GR3017445T3 - (+)-Isomers of endoetheno/endoethano-epoxymorphinan derivatives as antitussive agents. - Google Patents

(+)-Isomers of endoetheno/endoethano-epoxymorphinan derivatives as antitussive agents.

Info

Publication number
GR3017445T3
GR3017445T3 GR950402571T GR950402571T GR3017445T3 GR 3017445 T3 GR3017445 T3 GR 3017445T3 GR 950402571 T GR950402571 T GR 950402571T GR 950402571 T GR950402571 T GR 950402571T GR 3017445 T3 GR3017445 T3 GR 3017445T3
Authority
GR
Greece
Prior art keywords
alkyl
hydrido
phenyl
endoetheno
endoethano
Prior art date
Application number
GR950402571T
Other languages
English (en)
Inventor
Kenner C Rice
John M Farah Jr
Neile A Grayson
Original Assignee
Searle & Co
Nat Inst Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, Nat Inst Health filed Critical Searle & Co
Publication of GR3017445T3 publication Critical patent/GR3017445T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Epoxy Resins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
GR950402571T 1989-08-24 1995-09-20 (+)-Isomers of endoetheno/endoethano-epoxymorphinan derivatives as antitussive agents. GR3017445T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39821389A 1989-08-24 1989-08-24
US56873290A 1990-08-20 1990-08-20

Publications (1)

Publication Number Publication Date
GR3017445T3 true GR3017445T3 (en) 1995-12-31

Family

ID=27016167

Family Applications (1)

Application Number Title Priority Date Filing Date
GR950402571T GR3017445T3 (en) 1989-08-24 1995-09-20 (+)-Isomers of endoetheno/endoethano-epoxymorphinan derivatives as antitussive agents.

Country Status (11)

Country Link
EP (1) EP0418591B1 (el)
JP (1) JP3313361B2 (el)
KR (1) KR0172596B1 (el)
AT (1) ATE124046T1 (el)
CA (1) CA2023858C (el)
DE (1) DE69020277T2 (el)
DK (1) DK0418591T3 (el)
ES (1) ES2072946T3 (el)
GR (1) GR3017445T3 (el)
IE (1) IE67526B1 (el)
PT (1) PT95069B (el)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE166229T1 (de) * 1992-12-22 1998-06-15 Toray Industries Antitussivum
KR100204659B1 (ko) * 1996-05-28 1999-06-15 강재헌 신규한 부프레노핀계 진통제용 화합물
ES2297882T3 (es) 1997-03-27 2008-05-01 Toray Industries, Inc. Derivados de morfinano y usos medicos de los mismos.
ES2329296T3 (es) * 2006-01-05 2009-11-24 Mallinckrodt, Inc. El uso de oripavina como material de partida para buprenorfina.
ES2392594T3 (es) 2006-10-17 2012-12-12 Penick Corporation Procedimiento para preparar oximorfona
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US8530494B2 (en) 2008-07-30 2013-09-10 Purdue Pharma Lp Buprenophine analogs
PL2344507T5 (pl) 2008-09-30 2021-10-11 SpecGx LLC Sposoby zwiększania wydajności hydrolizy grupy 3-O-metylowej i 17-N-nitrylowej w wytwarzaniu pochodnych alkaloidów opiatowych
TWI541246B (zh) 2008-12-08 2016-07-11 歐陸斯迪公司 二氫羥戊甲嗎啡
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398807A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398806A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
CN102325776A (zh) 2009-02-23 2012-01-18 马林克罗特公司 (+)-***喃*季盐及其制备方法
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
JP5864417B2 (ja) * 2009-07-16 2016-02-17 マリンクロッド エルエルシー トール様受容体９のアンタゴニストとしての（＋）−モルフィナンおよびその治療的使用
WO2012008984A1 (en) 2010-07-16 2012-01-19 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
MX2014002630A (es) 2011-09-08 2014-04-14 Mallinckrodt Llc Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
US11505556B2 (en) 2017-12-12 2022-11-22 Xalud Therapeutics, Inc. Halogenated derivatives of morphinans and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1178537A (en) * 1966-10-20 1970-01-21 Reckitt & Sons Ltd Antitussive and Analgesic Compositions
GB1300419A (en) * 1969-05-16 1972-12-20 Organon Labor Ltd New morphinone derivatives and their preparation
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4806543A (en) * 1986-11-25 1989-02-21 Board Of Trustees Of The Leland Stanford Junior University Method and compositions for reducing neurotoxic injury

