FR2401916A1 - Nouveaux derives de 5-hydroxy-1h-imidazole-4-carboxamide substitues en position 2, leur procede de production et composition pharmaceutique les contenant - Google Patents

Nouveaux derives de 5-hydroxy-1h-imidazole-4-carboxamide substitues en position 2, leur procede de production et composition pharmaceutique les contenant

Info

Publication number
FR2401916A1
FR2401916A1 FR7825487A FR7825487A FR2401916A1 FR 2401916 A1 FR2401916 A1 FR 2401916A1 FR 7825487 A FR7825487 A FR 7825487A FR 7825487 A FR7825487 A FR 7825487A FR 2401916 A1 FR2401916 A1 FR 2401916A1
Authority
FR
France
Prior art keywords
imidazole
hydroxy
pharmaceutical composition
composition containing
production process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7825487A
Other languages
English (en)
Other versions
FR2401916B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10764177A external-priority patent/JPS5441874A/ja
Priority claimed from JP12499277A external-priority patent/JPS5459273A/ja
Priority claimed from JP12499577A external-priority patent/JPS5459284A/ja
Priority claimed from JP2890078A external-priority patent/JPS54122272A/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of FR2401916A1 publication Critical patent/FR2401916A1/fr
Application granted granted Critical
Publication of FR2401916B1 publication Critical patent/FR2401916B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention a trait au domaine de la chimie pharmaceutique. Elle concerne, à titre de composés nouveaux, des dérivés de 5-hydroxy- 1H-imidazole-4-carboxamide portant un substituant en position 2. On obtient ces composés par un procédé dont l'une des variantes consiste à faire réagir l' alpha -aminomalonamide avec un imidoester. Les nouveaux composés de l'invention sont doués d'activité anticancéreuse et d'activité immonostimulante.
FR7825487A 1977-09-06 1978-09-05 Nouveaux derives de 5-hydroxy-1h-imidazole-4-carboxamide substitues en position 2, leur procede de production et composition pharmaceutique les contenant Granted FR2401916A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP10764177A JPS5441874A (en) 1977-09-06 1977-09-06 Novel 2-substituted imidazole derivative
JP12499277A JPS5459273A (en) 1977-10-17 1977-10-17 Novel 2-arylimidazole derivative
JP12499577A JPS5459284A (en) 1977-10-17 1977-10-17 Novel 2-pyridylimidazole derivative
JP2890078A JPS54122272A (en) 1978-03-13 1978-03-13 Novel 2-substituted phenylimidazole derivative

Publications (2)

Publication Number Publication Date
FR2401916A1 true FR2401916A1 (fr) 1979-03-30
FR2401916B1 FR2401916B1 (fr) 1982-07-02

Family

ID=27458967

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7825487A Granted FR2401916A1 (fr) 1977-09-06 1978-09-05 Nouveaux derives de 5-hydroxy-1h-imidazole-4-carboxamide substitues en position 2, leur procede de production et composition pharmaceutique les contenant

Country Status (14)

Country Link
US (1) US4218457A (fr)
AT (1) AT367412B (fr)
AU (1) AU507066B1 (fr)
BE (1) BE870236A (fr)
CA (1) CA1110623A (fr)
CH (1) CH636862A5 (fr)
DE (1) DE2838892A1 (fr)
DK (1) DK392578A (fr)
FR (1) FR2401916A1 (fr)
GB (1) GB2004544B (fr)
HU (1) HU184188B (fr)
IT (1) IT1160633B (fr)
NL (1) NL7809075A (fr)
SE (1) SE442865B (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003998A2 (fr) * 2007-07-02 2009-01-08 Boehringer Ingelheim International Gmbh Nouveaux composés chimiques
US8198308B2 (en) 2006-07-07 2012-06-12 Boehringer Ingelheim International Gmbh Chemical compounds
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
US8778929B2 (en) 2008-09-29 2014-07-15 Boehringer Ingelheim International Gmbh Substituted heteroaryl inhibitors of B-RAF
US8865703B2 (en) 2010-03-26 2014-10-21 Boehringer Ingelheim International Gmbh Pyridyltriazoles
US8889665B2 (en) 2007-07-02 2014-11-18 Boehringer Ingelheim International Gmbh Chemical compounds
US9290507B2 (en) 2010-03-26 2016-03-22 Boehringer Ingelheim International Gmbh B-RAF kinase inhibitors

