HK1214593A1 - 化合物以及其使用方法 - Google Patents

化合物以及其使用方法

Info

Publication number
HK1214593A1
HK1214593A1 HK16102486.9A HK16102486A HK1214593A1 HK 1214593 A1 HK1214593 A1 HK 1214593A1 HK 16102486 A HK16102486 A HK 16102486A HK 1214593 A1 HK1214593 A1 HK 1214593A1
Authority
HK
Hong Kong
Prior art keywords
compounds
methods
Prior art date
Application number
HK16102486.9A
Other languages
English (en)
Inventor
．勒米厄
．泊泊威次-馬勒
．薩利圖如
．撒德斯
．特維斯
陳永勝
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of HK1214593A1 publication Critical patent/HK1214593A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
HK16102486.9A 2012-11-22 2016-03-04 化合物以及其使用方法 HK1214593A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2012/085023 WO2014079011A1 (en) 2012-11-22 2012-11-22 Heterocyclic compounds for inhibiting glutaminase and their methods of use
PCT/CN2013/000294 WO2014079136A1 (en) 2012-11-22 2013-03-15 Compounds, pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof
PCT/CN2013/001428 WO2014079150A1 (en) 2012-11-22 2013-11-21 Compounds and their methods of use

Publications (1)

Publication Number Publication Date
HK1214593A1 true HK1214593A1 (zh) 2016-07-29

Family

ID=50775393

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16102486.9A HK1214593A1 (zh) 2012-11-22 2016-03-04 化合物以及其使用方法

Country Status (36)

