GT200200210A - Alquinos como inhibidores de metaloproteinasa de matriz - Google Patents

Alquinos como inhibidores de metaloproteinasa de matriz

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Publication number
GT200200210A
GT200200210A GT200200210A GT200200210A GT200200210A GT 200200210 A GT200200210 A GT 200200210A GT 200200210 A GT200200210 A GT 200200210A GT 200200210 A GT200200210 A GT 200200210A GT 200200210 A GT200200210 A GT 200200210A
Authority
GT
Guatemala
Prior art keywords
alkins
inhibitors
matrix metaloproteinase
metaloproteinase inhibitors
matrix
Prior art date
Application number
GT200200210A
Other languages
English (en)
Inventor
Amy Mae Bunker
William Glen Harter
James Lester Hicks
Patrick Michael O'brien
Ly Thi Pham
Joseph Armand Picard
William Howard Roark
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Publication date
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Publication of GT200200210A publication Critical patent/GT200200210A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D515/04—Ortho-condensed systems

Abstract

LA PRESENTE INVENCION SE REFIERE A ALQUINOS COMO INHIBIDORES DE METALOPROTEINASA DE MATRIZ DE FORMULA GENERAL (I) EN DONDE B,G1,G2, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS VAN A PRODUCIR LA INHIBICION DE ENZIMAS METALOPROTEINASAS Y MAS ESPECIFICAMENTE LA MMP13 POR LO QUE SON DE UTILIDAD EN CASOS DE ARTRITIS, OSTEOARTRITIS, ARTRITIS REUMATOIDE, ATEROSCLEROSIS, ENTRE OTRAS DESCRITAS EN LA SOLICITUD.
GT200200210A 2001-10-12 2002-10-11 Alquinos como inhibidores de metaloproteinasa de matriz GT200200210A (es)

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JP4164028B2 (ja) 2008-10-08
BR0213233A (pt) 2005-01-04
EP1434585A1 (en) 2004-07-07
PA8556201A1 (es) 2003-06-30
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JP2005514334A (ja) 2005-05-19
PE20030607A1 (es) 2003-07-12
CA2462442A1 (en) 2003-04-24
WO2003032999A1 (en) 2003-04-24
UY27481A1 (es) 2003-05-30
US6849648B2 (en) 2005-02-01
MXPA04002537A (es) 2004-05-31
US20030144274A1 (en) 2003-07-31
SV2004001291A (es) 2004-05-07

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