FR2137712A1 - Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition - Google Patents

Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition

Info

Publication number: FR2137712A1
Authority: FR; France
Prior art keywords: radical; alkyl; prostanoic acid; salt; pharmaceutical
Prior art date: 1971-05-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

FR7216685A

Other languages

English (en)

French (fr)

Other versions

FR2137712B1 (ja

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Imperial Chemical Industries Ltd

Original Assignee

Imperial Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-05-11

Filing date

1972-05-10

Publication date

1972-12-29

1972-01-05 Priority claimed from GB3967272A external-priority patent/GB1348036A/en

1972-05-10 Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd

1972-12-29 Publication of FR2137712A1 publication Critical patent/FR2137712A1/fr

1976-04-16 Application granted granted Critical

1976-04-16 Publication of FR2137712B1 publication Critical patent/FR2137712B1/fr

Status Granted legal-status Critical Current

Links

WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical compound CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title abstract 4
150000003839 salts Chemical class 0.000 title abstract 3
-1 alkoxycarbonyl radical Chemical class 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 3
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
239000005977 Ethylene Substances 0.000 abstract 1
208000001953 Hypotension Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
IPEWNTLWCRYSRY-UHFFFAOYSA-N [CH2]C1=CC=CO1 Chemical compound [CH2]C1=CC=CO1 IPEWNTLWCRYSRY-UHFFFAOYSA-N 0.000 abstract 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005277 alkyl imino group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003433 contraceptive agent Substances 0.000 abstract 1
230000002254 contraceptive effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical compound O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
208000021822 hypotensive Diseases 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/535—Organo-phosphoranes
- C07F9/5352—Phosphoranes containing the structure P=C-

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)

FR7216685A 1971-05-11 1972-05-10 Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition Granted FR2137712A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB1413971		1971-05-11
GB3967272A GB1348036A (en)	1970-05-15	1972-01-05	Transistorized vertical deflection circuit

Publications (2)

Publication Number	Publication Date
FR2137712A1 true FR2137712A1 (en)	1972-12-29
FR2137712B1 FR2137712B1 (ja)	1976-04-16

Family

ID=26235892

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7216685A Granted FR2137712A1 (en)	1971-05-11	1972-05-10	Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition

Country Status (26)

Country	Link
JP (1)	JPS5611699B1 (ja)
AR (4)	AR194952A1 (ja)
AT (4)	AT328103B (ja)
AU (1)	AU462755B2 (ja)
BE (1)	BE783292A (ja)
CA (1)	CA1077033A (ja)
CH (3)	CH590223A5 (ja)
CS (1)	CS192456B2 (ja)
DD (1)	DD99155A5 (ja)
DE (1)	DE2223365C3 (ja)
DK (1)	DK134598B (ja)
EG (1)	EG10752A (ja)
ES (1)	ES402627A1 (ja)
FI (1)	FI63221C (ja)
FR (1)	FR2137712A1 (ja)
HK (1)	HK50176A (ja)
HU (1)	HU166717B (ja)
IE (1)	IE37602B1 (ja)
IL (1)	IL39376A (ja)
KE (1)	KE2634A (ja)
NL (1)	NL164272C (ja)
NO (1)	NO139521C (ja)
SE (4)	SE399705B (ja)
SU (1)	SU662007A3 (ja)
YU (1)	YU35876B (ja)
ZM (1)	ZM8172A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2184007A1 (ja) *	1972-05-10	1973-12-21	Upjohn Co
FR2205335A1 (ja) *	1972-11-08	1974-05-31	Pfizer
FR2378010A1 (fr) *	1977-01-24	1978-08-18	Searle & Co	Derives d'acide o-aryloxy prostyne-13 oique, leur procede de preparation et leur utilisation notamment comme contraceptifs
EP0349658A1 (en) *	1986-12-12	1990-01-10	SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu	New prostanoids and their use for increasing the birth rate in animal females
EP0362686A2 (en) *	1988-09-28	1990-04-11	SPOLANA a.s.	Method for preparing the (+)-isomer of cloprostenol
WO1997030710A1 (en) *	1996-02-22	1997-08-28	Vision Pharmaceuticals L.P.	Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3968144A (en) *	1973-05-21	1976-07-06	The Upjohn Company	5-Oxa-11-deoxy phenyl- and phenoxy-substituted prostalandin E1 analogs
US3966795A (en) *	1973-05-21	1976-06-29	The Upjohn Company	5-Oxa-11-deoxyphenyl- and phenoxy-substituted prostaglandin F1.sub.α analogs
US4387241A (en) *	1974-11-01	1983-06-07	American Cyanamid Company	Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
US4191774A (en) *	1978-01-18	1980-03-04	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T.	Novel 17-aza-PGF2α derivatives and pharmaceutical compositions containing the same
US4228296A (en) *	1979-01-24	1980-10-14	American Cyanamid Company	Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
US4929740A (en) *	1984-10-09	1990-05-29	Syntex (U.S.A.) Inc.	Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
CS265947B1 (en) *	1987-06-16	1989-11-14	Kral Josef	Means for farming animals' ovarian functions control
US5565492A (en) *	1988-07-18	1996-10-15	Alcon Laboratories, Inc.	Prostaglandin combinations in glaucoma therapy
US5352708A (en) *	1992-09-21	1994-10-04	Allergan, Inc.	Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5510383A (en) *	1993-08-03	1996-04-23	Alcon Laboratories, Inc.	Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6531504B2 (en) *	2001-05-17	2003-03-11	Allergan, Inc.	Prostanoic acid derivatives as agents for lowering intraocular pressure
CA2705150C (en) *	2007-11-09	2016-06-14	Allergan, Inc.	Substituted cyclopentanes having prostaglandin activity

1972
- 1972-04-27 IE IE557/72A patent/IE37602B1/xx unknown
- 1972-04-28 CA CA140,884A patent/CA1077033A/en not_active Expired
- 1972-05-04 HU HUIE502A patent/HU166717B/hu unknown
- 1972-05-08 ZM ZM81/72*UA patent/ZM8172A1/xx unknown
- 1972-05-08 AU AU42024/72A patent/AU462755B2/en not_active Expired
- 1972-05-08 IL IL39376A patent/IL39376A/xx unknown
- 1972-05-09 NO NO1648/72A patent/NO139521C/no unknown
- 1972-05-09 SE SE7206139A patent/SE399705B/xx unknown
- 1972-05-09 EG EG193/72A patent/EG10752A/xx active
- 1972-05-10 CH CH697472A patent/CH590223A5/xx not_active IP Right Cessation
- 1972-05-10 BE BE783292A patent/BE783292A/xx not_active IP Right Cessation
- 1972-05-10 FI FI1333/72A patent/FI63221C/fi active
- 1972-05-10 ES ES402627A patent/ES402627A1/es not_active Expired
- 1972-05-10 NL NL7206361.A patent/NL164272C/xx not_active IP Right Cessation
- 1972-05-10 CH CH1566776A patent/CH596166A5/xx not_active IP Right Cessation
- 1972-05-10 DK DK236272AA patent/DK134598B/da unknown
- 1972-05-10 CH CH1566676A patent/CH596165A5/xx not_active IP Right Cessation
- 1972-05-10 FR FR7216685A patent/FR2137712A1/fr active Granted
- 1972-05-10 SU SU721787999A patent/SU662007A3/ru active
- 1972-05-11 JP JP4684472A patent/JPS5611699B1/ja active Pending
- 1972-05-11 AR AR241955A patent/AR194952A1/es active
- 1972-05-11 CS CS723161A patent/CS192456B2/cs unknown
- 1972-05-11 DD DD162906A patent/DD99155A5/xx unknown
- 1972-05-11 YU YU1250/72A patent/YU35876B/xx unknown
- 1972-05-12 AT AT538973*7A patent/AT328103B/de not_active IP Right Cessation
- 1972-05-12 AT AT419172A patent/AT333447B/de not_active IP Right Cessation
- 1972-05-12 DE DE2223365A patent/DE2223365C3/de not_active Expired
- 1972-11-30 AR AR245419A patent/AR197101A1/es active
- 1972-11-30 AR AR245418A patent/AR197100A1/es active
- 1972-11-30 AR AR245420A patent/AR200484A1/es active
1973
- 1973-05-12 AT AT539073*7A patent/AT328104B/de not_active IP Right Cessation
- 1973-05-12 AT AT539173*7A patent/AT328105B/de not_active IP Right Cessation
1975
- 1975-04-15 SE SE7504335A patent/SE7504335L/xx unknown
- 1975-04-15 SE SE7504337A patent/SE7504337L/xx unknown
- 1975-04-15 SE SE7504336A patent/SE7504336L/xx unknown
1976
- 1976-05-31 KE KE2634*UA patent/KE2634A/xx unknown
- 1976-08-05 HK HK501/76*UA patent/HK50176A/xx unknown