Country Link
US (2) US10087172B2 (zh)
EP (2) EP3456719A1 (zh)
JP (2) JP6333277B2 (zh)
KR (1) KR20150085079A (zh)
CN (2) CN108727307A (zh)
AR (1) AR093598A1 (zh)
AU (2) AU2013347771B2 (zh)
BR (1) BR112015011830A2 (zh)
CA (1) CA2893510C (zh)
CL (1) CL2015001392A1 (zh)
CR (1) CR20150316A (zh)
CY (1) CY1120581T1 (zh)
DK (1) DK2922850T3 (zh)
EA (2) EA201890754A1 (zh)
EC (1) ECSP15026557A (zh)
ES (1) ES2690390T3 (zh)
HK (1) HK1214593A1 (zh)
HR (1) HRP20181628T1 (zh)
HU (1) HUE040111T2 (zh)
IL (1) IL238958B (zh)
LT (1) LT2922850T (zh)
MX (1) MX367389B (zh)
MY (1) MY177344A (zh)
NZ (1) NZ708382A (zh)
PE (1) PE20151072A1 (zh)
PH (2) PH12015501150A1 (zh)
PL (1) PL2922850T3 (zh)
PT (1) PT2922850T (zh)
RS (1) RS57859B1 (zh)
SA (1) SA515360469B1 (zh)
SG (2) SG11201504049VA (zh)
SI (1) SI2922850T1 (zh)
TR (1) TR201812360T4 (zh)
TW (2) TWI629268B (zh)
UA (1) UA117360C2 (zh)
WO (3) WO2014079011A1 (zh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8604016B2 (en) 2011-11-21 2013-12-10 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
MX2015005963A (es) 2012-11-16 2015-09-16 Calithera Biosciences Inc Inhibidores heterociclicos de glutaminasa.
EP2922832B1 (en) 2012-11-21 2019-10-09 Agios Pharmaceuticals, Inc. Glutaminase inhibitors and methods of use
WO2014079011A1 (en) 2012-11-22 2014-05-30 Agios Pharmaceuticals, Inc. Heterocyclic compounds for inhibiting glutaminase and their methods of use
CN105283182A (zh) * 2012-12-03 2016-01-27 卡利泰拉生物科技公司 用谷氨酰胺酶的杂环抑制剂治疗癌症
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
ME03780B (me) 2013-01-15 2021-04-20 Incyte Holdings Corp Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze
WO2015027124A1 (en) 2013-08-23 2015-02-26 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
JP6783663B2 (ja) 2014-01-06 2020-11-11 ライゼン・ファーマシューティカルズ・エスアー 新規グルタミナーゼ阻害剤
EA201691896A1 (ru) * 2014-03-21 2017-01-30 Аджиос Фармасьютикалз, Инк. Соединения и способы их применения
PT3137460T (pt) * 2014-04-30 2019-12-30 Pfizer Derivados de di-heterociclo ligado a cicloalquilo
GB201409624D0 (en) 2014-05-30 2014-07-16 Astrazeneca Ab 1,3,4-thiadiazole compounds and their use in treating cancer
DK3164394T3 (da) * 2014-07-03 2020-05-04 Univ Texas Gls1-inhibitorer til behandling af sygdomme
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016014890A1 (en) * 2014-07-24 2016-01-28 Calithera Biosciences, Inc. Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase
BR112017002403A2 (pt) 2014-08-07 2017-12-05 Calithera Biosciences Inc formas de cristais de inibidores de glutaminase
WO2016054388A1 (en) * 2014-10-03 2016-04-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Glutaminase inhibitors
JP6944377B2 (ja) 2015-04-06 2021-10-06 キャリセラ バイオサイエンシーズ， インコーポレイテッド グルタミナーゼの阻害剤を用いる肺がんの処置
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
ES2794868T3 (es) * 2015-06-30 2020-11-19 Univ Texas Inhibidores de GLS1 para el tratamiento de enfermedades
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
TW201718546A (zh) 2015-10-02 2017-06-01 英塞特公司 適用作pim激酶抑制劑之雜環化合物
JP6971239B2 (ja) 2015-10-05 2021-11-24 キャリセラ バイオサイエンシーズ， インコーポレイテッド グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法
TW201731511A (zh) * 2015-11-30 2017-09-16 阿斯特捷利康公司 １，３，４-噻二唑化合物及其在治療癌症中之用途
CN109503570B (zh) * 2015-12-18 2020-08-25 诺言医药科技(上海)有限公司 一种含有索拉非尼的药物组合物及其应用
CN108602782B (zh) 2015-12-22 2022-06-17 德克萨斯大学***董事会 N-甲基-1h-1,2,3-***-4-甲酰胺化合物的盐形式和多晶型物
CN109982703A (zh) 2016-08-25 2019-07-05 卡利泰拉生物科技公司 用谷氨酰胺酶抑制剂的组合疗法
KR20190040302A (ko) 2016-08-25 2019-04-17 칼리테라 바이오사이언시즈, 인코포레이티드 글루타미나제 억제제와의 병용 요법
RU2020112558A (ru) 2017-10-18 2021-11-18 Боард Оф Регентс, Зе Юниверсити Оф Тексас Систем Терапия на основе ингибитора глутаминазы
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
WO2020096916A2 (en) 2018-11-08 2020-05-14 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
WO2020191356A1 (en) * 2019-03-21 2020-09-24 Goncalves Marcus Anti-fructose therapy for colorectal and small intestine cancers
CN110746416A (zh) * 2019-09-05 2020-02-04 中国药科大学 含有三氮唑结构的谷氨酰胺酶gls1抑制剂或其可药用的盐、其制备方法及用途
CN112898200A (zh) * 2021-01-20 2021-06-04 都创(上海)医药科技股份有限公司 5-溴-6-甲氧基吡啶-2-羧酸酯的合成方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2037257A1 (en) 1970-07-28 1972-02-03 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Poly-(5-amino-1,3,4-thiadiazol-2-yl) derivs prepn - intermediates for drug and polymer prodn
US4070400A (en) 1975-10-16 1978-01-24 Merck & Co., Inc. Diphenyl polyamides having a cyclohexylene moiety
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
SU1761672A1 (ru) * 1990-05-22 1992-09-15 Белгородский технологический институт строительных материалов им.И.А.Гришманова Способ получени тонкодисперсного мела
CA2155759A1 (en) 1993-03-29 1994-10-13 Bernd Janssen 1-amino-3-phenoxy propane derivatives as modulators of multi-drug resistance
US5895748A (en) 1996-11-27 1999-04-20 Johnson; Keith R. Panel of antibodies for detecting cadherins and catenins in tissues and method of using the panel of antibodies
DE69923681T2 (de) 1998-06-18 2006-01-12 Bristol-Myers Squibb Co. Kohlenstoff substituierte aminothiazole als inhibitoren von cyclin-abhängigen kinasen
WO2000052204A2 (en) 1999-02-22 2000-09-08 Orntoft Torben F Gene expression in bladder tumors
AU2001249064A1 (en) 2000-02-22 2001-09-03 Mount Sinai School Of Medicine Of New York University N-cadherin modulated migration, invasion, and metastasis
US6974667B2 (en) 2000-06-14 2005-12-13 Gene Logic, Inc. Gene expression profiles in liver cancer
US6451828B1 (en) * 2000-08-10 2002-09-17 Elan Pharmaceuticals, Inc. Selective inhibition of glutaminase by bis-thiadiazoles
DK1388734T3 (da) 2002-08-01 2004-05-03 Mtm Lab Ag Metode til opløsningsbaseret diagnose
WO2006040569A1 (en) 2004-10-14 2006-04-20 Astex Therapeutics Limited Thiophene amide compounds for use in the treatment or prophylaxis of cancers
US20080182865A1 (en) 2005-03-11 2008-07-31 Witta Samir E Histone deacetylase inhibitors sensitize cancer cells to epidermal growth factor inhibitors
DE602006016085D1 (de) 2005-03-16 2010-09-23 Genentech Inc Biologische marker prediktiv für das ansprechen von krebs auf inhibitoren der kinase des rezeptors für epidermalen wachstumsfaktor
WO2008048967A1 (en) 2006-10-16 2008-04-24 University Of Rochester Tripodal cyclohexane derivatives and their use as carbohydrate receptors
CA2702462A1 (en) 2007-11-19 2009-05-28 Genentech, Inc. Compositions and methods for inhibiting tumor progression
JP2011516826A (ja) 2008-03-07 2011-05-26 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 間葉系様腫瘍細胞またはこの形成を阻害する作用剤の同定のための方法
US20120190565A1 (en) 2009-02-20 2012-07-26 Pangea Biosciences, Inc. Method Of Diagnosis Or Prognosis Of A Neoplasm Comprising Determining The Level Of Expression Of A Protein In Stromal Cells Adjacent To The Neoplasm
WO2010111504A2 (en) 2009-03-25 2010-09-30 Cornell University Inhibition of glutaminase c
US20120142028A1 (en) 2009-04-17 2012-06-07 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
US20130109643A1 (en) * 2010-05-10 2013-05-02 The Johns Hopkins University Metabolic inhibitor against tumors having an idh mutation
JP5944385B2 (ja) 2010-06-23 2016-07-05 ユニバーシティ オブ ルーイビル リサーチ ファウンデーション，インコーポレーテッド 癌を検出するための方法
US10064885B2 (en) 2010-07-09 2018-09-04 Massachusetts Institute Of Technology Metabolic gene, enzyme, and flux targets for cancer therapy
UY33930A (es) 2011-03-04 2012-10-31 Novartis Ag Inhibidores novedosos de quinasas
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
SG11201402305WA (en) * 2011-11-21 2014-06-27 Calithera Biosciences Inc Heterocyclic inhibitors of glutaminase
KR20140138956A (ko) 2012-03-15 2014-12-04 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 Ｅ-카드헤린의 세포외 도메인의 저해제를 포함하는 병용 치료법
EP2922832B1 (en) 2012-11-21 2019-10-09 Agios Pharmaceuticals, Inc. Glutaminase inhibitors and methods of use
WO2014079011A1 (en) 2012-11-22 2014-05-30 Agios Pharmaceuticals, Inc. Heterocyclic compounds for inhibiting glutaminase and their methods of use
US9029531B2 (en) 2012-11-22 2015-05-12 Agios Pharmaceuticals, Inc. Compounds and their methods of use
WO2014138391A1 (en) 2013-03-06 2014-09-12 The Johns Hopkins University Targeting glutamine metabolism in brain tumors
JP6783663B2 (ja) 2014-01-06 2020-11-11 ライゼン・ファーマシューティカルズ・エスアー 新規グルタミナーゼ阻害剤
EA201691896A1 (ru) 2014-03-21 2017-01-30 Аджиос Фармасьютикалз, Инк. Соединения и способы их применения

