FR2787789B1 - Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations - Google Patents

Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations

Info

Publication number
FR2787789B1
FR2787789B1 FR9816574A FR9816574A FR2787789B1 FR 2787789 B1 FR2787789 B1 FR 2787789B1 FR 9816574 A FR9816574 A FR 9816574A FR 9816574 A FR9816574 A FR 9816574A FR 2787789 B1 FR2787789 B1 FR 2787789B1
Authority
FR
France
Prior art keywords
benzoxepins
benzopyranes
dyslipidemia
atherosclerosis
diabetes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9816574A
Other languages
English (en)
Other versions
FR2787789A1 (fr
Inventor
Jean Jacques Berthelon
Daniel Guerrier
Michel Brunet
Jean Jacques Zeiller
Francis Contard
Guy Augert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9816574A priority Critical patent/FR2787789B1/fr
Application filed by LIPHA SAS filed Critical LIPHA SAS
Priority to KR1020017008402A priority patent/KR100684088B1/ko
Priority to CA2356680A priority patent/CA2356680C/fr
Priority to AU24329/00A priority patent/AU759892B2/en
Priority to PCT/EP1999/010114 priority patent/WO2000039113A1/fr
Priority to IDW00200101656A priority patent/ID29236A/id
Priority to BR9916633-0A priority patent/BR9916633A/pt
Priority to SK902-2001A priority patent/SK9022001A3/sk
Priority to CNB998151149A priority patent/CN1173967C/zh
Priority to CNB2004100476457A priority patent/CN1307171C/zh
Priority to RU2001120380/04A priority patent/RU2228333C2/ru
Priority to HU0104839A priority patent/HUP0104839A3/hu
Priority to CZ20012387A priority patent/CZ300086B6/cs
Priority to JP2000591024A priority patent/JP4607331B2/ja
Priority to US09/869,518 priority patent/US6596758B1/en
Priority to EP99967960A priority patent/EP1140893B1/fr
Priority to PL349448A priority patent/PL196524B1/pl
Publication of FR2787789A1 publication Critical patent/FR2787789A1/fr
Priority to NO20013242A priority patent/NO20013242D0/no
Priority to ZA200106177A priority patent/ZA200106177B/en
Publication of FR2787789B1 publication Critical patent/FR2787789B1/fr
Application granted granted Critical
Priority to HK02108653.9A priority patent/HK1047584B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
FR9816574A 1998-12-29 1998-12-29 Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations Expired - Lifetime FR2787789B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR9816574A FR2787789B1 (fr) 1998-12-29 1998-12-29 Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
CZ20012387A CZ300086B6 (cs) 1998-12-29 1999-12-20 Derivát benzopyranu a benzoxepinu, zpusob a meziprodukt pro jeho prípravu a farmaceutický prostredek s jeho obsahem
AU24329/00A AU759892B2 (en) 1998-12-29 1999-12-20 Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process
PCT/EP1999/010114 WO2000039113A1 (fr) 1998-12-29 1999-12-20 Benzopyranes et benzoxepines preparation pharmaceutiques les incluant et leur procede d'obtention
IDW00200101656A ID29236A (id) 1998-12-29 1999-12-20 Benzopiran-benzopiran dan benzoksepin-benzoksepin, komposisi-komposisi famaseutikal yang mengandungnya, dan proses penyiapannya
BR9916633-0A BR9916633A (pt) 1998-12-29 1999-12-20 Benzopiranos e benzoxepinas, composições farmacêuticas compreendendo-as e processo de preparação
SK902-2001A SK9022001A3 (en) 1998-12-29 1999-12-20 Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process
CNB998151149A CN1173967C (zh) 1998-12-29 1999-12-20 苯并吡喃和苯并氧杂�、含有它们的药物组合物及制备方法
CNB2004100476457A CN1307171C (zh) 1998-12-29 1999-12-20 苯并吡喃和苯并硫吡喃、含有它们的药物组合物及制备方法
RU2001120380/04A RU2228333C2 (ru) 1998-12-29 1999-12-20 Бензопираны и бензоксепины, содержащие их фармацевтические композиции, способ их получения
KR1020017008402A KR100684088B1 (ko) 1998-12-29 1999-12-20 벤조피란 및 벤즈옥세핀, 이들을 함유하는 제약학적조성물 및 제조 방법
HU0104839A HUP0104839A3 (en) 1998-12-29 1999-12-20 Benzopyrans and benzoxepines, pharamceutical compositions comprising them and preparation process
EP99967960A EP1140893B1 (fr) 1998-12-29 1999-12-20 Benzopyranes et benzoxepines, preparations pharmaceutiques les renfermant et procede de preparation
US09/869,518 US6596758B1 (en) 1998-12-29 1999-12-20 Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process
JP2000591024A JP4607331B2 (ja) 1998-12-29 1999-12-20 ベンゾピランおよびベンツオキセピン、それらを含む医薬組成物および製造方法
PL349448A PL196524B1 (pl) 1998-12-29 1999-12-20 Benzopirany i benzoksepiny oraz tiochromany i benzotiepiny, sposób ich otrzymywania, preparaty farmaceutyczne zawierające te związki oraz ich zastosowanie
CA2356680A CA2356680C (fr) 1998-12-29 1999-12-20 Benzopyranes et benzoxepines preparation pharmaceutiques les incluant et leur procede d'obtention
NO20013242A NO20013242D0 (no) 1998-12-29 2001-06-28 Benzopyraner og benzoksepiner, farmasöytiske preparater som omfatter dem, og fremgangsmåte for fremstilling av dem
ZA200106177A ZA200106177B (en) 1998-12-29 2001-07-26 Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process.
HK02108653.9A HK1047584B (zh) 1998-12-29 2002-11-29 苯並吡喃和苯並氧雜䓬、含有它們的藥物組合物及製備方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9816574A FR2787789B1 (fr) 1998-12-29 1998-12-29 Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations

