US6811779B2
(en)
|
1994-02-10 |
2004-11-02 |
Imclone Systems Incorporated |
Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
|
TW321649B
(en)
*
|
1994-11-12 |
1997-12-01 |
Zeneca Ltd |
|
GB9424233D0
(en)
*
|
1994-11-30 |
1995-01-18 |
Zeneca Ltd |
Quinazoline derivatives
|
GB9508538D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
GB9508535D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivative
|
DE69613367T2
(en)
*
|
1995-04-27 |
2002-04-18 |
Astrazeneca Ab |
CHINAZOLIN DERIVATIVES
|
GB9508565D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
GB9508537D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
SK285141B6
(en)
|
1996-02-13 |
2006-07-07 |
Astrazeneca Uk Limited |
Use of quinazoline derivative, quinazoline derivative, process for preparation thereof and pharmaceutical composition containing thereof
|
GB9603095D0
(en)
*
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
GB9603097D0
(en)
*
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
EP0885198B1
(en)
|
1996-03-05 |
2001-12-19 |
AstraZeneca AB |
4-anilinoquinazoline derivatives
|
EP0892789B2
(en)
|
1996-04-12 |
2009-11-18 |
Warner-Lambert Company LLC |
Irreversible inhibitors of tyrosine kinases
|
GB9607729D0
(en)
*
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
DE69734513T2
(en)
*
|
1996-06-24 |
2006-07-27 |
Pfizer Inc. |
PHENYLAMINO-SUBSTITUTED TRICYCL DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
US6225318B1
(en)
|
1996-10-17 |
2001-05-01 |
Pfizer Inc |
4-aminoquinazolone derivatives
|
EP0837063A1
(en)
*
|
1996-10-17 |
1998-04-22 |
Pfizer Inc. |
4-Aminoquinazoline derivatives
|
US6002008A
(en)
*
|
1997-04-03 |
1999-12-14 |
American Cyanamid Company |
Substituted 3-cyano quinolines
|
DE19743435A1
(en)
|
1997-10-01 |
1999-04-08 |
Merck Patent Gmbh |
Benzamidine derivatives
|
US6706721B1
(en)
|
1998-04-29 |
2004-03-16 |
Osi Pharmaceuticals, Inc. |
N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
|
OA11769A
(en)
*
|
1998-04-29 |
2005-07-25 |
Pfizer Prod Inc |
N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate.
|
US6384223B1
(en)
|
1998-07-30 |
2002-05-07 |
American Home Products Corporation |
Substituted quinazoline derivatives
|
DE69939022D1
(en)
|
1998-08-18 |
2008-08-14 |
Univ California |
EPIDERMAL GROWTH FACTOR RECEPTOR ANTAGONISTS FOR THE TREATMENT OF STRONG PERFORATED MEAT SLEEK IN THE LUNG
|
JP3270834B2
(en)
|
1999-01-27 |
2002-04-02 |
ファイザー・プロダクツ・インク |
Heteroaromatic bicyclic derivatives useful as anticancer agents
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
RS49836B
(en)
*
|
1999-03-31 |
2008-08-07 |
Pfizer Products Inc., |
Process and intermediates for preparing anti-cancer compounds
|
MXPA01012899A
(en)
|
1999-06-21 |
2002-07-30 |
Boehringer Ingelheim Pharma |
Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof.
|
ATE377597T1
(en)
|
1999-07-09 |
2007-11-15 |
Glaxo Group Ltd |
ANILINOQUINAZOLINES AS PROTEIN TYROSINE KINASE INHIBITORS
|
US6933299B1
(en)
|
1999-07-09 |
2005-08-23 |
Smithkline Beecham Corporation |
Anilinoquinazolines as protein tyrosine kinase inhibitors
|
GB9922173D0
(en)
*
|
1999-09-21 |
1999-11-17 |
Zeneca Ltd |
Chemical compounds
|
CN1391561A
(en)
*
|
1999-09-21 |
2003-01-15 |
阿斯特拉曾尼卡有限公司 |
Quinazoline compounds and pharmaceutical compositions containing them
|
GB9925958D0
(en)
*
|
1999-11-02 |
1999-12-29 |
Bundred Nigel J |
Therapeutic use
|
ES2306306T3
(en)
|
1999-11-05 |
2008-11-01 |
Astrazeneca Ab |
NEW DERIVATIVES OF QUINAZOLINA.
