HK1074059A1 - Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives - Google Patents
Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivativesInfo
- Publication number
- HK1074059A1 HK1074059A1 HK05108017.7A HK05108017A HK1074059A1 HK 1074059 A1 HK1074059 A1 HK 1074059A1 HK 05108017 A HK05108017 A HK 05108017A HK 1074059 A1 HK1074059 A1 HK 1074059A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- acid derivatives
- hydroxybutyric acid
- substituted
- production
- enzymatic processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40243602P | 2002-08-09 | 2002-08-09 | |
PCT/US2003/025263 WO2004015132A2 (fr) | 2002-08-09 | 2003-08-11 | Production par voie enzymatique de derives de 3-acide hydroxybutyrique substitue en position 4 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1074059A1 true HK1074059A1 (en) | 2005-10-28 |
Family
ID=31715856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05108017.7A HK1074059A1 (en) | 2002-08-09 | 2005-09-13 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
Country Status (12)
Country | Link |
---|---|
US (1) | US7125693B2 (fr) |
EP (1) | EP1537222B1 (fr) |
JP (2) | JP4578240B2 (fr) |
AT (1) | ATE501264T1 (fr) |
AU (1) | AU2003258187A1 (fr) |
BR (1) | BR0305767A (fr) |
CA (1) | CA2493941A1 (fr) |
DE (1) | DE60336324D1 (fr) |
HK (1) | HK1074059A1 (fr) |
MX (1) | MXPA05001537A (fr) |
NO (1) | NO20041379L (fr) |
WO (1) | WO2004015132A2 (fr) |
Families Citing this family (30)
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JP4578240B2 (ja) | 2002-08-09 | 2010-11-10 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス |
JP2007502111A (ja) | 2003-08-11 | 2007-02-08 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体およびビシナルなシアノ,ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
US7541171B2 (en) | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
CA2535255A1 (fr) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Deshalogenases d'halohydrine ameliorees et polynucleotides correspondants |
US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
US7629157B2 (en) | 2003-08-11 | 2009-12-08 | Codexis, Inc. | Ketoreductase polypeptides and related polynucleotides |
KR20060064620A (ko) | 2003-08-11 | 2006-06-13 | 코덱시스, 인코포레이티드 | 개선된 글루코스 데히드로게나제 폴리펩티드 및 관련폴리뉴클레오티드 |
JP2008537477A (ja) * | 2005-02-23 | 2008-09-18 | コデクシス, インコーポレイテッド | 改良されたハロヒドリンデハロゲナーゼおよび関連のポリヌクレオチド |
ITMI20051971A1 (it) * | 2005-10-18 | 2007-04-19 | Dipharma Spa | Procedimento per la preparazione di - modafinil |
LT2821494T (lt) | 2007-03-16 | 2017-04-25 | Genomatica, Inc. | 1,4-butandiolio ir jo pirmtakų biosintezės būdai ir kompozicijos |
US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
WO2010030711A2 (fr) | 2008-09-10 | 2010-03-18 | Genomatica, Inc. | Microorganismes pour la production de 1,4-butanediol |
US8187856B2 (en) * | 2008-12-18 | 2012-05-29 | Codexis, Inc. | Recombinant halohydrin dehalogenase polypeptides |
CN107384846B (zh) | 2009-06-04 | 2021-08-10 | 基因组股份公司 | 生产1,4-丁二醇的微生物和相关方法 |
CA2764368C (fr) | 2009-06-04 | 2017-08-01 | Genomatica, Inc. | Procede d'extraction de composants d'un bouillon de fermentation |
