HK1207075A1 - Glucopyranosyl derivatives and their uses in medicine - Google Patents
Glucopyranosyl derivatives and their uses in medicineInfo
- Publication number
- HK1207075A1 HK1207075A1 HK15107713.4A HK15107713A HK1207075A1 HK 1207075 A1 HK1207075 A1 HK 1207075A1 HK 15107713 A HK15107713 A HK 15107713A HK 1207075 A1 HK1207075 A1 HK 1207075A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- medicine
- glucopyranosyl derivatives
- glucopyranosyl
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Crystallography & Structural Chemistry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310450401 | 2013-09-27 | ||
PCT/CN2014/087587 WO2015043511A1 (en) | 2013-09-27 | 2014-09-26 | Glucopyranosyl derivatives and their uses in medicine |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1207075A1 true HK1207075A1 (en) | 2016-01-22 |
Family
ID=52742084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15107713.4A HK1207075A1 (en) | 2013-09-27 | 2015-08-10 | Glucopyranosyl derivatives and their uses in medicine |
Country Status (8)
Country | Link |
---|---|
US (1) | US9394329B2 (xx) |
EP (1) | EP2895490B1 (xx) |
JP (1) | JP6450769B2 (xx) |
CN (1) | CN104513283B (xx) |
CA (1) | CA2889699C (xx) |
ES (1) | ES2605886T3 (xx) |
HK (1) | HK1207075A1 (xx) |
WO (1) | WO2015043511A1 (xx) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016173425A1 (en) * | 2015-04-30 | 2016-11-03 | Sunshine Lake Pharma Co., Ltd. | A glucopyranosyl derivative and preparation method and uses thereof |
CN106674294B (zh) * | 2015-11-06 | 2020-07-07 | 广东东阳光药业有限公司 | 吡喃葡萄糖基衍生物的结晶形式 |
CA3005920C (en) | 2015-11-27 | 2023-08-22 | Sunshine Lake Pharma Co., Ltd. | A complex of a glucopyranosyl derivative and preparation method and use thereof |
CN105646604A (zh) * | 2016-03-01 | 2016-06-08 | 孙霖 | 埃格列净晶型b及制备方法 |
CN105646603A (zh) * | 2016-03-01 | 2016-06-08 | 孙霖 | 埃格列净晶型a及制备方法 |
AU2017259388B2 (en) * | 2016-05-04 | 2019-04-11 | Youngene Therapeutics Co., Ltd. | Amine solvate of sodium-glucose linked transporter inhibitor, and preparation method and application thereof |
CN107778336B (zh) * | 2016-08-24 | 2022-09-27 | 宜昌东阳光长江药业股份有限公司 | 吡喃葡萄糖基衍生物的结晶形式 |
CN106674245B (zh) * | 2017-01-10 | 2019-07-26 | 北京中海康医药科技发展有限公司 | 吡喃葡萄糖基衍生物的制备及医药上的应用 |
JP2019001746A (ja) * | 2017-06-15 | 2019-01-10 | 株式会社クラレ | ジオールの製造方法 |
CN107986972A (zh) * | 2017-11-10 | 2018-05-04 | 潍坊润安化学科技有限公司 | 一种3-(4-硝基苯氧基)丙酸制备方法 |
CN114796250A (zh) * | 2021-01-27 | 2022-07-29 | 宜昌东阳光长江药业股份有限公司 | 一种含有吡喃葡萄糖基衍生物的药物组合物 |
WO2022204907A1 (en) * | 2021-03-30 | 2022-10-06 | Sunshine Lake Pharma Co., Ltd. | Method for preparing cocrystal of l-pyroglutamic acid and glucopyranosyl derivative |
CN114835563B (zh) * | 2022-05-23 | 2024-04-26 | 浙江中欣氟材股份有限公司 | 一种4,4`-二氟二苯甲酮的合成方法 |
CN117430571A (zh) * | 2022-07-15 | 2024-01-23 | 宜昌东阳光长江药业股份有限公司 | 一种制备吡喃葡萄糖基衍生物的关键中间体及其制备方法 |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
JP4902348B2 (ja) * | 2004-03-04 | 2012-03-21 | キッセイ薬品工業株式会社 | 含窒素縮合環誘導体、それを含有する医薬組成物およびその医薬用途 |
DE102004012676A1 (de) * | 2004-03-16 | 2005-10-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
WO2006018150A1 (de) | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
CA2595257A1 (en) | 2005-02-23 | 2006-08-31 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors |
ATE453656T1 (de) | 2005-04-15 | 2010-01-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte (heteroaryloxy- benzyl)-benzen-derivate als sglt-inhibitoren |
WO2007000445A1 (en) | 2005-06-29 | 2007-01-04 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
DE602006014411D1 (de) | 2005-07-27 | 2010-07-01 | Boehringer Ingelheim Pharma | Glucopyranosyl-substituierte ((hetero)cycloalyklethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters (sglt) |
