HUT77372A - Új benzil-pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents
Új benzil-pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukraInfo
- Publication number
- HUT77372A HUT77372A HU9701973A HU9701973A HUT77372A HU T77372 A HUT77372 A HU T77372A HU 9701973 A HU9701973 A HU 9701973A HU 9701973 A HU9701973 A HU 9701973A HU T77372 A HUT77372 A HU T77372A
- Authority
- HU
- Hungary
- Prior art keywords
- pct
- producing
- pharmaceutical compositions
- compositions containing
- date
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH353694 | 1994-11-24 | ||
| CH270495 | 1995-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUT77372A true HUT77372A (hu) | 1998-03-30 |
Family
ID=25691190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9701973A HUT77372A (hu) | 1994-11-24 | 1995-11-13 | Új benzil-pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5763450A (hu) |
| EP (1) | EP0793656B1 (hu) |
| JP (1) | JP3117721B2 (hu) |
| KR (1) | KR100417508B1 (hu) |
| CN (1) | CN1136198C (hu) |
| AT (1) | ATE235471T1 (hu) |
| AU (1) | AU704911B2 (hu) |
| BR (1) | BR9509768A (hu) |
| CA (1) | CA2205406C (hu) |
| CZ (1) | CZ157597A3 (hu) |
| DE (1) | DE69530104T2 (hu) |
| DK (1) | DK0793656T3 (hu) |
| ES (1) | ES2193205T3 (hu) |
| FI (1) | FI972194A (hu) |
| HU (1) | HUT77372A (hu) |
| MX (1) | MX9703687A (hu) |
| NO (1) | NO308845B1 (hu) |
| NZ (1) | NZ296532A (hu) |
| PL (1) | PL320458A1 (hu) |
| PT (1) | PT793656E (hu) |
| WO (1) | WO1996016046A2 (hu) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
| EP0966464B1 (en) * | 1997-03-03 | 2003-05-28 | Basilea Pharmaceutica AG | Substituted 2,4-diaminopyrimidines |
| TR199902140T2 (en) * | 1997-03-03 | 2000-04-21 | F. Hoffmann-La Roche Ag | S�bstit�e edilmi� 2,4-diaminopirimidinler. |
| WO1999000359A1 (fr) | 1997-06-27 | 1999-01-07 | Fujisawa Pharmaceutical Co., Ltd. | Derives de noyau aromatique |
| US6893815B1 (en) * | 1997-06-30 | 2005-05-17 | Isis Pharmaceuticals, Inc. | Nucleobase heterocyclic combinatorialization |
| JP4370002B2 (ja) * | 1997-08-08 | 2009-11-25 | 富山化学工業株式会社 | キノロンカルボン酸誘導体またはその塩 |
| PL341364A1 (en) * | 1997-12-22 | 2001-04-09 | Upjohn Co | 4-hydroxyqinoline-3-carboxamides and hydrazides as antiviral agents |
| ATE342897T1 (de) * | 1998-04-06 | 2006-11-15 | Toyama Chemical Co Ltd | Chinoloncarbonsäurederivate oder deren salze |
| ATE425142T1 (de) * | 1999-04-23 | 2009-03-15 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| EP1230224B1 (de) | 1999-11-04 | 2004-12-29 | Basilea Pharmaceutica AG | Substituierte 5-benzyl-2,4-diaminopyrimidine |
| US7612065B2 (en) | 2000-04-21 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-JUN N-terminal kinases (JNK) |
| PE20011349A1 (es) | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales |
| HUP0301189A3 (en) | 2000-07-24 | 2003-11-28 | Bayer Cropscience Ag | Pyrazolyl biphenyl carboxamides, intermediates, preparation and use thereof for controlling undesired microorganisms |
| BRPI0112676B1 (pt) * | 2000-07-24 | 2015-10-06 | Bayer Cropscience Ag | "bifenilcarboxamidas, seu processo de preparação, e composição e processo para combater microorganismos indesejados". |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| CA2462442A1 (en) * | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkyne matrix metalloproteinase inhibitors |
| US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| EP1403271B1 (en) * | 2002-09-25 | 2005-11-16 | Degussa AG | Method of producing 5-formyl-2-furylboronic acid |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| EP1924564B1 (en) * | 2005-09-01 | 2016-11-09 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| US8268825B2 (en) | 2005-09-26 | 2012-09-18 | The Board Of Regents For Oklahoma State University | Method for the treatment of anthrax infections |
| ES2466667T3 (es) * | 2006-10-04 | 2014-06-10 | F. Hoffmann-La Roche Ag | Proceso para síntesis de derivados de fenoxi diaminopirimidina |
| AU2008242767A1 (en) | 2007-04-20 | 2008-10-30 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| US8853228B2 (en) * | 2007-06-04 | 2014-10-07 | University Of Connecticut | Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase |
| EP2628727A3 (en) | 2007-11-21 | 2013-12-25 | Decode Genetics EHF | Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| GB0815962D0 (en) * | 2008-09-02 | 2008-10-08 | Merlion Pharmaceuticals Pte Ltd | Hybrid antibacterial compounds and their use |
| BRPI0920765A2 (pt) | 2008-10-29 | 2015-08-18 | Deciphera Pharmaceuticals Llc | Amidas de cilopropano e análogos que exibem atividades anticâncer e antiproliferativas |
| ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
| CN102040591B (zh) * | 2009-10-15 | 2013-12-11 | 山东轩竹医药科技有限公司 | 7-苯基喹诺酮类化合物 |
| ES2458355T3 (es) * | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| RU2013144207A (ru) | 2011-03-02 | 2015-04-10 | Новартис Аг | Комбинированные вакцины с пониженными дозами антигена и/или адъюванта |
| CA2866406A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of booster vaccines |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| MX2022001863A (es) | 2019-08-12 | 2022-05-30 | Deciphera Pharmaceuticals Llc | Metodos para tratar los tumores del estroma gastrointestinal. |
| BR112022013169A2 (pt) | 2019-12-30 | 2022-09-13 | Deciphera Pharmaceuticals Llc | Composições de 1-(4-bromo-5-(1-etil-7-(metilamino)-2-oxo-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofeil)-3-fenilurea |
| RS65058B1 (sr) | 2019-12-30 | 2024-02-29 | Deciphera Pharmaceuticals Llc | Formulacije inhibitora amorfne kinaze i postupci njihove primene |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
| US4039543A (en) * | 1974-12-24 | 1977-08-02 | Hoffmann-La Roche Inc. | Benzylpyrimidines |
| JPH07509215A (ja) * | 1990-11-14 | 1995-10-12 | カイロン コーポレイション | ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物 |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
-
1995
- 1995-11-13 US US08/836,857 patent/US5763450A/en not_active Expired - Lifetime
- 1995-11-13 EP EP95939267A patent/EP0793656B1/en not_active Expired - Lifetime
- 1995-11-13 WO PCT/EP1995/004451 patent/WO1996016046A2/en active IP Right Grant
- 1995-11-13 AU AU41161/96A patent/AU704911B2/en not_active Ceased
- 1995-11-13 NZ NZ296532A patent/NZ296532A/en unknown
- 1995-11-13 BR BR9509768A patent/BR9509768A/pt not_active Application Discontinuation
- 1995-11-13 HU HU9701973A patent/HUT77372A/hu unknown
- 1995-11-13 ES ES95939267T patent/ES2193205T3/es not_active Expired - Lifetime
- 1995-11-13 PL PL95320458A patent/PL320458A1/xx unknown
- 1995-11-13 PT PT95939267T patent/PT793656E/pt unknown
- 1995-11-13 AT AT95939267T patent/ATE235471T1/de not_active IP Right Cessation
- 1995-11-13 KR KR1019970703472A patent/KR100417508B1/ko not_active IP Right Cessation
- 1995-11-13 DK DK95939267T patent/DK0793656T3/da active
- 1995-11-13 CN CNB951963988A patent/CN1136198C/zh not_active Expired - Fee Related
- 1995-11-13 CA CA002205406A patent/CA2205406C/en not_active Expired - Fee Related
- 1995-11-13 JP JP08516521A patent/JP3117721B2/ja not_active Expired - Lifetime
- 1995-11-13 MX MX9703687A patent/MX9703687A/es not_active IP Right Cessation
- 1995-11-13 DE DE69530104T patent/DE69530104T2/de not_active Expired - Lifetime
- 1995-11-13 CZ CZ971575A patent/CZ157597A3/cs unknown
-
1997
- 1997-05-22 FI FI972194A patent/FI972194A/fi not_active IP Right Cessation
- 1997-05-26 NO NO972393A patent/NO308845B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9509768A (pt) | 1998-07-07 |
| CA2205406C (en) | 2008-02-05 |
| WO1996016046A2 (en) | 1996-05-30 |
| NO972393D0 (no) | 1997-05-26 |
| PL320458A1 (en) | 1997-09-29 |
| DE69530104D1 (de) | 2003-04-30 |
| FI972194A0 (fi) | 1997-05-22 |
| NO972393L (no) | 1997-05-29 |
| CA2205406A1 (en) | 1996-05-30 |
| KR100417508B1 (ko) | 2004-03-18 |
| FI972194A (fi) | 1997-05-22 |
| JP3117721B2 (ja) | 2000-12-18 |
| CN1166831A (zh) | 1997-12-03 |
| MX9703687A (es) | 1997-08-30 |
| DE69530104T2 (de) | 2003-12-24 |
| NO308845B1 (no) | 2000-11-06 |
| WO1996016046A3 (en) | 1996-07-25 |
| US5763450A (en) | 1998-06-09 |
| ES2193205T3 (es) | 2003-11-01 |
| EP0793656B1 (en) | 2003-03-26 |
| EP0793656A1 (en) | 1997-09-10 |
| DK0793656T3 (da) | 2003-07-21 |
| CN1136198C (zh) | 2004-01-28 |
| AU704911B2 (en) | 1999-05-06 |
| JPH11507009A (ja) | 1999-06-22 |
| PT793656E (pt) | 2003-07-31 |
| CZ157597A3 (en) | 1997-09-17 |
| NZ296532A (en) | 2000-02-28 |
| AU4116196A (en) | 1996-06-17 |
| ATE235471T1 (de) | 2003-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFD9 | Temporary protection cancelled due to non-payment of fee |