EP2446025B1 (fr) | 2009-06-22 | 2018-08-08 | Codexis, Inc. | Voie stéréosélective à médiation par une cétoréductase vers des alpha chloroalcools |
CN105441374A (zh) | 2009-10-13 | 2016-03-30 | 基因组股份公司 | 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法 |
WO2011066076A1 (fr) | 2009-11-25 | 2011-06-03 | Genomatica, Inc. | Micro-organismes et procédés pour la coproduction de 1,4-butanediol et de gamma-butyrolactone |
US9080192B2 (en) | 2010-02-10 | 2015-07-14 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
EP2590991B1 (fr) | 2010-06-30 | 2016-01-20 | Codexis, Inc. | Anhydrases carboniques de classe bêta très stables et utiles dans des systèmes de capture du carbone |
CN102168117B (zh) * | 2011-01-12 | 2014-05-07 | 江苏阿尔法药业有限公司 | 一种制备(r)-4-氰基-3-羟基丁酸乙酯的方法 |
JP5705580B2 (ja) | 2011-02-21 | 2015-04-22 | 公益財団法人微生物化学研究会 | チオアミド化合物、チオアミド化合物の製造方法、[(4r,6r)−6−アミノエチル−1,3−ジオキサン−4−イル]アセテート誘導体の製造方法、及びアトルバスタチンの製造方法 |
CN102676597A (zh) * | 2011-03-16 | 2012-09-19 | 苏州国镝医药科技有限公司 | 生物酶手性合成立普妥中间体ats-5 |
WO2013184602A2 (fr) | 2012-06-04 | 2013-12-12 | Genomatica, Inc. | Microorganismes et procédés de production du 4-hydroxybutyrate, 1,4-butanediol et composés associés |
CN103695486A (zh) * | 2014-01-03 | 2014-04-02 | 黄冈华阳药业有限公司 | 一种(3r,5r)-6-氰基-3,5-二羟基己酸叔丁酯的生物制备方法 |
CN105368886A (zh) * | 2015-12-11 | 2016-03-02 | 江苏万年长药业有限公司 | 一种树脂固定卤醇脱卤酶催化合成(r)-4-氰基-3-羟基丁酸乙酯的工艺 |
CN109439700A (zh) * | 2018-11-09 | 2019-03-08 | 浙江宏元药业股份有限公司 | 一种脱卤酶高效催化合成他汀类药物中间体的方法 |
CN111876448A (zh) * | 2020-08-03 | 2020-11-03 | 连云港宏业化工有限公司 | 4-氰基-3-羟基丁酸乙酯合成方法 |
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US5244796A (en) * | 1990-10-12 | 1993-09-14 | Syracuse University | Cloned leuconostoc mesenteroides glucose-6-phosphate dehydrogenase genes and method of making glucose-6-phospate dehydrogenase |
US5155251A (en) * | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
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CA2117482C (fr) * | 1992-03-13 | 2005-02-15 | Maria-Regina Kula | Nouvelles reductases d'ester cetonique; preparation et utilisation pour les reactions enzymatiques d'oxydoreduction |
US5413921A (en) * | 1992-05-28 | 1995-05-09 | Ajinomoto Co., Ltd. | Method of the production of (s)-gamma-halogenated-γ-hydroxybutyric acid esters |
JP3171931B2 (ja) * | 1992-06-02 | 2001-06-04 | 高砂香料工業株式会社 | (R)−(−)−4−シアノ−3−ヒドロキシ酪酸t−ブチルエステル及びその製造方法 |
JP3155107B2 (ja) * | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性4−ハロ−3−ヒドロキシ酪酸エステルの製造方法 |
JPH08336393A (ja) * | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
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US5908953A (en) * | 1996-12-18 | 1999-06-01 | Mitsubishi Chemical Corporation | Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester |
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JP2000236883A (ja) * | 1998-12-21 | 2000-09-05 | Daicel Chem Ind Ltd | 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするdnaおよびこれを利用したアルコールの製造方法 |
KR100313668B1 (ko) * | 1999-02-03 | 2001-11-26 | 박영구 | (r)-4-시아노-3-히드록시부티르산 에스테르의 제조방법 |
