HK1052934B - 異噁唑及其作為erk抑制物的用途 - Google Patents
異噁唑及其作為erk抑制物的用途Info
- Publication number
- HK1052934B HK1052934B HK03105158.4A HK03105158A HK1052934B HK 1052934 B HK1052934 B HK 1052934B HK 03105158 A HK03105158 A HK 03105158A HK 1052934 B HK1052934 B HK 1052934B
- Authority
- HK
- Hong Kong
- Prior art keywords
- sup
- inhibitors
- erk
- isoxazoles
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Anesthesiology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23295600P | 2000-09-15 | 2000-09-15 | |
PCT/US2001/028790 WO2002022610A1 (en) | 2000-09-15 | 2001-09-14 | Isoxazoles and their use as inhibitors of erk |
Publications (2)
Publication Number | Publication Date |
---|---|
HK1052934A1 HK1052934A1 (en) | 2003-10-03 |
HK1052934B true HK1052934B (zh) | 2007-01-12 |
Family
ID=22875248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK03105158.4A HK1052934B (zh) | 2000-09-15 | 2003-07-16 | 異噁唑及其作為erk抑制物的用途 |
Country Status (16)
Country | Link |
---|---|
US (3) | US6495582B1 (zh) |
EP (1) | EP1317453B1 (zh) |
JP (1) | JP4052573B2 (zh) |
AT (1) | ATE335737T1 (zh) |
AU (1) | AU2001290940A1 (zh) |
CA (1) | CA2422376A1 (zh) |
DE (1) | DE60122176T2 (zh) |
ES (1) | ES2269458T3 (zh) |
HK (1) | HK1052934B (zh) |
HU (1) | HUP0302991A3 (zh) |
IL (1) | IL154710A0 (zh) |
MX (1) | MXPA03002296A (zh) |
NO (1) | NO325089B1 (zh) |
NZ (1) | NZ525016A (zh) |
WO (1) | WO2002022610A1 (zh) |
ZA (1) | ZA200301696B (zh) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2255294T3 (es) * | 1998-08-07 | 2006-06-16 | Chiron Corporation | Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos. |
US20020142982A1 (en) * | 1999-09-02 | 2002-10-03 | Timothy Hla | Method for regulating angiogenesis |
JP4101053B2 (ja) | 2000-08-10 | 2008-06-11 | 田辺三菱製薬株式会社 | プロリン誘導体及びその医薬用途 |
US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
EP1318997B1 (en) * | 2000-09-15 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6653300B2 (en) * | 2000-12-21 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6589997B2 (en) * | 2001-06-29 | 2003-07-08 | North Shore-Long Island Jewish Health System | Small-molecule modulators of hepatocyte growth factor/scatter factor activities |
ATE491701T1 (de) | 2001-08-03 | 2011-01-15 | Vertex Pharma | Von pyrazol abgeleitete kinaseinhibitoren und deren verwendung |
BR0211742A (pt) * | 2001-08-06 | 2004-08-24 | Pharmacia Italia Spa | Derivados de aminoisoxazole ativos como inibidores de cinase |
SG159380A1 (en) * | 2002-02-06 | 2010-03-30 | Vertex Pharma | Heteroaryl compounds useful as inhibitors of gsk-3 |
AU2003218215A1 (en) * | 2002-03-15 | 2003-09-29 | Vertex Pharmaceuticals, Inc. | Azolylaminoazines as inhibitors of protein kinases |
MY141867A (en) * | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
WO2004000318A2 (en) | 2002-06-21 | 2003-12-31 | Cellular Genomics, Inc. | Certain amino-substituted monocycles as kinase modulators |
NZ538426A (en) * | 2002-08-02 | 2007-05-31 | Vertex Pharma | Pyrazole compositions useful as inhibitors of glycogen synthase kinase-3 (GSK-3) |
US7196078B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
US8580782B2 (en) | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
US8673924B2 (en) | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
ATE469903T1 (de) | 2002-09-04 | 2010-06-15 | Schering Corp | Zur behandlung von krebserkrankungen geeignete pyrazolopyrimidine |
ES2346204T3 (es) | 2002-09-04 | 2010-10-13 | Schering Corporation | Pirazolopirimidinas adecuadas para el tratamiento de enfermedades cancerosas. |
US7605155B2 (en) | 2002-09-04 | 2009-10-20 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
US7601718B2 (en) * | 2003-02-06 | 2009-10-13 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
DE602004012578T2 (de) * | 2003-08-15 | 2008-12-11 | Vertex Pharmaceuticals Inc., Cambridge | Als inhibitoren von c-met geeignete pyrrolzusammensetzungen |
CN1902193B (zh) * | 2003-12-04 | 2011-07-13 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的喹喔啉 |
US8513437B2 (en) * | 2004-07-26 | 2013-08-20 | Ben Gurion University Of The Negev Research And Development Authority | Pyrrolidino-1,4-naphthoquinone deriviatives and their use for treating malignancies and cardiovascular diseases |
US7429667B2 (en) * | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
NZ560712A (en) | 2005-02-17 | 2010-12-24 | Synta Pharmaceuticals Corp | (3,4,5-trisubstituted-phenyl)isoxazole combretastin derivatives for the treatment of disorders |
ATE542814T1 (de) * | 2005-08-18 | 2012-02-15 | Vertex Pharma | Pyrazinkinaseinhibitoren |
EP1931661B1 (en) * | 2005-09-19 | 2008-11-19 | F.Hoffmann-La Roche Ag | Isoxazolo derivatives as gaba a alpha5 inverse agonists |
AU2006299338A1 (en) | 2005-10-06 | 2007-04-12 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidines as protein kinase inhibitors |
JP5102212B2 (ja) | 2005-10-06 | 2012-12-19 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼインヒビターとしてのピラゾロピリミジン |
AR056764A1 (es) * | 2005-11-03 | 2007-10-24 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de quinasa |
EP1945644A2 (en) | 2005-11-10 | 2008-07-23 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
KR101394245B1 (ko) * | 2005-12-30 | 2014-05-14 | 에스케이바이오팜 주식회사 | 아이속사졸 유도체 및 이의 용도 |
US7807672B2 (en) | 2006-02-16 | 2010-10-05 | Schering Corporation | Compounds that are ERK inhibitors |
US7842836B2 (en) | 2006-04-11 | 2010-11-30 | Ardea Biosciences | N-aryl-N'alkyl sulfamides as MEK inhibitors |
EA016674B1 (ru) * | 2006-04-18 | 2012-06-29 | Ардеа Байосайенсиз, Инк. | Пиридон сульфонамиды и пиридон сульфамиды в качестве ингибиторов mek |
US20090175852A1 (en) | 2006-06-06 | 2009-07-09 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
JP4968860B2 (ja) | 2006-10-31 | 2012-07-04 | シェーリング コーポレイション | アニリノピペラジン誘導体およびアニリノピペラジン誘導体を使用する方法 |
CA2668210C (en) | 2006-10-31 | 2013-03-12 | Schering Corporation | Anilinopiperazine derivatives and methods of use thereof |
CN101573345A (zh) | 2006-10-31 | 2009-11-04 | 先灵公司 | 作为蛋白激酶抑制剂的2-氨基噻唑-4-甲酰胺 |
ATE457311T1 (de) * | 2006-11-02 | 2010-02-15 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine |
ATE474835T1 (de) * | 2006-12-19 | 2010-08-15 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete aminopyrimidine |
MX2009009591A (es) * | 2007-03-09 | 2009-11-10 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de proteinas cinasas. |
AU2008226461A1 (en) * | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyridines useful as inhibitors of protein kinases |
EP2134707B1 (en) * | 2007-03-09 | 2013-09-11 | Vertex Pharmaceuticals, Inc. | Aminopyrimidines useful as inhibitors of protein kinases |
CN101679386A (zh) | 2007-04-13 | 2010-03-24 | 沃泰克斯药物股份有限公司 | 可用作激酶抑制剂的氨基嘧啶类化合物 |
US8509487B2 (en) * | 2007-04-19 | 2013-08-13 | Avago Technologies General Ip (Singapore) Pte. Ltd. | System and method for optically measuring a parameter of an object |
MX2009011810A (es) | 2007-05-02 | 2010-01-14 | Vertex Pharma | Tiazoles y pirazoles utiles como inhibidores de cinasa. |
CA2688584A1 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
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2001
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IL154710A0 (en) | 2003-10-31 |
CA2422376A1 (en) | 2002-03-21 |
HK1052934A1 (en) | 2003-10-03 |
NO325089B1 (no) | 2008-01-28 |
US6649640B2 (en) | 2003-11-18 |
US20050090536A1 (en) | 2005-04-28 |
HUP0302991A2 (hu) | 2003-12-29 |
EP1317453B1 (en) | 2006-08-09 |
US6495582B1 (en) | 2002-12-17 |
EP1317453A1 (en) | 2003-06-11 |
NZ525016A (en) | 2004-10-29 |
NO20031192D0 (no) | 2003-03-14 |
WO2002022610A1 (en) | 2002-03-21 |
ATE335737T1 (de) | 2006-09-15 |
NO20031192L (no) | 2003-05-13 |
DE60122176D1 (de) | 2006-09-21 |
US20030195241A1 (en) | 2003-10-16 |
ES2269458T3 (es) | 2007-04-01 |
JP4052573B2 (ja) | 2008-02-27 |
JP2004509119A (ja) | 2004-03-25 |
DE60122176T2 (de) | 2007-07-05 |
ZA200301696B (en) | 2004-04-28 |
AU2001290940A1 (en) | 2002-03-26 |
US7354919B2 (en) | 2008-04-08 |
HUP0302991A3 (en) | 2009-10-28 |
US20020177618A1 (en) | 2002-11-28 |
MXPA03002296A (es) | 2003-06-06 |
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