MX2014002630A - Produccion de alcaloides sin el aislamiento de compuestos intermediarios. - Google Patents
Produccion de alcaloides sin el aislamiento de compuestos intermediarios.Info
- Publication number
- MX2014002630A MX2014002630A MX2014002630A MX2014002630A MX2014002630A MX 2014002630 A MX2014002630 A MX 2014002630A MX 2014002630 A MX2014002630 A MX 2014002630A MX 2014002630 A MX2014002630 A MX 2014002630A MX 2014002630 A MX2014002630 A MX 2014002630A
- Authority
- MX
- Mexico
- Prior art keywords
- alkaloids
- intermediates
- isolation
- production
- processes
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Addiction (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención se refiere a procesos para la producción de alcaloides sin el aislamiento de compuesto intermediarios.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161532253P | 2011-09-08 | 2011-09-08 | |
PCT/US2012/054099 WO2013036729A1 (en) | 2011-09-08 | 2012-09-07 | Production of alkaloids without the isolation of intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014002630A true MX2014002630A (es) | 2014-04-14 |
Family
ID=46982922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014002630A MX2014002630A (es) | 2011-09-08 | 2012-09-07 | Produccion de alcaloides sin el aislamiento de compuestos intermediarios. |
Country Status (14)
Country | Link |
---|---|
US (1) | US8624031B2 (es) |
EP (1) | EP2753622B1 (es) |
JP (1) | JP2014526467A (es) |
KR (1) | KR20140063763A (es) |
CN (1) | CN103917543A (es) |
AU (1) | AU2012304484B2 (es) |
BR (1) | BR112014005421A2 (es) |
CA (1) | CA2845187A1 (es) |
ES (1) | ES2566620T3 (es) |
IL (1) | IL231292A0 (es) |
MX (1) | MX2014002630A (es) |
PL (1) | PL2753622T3 (es) |
RU (1) | RU2014112493A (es) |
WO (1) | WO2013036729A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2718211T3 (es) | 2013-05-24 | 2019-06-28 | Rhodes Tech | Compuestos cetales opioides y usos de los mismos |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE922827C (de) | 1951-02-08 | 1955-01-27 | Knoll Ag | Verfahren zur Herstellung von quartaeren Ammoniumsalzen, die 2 Tetrahydroisochinolinreste enthalten |
US2772270A (en) | 1954-10-21 | 1956-11-27 | M J Lewenstein | 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone |
DE1119284B (de) | 1959-09-02 | 1961-12-14 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von antagonistisch gegen Morphin und schmerzstillend wirkenden quartaeren Salzen des Normorphins und deren acylierten Derivaten |
FR1602610A (en) | 1962-10-10 | 1971-01-04 | 10.10.62.-17.4.63. 38445-15209 thebaine derivs | |
US3438989A (en) | 1967-03-10 | 1969-04-15 | Warner Lambert Pharmaceutical | Process for the production of ( ) dihydrothebainone |
US3717643A (en) | 1967-05-04 | 1973-02-20 | Sterling Drug Inc | N-substituted-norapomorphines |
FR2189403A1 (en) | 1972-06-15 | 1974-01-25 | Merck & Co Inc | Norcodeine prepn - by reduction of 1-halo-norcodeinones, novel intermedi-ates for narcotic antagonists |
US4089855A (en) | 1976-04-23 | 1978-05-16 | Cornell Research Foundation, Inc. | Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby |
EP0034480A3 (en) | 1980-02-14 | 1982-01-13 | Grigg, Ronald Ernest | Alkylation of amines |
US4368326A (en) | 1980-07-03 | 1983-01-11 | Rice Kenner C | Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone |
US4521601A (en) | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
US4795813A (en) | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US4443605A (en) | 1982-07-30 | 1984-04-17 | Miles Laboratories, Inc. | 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans |
FR2562072B1 (fr) | 1984-03-27 | 1989-07-07 | Mallinckrodt Inc | Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede |
HU197750B (en) | 1984-07-17 | 1989-05-29 | Alkaloida Vegyeszeti Gyar | Process for n-demethylation of morphine alkaloids |
US4775759A (en) | 1984-11-27 | 1988-10-04 | The United States Of America As Represented By The Department Of Health And Human Services | Synthesis and utilization of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy 6β-fluoromorphinans (foxy and cyclofoxy) as (18F)-labeled opioid ligands for position emission transaxial tomography (PETT) |
US4673679A (en) | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
US5668285A (en) | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