|
US7087613B2
(en)
|
1999-11-11 |
2006-08-08 |
Osi Pharmaceuticals, Inc. |
Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
|
UA74803C2
(en)
*
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
A stable polymorph of n-(3-ethynylphenyl)-6,7-bis(2-methoxyetoxy)-4-quinazolinamine hydrochloride, a method for producing thereof (variants) and pharmaceutical use
|
US7160889B2
(en)
|
2000-04-07 |
2007-01-09 |
Astrazeneca Ab |
Quinazoline compounds
|
UA73993C2
(en)
|
2000-06-06 |
2005-10-17 |
Астразенека Аб |
Quinazoline derivatives for the treatment of tumours and a pharmaceutical composition
|
EP1170011A1
(en)
*
|
2000-07-06 |
2002-01-09 |
Boehringer Ingelheim International GmbH |
Novel use of inhibitors of the epidermal growth factor receptor
|
EP1313727A1
(en)
|
2000-08-21 |
2003-05-28 |
AstraZeneca AB |
Quinazoline derivatives
|
EP1415987B1
(en)
|
2000-10-20 |
2007-02-28 |
Eisai R&D Management Co., Ltd. |
Nitrogenous aromatic ring compounds as anti cancer agents
|
US7776315B2
(en)
|
2000-10-31 |
2010-08-17 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pharmaceutical compositions based on anticholinergics and additional active ingredients
|
WO2002036587A2
(en)
|
2000-11-01 |
2002-05-10 |
Cor Therapeutics, Inc. |
Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
|
US7019012B2
(en)
|
2000-12-20 |
2006-03-28 |
Boehringer Ingelheim International Pharma Gmbh & Co. Kg |
Quinazoline derivatives and pharmaceutical compositions containing them
|
ES2705016T3
(en)
|
2001-02-19 |
2019-03-21 |
Novartis Int Pharmaceutical Ag |
Rapamycin derivative for the treatment of lung cancer
|
JP2002293773A
(en)
*
|
2001-03-30 |
2002-10-09 |
Sumika Fine Chemicals Co Ltd |
Method for producing quinazoline derivative
|
AU2002350105A1
(en)
|
2001-06-21 |
2003-01-08 |
Ariad Pharmaceuticals, Inc. |
Novel quinazolines and uses thereof
|
US6995171B2
(en)
|
2001-06-21 |
2006-02-07 |
Agouron Pharmaceuticals, Inc. |
Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents
|
CA2478050A1
(en)
|
2002-03-01 |
2003-09-12 |
Pfizer Inc. |
Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
US7078409B2
(en)
|
2002-03-28 |
2006-07-18 |
Beta Pharma, Inc. |
Fused quinazoline derivatives useful as tyrosine kinase inhibitors
|
US6924285B2
(en)
|
2002-03-30 |
2005-08-02 |
Boehringer Ingelheim Pharma Gmbh & Co. |
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
|
DE10221018A1
(en)
|
2002-05-11 |
2003-11-27 |
Boehringer Ingelheim Pharma |
Use of inhibitors of EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH) / prostatic hypertrophy
|
NZ560662A
(en)
|
2002-05-16 |
2009-09-25 |
Novartis Ag |
Use of EDG receptor binding agents in cancer
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
PT2263691E
(en)
|
2002-07-15 |
2012-11-12 |
Hoffmann La Roche |
Treatment of cancer with the recombinant humanized monoclonal anti-erbb2 antibody 2c4 (rhumab 2c4)
|
DK2345671T3
(en)
|
2002-09-27 |
2016-02-15 |
Xencor Inc |
Optimized Fc variants and methods for their formation
|
AU2003291394B2
(en)
*
|
2002-11-20 |
2009-06-25 |
Array Biopharma, Inc |
Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
|
US7488823B2
(en)
|
2003-11-10 |
2009-02-10 |
Array Biopharma, Inc. |
Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
|
JPWO2004060400A1
(en)
*
|
2003-01-06 |
2006-05-11 |
那波 宏之 |
Antipsychotic drug targeting epidermal growth factor receptor
|
GB0302882D0
(en)
*
|
2003-02-07 |
2003-03-12 |
Univ Cardiff |
Improvements in or relating to agents for the treatment of cardiovascular dysfunction and weight loss
|
US7148231B2
(en)
|
2003-02-17 |
2006-12-12 |
Hoffmann-La Roche Inc. |
[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
|
US7223749B2
(en)
|