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2184007A1 (ja) *	1972-05-10	1973-12-21	Upjohn Co
FR2205335A1 (ja) *	1972-11-08	1974-05-31	Pfizer
FR2378010A1 (fr) *	1977-01-24	1978-08-18	Searle & Co	Derives d'acide o-aryloxy prostyne-13 oique, leur procede de preparation et leur utilisation notamment comme contraceptifs
EP0349658A1 (en) *	1986-12-12	1990-01-10	SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu	New prostanoids and their use for increasing the birth rate in animal females
EP0362686A2 (en) *	1988-09-28	1990-04-11	SPOLANA a.s.	Method for preparing the (+)-isomer of cloprostenol
EP0362686A3 (en) *	1988-09-28	1990-08-29	Vysoka Skola Chemicko-Technologicka	Method for preparing the (+)-isomer of cloprostenol method for preparing the (+)-isomer of cloprostenol
WO1997030710A1 (en) *	1996-02-22	1997-08-28	Vision Pharmaceuticals L.P.	Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

Also Published As

Publication number	Publication date
AR197100A1 (es)	1974-03-15
DE2223365C3 (de)	1981-06-04
EG10752A (en)	1976-05-31
SE7504337L (sv)	1975-04-15
CH596165A5 (ja)	1978-02-28
NL164272B (nl)	1980-07-15
CH596166A5 (ja)	1978-02-28
AR200484A1 (es)	1974-11-15
AT328103B (de)	1976-03-10
SE7504336L (ja)	1975-04-15
DE2223365B2 (de)	1980-07-31
DD99155A5 (ja)	1973-07-20
ZM8172A1 (en)	1973-01-22
FI63221B (fi)	1983-01-31
AR194952A1 (es)	1973-08-30
CS192456B2 (en)	1979-08-31
ATA419172A (de)	1976-03-15
AT328105B (de)	1976-03-10
SE399705B (sv)	1978-02-27
NO139521B (no)	1978-12-18
AT333447B (de)	1976-11-25
IE37602B1 (en)	1977-08-31
HU166717B (ja)	1975-05-28
BE783292A (fr)	1972-11-10
YU35876B (en)	1981-08-31
IL39376A0 (en)	1972-07-26
ATA539173A (de)	1975-05-15
KE2634A (en)	1976-06-11
ES402627A1 (es)	1975-11-01
FR2137712B1 (ja)	1976-04-16
IL39376A (en)	1975-07-28
AT328104B (de)	1976-03-10
AU462755B2 (en)	1975-07-03
YU125072A (en)	1981-02-28
CH590223A5 (ja)	1977-07-29
FI63221C (fi)	1983-05-10
DE2223365A1 (de)	1972-12-07
DK134598B (da)	1976-12-06
NO139521C (no)	1979-03-28
DK134598C (ja)	1977-05-16
SE7504335L (ja)	1975-04-15
AU4202472A (en)	1973-11-15
ATA538973A (de)	1975-05-15
HK50176A (en)	1976-08-13
JPS5611699B1 (ja)	1981-03-16
NL7206361A (ja)	1972-11-14
IE37602L (en)	1972-11-11
AR197101A1 (es)	1974-03-15
CA1077033A (en)	1980-05-06
NL164272C (nl)	1980-12-15
SU662007A3 (ru)	1979-05-05
ATA539073A (de)	1975-05-15

Legal Events

Date	Code	Title	Description
1992-09-11	CC	Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)	Free format text: 92C0180, 920507
1993-02-19	CB	Supplementary protection certificate (spc) granted (law of 25 june 1990)	Free format text: 92C0179, 720510
1993-02-26	CB	Supplementary protection certificate (spc) granted (law of 25 june 1990)	Free format text: 92C0180, 720510
1993-04-23	CL	Concession to grant licences

Publication	Publication Date	Title
FR2137712A1 (en)	1972-12-29	Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition
GB1409843A (en)	1975-10-15	Prostaglandin intermediates
ES307300A1 (es)	1965-05-01	Procedimiento para la preparacion de nuevos 6,7-benzomorfanos sustituidos.
AU537414B2 (en)	1984-06-21	Pyroglutamic acid derivatives
PH20468A (en)	1987-01-14	Novel pharmaceutically active di-esters of 3,5-dicarboxy-4-substituted-pyridines and pyrans
KR870001193A (ko)	1987-03-12	β-락탐 항생물질의 제조방법
GB1475271A (en)	1977-06-01	1-aryl-2-1-imidazolyl-alkyl ethers and thioethers and their use as antifungal agents
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