US4912114A (en) | 1988-03-18 | 1990-03-27 | Sandoz Ltd. | Morphinan derivatives |
US4991391A (en) | 1989-01-27 | 1991-02-12 | Westinghouse Electric Corp. | System for cooling in a gas turbine |
PT95069B (pt) | 1989-08-24 | 1997-10-31 | Searle & Co | Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos |
US5208338A (en) | 1991-06-14 | 1993-05-04 | The United States Of America As Represented By The Department Of Health & Human Services. | Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans |
DE4132159A1 (de) | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
CH683005A5 (it) | 1991-10-30 | 1993-12-31 | Aldo Massarotti | Procedimento per la preparazione, mediante ossidazione di N-ossidi per le terapie dei tossicomani da oppiati. |
NZ246687A (en) | 1992-01-23 | 1996-12-20 | Toray Industries | Morphinan derivative and pharmaceutical compositions thereof |
CN1111900A (zh) | 1993-06-30 | 1995-11-15 | 东丽株式会社 | 止咳药 |
WO1995032973A1 (en) | 1994-05-31 | 1995-12-07 | Mallinckrodt Chemical, Inc. | The preparation of nalbuphine having low levels of beta-epimer |
CN1045442C (zh) | 1994-07-20 | 1999-10-06 | 中国科学院上海药物研究所 | 左、右旋氯斯库利啉及它的制备方法和用途 |
EP1300381B1 (en) | 1995-12-06 | 2006-03-08 | Japan Science and Technology Agency | Process for preparing optically active alcohols |
DE19548399A1 (de) | 1995-12-22 | 1997-06-26 | Basf Ag | Rutheniumkomplexe mit einem chiralen, zweizähnigen Phosphinoxazolin-Liganden zur enantioselektiven Transferhydrierung von prochiralen Ketonen |
GB9616253D0 (en) | 1996-08-01 | 1996-09-11 | Johnson Matthey Plc | Preparation of narcotic analgesics |
ATE263563T1 (de) | 1996-11-25 | 2004-04-15 | Toray Industries | Mittel gegen juckreiz |
PT102006B (pt) | 1997-05-19 | 2000-06-30 | Hovione Sociedade Quimica S A | Novo processo de preparacao de azitromicina |
JP2002503693A (ja) | 1998-02-20 | 2002-02-05 | アブマックス,インコーポレイティド | エピモルフィン型化合物及びその使用 |
GB9821067D0 (en) | 1998-09-29 | 1998-11-18 | Zeneca Ltd | Transfer hydrogenation process |
WO2001014382A1 (fr) | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif |
WO2001074819A1 (fr) | 2000-04-03 | 2001-10-11 | Toray Industries, Inc. | Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif |
JP4024992B2 (ja) | 2000-04-27 | 2007-12-19 | オリバー ヤオ−プ フ | ポリナルブフィン誘導体及びそれを製造するための方法 |
AUPQ968300A0 (en) | 2000-08-25 | 2000-09-21 | Glaxo Wellcome Australia Ltd | Chemical methods |
IL160193A0 (en) | 2001-08-23 | 2004-07-25 | Akzo Nobel Nv | Process for the preparation of a 14-hydroxynormorphinone derivative |
DE10229842A1 (de) | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
EP1562953B1 (en) | 2002-11-08 | 2009-09-30 | Mallinckrodt Inc. | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
MXPA05009757A (es) | 2003-03-13 | 2005-12-05 | Controlled Chemicals Inc | Conjugados de oxicodona con menor potencial de abuso y duracion de accion extendida. |
CA2520030A1 (en) | 2003-03-26 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Process to produce enantiomerically enriched alcohols and amines |
CA2539659C (en) | 2003-09-22 | 2013-03-26 | Johnson Matthey Public Limited Company | Process for the synthesis of morphinane compounds and intermediates thereof |
US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
SK286047B6 (sk) | 2004-04-13 | 2008-01-07 | Zentiva, A. S. | Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu |
US6887999B1 (en) | 2004-05-21 | 2005-05-03 | Acura Pharmaceuticals, Inc. | Preparation of dihydrocodeine from codeine |
CA2574362A1 (en) | 2004-07-23 | 2006-01-26 | Pliva-Istrazivanje I Razvoj D.O.O. | Process |
GB0421687D0 (en) | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
MX2007005389A (es) | 2004-11-05 | 2007-12-07 | Rensselaer Polytech Inst | 4-hidroxibenzomorfanos. |
US9662390B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
KR101333620B1 (ko) | 2005-04-06 | 2013-11-27 | 도레이 카부시키가이샤 | 모르피난 유도체의 결정 및 그 제조법 |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
JP2009519960A (ja) | 2005-12-15 | 2009-05-21 | ナチュアメッド グループ コーポレーション | シノメニン派生物の調合と使用 |
WO2007137785A2 (en) | 2006-05-25 | 2007-12-06 | Alpharma (Bermuda) Investments Ltd | Process useful in the preparation of morphinan antagonists |
RU2009112685A (ru) | 2006-09-20 | 2010-10-27 | Маллинкродт Инк. (Us) | Получение замещенных морфинан-6-онов и их солей и промежуточных соединений |