CA2620566A1 (en) | 2005-08-30 | 2007-03-08 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
JP5384343B2 (ja) | 2006-08-15 | 2014-01-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル−置換シクロプロピルベンゼン誘導体、そのような化合物を含む医薬組成物、sglt阻害剤としてのそれらの使用及びそれらの製造方法 |
CA2664095A1 (en) | 2006-09-21 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted difluorobenzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
WO2008055870A1 (en) | 2006-11-06 | 2008-05-15 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzyl-benzonitrile derivatives, medicaments containing such compounds, their use and process for their manufacture |
CN101801989B (zh) | 2007-07-26 | 2015-11-25 | 莱西肯医药有限公司 | 用于制备钠-葡萄糖协同转运蛋白2抑制剂的方法和化合物 |
CA2697349C (en) | 2007-08-23 | 2012-04-24 | Theracos, Inc. | Benzylbenzene derivatives and methods of use |
CL2009000309A1 (es) | 2008-02-13 | 2009-06-26 | Sanofi Aventis | Derivados fluoroglicosidos aromaticos, composicion farmaceutica que contenga estos compuestos, procedimiento para prepararla y su uso en el tratamiento de la diabetes tipo 1 y 2. |
EA018492B1 (ru) * | 2008-08-28 | 2013-08-30 | Пфайзер Инк. | Диоксабицикло[3.2.1]октан-2,3,4-триольные производные |
MX2011002990A (es) | 2008-09-19 | 2011-04-11 | Novartis Ag | Derivados de glucosido y usos de los mismos como inhibidores de sglt. |
US20110230403A1 (en) | 2008-09-19 | 2011-09-22 | Novartis Ag | Glycoside derivatives and uses thereof |
WO2010048358A2 (en) | 2008-10-22 | 2010-04-29 | Auspex Pharmaceutical, Inc. | Ethoxyphenylmethyl inhibitors of sglt2 |
IN2012DN02751A (xx) | 2009-09-30 | 2015-09-18 | Boehringer Ingelheim Int | |
CA2778384A1 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Glycoside derivative and uses thereof |
GEP20146104B (en) | 2009-11-02 | 2014-05-27 | Pfizer | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
CN102134226B (zh) | 2010-01-26 | 2013-06-12 | 天津药物研究院 | 一类苯基c-葡萄糖苷衍生物、其制备方法和用途 |
WO2012003811A1 (en) | 2010-07-09 | 2012-01-12 | Zhejiang Beta Pharma Inc. | C-aryl glucoside sglt2 inhibitors and method |
CN102372722A (zh) * | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用 |
JP2013224263A (ja) | 2010-08-19 | 2013-10-31 | Taisho Pharmaceutical Co Ltd | 4−イソプロピルフェニルグルシトール化合物 |
JP5532138B2 (ja) | 2010-08-20 | 2014-06-25 | 大正製薬株式会社 | 4−イソプロピル−6−メトキシフェニルグルシトール化合物 |
WO2012025857A1 (en) | 2010-08-23 | 2012-03-01 | Hetero Research Foundation | Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors |
WO2012109996A1 (zh) | 2011-02-18 | 2012-08-23 | 上海璎黎科技有限公司 | 一种芳基糖苷类化合物及其制备方法和应用 |
CN102675378A (zh) | 2011-03-09 | 2012-09-19 | 天津药物研究院 | 一类含环丙烷结构的c-葡萄糖苷衍生物、其制备方法和用途 |
US8614195B2 (en) | 2011-04-14 | 2013-12-24 | Novartis Ag | Glycoside derivatives and uses thereof |
BR112013026361A2 (pt) | 2011-04-14 | 2016-12-27 | Novartis Ag | derivados de glicosídeo e usos dos mesmos |
AU2012248061C1 (en) | 2011-04-25 | 2016-07-14 | Beijing Prelude Pharm. Sci. & Tech. Co., Ltd. | Inhibitor of sodium-dependent glucose transport protein and preparation method therefor and use thereof |
US20140228303A1 (en) | 2011-06-13 | 2014-08-14 | Panacea Biotec Ltd | Novel sglt inhibitors |
US9562029B2 (en) | 2011-06-25 | 2017-02-07 | Xuanzhu Pharma Co., Ltd. | C-glycoside derivatives |
WO2013038429A2 (en) | 2011-09-13 | 2013-03-21 | Panacea Biotec Ltd. | Novel sglt inhibitors |
CN102408459B (zh) | 2011-09-29 | 2014-07-23 | 天津药物研究院 | 一类含异头位烷基的苯基c-葡萄糖苷衍生物、其制备方法和用途 |
US8697658B2 (en) | 2011-12-15 | 2014-04-15 | National Health Research Institutes | Glycoside compounds |
WO2013178064A1 (zh) | 2012-05-29 | 2013-12-05 | 广东东阳光药业有限公司 | 吡喃葡萄糖基衍生物、其制备方法及其在医药上的应用 |
CN103570657A (zh) | 2012-07-19 | 2014-02-12 | 天津药物研究院 | 一类含偕二甲基的苯基c-葡萄糖苷衍生物、其制备方法和用途 |
