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| PL3601253T3 (pl) | 2017-03-28 | 2022-01-17 | Bayer Aktiengesellschaft | Nowe hamujące ptefb związki makrocykliczne |
| MX2020003487A (es) * | 2017-10-17 | 2020-07-22 | Merck Patent Gmbh | Compuestos inhibidores de pirimidina tbk/ikkepsilon y usos de los mismos. |
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| AU770600B2 (en) | 1999-10-07 | 2004-02-26 | Amgen, Inc. | Triazine kinase inhibitors |
| PT2311825E (pt) | 2000-12-21 | 2016-01-22 | Novartis Ag | Piramidinaminas como moduladores da angiogénese |
| GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| US7291616B2 (en) | 2001-10-31 | 2007-11-06 | Cell Therapeutics, Inc. | Aryl triazines as LPAAT-β inhibitors and uses thereof |
| ES2392426T3 (es) | 2002-07-18 | 2012-12-10 | Janssen Pharmaceutica Nv | Inhibidores de quinasas con triazina sustituida |
| DE10239042A1 (de) | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
| WO2004072063A1 (en) | 2003-02-07 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl substituted pyrolls useful as inhibitors of protein kinases |
| EP1678147B1 (en) | 2003-09-15 | 2012-08-08 | Lead Discovery Center GmbH | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
| DE10349423A1 (de) | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| ATE450517T1 (de) | 2004-10-05 | 2009-12-15 | Syngenta Ltd | Isoxazolinderivate und ihre verwendung als herbizide |
| WO2006064251A1 (en) | 2004-12-17 | 2006-06-22 | Astrazeneca Ab | 4- (4- (imidazol-4-yl) pyrimidin-2-ylamino) benzamides as cdk inhibitors |
| DE102005062742A1 (de) | 2005-12-22 | 2007-06-28 | Bayer Schering Pharma Ag | Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel |
| EP1803723A1 (de) | 2006-01-03 | 2007-07-04 | Bayer Schering Pharma Aktiengesellschaft | (2,4,9-triaza-1(2,4)-pyrimidina-3(1,3)-benzenacyclononaphan-3^4-yl)-sulfoximid derivate als selektive inhibitoren der aurora kinase zur behandlung von krebs |
| DE102006041382A1 (de) | 2006-08-29 | 2008-03-20 | Bayer Schering Pharma Ag | Carbamoyl-Sulfoximide als Proteinkinaseinhibitoren |
| DE102006042143A1 (de) | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| WO2008060248A1 (en) | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
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| JP5566880B2 (ja) * | 2007-04-24 | 2014-08-06 | インゲニウム ファーマシューティカルズ ジーエムビーエイチ | プロテインキナーゼの阻害剤としての４，６−二置換アミノピリミジン誘導体 |
| JP5379787B2 (ja) | 2007-04-24 | 2013-12-25 | インゲニウム ファーマシューティカルズ ジーエムビーエイチ | プロテインキナーゼの阻害剤 |
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| US8530480B2 (en) | 2007-09-04 | 2013-09-10 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
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| GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
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| CN102731413A (zh) | 2011-04-15 | 2012-10-17 | 上海医药工业研究院 | 一种脲类化合物、其制备方法、其中间体及其应用 |
| EP2699554B1 (en) | 2011-04-19 | 2016-11-02 | Bayer Intellectual Property GmbH | Substituted 4-aryl-n-phenyl-1,3,5-triazin-2-amines |
| EP2527332A1 (en) | 2011-05-24 | 2012-11-28 | Bayer Intellectual Property GmbH | 4-Aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group as CDK9 inhibitors |
| JP5976814B2 (ja) | 2011-09-16 | 2016-08-24 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | スルホキシイミン基を含有する二置換５−フルオロピリミジン誘導体 |
| EP2755956B1 (en) | 2011-09-16 | 2016-05-18 | Bayer Intellectual Property GmbH | 2,4-disubstituted 5-fluoro-pyrimidines as selective cdk9 inhibtors |
| CN105102434A (zh) | 2012-10-18 | 2015-11-25 | 拜耳药业股份公司 | 含砜基团的4-(邻)-氟苯基-5-氟嘧啶-2-基胺 |
| EP2909200B1 (en) * | 2012-10-18 | 2016-11-23 | Bayer Pharma Aktiengesellschaft | N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group |
