DOP2002000473A - Alquinos como inhibidores de metaloproteinasa de matriz - Google Patents
Alquinos como inhibidores de metaloproteinasa de matrizInfo
- Publication number
- DOP2002000473A DOP2002000473A DO2002000473A DO2002000473A DOP2002000473A DO P2002000473 A DOP2002000473 A DO P2002000473A DO 2002000473 A DO2002000473 A DO 2002000473A DO 2002000473 A DO2002000473 A DO 2002000473A DO P2002000473 A DOP2002000473 A DO P2002000473A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- alkins
- matrix metaloproteinase
- metaloproteinase inhibitors
- inhibitors
- mmp
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P17/06—Antipsoriatics
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Los compuestos de formula I O una sal farmacéuticamente aceptable de los mismos, o un tautomero de los mismos, en la que G1, G2 y B son como se definen en la solicitud, son inhibidores selectivos de la MMP-13. Los compuestos son útiles para el tratamiento de enfermedades mediadas por la MMP-13, incluyendo el cáncer y la artritis
Applications Claiming Priority (1)
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US32921601P | 2001-10-12 | 2001-10-12 |
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DOP2002000473A true DOP2002000473A (es) | 2003-04-15 |
Family
ID=23284384
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DO2002000473A DOP2002000473A (es) | 2001-10-12 | 2002-09-27 | Alquinos como inhibidores de metaloproteinasa de matriz |
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US (1) | US6849648B2 (es) |
EP (1) | EP1434585A1 (es) |
JP (1) | JP4164028B2 (es) |
BR (1) | BR0213233A (es) |
CA (1) | CA2462442A1 (es) |
DO (1) | DOP2002000473A (es) |
GT (1) | GT200200210A (es) |
HN (1) | HN2002000291A (es) |
MX (1) | MXPA04002537A (es) |
PA (1) | PA8556201A1 (es) |
PE (1) | PE20030607A1 (es) |
SV (1) | SV2004001291A (es) |
UY (1) | UY27481A1 (es) |
WO (1) | WO2003032999A1 (es) |
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AU2003249505A1 (en) * | 2002-07-17 | 2004-02-02 | Warner-Lambert Company Llc | Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib |
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AU2003281167A1 (en) * | 2002-07-17 | 2004-02-02 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
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PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
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-
2002
- 2002-08-02 MX MXPA04002537A patent/MXPA04002537A/es active IP Right Grant
- 2002-08-02 EP EP02751510A patent/EP1434585A1/en not_active Withdrawn
- 2002-08-02 BR BR0213233-8A patent/BR0213233A/pt not_active IP Right Cessation
- 2002-08-02 CA CA002462442A patent/CA2462442A1/en not_active Abandoned
- 2002-08-02 WO PCT/IB2002/003057 patent/WO2003032999A1/en active Application Filing
- 2002-08-02 JP JP2003535802A patent/JP4164028B2/ja not_active Expired - Fee Related
- 2002-09-27 DO DO2002000473A patent/DOP2002000473A/es unknown
- 2002-10-04 US US10/264,764 patent/US6849648B2/en not_active Expired - Fee Related
- 2002-10-09 UY UY27481A patent/UY27481A1/es not_active Application Discontinuation
- 2002-10-09 HN HN2002000291A patent/HN2002000291A/es unknown
- 2002-10-11 PA PA20028556201A patent/PA8556201A1/es unknown
- 2002-10-11 PE PE2002001006A patent/PE20030607A1/es not_active Application Discontinuation
- 2002-10-11 GT GT200200210A patent/GT200200210A/es unknown
- 2002-10-11 SV SV2002001291A patent/SV2004001291A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6849648B2 (en) | 2005-02-01 |
JP2005514334A (ja) | 2005-05-19 |
BR0213233A (pt) | 2005-01-04 |
CA2462442A1 (en) | 2003-04-24 |
JP4164028B2 (ja) | 2008-10-08 |
WO2003032999A1 (en) | 2003-04-24 |
US20030144274A1 (en) | 2003-07-31 |
PE20030607A1 (es) | 2003-07-12 |
UY27481A1 (es) | 2003-05-30 |
EP1434585A1 (en) | 2004-07-07 |
HN2002000291A (es) | 2002-12-20 |
GT200200210A (es) | 2003-06-25 |
PA8556201A1 (es) | 2003-06-30 |
MXPA04002537A (es) | 2004-05-31 |
SV2004001291A (es) | 2004-05-07 |
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