FR2137712A1 - Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition - Google Patents
Novel prostanoic acid or its salt used as pharmaceutical or veterinary compositionInfo
- Publication number
- FR2137712A1 FR2137712A1 FR7216685A FR7216685A FR2137712A1 FR 2137712 A1 FR2137712 A1 FR 2137712A1 FR 7216685 A FR7216685 A FR 7216685A FR 7216685 A FR7216685 A FR 7216685A FR 2137712 A1 FR2137712 A1 FR 2137712A1
- Authority
- FR
- France
- Prior art keywords
- radical
- alkyl
- prostanoic acid
- salt
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical compound CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- -1 alkoxycarbonyl radical Chemical class 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- IPEWNTLWCRYSRY-UHFFFAOYSA-N [CH2]C1=CC=CO1 Chemical compound [CH2]C1=CC=CO1 IPEWNTLWCRYSRY-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005277 alkyl imino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 230000002254 contraceptive effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical compound O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/535—Organo-phosphoranes
- C07F9/5352—Phosphoranes containing the structure P=C-
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1413971 | 1971-05-11 | ||
GB3967272A GB1348036A (en) | 1970-05-15 | 1972-01-05 | Transistorized vertical deflection circuit |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2137712A1 true FR2137712A1 (en) | 1972-12-29 |
FR2137712B1 FR2137712B1 (de) | 1976-04-16 |
Family
ID=26235892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7216685A Granted FR2137712A1 (en) | 1971-05-11 | 1972-05-10 | Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition |
Country Status (26)
Country | Link |
---|---|
JP (1) | JPS5611699B1 (de) |
AR (4) | AR194952A1 (de) |
AT (4) | AT333447B (de) |
AU (1) | AU462755B2 (de) |
BE (1) | BE783292A (de) |
CA (1) | CA1077033A (de) |
CH (3) | CH596166A5 (de) |
CS (1) | CS192456B2 (de) |
DD (1) | DD99155A5 (de) |
DE (1) | DE2223365C3 (de) |
DK (1) | DK134598B (de) |
EG (1) | EG10752A (de) |
ES (1) | ES402627A1 (de) |
FI (1) | FI63221C (de) |
FR (1) | FR2137712A1 (de) |
HK (1) | HK50176A (de) |
HU (1) | HU166717B (de) |
IE (1) | IE37602B1 (de) |
IL (1) | IL39376A (de) |
KE (1) | KE2634A (de) |
NL (1) | NL164272C (de) |
NO (1) | NO139521C (de) |
SE (4) | SE399705B (de) |
SU (1) | SU662007A3 (de) |
YU (1) | YU35876B (de) |
ZM (1) | ZM8172A1 (de) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2184007A1 (de) * | 1972-05-10 | 1973-12-21 | Upjohn Co | |
FR2205335A1 (de) * | 1972-11-08 | 1974-05-31 | Pfizer | |
FR2378010A1 (fr) * | 1977-01-24 | 1978-08-18 | Searle & Co | Derives d'acide o-aryloxy prostyne-13 oique, leur procede de preparation et leur utilisation notamment comme contraceptifs |
EP0349658A1 (de) * | 1986-12-12 | 1990-01-10 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | Prostanoide und ihre Anwendung für die Erhöhung der Geburtenrate bei weiblichen Tieren |
EP0362686A2 (de) * | 1988-09-28 | 1990-04-11 | SPOLANA a.s. | Verfahren zur Herstellung des (+)-Isomers von Cloprostenol |
WO1997030710A1 (en) * | 1996-02-22 | 1997-08-28 | Vision Pharmaceuticals L.P. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3966795A (en) * | 1973-05-21 | 1976-06-29 | The Upjohn Company | 5-Oxa-11-deoxyphenyl- and phenoxy-substituted prostaglandin F1.sub.α analogs |
US3968144A (en) * | 1973-05-21 | 1976-07-06 | The Upjohn Company | 5-Oxa-11-deoxy phenyl- and phenoxy-substituted prostalandin E1 analogs |
US4387241A (en) * | 1974-11-01 | 1983-06-07 | American Cyanamid Company | Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives |
US4191774A (en) * | 1978-01-18 | 1980-03-04 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | Novel 17-aza-PGF2α derivatives and pharmaceutical compositions containing the same |
US4228296A (en) * | 1979-01-24 | 1980-10-14 | American Cyanamid Company | Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives |
US4929740A (en) * | 1984-10-09 | 1990-05-29 | Syntex (U.S.A.) Inc. | Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives |
CS265947B1 (en) * | 1987-06-16 | 1989-11-14 | Kral Josef | Means for farming animals' ovarian functions control |
US5565492A (en) * | 1988-07-18 | 1996-10-15 | Alcon Laboratories, Inc. | Prostaglandin combinations in glaucoma therapy |
US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
US6531504B2 (en) * | 2001-05-17 | 2003-03-11 | Allergan, Inc. | Prostanoic acid derivatives as agents for lowering intraocular pressure |
RU2481339C2 (ru) * | 2007-11-09 | 2013-05-10 | Аллерган, Инк. | Замещенные циклопентаны, обладающие простагландиновой активностью |
-
1972
- 1972-04-27 IE IE557/72A patent/IE37602B1/xx unknown
- 1972-04-28 CA CA140,884A patent/CA1077033A/en not_active Expired
- 1972-05-04 HU HUIE502A patent/HU166717B/hu unknown
- 1972-05-08 ZM ZM81/72*UA patent/ZM8172A1/xx unknown
- 1972-05-08 AU AU42024/72A patent/AU462755B2/en not_active Expired
- 1972-05-08 IL IL39376A patent/IL39376A/xx unknown
- 1972-05-09 NO NO1648/72A patent/NO139521C/no unknown
- 1972-05-09 SE SE7206139A patent/SE399705B/xx unknown
- 1972-05-09 EG EG193/72A patent/EG10752A/xx active
- 1972-05-10 NL NL7206361.A patent/NL164272C/xx not_active IP Right Cessation
- 1972-05-10 SU SU721787999A patent/SU662007A3/ru active
- 1972-05-10 FR FR7216685A patent/FR2137712A1/fr active Granted
- 1972-05-10 ES ES402627A patent/ES402627A1/es not_active Expired
- 1972-05-10 CH CH1566776A patent/CH596166A5/xx not_active IP Right Cessation
- 1972-05-10 CH CH697472A patent/CH590223A5/xx not_active IP Right Cessation
- 1972-05-10 DK DK236272AA patent/DK134598B/da unknown
- 1972-05-10 FI FI1333/72A patent/FI63221C/fi active
- 1972-05-10 BE BE783292A patent/BE783292A/xx not_active IP Right Cessation
- 1972-05-10 CH CH1566676A patent/CH596165A5/xx not_active IP Right Cessation
- 1972-05-11 JP JP4684472A patent/JPS5611699B1/ja active Pending
- 1972-05-11 DD DD162906A patent/DD99155A5/xx unknown
- 1972-05-11 YU YU1250/72A patent/YU35876B/xx unknown
- 1972-05-11 AR AR241955A patent/AR194952A1/es active
- 1972-05-11 CS CS723161A patent/CS192456B2/cs unknown
- 1972-05-12 DE DE2223365A patent/DE2223365C3/de not_active Expired
- 1972-05-12 AT AT419172A patent/AT333447B/de not_active IP Right Cessation
- 1972-05-12 AT AT538973*7A patent/AT328103B/de not_active IP Right Cessation
- 1972-11-30 AR AR245418A patent/AR197100A1/es active
- 1972-11-30 AR AR245420A patent/AR200484A1/es active
- 1972-11-30 AR AR245419A patent/AR197101A1/es active
-
1973
- 1973-05-12 AT AT539173*7A patent/AT328105B/de not_active IP Right Cessation
- 1973-05-12 AT AT539073*7A patent/AT328104B/de not_active IP Right Cessation
-
1975
- 1975-04-15 SE SE7504336A patent/SE7504336L/xx unknown
- 1975-04-15 SE SE7504337A patent/SE7504337L/xx unknown
- 1975-04-15 SE SE7504335A patent/SE7504335L/xx unknown
-
1976
- 1976-05-31 KE KE2634*UA patent/KE2634A/xx unknown
- 1976-08-05 HK HK501/76*UA patent/HK50176A/xx unknown
Non-Patent Citations (1)
Title |
---|
NEANT * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2184007A1 (de) * | 1972-05-10 | 1973-12-21 | Upjohn Co | |
FR2205335A1 (de) * | 1972-11-08 | 1974-05-31 | Pfizer | |
FR2378010A1 (fr) * | 1977-01-24 | 1978-08-18 | Searle & Co | Derives d'acide o-aryloxy prostyne-13 oique, leur procede de preparation et leur utilisation notamment comme contraceptifs |
EP0349658A1 (de) * | 1986-12-12 | 1990-01-10 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | Prostanoide und ihre Anwendung für die Erhöhung der Geburtenrate bei weiblichen Tieren |
EP0362686A2 (de) * | 1988-09-28 | 1990-04-11 | SPOLANA a.s. | Verfahren zur Herstellung des (+)-Isomers von Cloprostenol |
EP0362686A3 (en) * | 1988-09-28 | 1990-08-29 | Vysoka Skola Chemicko-Technologicka | Method for preparing the (+)-isomer of cloprostenol method for preparing the (+)-isomer of cloprostenol |
WO1997030710A1 (en) * | 1996-02-22 | 1997-08-28 | Vision Pharmaceuticals L.P. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CC | Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990) |
Free format text: 92C0180, 920507 |
|
CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0179, 720510 |
|
CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0180, 720510 |
|
CL | Concession to grant licences |