Also Published As

Publication number Publication date
AU2018202954A1 (en) 2018-05-17
KR20150085079A (ko) 2015-07-22
MX2015006493A (es) 2015-08-05
PL2922850T3 (pl) 2018-12-31
US10689375B2 (en) 2020-06-23
EP2922850A4 (en) 2016-05-18
CY1120581T1 (el) 2019-07-10
AU2013347771A1 (en) 2015-06-11
SG11201504049VA (en) 2015-07-30
TWI629268B (zh) 2018-07-11
US10087172B2 (en) 2018-10-02
CN104936954B (zh) 2018-08-14
WO2014079150A1 (en) 2014-05-30
MY177344A (en) 2020-09-13
ECSP15026557A (es) 2016-01-29
EA201890754A1 (ru) 2018-08-31
HUE040111T2 (hu) 2019-02-28
MX367389B (es) 2019-08-19
EA030646B1 (ru) 2018-09-28
NZ708382A (en) 2020-04-24
CN104936954A (zh) 2015-09-23
EP2922850A1 (en) 2015-09-30
US20190084976A1 (en) 2019-03-21
JP6333277B2 (ja) 2018-05-30
PH12017502141A1 (en) 2019-02-27
EP2922850B1 (en) 2018-07-18
EA201590987A1 (ru) 2015-12-30
CA2893510C (en) 2021-01-19
CA2893510A1 (en) 2014-05-30
WO2014079136A1 (en) 2014-05-30
PT2922850T (pt) 2018-10-15
UA117360C2 (uk) 2018-07-25
SI2922850T1 (sl) 2018-10-30
AU2013347771B2 (en) 2018-02-01
SG10201609940RA (en) 2016-12-29
DK2922850T3 (en) 2018-10-08
JP2018150316A (ja) 2018-09-27
ES2690390T3 (es) 2018-11-20
AR093598A1 (es) 2015-06-10
HRP20181628T1 (hr) 2018-12-14
BR112015011830A2 (pt) 2017-07-11
TR201812360T4 (tr) 2018-09-21
EP3456719A1 (en) 2019-03-20
PH12015501150B1 (en) 2015-08-17
CR20150316A (es) 2015-08-28
WO2014079011A1 (en) 2014-05-30
JP2016500082A (ja) 2016-01-07
CN108727307A (zh) 2018-11-02
TW201427963A (zh) 2014-07-16
IL238958B (en) 2019-09-26
RS57859B1 (sr) 2018-12-31
TW201906825A (zh) 2019-02-16
PH12015501150A1 (en) 2015-08-17
US20150291576A1 (en) 2015-10-15
SA515360469B1 (ar) 2017-07-11
IL238958A0 (en) 2015-07-30
CL2015001392A1 (es) 2016-04-22
PE20151072A1 (es) 2015-08-26
LT2922850T (lt) 2018-09-10

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20221119