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JP2001335554A (ja) * | 2000-05-30 | 2001-12-04 | Mitsubishi Chemicals Corp | (r)−4−シアノ−3−ヒドロキシ酪酸低級アルキルエステルの製造方法 |
JP2002201169A (ja) * | 2000-10-31 | 2002-07-16 | Sumitomo Chem Co Ltd | 4−シアノ−3−オキソブタン酸エステルの製造法 |
DE60105734T2 (de) * | 2000-10-31 | 2006-02-16 | Sumitomo Chemical Co. Ltd. | Verfahren zur Herstellung von 4-Cyano-4-Oxobuttersäureester und 4-Cyano-3-Hydroxybuttersäureester |
JP4603171B2 (ja) * | 2001-01-22 | 2010-12-22 | ダイセル化学工業株式会社 | (s)−4−ハロ−3−ヒドロキシ酪酸エステルの製造に有用な酵素をコードする遺伝子、その取得方法、およびこれを利用した光学活性アルコールの製造方法 |
CA2450867A1 (fr) | 2001-07-02 | 2003-01-16 | Kaneka Corporation | Methode permettant de modifier un enzyme et |
JP4578240B2 (ja) | 2002-08-09 | 2010-11-10 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス |
JP2007502111A (ja) | 2003-08-11 | 2007-02-08 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体およびビシナルなシアノ,ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
KR20060064620A (ko) | 2003-08-11 | 2006-06-13 | 코덱시스, 인코포레이티드 | 개선된 글루코스 데히드로게나제 폴리펩티드 및 관련폴리뉴클레오티드 |
US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
CA2535255A1 (fr) * | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Deshalogenases d'halohydrine ameliorees et polynucleotides correspondants |
US7629157B2 (en) | 2003-08-11 | 2009-12-08 | Codexis, Inc. | Ketoreductase polypeptides and related polynucleotides |
-
2003
- 2003-08-11 JP JP2004528083A patent/JP4578240B2/ja not_active Expired - Lifetime
- 2003-08-11 AT AT03785237T patent/ATE501264T1/de not_active IP Right Cessation
- 2003-08-11 AU AU2003258187A patent/AU2003258187A1/en not_active Abandoned
- 2003-08-11 CA CA002493941A patent/CA2493941A1/fr not_active Abandoned
- 2003-08-11 EP EP03785237A patent/EP1537222B1/fr not_active Expired - Lifetime
- 2003-08-11 MX MXPA05001537A patent/MXPA05001537A/es unknown
- 2003-08-11 US US10/639,159 patent/US7125693B2/en not_active Expired - Lifetime
- 2003-08-11 DE DE60336324T patent/DE60336324D1/de not_active Expired - Lifetime
- 2003-08-11 BR BR0305767-4A patent/BR0305767A/pt not_active IP Right Cessation
- 2003-08-11 WO PCT/US2003/025263 patent/WO2004015132A2/fr active Application Filing
-
2004
- 2004-04-02 NO NO20041379A patent/NO20041379L/no not_active Application Discontinuation
-
2005
- 2005-09-13 HK HK05108017.7A patent/HK1074059A1/xx not_active IP Right Cessation
-
2010
- 2010-05-19 JP JP2010115827A patent/JP2010172348A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1537222B1 (fr) | 2011-03-09 |
DE60336324D1 (de) | 2011-04-21 |
ATE501264T1 (de) | 2011-03-15 |
MXPA05001537A (es) | 2005-11-17 |
WO2004015132A2 (fr) | 2004-02-19 |
AU2003258187A8 (en) | 2004-02-25 |
BR0305767A (pt) | 2005-05-24 |
EP1537222A4 (fr) | 2008-10-01 |
NO20041379L (no) | 2004-06-01 |
WO2004015132A3 (fr) | 2005-04-14 |
JP2010172348A (ja) | 2010-08-12 |
JP4578240B2 (ja) | 2010-11-10 |
AU2003258187A1 (en) | 2004-02-25 |
JP2005535330A (ja) | 2005-11-24 |
EP1537222A2 (fr) | 2005-06-08 |
US7125693B2 (en) | 2006-10-24 |
CA2493941A1 (fr) | 2004-02-19 |
US20040137585A1 (en) | 2004-07-15 |
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