PT649846E - Derivados da galantamina processo para a sua preparacao e sua utilizacao como medicamentos - Google Patents

Derivados da galantamina processo para a sua preparacao e sua utilizacao como medicamentos

Info

Publication number
PT649846E
PT649846E PT94115961T PT94115961T PT649846E PT 649846 E PT649846 E PT 649846E PT 94115961 T PT94115961 T PT 94115961T PT 94115961 T PT94115961 T PT 94115961T PT 649846 E PT649846 E PT 649846E
Authority
PT
Portugal
Prior art keywords
medicines
preparation
compounds
derivatives process
galantamine derivatives
Prior art date
Application number
PT94115961T
Other languages
English (en)
Inventor
Larry Davis
Raymond W Kosley Jr
Veronica Taberna
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of PT649846E publication Critical patent/PT649846E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
PT94115961T 1993-10-15 1994-10-10 Derivados da galantamina processo para a sua preparacao e sua utilizacao como medicamentos PT649846E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/137,444 US6316439B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (1)

Publication Number Publication Date
PT649846E true PT649846E (pt) 2002-06-28

Family

ID=22477461

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94115961T PT649846E (pt) 1993-10-15 1994-10-10 Derivados da galantamina processo para a sua preparacao e sua utilizacao como medicamentos

Country Status (23)

Country Link
US (1) US6316439B1 (pt)
EP (1) EP0649846B1 (pt)
JP (1) JP2664343B2 (pt)
KR (1) KR100227957B1 (pt)
CN (1) CN1039910C (pt)
AT (1) ATE211474T1 (pt)
AU (1) AU696170B2 (pt)
CA (1) CA2118172C (pt)
CZ (1) CZ283731B6 (pt)
DE (1) DE69429570T2 (pt)
DK (1) DK0649846T3 (pt)
EG (1) EG20726A (pt)
ES (1) ES2170759T3 (pt)
FI (1) FI108722B (pt)
IL (1) IL111275A (pt)
NO (1) NO307464B1 (pt)
NZ (1) NZ264682A (pt)
PL (1) PL177549B1 (pt)
PT (1) PT649846E (pt)
RO (1) RO114134B1 (pt)
RU (1) RU2109743C1 (pt)
TW (1) TW289754B (pt)
ZA (1) ZA948061B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
MXPA02005667A (es) * 1999-12-10 2004-09-10 Bonnie Davis Analogos de galantamina y licoramina como moduladores de los receptores nicotinicos.
EP1401840A4 (en) * 2001-04-30 2007-05-16 Bayer Corp NEW 4-AMINO-5,6-SUBSTITUTED THIOPHENO 2,3 D | PYRIMIDINE
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040254146A1 (en) * 2002-05-21 2004-12-16 Nastech Pharmaceutical Company Inc. Carboxylate salts of galantamine and their pharmaceutical use
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CA2552114A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
US20050191349A1 (en) * 2003-12-31 2005-09-01 Garth Boehm Galantamine formulations
US20080045500A1 (en) * 2004-07-01 2008-02-21 Eisai R&D Management Co., Ltd. Nerve Regeneration Stimulator
JP2008525439A (ja) * 2004-12-23 2008-07-17 ボイジャー・ファーマシューティカル・コーポレーション アルツハイマー病の治療のための酢酸ロイプロリド及びアセチルコリンエステラーゼインヒビターまたはｎｍｄａレセプターアゴニスト
WO2006124584A2 (en) * 2005-05-13 2006-11-23 Alza Corporation Multilayer drug delivery system with barrier against reservoir material flow
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1937226A2 (en) * 2005-09-23 2008-07-02 Alza Corporation Transdermal galantamine delivery system
EP2137192B8 (en) 2008-04-14 2014-06-11 Neurodyn Life Sciences Inc. Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
RU2012106605A (ru) * 2009-07-23 2013-08-27 ШАЙЕ ЭлЭлСи Аминокислотные и пептидные пролекарства галантамина и их применение
AU2015258814B2 (en) * 2014-05-16 2018-04-05 Synaptec Development Llc Clearance of amyloid ss
EP4029867A1 (en) 2021-01-13 2022-07-20 Alpha Cognition Inc. Solid forms of galantamine benzoate gluconate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
AU632458B2 (en) * 1987-05-04 1993-01-07 Bonnie Davis Compounds for the treatment of alzheimer's disease
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
EP0515301A3 (en) 1991-05-14 1993-06-16 Ernir Snorrason Improvements in benzodiazepine treatment by cholinesterterase inhibitors
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
ES2170759T3 (es) 2002-08-16
PL177549B1 (pl) 1999-12-31
EP0649846A1 (en) 1995-04-26
IL111275A0 (en) 1994-12-29
KR950011445A (ko) 1995-05-15
JPH07188239A (ja) 1995-07-25
KR100227957B1 (ko) 1999-11-01
IL111275A (en) 2003-01-12
NO943895D0 (no) 1994-10-14
DK0649846T3 (da) 2002-04-15
NZ264682A (en) 1995-07-26
FI108722B (fi) 2002-03-15
CZ283731B6 (cs) 1998-06-17
EP0649846B1 (en) 2002-01-02
RU2109743C1 (ru) 1998-04-27
ZA948061B (en) 1995-06-06
RU94036745A (ru) 1996-12-10
CA2118172A1 (en) 1995-04-16
US6316439B1 (en) 2001-11-13
FI944823A0 (fi) 1994-10-13
FI944823A (fi) 1995-04-16
AU696170B2 (en) 1998-09-03
DE69429570T2 (de) 2002-08-29
RO114134B1 (ro) 1999-01-29
JP2664343B2 (ja) 1997-10-15
AU7581394A (en) 1995-05-04
NO943895L (no) 1995-04-18
TW289754B (pt) 1996-11-01
NO307464B1 (no) 2000-04-10
ATE211474T1 (de) 2002-01-15
DE69429570D1 (de) 2002-02-07
CN1108657A (zh) 1995-09-20
PL305457A1 (en) 1995-04-18
CZ254594A3 (en) 1995-07-12
CN1039910C (zh) 1998-09-23
CA2118172C (en) 2000-01-04
EG20726A (en) 1999-12-29

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