BRPI0417520A - 1h-pirrolo[3,2-b, 3,2-c, e 2,3-c]piridina-2-carboxamidas substituìdas e análogos relatados como inibidores de caseìna cinase i-epsilon - Google Patents

1h-pirrolo[3,2-b, 3,2-c, e 2,3-c]piridina-2-carboxamidas substituìdas e análogos relatados como inibidores de caseìna cinase i-epsilon

Info

Publication number
BRPI0417520A
BRPI0417520A BRPI0417520-4A BRPI0417520A BRPI0417520A BR PI0417520 A BRPI0417520 A BR PI0417520A BR PI0417520 A BRPI0417520 A BR PI0417520A BR PI0417520 A BRPI0417520 A BR PI0417520A
Authority
BR
Brazil
Prior art keywords
carboxamides
inhibitors
casein kinase
substituted
formula
Prior art date
Application number
BRPI0417520-4A
Other languages
English (en)
Inventor
William A Metz
Frank Halley
Gilles Dutruc-Rosset
Yong Mi Choi-Sledeski
Gregory B Poli
David M Fink
Gilles Doerflinger
Bao-Guo Huang
Ann Marie Gelormini
Andrew Giovanni
Joachim E Roehr
Joseph T Tsay
Fernando Camacho
William J Hurst
Stephen W Harnish
Yulin Chiang
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BRPI0417520A publication Critical patent/BRPI0417520A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"1H-PIRROLO¢3,2-B, 3,2-C, E 2,3-C!PIRIDINA-2-CARBOXAMIDAS SUBSTITUìDAS E ANáLOGOS RELATADOS COMO INIBIDORES DE CASEìNA CINASE I-EPSILON". A presente invenção descreve e reivindica 1H-pirrol¢3,2-b!piridina-2-carboxamidas substituídas, 1H-pirrol¢3,2-c!piridina-2-carboxamidas e 1H-pirrol¢2,3-c!piridina-2-carboxamidas (Compostos de fórmula (I)) como inibidores de caseína cinase lsym>humana, e métodos de emprego dos referidos compostos de fórmula (I) para tratar doenças do sistema nervoso central e distúrbios incluindo distúrbios do humor e distúrbios do sono. Composições farmacêuticas compreendendo compostos de fórmula (I) e métodos para a preparação de compostos de fórmula (I) são também descritos e reivindicados.
BRPI0417520-4A 2003-12-11 2004-12-01 1h-pirrolo[3,2-b, 3,2-c, e 2,3-c]piridina-2-carboxamidas substituìdas e análogos relatados como inibidores de caseìna cinase i-epsilon BRPI0417520A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52876403P 2003-12-11 2003-12-11
PCT/US2004/040080 WO2005061498A1 (en) 2003-12-11 2004-12-01 Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon

Publications (1)

Publication Number Publication Date
BRPI0417520A true BRPI0417520A (pt) 2007-03-06

Family

ID=34710096

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417520-4A BRPI0417520A (pt) 2003-12-11 2004-12-01 1h-pirrolo[3,2-b, 3,2-c, e 2,3-c]piridina-2-carboxamidas substituìdas e análogos relatados como inibidores de caseìna cinase i-epsilon

Country Status (21)

Country Link
US (2) US7402672B2 (pt)
EP (1) EP1747220B1 (pt)
JP (1) JP4691506B2 (pt)
KR (1) KR20060113754A (pt)
CN (1) CN100439367C (pt)
AT (1) ATE428711T1 (pt)
AU (1) AU2004303826A1 (pt)
BR (1) BRPI0417520A (pt)
CA (1) CA2549183A1 (pt)
DE (1) DE602004020685D1 (pt)
DK (1) DK1747220T3 (pt)
ES (1) ES2324871T3 (pt)
HK (1) HK1098742A1 (pt)
HR (1) HRP20090380T1 (pt)
IL (1) IL175875A0 (pt)
PL (1) PL1747220T3 (pt)
PT (1) PT1747220E (pt)
RS (1) RS50823B (pt)
SI (1) SI1747220T1 (pt)
TW (1) TW200530234A (pt)
WO (1) WO2005061498A1 (pt)