Publications (2)

Publication Number Publication Date
FR2787789A1 FR2787789A1 (fr) 2000-06-30
FR2787789B1 true FR2787789B1 (fr) 2002-06-14

Family

ID=9534619

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9816574A Expired - Lifetime FR2787789B1 (fr) 1998-12-29 1998-12-29 Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations

Country Status (19)

Country Link
US (1) US6596758B1 (fr)
EP (1) EP1140893B1 (fr)
JP (1) JP4607331B2 (fr)
KR (1) KR100684088B1 (fr)
CN (2) CN1307171C (fr)
AU (1) AU759892B2 (fr)
BR (1) BR9916633A (fr)
CA (1) CA2356680C (fr)
CZ (1) CZ300086B6 (fr)
FR (1) FR2787789B1 (fr)
HK (1) HK1047584B (fr)
HU (1) HUP0104839A3 (fr)
ID (1) ID29236A (fr)
NO (1) NO20013242D0 (fr)
PL (1) PL196524B1 (fr)
RU (1) RU2228333C2 (fr)
SK (1) SK9022001A3 (fr)
WO (1) WO2000039113A1 (fr)
ZA (1) ZA200106177B (fr)

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BR0213094A (pt) * 2001-10-04 2004-10-13 Wyeth Corp Derivados de cromano como ligandos de 5-hidroxi-triptamina-6
FR2845386B1 (fr) * 2002-10-07 2006-06-30 Merck Sante Sas Nouveaux derives metastables de benzoxepines utilisables dans le traitement des dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparation
JP2006514666A (ja) * 2003-02-26 2006-05-11 中国科学院上海薬物研究所 ベンゾピラン系化合物、その製造方法及び用途
AU2004278414B2 (en) 2003-10-01 2012-05-24 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US6887896B1 (en) * 2003-10-29 2005-05-03 Allergan, Inc. 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
PT1535612E (pt) * 2003-11-28 2006-12-29 Merck Sante Sas Tratamento da hiperuricemia
DK1591434T3 (da) 2004-04-27 2007-09-17 Merck Sante Sas Nye 1-methoxy-2-phenyl-ethener anvendelig til fremstiling af 5-carboxaldehyd-2-3-dihydrobenzoxepiner
PL1600446T3 (pl) * 2004-05-18 2008-03-31 Merck Sante Sas Nowe pochodne 3,3-dimetylo-5-cyjano-benzoksepin użyteczne do otrzymywania pochodnych 5-formylo-benzoksepin
ATE518850T1 (de) * 2004-06-25 2011-08-15 Merck Sante Sas 5-alkenon-3,3-dimethyl-benzoxepinderivate und ihre verwendung in der herstellung von antidiabetischen pentadiensäuren
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
US20070021612A1 (en) * 2004-11-04 2007-01-25 University Of Notre Dame Du Lac Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
BRPI0519013A2 (pt) * 2004-12-13 2009-11-03 Lilly Co Eli composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto
AU2006214892B2 (en) * 2005-02-16 2013-06-27 Kt & G Co., Ltd Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2063886A2 (fr) * 2006-09-12 2009-06-03 Adolor Corporation Utilisation de composés spiro contenant une function amine pour l'amélioration de la fonction cognitive
CN101172978A (zh) * 2006-11-02 2008-05-07 中国人民解放军军事医学科学院毒物药物研究所 六元杂环化合物,其制备方法及其医药用途