2003-02-20 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
PA8595001A1
(en)
|
2003-03-04 |
2004-09-28 |
Pfizer Prod Inc |
NEW CONDENSED HETEROAROMATIC COMPOUNDS THAT ARE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF)
|
US7994159B2
(en)
|
2003-03-10 |
2011-08-09 |
Eisai R&D Management Co., Ltd. |
c-Kit kinase inhibitor
|
GB0309850D0
(en)
|
2003-04-30 |
2003-06-04 |
Astrazeneca Ab |
Quinazoline derivatives
|
TW200505442A
(en)
|
2003-05-19 |
2005-02-16 |
Genomics Inst Of The Novartis Res Foundation |
Immunosuppressant compounds and compositions
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
AU2004291709C1
(en)
|
2003-05-30 |
2010-03-11 |
Astrazeneca Uk Limited |
Process
|
JP2007500248A
(en)
|
2003-06-09 |
2007-01-11 |
ワクサル,サムエル |
Method for inhibiting receptor tyrosine kinase by extracellular antagonist and intracellular antagonist
|
ATE373661T1
(en)
|
2003-06-10 |
2007-10-15 |
Hoffmann La Roche |
1.3.4-TRIAZA-PHENALEN AND 1,3,4,6-TETRAAZAPHENALEN DERIVATIVES
|
WO2006074147A2
(en)
|
2005-01-03 |
2006-07-13 |
Myriad Genetics, Inc. |
Nitrogen containing bicyclic compounds and therapeutical use thereof
|
US8309562B2
(en)
|
2003-07-03 |
2012-11-13 |
Myrexis, Inc. |
Compounds and therapeutical use thereof
|
GB0317665D0
(en)
|
2003-07-29 |
2003-09-03 |
Astrazeneca Ab |
Qinazoline derivatives
|
MXPA06002296A
(en)
|
2003-08-29 |
2006-05-22 |
Pfizer |
Thienopyridine-phenylacet amides and their derivatives useful as new anti-angiogenic agents.
|
JP4795952B2
(en)
|
2003-09-16 |
2011-10-19 |
アストラゼネカ アクチボラグ |
Quinazoline derivatives as tyrosine kinase inhibitors
|
GB0322409D0
(en)
|
2003-09-25 |
2003-10-29 |
Astrazeneca Ab |
Quinazoline derivatives
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
DE10349113A1
(en)
|
2003-10-17 |
2005-05-12 |
Boehringer Ingelheim Pharma |
Process for the preparation of aminocrotonyl compounds
|
SI1725249T1
(en)
|
2003-11-06 |
2014-04-30 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
JP4303726B2
(en)
|
2003-11-11 |
2009-07-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
Urea derivative and method for producing the same
|
GB0326459D0
(en)
|
2003-11-13 |
2003-12-17 |
Astrazeneca Ab |
Quinazoline derivatives
|
BRPI0418102A
(en)
|
2003-12-23 |
2007-04-27 |
Pfizer |
quinoline derivatives
|
US7632840B2
(en)
|
2004-02-03 |
2009-12-15 |
Astrazeneca Ab |
Quinazoline compounds for the treatment of hyperproliferative disorders
|
CA2557433C
(en)
*
|
2004-02-19 |
2013-05-14 |
Rexahn Corporation |
Quinazoline derivatives and therapeutic use thereof
|
US7598350B2
(en)
|
2004-03-19 |
2009-10-06 |
Imclone Llc |
Human anti-epidermal growth factor receptor antibody
|
EP1733056B1
(en)
|
2004-03-31 |
2013-05-22 |
The General Hospital Corporation |
Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
|
KR20080083220A
(en)
|
2004-04-07 |
2008-09-16 |
노파르티스 아게 |
Inhibitors of iap
|
US8080577B2
(en)
|
2004-05-06 |
2011-12-20 |
Bioresponse, L.L.C. |
Diindolylmethane formulations for the treatment of leiomyomas
|
EP2286844A3
(en)
|
2004-06-01 |
2012-08-22 |
Genentech, Inc. |
Antibody-drug conjugates and methods
|
EP1765313A2
(en)
|
2004-06-24 |
2007-03-28 |
Novartis Vaccines and Diagnostics, Inc. |
Compounds for immunopotentiation
|
CN101987870B
(en)
|
2004-07-15 |
2013-07-03 |
赞科股份有限公司 |
Optimized Fc variants
|
US20060035893A1
(en)
|
2004-08-07 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
|
JP4834553B2
(en)
|
2004-09-17 |
2011-12-14 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
Pharmaceutical composition
|
WO2006034488A2
(en)
|
2004-09-23 |
2006-03-30 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
JO3000B1
(en)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
Antibody Formulations.
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
EP2845865A1
(en)
|
2004-11-12 |
2015-03-11 |
Xencor Inc. |
Fc variants with altered binding to FcRn
|
DE602005026865D1
(en)
|
2004-12-14 |
2011-04-21 |
Astrazeneca Ab |
PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUM-MEANS
|
PE20060777A1
(en)
|
2004-12-24 |
2006-10-06 |
Boehringer Ingelheim Int |
INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
|
US7989486B2
(en)
|
2004-12-30 |
2011-08-02 |
Bioresponse, L.L.C. |
Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
|
US8258145B2
(en)
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
US7625911B2
(en)
|
2005-01-12 |
2009-12-01 |
Mai De Ltd. |
Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
|
TWI441646B
(en)
|
2005-01-21 |
2014-06-21 |
Genentech Inc |
Use of pertuzumab in the manufacture of a medicament for treating cancer in a human patient
|
AU2006207321B2
(en)
|
2005-01-21 |
2012-09-06 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
GB0501999D0
(en)
*
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
ES2440481T3
(en)
|
2005-02-23 |
2014-01-29 |
Genentech, Inc. |
Time extension until disease progression or survival in ovarian cancer patients using pertuzumab
|
JP4137174B2
(en)
*
|
2005-02-23 |
2008-08-20 |
塩野義製薬株式会社 |
Quinazoline derivatives having tyrosine kinase inhibitory action
|
AU2006217738A1
(en)
|
2005-02-26 |
2006-08-31 |
Astrazeneca Ab |
Quinazoline derivatives as tyrosine kinase inhibitors
|
EP1859793B1
(en)
|
2005-02-28 |
2011-04-20 |
Eisai R&D Management Co., Ltd. |
Novel combinational use of a sulfonamide compound in the treatment of cancer
|
AU2006235487B2
(en)
*
|
2005-04-12 |
2011-12-22 |
Elan Pharma International Limited |
Nanoparticulate quinazoline derivative formulations
|
CN1854130B
(en)
*
|
2005-04-15 |
2011-04-20 |
中国医学科学院药物研究所 |
Chinazoline derivative, its production, medicinal composition and use
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
EP2100614B8
(en)
|
2005-06-17 |
2013-11-20 |
ImClone LLC |
Antibody against PDGFR-alpha for use in the treatment of tumours
|
JP4989476B2
(en)
|
2005-08-02 |
2012-08-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
Methods for assaying the effects of angiogenesis inhibitors
|
ES2370054T3
(en)
|
2005-08-24 |
2011-12-12 |
Bristol-Myers Squibb Company |
BIOMARKERS AND PROCEDURES TO DETERMINE THE SENSITIVITY TO MODULATORS OF THE RECEIVER OF THE EPIDERMAL GROWTH FACTOR.
|
US7820683B2
(en)
|
2005-09-20 |
2010-10-26 |
Astrazeneca Ab |
4-(1H-indazol-5-yl-amino)-quinazoline compounds as erbB receptor tyrosine kinase inhibitors for the treatment of cancer
|
DK1931709T3
(en)
|
2005-10-03 |
2017-03-13 |
Xencor Inc |
FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
|
CA2627598C
(en)
|
2005-11-07 |
2013-06-25 |
Eisai R & D Management Co., Ltd. |
Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
|
EP3173084B1
(en)
|
2005-11-11 |
2019-10-23 |
Boehringer Ingelheim International GmbH |
Quinazoline derivatives for the treatment of cancer diseases
|
ES2481671T3
(en)
|
2005-11-21 |
2014-07-31 |
Novartis Ag |
MTOR inhibitors in the treatment of endocrine tumors
|
WO2007060691A2
(en)
*
|
2005-11-23 |
2007-05-31 |
Natco Pharma Limited |
A novel process for the preparation of erlotinib
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
PI-3 Kinase inhibitors and methods of their use
|
CN101003514A
(en)
|
2006-01-20 |
2007-07-25 |
上海艾力斯医药科技有限公司 |
Derivative of quinazoline, preparation method and usage
|
EA017265B1
(en)
|
2006-02-03 |
2012-11-30 |
Имклоун Элэлси |
Use of imc-a12 antibody being igf-ir inhibitor for treatment of prostate cancer
|
GB0605120D0
(en)
|
2006-03-14 |
2006-04-26 |
Novartis Ag |
Organic Compounds
|
EP2591775A1
(en)
|
2006-04-05 |
2013-05-15 |
Novartis AG |
Combinations comprising mtor inhibitors for treating cancer
|
MX2008012728A
(en)
|
2006-04-05 |
2008-10-14 |
Novartis Ag |
Combinations comprising bcr-abl/c-kit/pdgf-r tk inhibitors for treating cancer.
|
AR060358A1
(en)
|
2006-04-06 |
2008-06-11 |
Novartis Vaccines & Diagnostic |
QUINAZOLINS FOR THE INHIBITION OF PDK 1
|
RU2008145225A
(en)
|
2006-04-19 |
2010-05-27 |
Новартис АГ (CH) |
INDAZOLE COMPOUNDS AND CD7 INHIBITION METHODS
|
JP2009536180A
(en)
|
2006-05-09 |
2009-10-08 |
ノバルティス アクチエンゲゼルシャフト |
Combinations comprising iron chelators and antineoplastic agents and their use
|
JP5190361B2
(en)
|
2006-05-18 |
2013-04-24 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
Antitumor agent for thyroid cancer
|
WO2007138613A2
(en)
*
|
2006-05-25 |
2007-12-06 |
Vittal Mallya Scientific Research Foundation |
A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride
|
WO2007138612A2
(en)
*
|
2006-05-25 |
2007-12-06 |
Vittal Mallya Scientific Research Foundation |
A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4- yl]-(3-ethynylphenyl)amine hydrochloride
|
CA2659307A1
(en)
|
2006-07-28 |
2008-01-31 |
Synthon B.V. |
Crystalline erlotinib
|
ES2457072T3
(en)
|
2006-08-14 |
2014-04-24 |
Xencor, Inc. |
Optimized antibodies that select as target CD19
|
US8865737B2
(en)
|
2006-08-28 |
2014-10-21 |
Eisai R&D Management Co., Ltd. |
Antitumor agent for undifferentiated gastric cancer
|
ATE522625T1
(en)
|
2006-09-12 |
2011-09-15 |
Genentech Inc |
METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF LUNG CANCER USING PDGFRA, KIT OR KDG GENE AS GENETIC MARKERS
|
CA2663599A1
(en)
|
2006-09-18 |
2008-03-27 |
Boehringer Ingelheim International Gmbh |
Method for treating cancer harboring egfr mutations
|
CA2664378A1
(en)
|
2006-09-29 |
2008-04-03 |
Novartis Ag |
Pyrazolopyrimidines as pi3k lipid kinase inhibitors
|
AU2007303846B2
(en)
|
2006-10-04 |
2011-03-10 |
Pfizer Products Inc. |
Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
|
JP5528807B2
(en)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
Compound drug
|
JP5528806B2
(en)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
Compound drug
|
US8586621B2
(en)
|
2006-10-27 |
2013-11-19 |
Michael A. Zeligs |
Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
|
US8372856B2
(en)
*
|
2006-10-27 |
2013-02-12 |
Synthon Bv |
Hydrates of erlotinib hydrochloride
|
EP1921070A1
(en)
|
2006-11-10 |
2008-05-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
|
US8343950B2
(en)
*
|
2006-12-15 |
2013-01-01 |
Concert Pharmaceuticals, Inc. |
Quinazoline derivatives and methods of treatment
|
US20100048503A1
(en)
|
2007-01-19 |
2010-02-25 |
Eisai R & D Management Co., Ltd. |
Composition for treatment of pancreatic cancer
|
AU2008211952B2
(en)
|
2007-01-29 |
2012-07-19 |
Eisai R & D Management Co., Ltd. |
Composition for treatment of undifferentiated-type of gastric cancer
|
WO2008095847A1
(en)
|
2007-02-06 |
2008-08-14 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
|
CN101245050A
(en)
|
2007-02-14 |
2008-08-20 |
上海艾力斯医药科技有限公司 |
4-aniline quinazoline derivative salt
|
RU2009134223A
(en)
|
2007-02-15 |
2011-03-20 |
Новартис АГ (CH) |
COMBINATION OF LBH589 WITH OTHER THERAPEUTIC MEDICINES FOR THE TREATMENT OF CANCER
|
EP2170844B1
(en)
|
2007-02-21 |
2016-05-04 |
Natco Pharma Limited |
Novel polymorphs of erlotinib hydrochloride and method of preparation
|
WO2008109440A2
(en)
|
2007-03-02 |
2008-09-12 |
Genentech, Inc. |
Predicting response to a her dimerisation inhibitor based on low her3 expression
|
EP2139868B1
(en)
*
|
2007-04-04 |
2015-07-29 |
Cipla Limited |
Process for preparation of erlotinib and its pharmaceutically acceptable salts
|
ES2659517T3
(en)
|
2007-05-30 |
2018-03-16 |
Xencor, Inc. |
Methods and compositions for inhibiting cells expressing CD32B
|
ES2417148T3
(en)
|
2007-06-08 |
2013-08-06 |
Genentech, Inc. |
Gene expression markers of tumor resistance to HER2 inhibitor treatment
|
US20100190777A1
(en)
|
2007-07-17 |
2010-07-29 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
WO2009030224A2
(en)
*
|
2007-09-07 |
2009-03-12 |
Schebo Biotech Ag |
Novel quinazoline compounds and the use thereof for treating cancerous diseases
|
US8080558B2
(en)
|
2007-10-29 |
2011-12-20 |
Natco Pharma Limited |
4-(tetrazol-5-yl)-quinazoline derivatives as anti-cancer agent
|
KR101513326B1
(en)
|
2007-11-09 |
2015-04-17 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
CL2008003449A1
(en)
|
2007-11-21 |
2010-02-19 |
Imclone Llc |
Antibody or fragments thereof against the macrophage / rum stimulating protein receptor; pharmaceutical composition comprising it; use to inhibit angiogenesis, tumor growth, proliferation, migration and invasion of tumor cells, activation of rum or phosphorylation of mapk and / or akt; and use to treat cancer.
|
PA8809001A1
(en)
|
2007-12-20 |
2009-07-23 |
Novartis Ag |
ORGANIC COMPOUNDS
|
EP3575317A1
(en)
|
2007-12-26 |
2019-12-04 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
JP2011509995A
(en)
|
2008-01-18 |
2011-03-31 |
ナトコ ファーマ リミテッド |
6,7-dialkoxyquinazoline derivatives useful for the treatment of cancer-related diseases
|
TWI472339B
(en)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof
|
AU2009211523B2
(en)
|
2008-02-07 |
2014-03-13 |
Boehringer Ingelheim International Gmbh |
Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production
|
EA020114B1
(en)
|
2008-03-24 |
2014-08-29 |
Новартис Аг |
Arylsulfonamide-based matrix metalloprotease inhibitors
|
CN101544609A
(en)
|
2008-03-25 |
2009-09-30 |
上海艾力斯医药科技有限公司 |
Crystallization form of 4-anilinoquinazoline derivatives
|
EP2628726A1
(en)
|
2008-03-26 |
2013-08-21 |
Novartis AG |
Hydroxamate-based inhibitors of deacetylases b
|
JP2011516426A
(en)
*
|
2008-03-28 |
2011-05-26 |
コンサート ファーマシューティカルズ インコーポレイテッド |
Quinazoline derivatives and methods of treatment
|
JP5739802B2
(en)
|
2008-05-13 |
2015-06-24 |
アストラゼネカ アクチボラグ |
4- (3-Chloro-2-fluoroanilino) -7-methoxy-6-{[1- (N-methylcarbamoylmethyl) piperidin-4-yl] oxy} quinazoline fumarate
|
DK2288727T3
(en)
|
2008-05-14 |
2013-10-21 |
Genomic Health Inc |
Predictors of patient response to treatment with EGF receptor inhibitors
|
CN101584696A
(en)
|
2008-05-21 |
2009-11-25 |
上海艾力斯医药科技有限公司 |
Composition containing quinazoline derivatives, preparation method and use
|
DE102008031039A1
(en)
|
2008-06-30 |
2009-12-31 |
Dömling, Alexander, Priv.-Doz. Dr. |
Use of N-phenylquinazolin-4-amine derivatives as receptor tyrosine kinase inhibitor for accompanying treatment of organ transplantations
|
CA2733153C
(en)
|
2008-08-08 |
2016-11-08 |
Boehringer Ingelheim International Gmbh |
Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
|
EP2344161B1
(en)
|
2008-10-16 |
2018-12-19 |
Celator Pharmaceuticals, Inc. |
Combinations of a liposomal water-soluble camptothecin with cetuximab or bevacizumab
|
CA2742986C
(en)
|
2008-11-07 |
2015-03-31 |
Triact Therapeutics, Inc. |
Use of catecholic butane derivatives in cancer therapy
|
EA018624B1
(en)
|
2008-11-11 |
2013-09-30 |
Эли Лилли Энд Компани |
P70 s6 kinase inhibitor and egfr inhibitor combination therapy
|
SG171785A1
(en)
|
2008-12-18 |
2011-07-28 |
Novartis Ag |
Hemifumarate salt of 1- [4- [1- ( 4 -cyclohexyl-3 -trifluoromethyl-benzyloxyimino ) -ethyl] -2 -ethyl-benzyl] -a zetidine-3-carboxylic acid
|
AU2009327405A1
(en)
|
2008-12-18 |
2011-06-30 |
Novartis Ag |
New polymorphic form of 1- (4- { l- [ (E) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic
|
BRPI0922466A2
(en)
|
2008-12-18 |
2018-10-23 |
Novartis Ag |
salts
|
WO2010083617A1
(en)
|
2009-01-21 |
2010-07-29 |
Oncalis Ag |
Pyrazolopyrimidines as protein kinase inhibitors
|
TW201031406A
(en)
|
2009-01-29 |
2010-09-01 |
Novartis Ag |
Substituted benzimidazoles for the treatment of astrocytomas
|
EP2213281A1
(en)
|
2009-02-02 |
2010-08-04 |
Ratiopharm GmbH |
Pharmaceutical composition comprising N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
EP2400990A2
(en)
|
2009-02-26 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
In situ methods for monitoring the emt status of tumor cells in vivo
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
US8465912B2
(en)
|
2009-02-27 |
2013-06-18 |
OSI Pharmaceuticals, LLC |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
EP2401614A1
(en)
|
2009-02-27 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
US20120064072A1
(en)
|
2009-03-18 |
2012-03-15 |
Maryland Franklin |
Combination Cancer Therapy Comprising Administration of an EGFR Inhibitor and an IGF-1R Inhibitor