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1151651A (fr) * 1979-08-08 1983-08-09 Takao Kiyohara Derives de 4-carbamoyl imidazolium-5-oleate, agents anti-tumeurs et immunosuppresseurs; compositions pharmaceutiques qui en renferment et preparation
AU530916B2 (en) * 1979-08-08 1983-08-04 Sumitomo Chemical Company, Limited 4-carbamoyl imidazolium-5-olate derivatives
US4464531A (en) * 1981-04-20 1984-08-07 Sumitomo Chemical Company, Limited 4-Carbamoylimidazolium-5-olate derivatives
US4503235A (en) * 1983-03-11 1985-03-05 Warner-Lambert Company Process for producing 4-carbamoyl-1H-imidazolium-5-olate
JPS60193997A (ja) * 1984-03-14 1985-10-02 Sumitomo Chem Co Ltd 新規シアノイミダゾ−ルリボヌクレオシド誘導体およびその製造法
US20090176837A1 (en) * 2005-07-12 2009-07-09 Sony Corporation Compounds with activity at retinoic acid receptors
JPWO2008136428A1 (ja) * 2007-04-27 2010-07-29 武田薬品工業株式会社 含窒素５員複素環化合物
JP5996532B2 (ja) 2010-07-15 2016-09-21 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 有害生物防除剤としての新規複素環式化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183754A1 (fr) * 1972-05-05 1973-12-21 Merck & Co Inc
FR2356643A1 (fr) * 1976-07-02 1978-01-27 Sumitomo Chemical Co 5-0-acyl-imidazole-4-carboxamides, leur obtention et composition pharmaceutique en contenant
FR2363329A1 (fr) * 1976-09-07 1978-03-31 Sumitomo Chemical Co Compositions renfermant du 4-carbamoyl-5-hydroxyimidazole, utiles comme agent pour le traitement de cancers, de rhumatismes et de nephrites

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1360982A (en) * 1970-08-27 1974-07-24 Beecham Group Ltd Derivatives of 1-phenyl-5-aminoimidazole and compositions thereof
US4140788A (en) * 1976-11-10 1979-02-20 Sumitomo Chemical Company, Limited N-Substituted imidazolecarboxamide derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183754A1 (fr) * 1972-05-05 1973-12-21 Merck & Co Inc
FR2356643A1 (fr) * 1976-07-02 1978-01-27 Sumitomo Chemical Co 5-0-acyl-imidazole-4-carboxamides, leur obtention et composition pharmaceutique en contenant
FR2363329A1 (fr) * 1976-09-07 1978-03-31 Sumitomo Chemical Co Compositions renfermant du 4-carbamoyl-5-hydroxyimidazole, utiles comme agent pour le traitement de cancers, de rhumatismes et de nephrites

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198308B2 (en) 2006-07-07 2012-06-12 Boehringer Ingelheim International Gmbh Chemical compounds
WO2009003998A2 (fr) * 2007-07-02 2009-01-08 Boehringer Ingelheim International Gmbh Nouveaux composés chimiques
WO2009003998A3 (fr) * 2007-07-02 2009-02-26 Boehringer Ingelheim Int Nouveaux composés chimiques
US8889665B2 (en) 2007-07-02 2014-11-18 Boehringer Ingelheim International Gmbh Chemical compounds
US8778929B2 (en) 2008-09-29 2014-07-15 Boehringer Ingelheim International Gmbh Substituted heteroaryl inhibitors of B-RAF
US8865703B2 (en) 2010-03-26 2014-10-21 Boehringer Ingelheim International Gmbh Pyridyltriazoles
US9290507B2 (en) 2010-03-26 2016-03-22 Boehringer Ingelheim International Gmbh B-RAF kinase inhibitors
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors

Also Published As

Publication number Publication date
GB2004544B (en) 1982-09-15
IT7869049A0 (it) 1978-09-05
DK392578A (da) 1979-03-07
AU507066B1 (en) 1980-01-31
GB2004544A (en) 1979-04-04
AT367412B (de) 1982-07-12
BE870236A (fr) 1979-03-05
CH636862A5 (de) 1983-06-30
SE7809373L (sv) 1979-03-07
ATA640778A (de) 1981-11-15
SE442865B (sv) 1986-02-03
DE2838892A1 (de) 1979-03-15
HU184188B (en) 1984-07-30
CA1110623A (fr) 1981-10-13
NL7809075A (nl) 1979-03-08
FR2401916B1 (fr) 1982-07-02
IT1160633B (it) 1987-03-11
US4218457A (en) 1980-08-19

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