EP2120925A4 (fr) * 2007-03-16 2010-04-07 Novogen Res Pty Ltd Procédé d'induction d'autophagie
EP2306965B1 (fr) * 2008-08-09 2015-12-02 Merck Patent GmbH Utilisation de composés d'indole comme produit cosmétique
US20110144130A1 (en) * 2008-08-12 2011-06-16 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of 5-(7-methoxy-3,3-dimethyl-2,3-dihydro-1-benzoxepin-5-yl)-3-methyl-penta-2,4-dienoic acid as a cosmetic
WO2016140979A1 (fr) * 2015-03-03 2016-09-09 Arizona Board Of Regents On Behalf Of Arizona State University Composés thérapeutiques
US10221143B2 (en) 2015-03-03 2019-03-05 Arizona Board Of Regents On Behalf Of Arizona State University Substituted anilines for treatment of animal diseases
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
CN108371712B (zh) * 2018-01-18 2020-12-25 华北理工大学 咖啡因与PPARγ激动剂联合制备AD药物中的用途
WO2022053416A1 (fr) 2020-09-08 2022-03-17 Merck Patent Gmbh Amélioration de la capacité de rétention d'eau de la peau par oxeglitazar

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EP0412939A3 (en) * 1989-08-11 1991-09-04 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
US4946860A (en) * 1989-11-03 1990-08-07 Rorer Pharmaceutical Corporation Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors
WO1993011755A1 (fr) * 1991-12-18 1993-06-24 The Salk Institute For Biological Studies Procedes permettant la modulation de processus utilisant des recepteurs de retinoides comme mediateurs et composes utiles dans ce contexte
JP2594409B2 (ja) * 1992-09-29 1997-03-26 アディール エ コンパニー トリエン側鎖を有する新規クロメン化合物
MX9704878A (es) * 1994-12-30 1997-11-29 Ligand Pharm Inc Nuevos compuestos retinoides trienoicos y metodos de uso.
US5675033A (en) * 1995-06-06 1997-10-07 Allergan 2,4-pentadienoic acid derivatives having retinoid-like biological activity

Also Published As

Publication number Publication date
CN1173967C (zh) 2004-11-03
KR20010101339A (ko) 2001-11-14
AU2432900A (en) 2000-07-31
PL196524B1 (pl) 2008-01-31
HK1047584B (zh) 2005-05-27
AU759892B2 (en) 2003-05-01
EP1140893B1 (fr) 2003-03-05
CN1554651A (zh) 2004-12-15
NO20013242L (no) 2001-06-28
PL349448A1 (en) 2002-07-29
HK1047584A1 (en) 2003-02-28
WO2000039113A1 (fr) 2000-07-06
CA2356680A1 (fr) 2000-07-06
FR2787789A1 (fr) 2000-06-30
CZ20012387A3 (cs) 2001-11-14
ZA200106177B (en) 2002-12-24
US6596758B1 (en) 2003-07-22
BR9916633A (pt) 2001-09-25
JP4607331B2 (ja) 2011-01-05
JP2003517449A (ja) 2003-05-27
ID29236A (id) 2001-08-16
RU2228333C2 (ru) 2004-05-10
CZ300086B6 (cs) 2009-01-28
NO20013242D0 (no) 2001-06-28
CN1307171C (zh) 2007-03-28
HUP0104839A2 (hu) 2002-04-29
KR100684088B1 (ko) 2007-02-16
SK9022001A3 (en) 2002-04-04
HUP0104839A3 (en) 2003-01-28
CN1359383A (zh) 2002-07-17
CA2356680C (fr) 2010-03-23
EP1140893A1 (fr) 2001-10-10

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