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BRPI0514397A (pt) * 2004-08-19 2008-06-10 Aventis Pharma Inc derivados de 3-ariltioindol-2-carboxamida e análogos destes como inibidores de caseìna cinase iépsilon
JO2724B1 (en) 2004-08-19 2013-09-15 افينتس فارماسوتيكالز انك 3-Alternative-5 -6-Amino Alkyl Indole-2-Carboxyl Acid Amide and Related Isotopes as Casein Kinase Inhibitors
JO2629B1 (en) * 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
JP2009507024A (ja) * 2005-09-01 2009-02-19 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害剤化合物およびその使用方法
WO2007048064A2 (en) * 2005-10-21 2007-04-26 Exelixis, Inc. Amino-pyrimidines as casein kinase ii (ck2) modulators
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
FR2918986B1 (fr) 2007-07-19 2009-09-04 Sanofi Aventis Sa Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique
FR2939134A1 (fr) 2008-12-01 2010-06-04 Sanofi Aventis Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940285A1 (fr) 2008-12-19 2010-06-25 Sanofi Aventis Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940284B1 (fr) 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
FR2945289A1 (fr) 2009-05-11 2010-11-12 Sanofi Aventis Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique
IN2012DN03182A (pt) * 2009-10-28 2015-09-25 Pfizer
FR2960876B1 (fr) * 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
WO2014111871A1 (en) 2013-01-17 2014-07-24 Aurigene Discovery Technologies Limited 4,5-dihydroisoxazole derivatives as nampt inhibitors
WO2014182033A1 (en) * 2013-05-08 2014-11-13 Yuhan Corporation Process for the preparation of pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof
KR101657599B1 (ko) * 2013-05-20 2016-09-19 주식회사유한양행 피롤로[2,3-c]피리딘 유도체 또는 이의 약학적으로 허용가능한 염의 제조방법
AR098414A1 (es) * 2013-11-14 2016-05-26 Bristol Myers Squibb Co PIPERAZINAS DE PIRAZOLO SUSTITUIDO COMO INHIBIDORES DE CASEÍNA QUINASA 1 d/e
CN104945313A (zh) * 2015-06-19 2015-09-30 洪帅金 一种2-甲基-3-溴吡啶的制备方法
CN104974082A (zh) * 2015-07-26 2015-10-14 陈吉美 一种2-甲基-4-溴吡啶的制备方法
CN105198802A (zh) * 2015-11-03 2015-12-30 江苏梦得电镀化学品有限公司 一种2-甲基-3-溴吡啶的制备方法
US10973820B2 (en) 2017-12-13 2021-04-13 Facio Intellectual Property B.V. Compounds for treatment of diseases related to DUX4 expression
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合

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Also Published As

Publication number Publication date
EP1747220B1 (en) 2009-04-15
CA2549183A1 (en) 2005-07-07
JP4691506B2 (ja) 2011-06-01
EP1747220A1 (en) 2007-01-31
US20050131012A1 (en) 2005-06-16
WO2005061498A1 (en) 2005-07-07
HK1098742A1 (en) 2007-07-27
TW200530234A (en) 2005-09-16
HRP20090380T1 (hr) 2009-08-31
DE602004020685D1 (de) 2009-05-28
ATE428711T1 (de) 2009-05-15
JP2007513950A (ja) 2007-05-31
RS50823B (sr) 2010-08-31
US7402672B2 (en) 2008-07-22
US7626027B2 (en) 2009-12-01
CN100439367C (zh) 2008-12-03
ES2324871T3 (es) 2009-08-18
PL1747220T3 (pl) 2009-09-30
AU2004303826A1 (en) 2005-07-07
PT1747220E (pt) 2009-07-08
CN1906194A (zh) 2007-01-31
SI1747220T1 (sl) 2009-08-31
IL175875A0 (en) 2006-10-05
KR20060113754A (ko) 2006-11-02
US20080200496A1 (en) 2008-08-21
DK1747220T3 (da) 2009-08-10

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: AVENTIS PHARMACEUTICALS, INC. (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.