HK1187615A1 - 吡咯並六元雜芳環類衍生物、其製備方法及其在醫藥上的應用 - Google Patents

吡咯並六元雜芳環類衍生物、其製備方法及其在醫藥上的應用

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Publication number
HK1187615A1
HK1187615A1 HK14100596.2A HK14100596A HK1187615A1 HK 1187615 A1 HK1187615 A1 HK 1187615A1 HK 14100596 A HK14100596 A HK 14100596A HK 1187615 A1 HK1187615 A1 HK 1187615A1
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HK
Hong Kong
Prior art keywords
pyrrole
preparation
membered heteroaryl
heteroaryl ring
method therefor
Prior art date
Application number
HK14100596.2A
Other languages
English (en)
Inventor
張學軍
董慶
劉柏年
朱耀平
李曉濤
蘭炯
Original Assignee
江蘇恒瑞醫藥股份有限公司
江蘇省連雲港市
上海恒瑞醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江蘇恒瑞醫藥股份有限公司, 江蘇省連雲港市, 上海恒瑞醫藥有限公司 filed Critical 江蘇恒瑞醫藥股份有限公司
Publication of HK1187615A1 publication Critical patent/HK1187615A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
HK14100596.2A 2011-12-21 2014-01-20 吡咯並六元雜芳環類衍生物、其製備方法及其在醫藥上的應用 HK1187615A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201110434071 2011-12-21
PCT/CN2012/086922 WO2013091539A1 (zh) 2011-12-21 2012-12-19 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
HK1187615A1 true HK1187615A1 (zh) 2014-04-11

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HK14100596.2A HK1187615A1 (zh) 2011-12-21 2014-01-20 吡咯並六元雜芳環類衍生物、其製備方法及其在醫藥上的應用

Country Status (23)

Country Link
US (3) US9527851B2 (zh)
EP (1) EP2796460B1 (zh)
JP (1) JP6075736B2 (zh)
KR (1) KR102032934B1 (zh)
CN (1) CN103415520B8 (zh)
AU (1) AU2012357296B2 (zh)
BR (1) BR112014014325B1 (zh)
CA (1) CA2857977C (zh)
CY (1) CY1121161T1 (zh)
DK (1) DK2796460T3 (zh)
ES (1) ES2682755T3 (zh)
HK (1) HK1187615A1 (zh)
HR (1) HRP20181201T1 (zh)
HU (1) HUE039111T2 (zh)
LT (1) LT2796460T (zh)
MX (1) MX358679B (zh)
PL (1) PL2796460T3 (zh)
PT (1) PT2796460T (zh)
RS (1) RS57621B1 (zh)
RU (1) RU2618673C2 (zh)
SI (1) SI2796460T1 (zh)
TW (1) TWI601728B (zh)
WO (1) WO2013091539A1 (zh)

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EP3290421B1 (en) * 2013-02-22 2019-01-02 Pfizer Inc Combination of pyrrolo [2, 3 -d]pyrimidine derivatives with one or more additional agents as inhibitors of janus- related kinases (jak)
US9422300B2 (en) * 2013-06-07 2016-08-23 Jiangsu Hengrui Medicine Co., Ltd. Bisulfate of janus kinase (JAK) inhibitor and preparation method therefor
EP3461827B1 (en) 2013-09-26 2022-02-23 Cadent Therapeutics, Inc. Selective octahydro-cyclopenta[c]pyrrole negative modulators of nr2b
PE20161246A1 (es) 2013-12-05 2016-11-25 Pfizer Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinilo
KR101710127B1 (ko) * 2014-08-29 2017-02-27 한화제약주식회사 야누스인산화효소 억제제로서의 치환된 N-(피롤리딘-3-일)-7H-피롤로[2,3-d]피리미딘-4-아민
JO3579B1 (ar) 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
CN105566327A (zh) 2014-10-09 2016-05-11 江苏恒瑞医药股份有限公司 一种jak激酶抑制剂的硫酸氢盐的i型结晶及其制备方法
ES2754548T3 (es) * 2014-11-05 2020-04-20 Jiangsu Hengrui Medicine Co Forma cristalina de bisulfato inhibidor de quinasa JAK y un método de preparación del mismo
CN105712998B (zh) * 2014-12-05 2019-12-13 上海润诺生物科技有限公司 氮杂吲哚类衍生物、其制备方法及其在医药上的应用
PL3305788T3 (pl) * 2015-05-29 2021-03-08 Wuxi Fortune Pharmaceutical Co., Ltd Inhibitor kinazy janusowej
JP6875407B2 (ja) * 2016-02-19 2021-05-26 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． Ｊａｋキナーゼ阻害剤またはその薬剤的に許容される塩を含有する医薬組成物
CN107098908B (zh) * 2016-02-23 2021-01-08 欣凯医药科技(上海)有限公司 一种吡咯并嘧啶类化合物的制备方法和应用
CN108884100B (zh) * 2016-11-23 2021-04-06 江苏恒瑞医药股份有限公司 吡咯并六元杂芳环类衍生物的制备方法及中间体
US20200095241A1 (en) 2016-12-22 2020-03-26 Bayer Cropscience Aktiengesellschaft Substituted 1,2,4-thiadiazolylpyrrolones and 1,2,4-thiadiazolylhydantoins and salts thereof and use thereof as herbicides
MX2019007374A (es) 2016-12-22 2019-09-18 Bayer Cropscience Ag Heteroarilpirrolonas sustituidas y sus sales y su uso como ingredientes activos herbicidas.
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