GT200500215A - Amidas sustituidas de àcido tienopirrolcarboxìlico, amidas del àcido pirrolotiazolcarboxìlico y anàlogos relacionados como inhibidores de la epsilon caseìna quinasa i - Google Patents

Amidas sustituidas de àcido tienopirrolcarboxìlico, amidas del àcido pirrolotiazolcarboxìlico y anàlogos relacionados como inhibidores de la epsilon caseìna quinasa i

Info

Publication number
GT200500215A
GT200500215A GT200500215A GT200500215A GT200500215A GT 200500215 A GT200500215 A GT 200500215A GT 200500215 A GT200500215 A GT 200500215A GT 200500215 A GT200500215 A GT 200500215A GT 200500215 A GT200500215 A GT 200500215A
Authority
GT
Guatemala
Prior art keywords
acid
quinasa
inhibitors
tienopirrolcarboxylic
pirrolotiazolcarboxylic
Prior art date
Application number
GT200500215A
Other languages
English (en)
Inventor
David Marc Fink
Yulin Chiang
Nicola Dawn Collar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200500215A publication Critical patent/GT200500215A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

LA PRESENTE INVENCIÒN SE REFIERE A COMPUESTOS DE LAS FÒRMULAS GENERALES I Y II EN LAS QUE M,L,X,R1,R2,R3,R4, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON INHIBIDORES DE LA FOSFORILACIÒN DE LA CASEÌNA QUINASA POR LO QUE SON DE UTILIDAD EN EL TRATAMIENTO Y/O LA PREVENCIÒN DE ENFERMEDADES Y TRASTORNOS ASOCIADOS CON EL SISTEMA NERVIOSO CENTRAL.
GT200500215A 2004-08-19 2005-08-09 Amidas sustituidas de àcido tienopirrolcarboxìlico, amidas del àcido pirrolotiazolcarboxìlico y anàlogos relacionados como inhibidores de la epsilon caseìna quinasa i GT200500215A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60334704P 2004-08-19 2004-08-19

Publications (1)

Publication Number Publication Date
GT200500215A true GT200500215A (es) 2006-03-27

Family

ID=35695546

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200500215A GT200500215A (es) 2004-08-19 2005-08-09 Amidas sustituidas de àcido tienopirrolcarboxìlico, amidas del àcido pirrolotiazolcarboxìlico y anàlogos relacionados como inhibidores de la epsilon caseìna quinasa i

Country Status (31)

Country Link
US (2) US7393867B2 (es)
EP (1) EP1784409B1 (es)
JP (1) JP4869232B2 (es)
KR (1) KR20070045263A (es)
CN (1) CN100562521C (es)
AR (1) AR051008A1 (es)
AT (1) ATE471326T1 (es)
AU (1) AU2005272584B2 (es)
BR (1) BRPI0514419A (es)
CA (1) CA2577879C (es)
CY (1) CY1110775T1 (es)
DE (1) DE602005021889D1 (es)
DK (1) DK1784409T3 (es)
ES (1) ES2347166T3 (es)
GT (1) GT200500215A (es)
HK (1) HK1105198A1 (es)
HR (1) HRP20100475T1 (es)
IL (1) IL181158A0 (es)
JO (1) JO2629B1 (es)
MY (1) MY139831A (es)
PA (1) PA8642801A1 (es)
PE (1) PE20060630A1 (es)
PL (1) PL1784409T3 (es)
PT (1) PT1784409E (es)
RS (1) RS51413B (es)
RU (1) RU2403257C2 (es)
SI (1) SI1784409T1 (es)
SV (1) SV2006002190A (es)
TW (1) TWI372149B (es)
UY (1) UY29077A1 (es)
WO (1) WO2006021000A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1922149A (zh) 2003-12-29 2007-02-28 塞普拉科公司 吡咯和吡唑daao抑制剂
CN104276955A (zh) 2006-01-06 2015-01-14 赛诺维信制药公司 基于四氢萘酮的单胺再摄取抑制剂
EP1976513B1 (en) 2006-01-06 2016-08-24 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
AU2007233041B2 (en) 2006-03-31 2013-05-02 Sepracor Inc. Preparation of chiral amides and amines
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
EP1955699A1 (en) * 2007-02-08 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Use of flibanserin for the treatment of insomnia
JP5420534B2 (ja) 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
JP4748823B2 (ja) * 2009-02-12 2011-08-17 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
RU2552993C2 (ru) * 2009-05-28 2015-06-10 Вертекс Фармасьютикалз Инкорпорейтед Аминопиразол триазолотиадиазольные ингибиторы протеинкиназы с-мет
KR101421852B1 (ko) * 2009-10-28 2014-07-22 화이자 인코포레이티드 카세인 키나제 억제제로서의 이미다졸 유도체
DE102009058280A1 (de) * 2009-12-14 2011-06-16 Merck Patent Gmbh Thiazolderivate
CA2807359C (en) * 2010-08-09 2020-07-07 Pharmadesign, Inc. Inhibitor of casein kinase 1.delta. and casein kinase 1.epsilon.
CN109748927A (zh) * 2017-11-03 2019-05-14 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物、其制备方法、药用组合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4583682B2 (ja) * 1999-06-08 2010-11-17 アベンティスユービー・セカンド・インコーポレイテッド 概日リズムタンパク質の変化に関するスクリーニング方法
BRPI0417520A (pt) * 2003-12-11 2007-03-06 Aventis Pharma Inc 1h-pirrolo[3,2-b, 3,2-c, e 2,3-c]piridina-2-carboxamidas substituìdas e análogos relatados como inibidores de caseìna cinase i-epsilon

Also Published As

Publication number Publication date
TWI372149B (en) 2012-09-11
HK1105198A1 (en) 2008-02-06
AU2005272584B2 (en) 2010-11-11
ES2347166T3 (es) 2010-10-26
HRP20100475T1 (hr) 2010-10-31
WO2006021000A2 (en) 2006-02-23
CA2577879A1 (en) 2006-02-23
EP1784409A2 (en) 2007-05-16
UY29077A1 (es) 2006-03-31
EP1784409B1 (en) 2010-06-16
KR20070045263A (ko) 2007-05-02
PT1784409E (pt) 2010-09-06
DE602005021889D1 (en) 2010-07-29
SV2006002190A (es) 2006-05-24
TW200621788A (en) 2006-07-01
US7652046B2 (en) 2010-01-26
CN100562521C (zh) 2009-11-25
US20080227822A1 (en) 2008-09-18
MY139831A (en) 2009-10-30
WO2006021000A3 (en) 2006-06-15
JO2629B1 (en) 2012-06-24
RU2403257C2 (ru) 2010-11-10
AU2005272584A1 (en) 2006-02-23
JP4869232B2 (ja) 2012-02-08
RU2007109812A (ru) 2008-09-27
DK1784409T3 (da) 2010-09-27
CN101001861A (zh) 2007-07-18
PE20060630A1 (es) 2006-08-03
ATE471326T1 (de) 2010-07-15
CA2577879C (en) 2011-07-12
AR051008A1 (es) 2006-12-13
US7393867B2 (en) 2008-07-01
CY1110775T1 (el) 2015-06-10
PL1784409T3 (pl) 2010-10-29
RS51413B (en) 2011-02-28
JP2008510712A (ja) 2008-04-10
PA8642801A1 (es) 2006-05-16
IL181158A0 (en) 2007-07-04
BRPI0514419A (pt) 2008-06-10
SI1784409T1 (sl) 2010-10-29
US20070299112A1 (en) 2007-12-27

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