Also Published As

Publication number Publication date
KR910004625A (ko) 1991-03-29
EP0418591B1 (en) 1995-06-21
CA2023858A1 (en) 1991-02-25
KR0172596B1 (ko) 1999-02-01
ES2072946T3 (es) 1995-08-01
IE903099A1 (en) 1991-02-27
IE67526B1 (en) 1996-04-03
ATE124046T1 (de) 1995-07-15
JP3313361B2 (ja) 2002-08-12
PT95069A (pt) 1991-04-18
EP0418591A3 (en) 1991-08-07
JPH03163083A (ja) 1991-07-15
CA2023858C (en) 2002-01-01
PT95069B (pt) 1997-10-31
DE69020277T2 (de) 1995-12-21
DK0418591T3 (da) 1995-08-14
EP0418591A2 (en) 1991-03-27
DE69020277D1 (de) 1995-07-27

Similar Documents

Publication Publication Date Title
EP0418591A3 (en) (+)-isomers of endoetheno/endoethano-epoxymorphinan derivatives as antitussive agents
NO894299L (no) Fremgangsmaate for fremstilling av pyrimidindion-derivater.
NZ225339A (en) Compounds having biocidal properties and pharmaceutical compositions
NO893628D0 (no) Biocid preparat.
IT8519525A0 (it) Composizioni lubrificanti aventi migliorate proprieta'di filmatura
FI921522A (fi) Pyrazolopyridinfoerening och foerfarande foer dess framstaellning
EP0539114A3 (en) Halopropargylated cyclic quaternary ammonium compound as antimicrobial agents
IT8947539A0 (it) Sali cefalosporinici e relative composizioni iniettabili, nonche' procedimento di preparazione
ES2063452T3 (es) Preparacion y uso de esteres y derivados de n-yodopropargil oxicarbonil aminoacido como agentes antimicrobianos.
PT81855A (en) Therapeutic agents
IL86725A (en) 1-alkyl-n-cycloalkyl- 6-methyl-ergoline-8'- carboxamides, their preparation and pharmaceutical compositions containing them
IL94897A0 (en) Improved herbicidal compositions containing bipyridilium salts
DK0420121T3 (da) Antitumormiddel
IL85822A (en) 7-alkanesulphonoamido-1,2,4,5-tetrahydro-3h-3-benzazepine derivatives,their preparation and pharmaceutical compositions containing them
SE8600046D0 (sv) Use of an ester compound as a temporary bactericide and product containing said ester compound
NZ220596A (en) 3-(substituted oxy)-2-benzoyl-cyclohex-2-enone derivatives and herbicidal compositions
EP0318357A3 (en) 1,3-butanediol acetoacetate and its use in parenteral and oral nutrition
GR3007219T3 (el)
MX9101831A (es) Composiciones de dextrometorfano contra la tos
ES2001969A6 (es) Procedimiento para preparar compuestos de fosfonamido
ES8403889A1 (es) Un metodo para preparar un compuesto de 1,4-dihidropiridina.
AU3005589A (en) N-(lower alkyl)-2-(3'-ureidobenzyl)-pyrrolidines
GB2202450B (en) Golfer's accessory
FI841207A0 (fi) Troponderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutisk komposition.
GR880100452A (el) Μυκητοκτονες συνθεσεις με βαση νικοτινικα παραγωγα,νεα νικοτινικα παραγωγα και η παρασκευη τους