| CA2891358C (en) | 2012-11-15 | 2021-05-18 | Bayer Pharma Aktiengesellschaft | 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group |
| WO2014076028A1 (en) | 2012-11-15 | 2014-05-22 | Bayer Pharma Aktiengesellschaft | 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfoximine group |
| WO2015001021A1 (en) | 2013-07-04 | 2015-01-08 | Bayer Pharma Aktiengesellschaft | Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors |
| CA2942119A1 (en) | 2014-03-13 | 2015-09-17 | Bayer Pharma Aktiengesellschaft | 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group |
-
2013
- 2013-10-23 TW TW102138303A patent/TW201418243A/zh unknown
- 2013-11-13 MA MA38091A patent/MA38091B1/fr unknown
- 2013-11-13 AU AU2013346866A patent/AU2013346866A1/en not_active Abandoned
- 2013-11-13 AP AP2015008436A patent/AP2015008436A0/xx unknown
- 2013-11-13 ES ES13794844.4T patent/ES2622566T3/es active Active
- 2013-11-13 EA EA201590892A patent/EA201590892A1/ru unknown
- 2013-11-13 US US14/443,368 patent/US9650361B2/en active Active
- 2013-11-13 CA CA2891361A patent/CA2891361C/en active Active
- 2013-11-13 JP JP2015542253A patent/JP6263194B2/ja active Active
- 2013-11-13 CN CN201380070435.7A patent/CN104918932B/zh active Active
- 2013-11-13 KR KR1020157015425A patent/KR20150082604A/ko not_active Application Discontinuation
- 2013-11-13 EP EP13794844.4A patent/EP2920164B1/en active Active
- 2013-11-13 WO PCT/EP2013/073683 patent/WO2014076111A1/en active Application Filing
- 2013-11-13 MX MX2015006171A patent/MX2015006171A/es unknown
- 2013-11-13 BR BR112015010484A patent/BR112015010484A2/pt not_active IP Right Cessation
- 2013-11-13 SG SG11201503274WA patent/SG11201503274WA/en unknown
- 2013-11-13 PE PE2015000632A patent/PE20151142A1/es not_active Application Discontinuation
- 2013-11-15 AR ARP130104209A patent/AR093503A1/es unknown
- 2013-11-15 UY UY0001035138A patent/UY35138A/es unknown
-
2015
- 2015-04-19 IL IL238370A patent/IL238370A0/en unknown
- 2015-05-14 TN TNP2015000186A patent/TN2015000186A1/fr unknown
- 2015-05-14 PH PH12015501076A patent/PH12015501076A1/en unknown
- 2015-05-15 CU CUP2015000051A patent/CU20150051A7/es unknown
- 2015-05-15 CR CR20150257A patent/CR20150257A/es unknown
- 2015-05-15 DO DO2015000117A patent/DOP2015000117A/es unknown
- 2015-05-15 CL CL2015001319A patent/CL2015001319A1/es unknown
-
2016
- 2016-03-16 HK HK16103031.7A patent/HK1215027A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2891361A1 (en) | 2014-05-22 |
| UY35138A (es) | 2014-06-30 |
| CN104918932A (zh) | 2015-09-16 |
| JP2016501194A (ja) | 2016-01-18 |
| CR20150257A (es) | 2015-07-01 |
| CA2891361C (en) | 2021-07-20 |
| KR20150082604A (ko) | 2015-07-15 |
| CU20150051A7 (es) | 2015-11-27 |
| EP2920164A1 (en) | 2015-09-23 |
| EA201590892A1 (ru) | 2015-11-30 |
| EP2920164B1 (en) | 2017-02-01 |
| AR093503A1 (es) | 2015-06-10 |
| JP6263194B2 (ja) | 2018-01-17 |
| MX2015006171A (es) | 2015-08-10 |
| TN2015000186A1 (en) | 2016-10-03 |
| AP2015008436A0 (en) | 2015-05-31 |
| MA38091A3 (fr) | 2017-03-31 |
| CL2015001319A1 (es) | 2015-07-17 |
| ES2622566T3 (es) | 2017-07-06 |
| MA38091B1 (fr) | 2018-05-31 |
| US9650361B2 (en) | 2017-05-16 |
| WO2014076111A1 (en) | 2014-05-22 |
| BR112015010484A2 (pt) | 2017-07-11 |
| SG11201503274WA (en) | 2015-06-29 |
| CN104918932B (zh) | 2017-07-18 |
| US20150291559A1 (en) | 2015-10-15 |
| TW201418243A (zh) | 2014-05-16 |
| MA38091A2 (fr) | 2016-10-31 |
| AU2013346866A1 (en) | 2015-05-21 |
| DOP2015000117A (es) | 2015-06-15 |
| PH12015501076A1 (en) | 2015-08-03 |
| PE20151142A1 (es) | 2015-08-23 |
| IL238370A0 (en) | 2015-06-30 |
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