FR2906252B1 (fr) | 2006-09-21 | 2008-11-28 | Sanofi Aventis Sa | Procede de preparation d'halogenures de n-aklyl naltrexone |
WO2008064353A2 (en) | 2006-11-22 | 2008-05-29 | Progenics Pharmaceuticals, Inc. | 7,8-saturated-4,5-epoxy-morphinanium analogs |
BRPI0719587A2 (pt) | 2006-11-22 | 2013-12-17 | Progenics Pharm Inc | (s)-n-estereoisômeros de análogos de 7,8-saturados-4,5-epóxi-morfinano |
BRPI0719593A2 (pt) | 2006-11-22 | 2013-12-17 | Progenics Pharm Inc | Processos para sintetizar os análogos de 4,5-epóxi-morfinano quaternário e isolar seus n-estereoisômeros |
MX2009005461A (es) | 2006-11-22 | 2009-08-28 | Progenics Pharm Inc | N-oxidos de analogos de 4,5-epoxi-morfinano. |
EP2222642B1 (en) | 2007-12-17 | 2014-02-12 | Mallinckrodt LLC | Process and compounds for the production of (+) opiates |
NZ591756A (en) * | 2008-09-16 | 2013-04-26 | Mallinckrodt Llc | Processes for the synthesis of five and six membered heterocyclic rings |
ES2439015T3 (es) | 2008-09-30 | 2014-01-21 | Mallinckrodt Llc | Procedimientos de aminación selectiva de cetomorfinanos |
WO2010096788A1 (en) | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-morphinanium quaternary salts and processes for their production |
-
2012
- 2012-09-07 EP EP12769528.6A patent/EP2753622B1/en active Active
- 2012-09-07 WO PCT/US2012/054099 patent/WO2013036729A1/en active Application Filing
- 2012-09-07 RU RU2014112493/04A patent/RU2014112493A/ru not_active Application Discontinuation
- 2012-09-07 KR KR1020147008968A patent/KR20140063763A/ko not_active Application Discontinuation
- 2012-09-07 JP JP2014529883A patent/JP2014526467A/ja not_active Withdrawn
- 2012-09-07 PL PL12769528T patent/PL2753622T3/pl unknown
- 2012-09-07 US US13/606,370 patent/US8624031B2/en active Active
- 2012-09-07 ES ES12769528.6T patent/ES2566620T3/es active Active
- 2012-09-07 AU AU2012304484A patent/AU2012304484B2/en active Active
- 2012-09-07 MX MX2014002630A patent/MX2014002630A/es not_active Application Discontinuation
- 2012-09-07 CA CA2845187A patent/CA2845187A1/en not_active Abandoned
- 2012-09-07 CN CN201280054880.XA patent/CN103917543A/zh active Pending
- 2012-09-07 BR BR112014005421A patent/BR112014005421A2/pt not_active IP Right Cessation
-
2014
- 2014-03-04 IL IL231292A patent/IL231292A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL2753622T3 (pl) | 2016-07-29 |
WO2013036729A1 (en) | 2013-03-14 |
JP2014526467A (ja) | 2014-10-06 |
CN103917543A (zh) | 2014-07-09 |
KR20140063763A (ko) | 2014-05-27 |
IL231292A0 (en) | 2014-04-30 |
CA2845187A1 (en) | 2013-03-14 |
ES2566620T3 (es) | 2016-04-14 |
EP2753622B1 (en) | 2016-01-20 |
AU2012304484A1 (en) | 2014-02-27 |
RU2014112493A (ru) | 2015-10-20 |
US20130066080A1 (en) | 2013-03-14 |
US8624031B2 (en) | 2014-01-07 |
AU2012304484B2 (en) | 2016-07-28 |
BR112014005421A2 (pt) | 2017-04-04 |
EP2753622A1 (en) | 2014-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL2744768T3 (pl) | Sposób wytwarzania klinkieru zawierającego ternezyt | |
HRP20160692T1 (hr) | Postupak za proizvodnju intermedijera estetrola | |
IN2014CN04160A (es) | ||
MX2013015147A (es) | Procesos y compuestos intermediarios para producir azaindoles. | |
GB201103836D0 (en) | Conjugation process | |
MX370649B (es) | Proceso para la preparacion de teneligliptina. | |
IN2012MU03723A (es) | ||
ZA201308445B (en) | Process for the production of estetrol intermediates | |
MX2013007567A (es) | Procedimiento para preparar poliestereteroles. | |
IN2014DN09450A (es) | ||
ZA201205844B (en) | Process for the production of anhydrides | |
MX2015013589A (es) | Proceso e intermediario para la preparacion de pregabalina. | |
MX2012010443A (es) | Proceso para la preparacion de 1-alquiltetrazoles 5-sustituidos. | |
IN2013MU01113A (es) | ||
IN2014DN09451A (es) | ||
WO2014118606A3 (en) | A novel process for the preparation of silodosin | |
IN2014DN10209A (es) | ||
MX337610B (es) | Proceso para la preparacion de (r)-2-acetamido-n-bencil-3-metoxipr opionamida e intermediarios de la misma. | |
MX2014003936A (es) | Procedimiento para preparar ditiina-tetracarboximidas. | |
MX2014002630A (es) | Produccion de alcaloides sin el aislamiento de compuestos intermediarios. | |
WO2014170909A3 (en) | Process for pomalidomide | |
IN2014DN07498A (es) | ||
IN2014CN02645A (es) | ||
IN2013MU01305A (es) | ||
IN2014MU00069A (es) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |