TWI372149B - Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase iε - Google Patents

Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase iε

Info

Publication number
TWI372149B
TWI372149B TW094128282A TW94128282A TWI372149B TW I372149 B TWI372149 B TW I372149B TW 094128282 A TW094128282 A TW 094128282A TW 94128282 A TW94128282 A TW 94128282A TW I372149 B TWI372149 B TW I372149B
Authority
TW
Taiwan
Prior art keywords
carboxylic acid
acid amides
pyrrolothiazole
inhibitors
casein kinase
Prior art date
Application number
TW094128282A
Other languages
English (en)
Other versions
TW200621788A (en
Inventor
David Marc Fink
Yulin Chiang
Nicola Dawn Collar
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of TW200621788A publication Critical patent/TW200621788A/zh
Application granted granted Critical
Publication of TWI372149B publication Critical patent/TWI372149B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
TW094128282A 2004-08-19 2005-08-19 Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase iε TWI372149B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60334704P 2004-08-19 2004-08-19

Publications (2)

Publication Number Publication Date
TW200621788A TW200621788A (en) 2006-07-01
TWI372149B true TWI372149B (en) 2012-09-11

Family

ID=35695546

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094128282A TWI372149B (en) 2004-08-19 2005-08-19 Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase iε

Country Status (31)

Country Link
US (2) US7393867B2 (zh)
EP (1) EP1784409B1 (zh)
JP (1) JP4869232B2 (zh)
KR (1) KR20070045263A (zh)
CN (1) CN100562521C (zh)
AR (1) AR051008A1 (zh)
AT (1) ATE471326T1 (zh)
AU (1) AU2005272584B2 (zh)
BR (1) BRPI0514419A (zh)
CA (1) CA2577879C (zh)
CY (1) CY1110775T1 (zh)
DE (1) DE602005021889D1 (zh)
DK (1) DK1784409T3 (zh)
ES (1) ES2347166T3 (zh)
GT (1) GT200500215A (zh)
HK (1) HK1105198A1 (zh)
HR (1) HRP20100475T1 (zh)
IL (1) IL181158A0 (zh)
JO (1) JO2629B1 (zh)
MY (1) MY139831A (zh)
PA (1) PA8642801A1 (zh)
PE (1) PE20060630A1 (zh)
PL (1) PL1784409T3 (zh)
PT (1) PT1784409E (zh)
RS (1) RS51413B (zh)
RU (1) RU2403257C2 (zh)
SI (1) SI1784409T1 (zh)
SV (1) SV2006002190A (zh)
TW (1) TWI372149B (zh)
UY (1) UY29077A1 (zh)
WO (1) WO2006021000A2 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0418244A (pt) 2003-12-29 2007-04-17 Sepracor Inc composto, métodos para aumentar a concentração de d-serina e/ou diminuir a concentração de produtos tóxicos da oxidação de d-serina pela daao em um mamìfero, para tratar a esquizofrenia, para tratar ou prevenir a perda de memória e/ou cognição associadas com o mal de alzheimer, para tratar a ataxia ou para prevenir a perda da função neuronal caracterìstica de doenças neurodegenerativas, para intensificar a aprendizagem, memória e/ou cognição e para tratar dor neuropática, e, composição farmacêutica
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
NZ569630A (en) 2006-01-06 2011-09-30 Sepracor Inc Cycloalkylamines as monoamine reuptake inhibitors
EP2816024B8 (en) 2006-03-31 2018-04-04 Sunovion Pharmaceuticals Inc. Chiral amines
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
EP1955699A1 (en) * 2007-02-08 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Use of flibanserin for the treatment of insomnia
RU2470011C2 (ru) 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов
US9018238B2 (en) 2009-02-12 2015-04-28 Pharmadesign, Inc. Inhibitor of casein kinase 1δ and casein kinase 1ε
SG176574A1 (en) * 2009-05-28 2012-01-30 Vertex Pharma Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase
IN2012DN03182A (zh) * 2009-10-28 2015-09-25 Pfizer
DE102009058280A1 (de) * 2009-12-14 2011-06-16 Merck Patent Gmbh Thiazolderivate
JP5181156B2 (ja) 2010-08-09 2013-04-10 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
CN109748927A (zh) * 2017-11-03 2019-05-14 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物、其制备方法、药用组合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL146729A0 (en) * 1999-06-08 2002-07-25 Aventis Pharma Inc Screening methods for altering circadian rhythm proteins
DE602004020685D1 (de) * 2003-12-11 2009-05-28 Aventis Pharma Inc Substituierte 1h-pyrroloä3,2-b, 3,2-c und 2,3-cüpyridin-2-carbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i-epsilon

Also Published As

Publication number Publication date
AU2005272584A1 (en) 2006-02-23
MY139831A (en) 2009-10-30
CA2577879A1 (en) 2006-02-23
TW200621788A (en) 2006-07-01
ES2347166T3 (es) 2010-10-26
US7652046B2 (en) 2010-01-26
DK1784409T3 (da) 2010-09-27
US20080227822A1 (en) 2008-09-18
EP1784409B1 (en) 2010-06-16
US20070299112A1 (en) 2007-12-27
CA2577879C (en) 2011-07-12
SV2006002190A (es) 2006-05-24
CN100562521C (zh) 2009-11-25
BRPI0514419A (pt) 2008-06-10
IL181158A0 (en) 2007-07-04
HK1105198A1 (en) 2008-02-06
PT1784409E (pt) 2010-09-06
EP1784409A2 (en) 2007-05-16
WO2006021000A3 (en) 2006-06-15
AR051008A1 (es) 2006-12-13
ATE471326T1 (de) 2010-07-15
PE20060630A1 (es) 2006-08-03
HRP20100475T1 (hr) 2010-10-31
UY29077A1 (es) 2006-03-31
PA8642801A1 (es) 2006-05-16
SI1784409T1 (sl) 2010-10-29
RU2403257C2 (ru) 2010-11-10
DE602005021889D1 (en) 2010-07-29
KR20070045263A (ko) 2007-05-02
RU2007109812A (ru) 2008-09-27
JP2008510712A (ja) 2008-04-10
JP4869232B2 (ja) 2012-02-08
US7393867B2 (en) 2008-07-01
AU2005272584B2 (en) 2010-11-11
WO2006021000A2 (en) 2006-02-23
CN101001861A (zh) 2007-07-18
GT200500215A (es) 2006-03-27
JO2629B1 (en) 2012-06-24
RS51413B (en) 2011-02-28
PL1784409T3 (pl) 2010-10-29
CY1110775T1 (el) 2015-06-10

Similar Documents

Publication Publication Date Title
TWI372149B (en) Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase iε
IL181169A0 (en) Trifluoromethyl substituted benzamides as kinase inhibitors
IL186526A0 (en) Substituted amide derivatives as protein kinase inhibitors
IL198487A0 (en) 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors
IL181720A0 (en) Bicyclic amides as kinase inhibitors
IL198398A0 (en) 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors
ZA200704106B (en) Inhibitors of c-fms kinase
PL1711481T5 (pl) Krystaliczny monohydrat jako inhibitor kinazy
EP1737845A4 (en) DISPLAY HEMMER OF IL-12 PRODUCTION
IL177278A0 (en) Pyrazolotriazines as kinase inhibitors
EP1756092A4 (en) NEW INHIBITORS OF RHO-KINASEN
PL1874770T3 (pl) Fenyloacetamidy odpowiednie jako inhibitory kinaz białkowych
IL184504A0 (en) 4-(2,6-dichlorobenzoylamino)-1h-pyrazole-3-carboxylic acid piperidin-4-ylamid acid addition salts as kinase inhibitors
PT2225238E (pt) Derivados de amidas do ácido 6,7-di-hidro-5h-imidazo[1,2- a]imidazol-3-carboxílico
IL172167A0 (en) Pharmaceutically useful salts of carboxylic acid derivatives
AP2076A (en) New Heterocyclic carboxylic acid amide derivatives
IL187631A0 (en) Novel piperidine carboxylic acid amide derivatives
AU2003291867A8 (en) Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex
IL172168A0 (en) Pharmaceutically useful salts of carboxylic acid derivatives
IL182735A0 (en) Inhibitors of c-fms kinase
ZA200709852B (en) Spiro-benzimidazoles as inhibitors of gastric acid secretion
HK1105196A1 (en) 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase i
ZA200700650B (en) Bicyclic amides as kinase inhibitors
ZA200700751B (en) Azalndoles useful as inhibitors of protein kinases
EP1971333A4 (en) AMINO ACID DERIVATIVES OF PROTEIN KINASE INHIBITORS ON INDOLINONE BASE

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees