HK1068888A1 - Dihydro-benzo ÄbÜ Ä1,4Üdiazepin-2-one derivatives as mglur2 antagonists ii - Google Patents

Dihydro-benzo ÄbÜ Ä1,4Üdiazepin-2-one derivatives as mglur2 antagonists ii

Info

Publication number
HK1068888A1
HK1068888A1 HK05101555A HK05101555A HK1068888A1 HK 1068888 A1 HK1068888 A1 HK 1068888A1 HK 05101555 A HK05101555 A HK 05101555A HK 05101555 A HK05101555 A HK 05101555A HK 1068888 A1 HK1068888 A1 HK 1068888A1
Authority
HK
Hong Kong
Prior art keywords
äbü
benzo
dihydro
derivatives
mglur2 antagonists
Prior art date
Application number
HK05101555A
Other languages
English (en)
Inventor
Geo Adam
Erwin Goetschi
Vincent Mutel
Juergen Wichmann
Thomas Johannes Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1068888A1 publication Critical patent/HK1068888A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK05101555A 2001-04-12 2005-02-24 Dihydro-benzo ÄbÜ Ä1,4Üdiazepin-2-one derivatives as mglur2 antagonists ii HK1068888A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01109125 2001-04-12
PCT/EP2002/003644 WO2002083652A1 (en) 2001-04-12 2002-04-02 DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II

Publications (1)

Publication Number Publication Date
HK1068888A1 true HK1068888A1 (en) 2005-05-06

Family

ID=8177126

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05101555A HK1068888A1 (en) 2001-04-12 2005-02-24 Dihydro-benzo ÄbÜ Ä1,4Üdiazepin-2-one derivatives as mglur2 antagonists ii

Country Status (38)

Country Link
US (1) US6544985B2 (xx)
EP (1) EP1379511B1 (xx)
JP (1) JP4071115B2 (xx)
KR (1) KR100566171B1 (xx)
CN (1) CN1264825C (xx)
AR (1) AR035816A1 (xx)
AT (1) ATE299868T1 (xx)
AU (1) AU2002312788B2 (xx)
BG (1) BG108254A (xx)
BR (1) BR0208891A (xx)
CA (1) CA2442557C (xx)
CZ (1) CZ20033003A3 (xx)
DE (1) DE60205100T2 (xx)
DK (1) DK1379511T3 (xx)
EC (1) ECSP034797A (xx)
ES (1) ES2246012T3 (xx)
GT (1) GT200200073A (xx)
HK (1) HK1068888A1 (xx)
HR (1) HRP20030792A2 (xx)
HU (1) HUP0400851A3 (xx)
IL (2) IL157873A0 (xx)
JO (1) JO2285B1 (xx)
MA (1) MA27012A1 (xx)
MX (1) MXPA03009311A (xx)
MY (1) MY140271A (xx)
NO (1) NO20034576L (xx)
NZ (1) NZ528315A (xx)
PA (1) PA8543301A1 (xx)
PE (1) PE20021041A1 (xx)
PL (1) PL367064A1 (xx)
PT (1) PT1379511E (xx)
RU (1) RU2263112C2 (xx)
SI (1) SI1379511T1 (xx)
SK (1) SK13682003A3 (xx)
UY (1) UY27258A1 (xx)
WO (1) WO2002083652A1 (xx)
YU (1) YU79003A (xx)
ZA (1) ZA200307243B (xx)

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Also Published As

Publication number Publication date
BG108254A (bg) 2004-09-30
HUP0400851A2 (hu) 2004-07-28
MA27012A1 (fr) 2004-12-20
YU79003A (sh) 2006-05-25
NO20034576L (no) 2003-11-12
US20020193367A1 (en) 2002-12-19
BR0208891A (pt) 2004-04-20
HUP0400851A3 (en) 2010-03-29
JP2004529925A (ja) 2004-09-30
CN1535266A (zh) 2004-10-06
IL157873A0 (en) 2004-03-28
JO2285B1 (en) 2005-09-12
RU2003130637A (ru) 2005-04-10
KR100566171B1 (ko) 2006-03-29
PE20021041A1 (es) 2002-11-19
CN1264825C (zh) 2006-07-19
MXPA03009311A (es) 2004-02-12
EP1379511B1 (en) 2005-07-20
HRP20030792A2 (en) 2005-10-31
MY140271A (en) 2009-12-31
PL367064A1 (en) 2005-02-21
KR20030087076A (ko) 2003-11-12
UY27258A1 (es) 2002-10-31
DK1379511T3 (da) 2005-11-07
NZ528315A (en) 2005-04-29
RU2263112C2 (ru) 2005-10-27
WO2002083652A1 (en) 2002-10-24
CZ20033003A3 (cs) 2004-05-12
AR035816A1 (es) 2004-07-14
ECSP034797A (es) 2003-12-01
CA2442557C (en) 2008-12-23
EP1379511A1 (en) 2004-01-14
PA8543301A1 (es) 2003-01-24
NO20034576D0 (no) 2003-10-10
SI1379511T1 (en) 2005-10-31
SK13682003A3 (sk) 2004-07-07
IL157873A (en) 2008-11-26
ATE299868T1 (de) 2005-08-15
GT200200073A (es) 2002-11-07
ES2246012T3 (es) 2006-02-01
CA2442557A1 (en) 2002-10-24
AU2002312788B2 (en) 2005-11-10
ZA200307243B (en) 2004-12-16
DE60205100T2 (de) 2006-06-01
PT1379511E (pt) 2005-10-31
DE60205100D1 (de) 2005-08-25
US6544985B2 (en) 2003-04-08
JP4071115B2 (ja) 2008-04-02

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Effective date: 20100402