CN103772449B (zh) | 2012-10-26 | 2017-12-26 | 上海阳帆医药科技有限公司 | C‑芳基葡萄糖苷衍生物及其制备方法与用途 |
EP2933250B1 (en) | 2012-12-17 | 2017-08-09 | Tianjin Institute Of Pharmaceutical Research | Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof |
EP2968258B1 (en) | 2013-03-11 | 2020-02-12 | Janssen Pharmaceutica NV | Dual sglt1/sglt2 inhibitors |
CN104059042B (zh) | 2013-03-22 | 2017-02-08 | 正大天晴药业集团股份有限公司 | C-三芳基葡萄糖苷类sglt-2抑制剂 |
CN104619713B (zh) | 2013-05-24 | 2017-06-16 | 四川海思科制药有限公司 | 氧杂双环衍生物、制备方法及其应用 |
WO2014206349A1 (zh) | 2013-06-28 | 2014-12-31 | 四川海思科制药有限公司 | 氧杂-硫杂-双环[3.2.1]辛烷衍生物、制备方法及其用途 |
WO2015027963A1 (zh) | 2013-09-02 | 2015-03-05 | 四川海思科制药有限公司 | 芳环类衍生物、其药物组合物及其应用 |
JP6353054B2 (ja) | 2013-09-09 | 2018-07-04 | ヤンジェン セラピューティクス カンパニー リミテッド | C−アリールグルコシド誘導体、その製造方法およびその医薬適用 |
CN104017031A (zh) * | 2014-06-21 | 2014-09-03 | 李友香 | 降血糖药物和组合物 |
-
2014
- 2014-09-26 US US14/435,730 patent/US9394329B2/en active Active
- 2014-09-26 WO PCT/CN2014/087587 patent/WO2015043511A1/en active Application Filing
- 2014-09-26 ES ES14847239.2T patent/ES2605886T3/es active Active
- 2014-09-26 CA CA2889699A patent/CA2889699C/en active Active
- 2014-09-26 EP EP14847239.2A patent/EP2895490B1/en active Active
- 2014-09-26 JP JP2016544709A patent/JP6450769B2/ja active Active
- 2014-09-26 CN CN201410505453.XA patent/CN104513283B/zh active Active
-
2015
- 2015-08-10 HK HK15107713.4A patent/HK1207075A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2895490A4 (en) | 2015-10-28 |
CN104513283A (zh) | 2015-04-15 |
JP2016535074A (ja) | 2016-11-10 |
EP2895490A1 (en) | 2015-07-22 |
ES2605886T3 (es) | 2017-03-16 |
EP2895490B1 (en) | 2016-10-19 |
US9394329B2 (en) | 2016-07-19 |
CA2889699A1 (en) | 2015-04-02 |
WO2015043511A1 (en) | 2015-04-02 |
CN104513283B (zh) | 2018-01-16 |
AU2014327928A1 (en) | 2015-05-14 |
US20150266916A1 (en) | 2015-09-24 |
JP6450769B2 (ja) | 2019-01-09 |
CA2889699C (en) | 2017-06-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1207075A1 (en) | Glucopyranosyl derivatives and their uses in medicine | |
HK1216251A1 (zh) | 吡唑並吡咯烷衍生物及其治病作用 | |
ZA201505735B (en) | Cancer drug and uses | |
ZA201508948B (en) | Phenol derivative and preparation method and use in medicine thereof | |
GB2516343B (en) | Improvements in and relating to ophthalmoscopes | |
PL3004112T3 (pl) | Pochodne pirazolo-pirolidyn-4-onu oraz ich zastosowanie w leczeniu choroby | |
HK1220111A1 (zh) | 人類 淋巴細胞中類肝素酶的表達 | |
IL244901A0 (en) | Derivatives of aminotetralin and aminoindan, pharmaceutical compositions containing them and their use in therapy | |
IL239904A0 (en) | Inhibitory oligonucleotides and their use in therapy | |
PT3064491T (pt) | Derivado de sulfonamida e sua utilização medicinal | |
EP3072892A4 (en) | Pyridine derivative and medical use thereof | |
EP3010345A4 (en) | Expanded therapeutic potential in nitroheteroaryl antimicrobials | |
EP2994197A4 (en) | PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | |
HK1219233A1 (zh) | 美羅培南衍生物及其用途 | |
GB201308753D0 (en) | Compounds and their use in therapy | |
EP2968398B8 (en) | Modified hyaluronan and uses thereof in cancer treatment | |
EP3055286A4 (en) | 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use | |
EP2970138A4 (en) | PYRAZONE DERIVATIVES AND USES THEREOF | |
GB201312131D0 (en) | Drug combination and its use in therapy | |
GB201312128D0 (en) | Drug combination and its use in therapy | |
GB201312129D0 (en) | Drug combination and its use in therapy | |
GB201320958D0 (en) | Improvements in and relating to medical devices | |
AP2015008849A0 (en) | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | |
GB201308217D0 (en) | Compounds and their use in therapy | |
AU2013901916A0 (en) | An Agent and Use Thereof in Therapy |