|
US8440823B2
(en)
*
|
2009-03-26 |
2013-05-14 |
Ranbaxy Laboratories Limited |
Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
|
KR101360725B1
(en)
|
2009-06-26 |
2014-02-07 |
노파르티스 아게 |
1,3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp17
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
EP2451445B1
(en)
|
2009-07-06 |
2019-04-03 |
Boehringer Ingelheim International GmbH |
Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
|
US9050341B2
(en)
*
|
2009-07-14 |
2015-06-09 |
Natco Pharma Limited |
Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
CA2770873A1
(en)
|
2009-08-12 |
2011-02-17 |
Novartis Ag |
Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
|
IN2012DN01961A
(en)
|
2009-08-17 |
2015-08-21 |
Intellikine Llc |
|
EP2467383A1
(en)
|
2009-08-20 |
2012-06-27 |
Novartis AG |
Heterocyclic oxime compounds
|
US20120149661A1
(en)
|
2009-08-26 |
2012-06-14 |
Novartis Ag |
Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
EP2494070A2
(en)
|
2009-10-30 |
2012-09-05 |
Bristol-Myers Squibb Company |
Methods for treating cancer in patients having igf-1r inhibitor resistance
|
MY156209A
(en)
|
2009-11-04 |
2016-01-29 |
Novartis Ag |
Heterocyclic sulfonamide derivatives useful mek inhibitors
|
US20120316187A1
(en)
|
2009-11-13 |
2012-12-13 |
Pangaea Biotech, S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
BR112012012983A2
(en)
|
2009-12-04 |
2020-09-15 |
Genentech Inc |
method of synthesizing a multispecific antibody, method of synthesizing a panel of multispecific antibodies, method of synthesizing an antibody analog, method of synthesizing a panel of antibody analogs and compositions
|
EP2509964B1
(en)
|
2009-12-08 |
2014-04-30 |
Novartis AG |
Heterocyclic sulfonamide derivatives
|
CU24130B1
(en)
|
2009-12-22 |
2015-09-29 |
Novartis Ag |
ISOQUINOLINONES AND REPLACED QUINAZOLINONES
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
EP2348020A1
(en)
|
2009-12-23 |
2011-07-27 |
Esteve Química, S.A. |
Preparation process of erlotinib
|
RU2012132278A
(en)
|
2010-01-12 |
2014-02-20 |
Ф. Хоффманн-Ля Рош Аг |
TRICYCLIC HETEROCYCLIC COMPOUNDS CONTAINING THEIR COMPOSITIONS AND WAYS OF THEIR APPLICATION
|
EP2542692B1
(en)
|
2010-03-04 |
2016-08-24 |
Carpén, Olli |
Method for selecting patients for treatment with an egfr inhibitor
|
BR112012023382A2
(en)
|
2010-03-17 |
2018-05-15 |
F Hoffmann La Roche Ag T |
imidazopyridine compounds, compositions and methods of use.
|
WO2011120134A1
(en)
|
2010-03-29 |
2011-10-06 |
Zymeworks, Inc. |
Antibodies with enhanced or suppressed effector function
|
MX2012011887A
(en)
|
2010-04-16 |
2012-11-30 |
Genentech Inc |
Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy.
|
DE202010006543U1
(en)
|
2010-05-07 |
2010-09-09 |
Ratiopharm Gmbh |
Erlotinibresinat
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
EP2592083A4
(en)
|
2010-05-21 |
2014-01-22 |
Shenzhen Salubris Pharm Co Ltd |
Fused quinazoline derivatives and uses thereof
|
WO2011147102A1
(en)
*
|
2010-05-28 |
2011-12-01 |
翔真生物科技股份有限公司 |
Synthetic method for 6,7-substituents-4-aniline quinazoline
|
CA2802644C
(en)
|
2010-06-25 |
2017-02-21 |
Eisai R & D Management Co., Ltd. |
Antitumor agent using compounds having kinase inhibitory effect in combination
|
UA112517C2
(en)
|
2010-07-06 |
2016-09-26 |
Новартіс Аг |
TETRAHYDROPYRIDOPYRIMIDINE DERIVATIVES
|
US8952022B2
(en)
*
|
2010-07-23 |
2015-02-10 |
Generics [Uk] Limited |
Pure erlotinib
|
AR082418A1
(en)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO
|
WO2012035039A1
(en)
|
2010-09-15 |
2012-03-22 |
F. Hoffmann-La Roche Ag |
Azabenzothiazole compounds, compositions and methods of use
|
US8946260B2
(en)
|
2010-09-16 |
2015-02-03 |
Novartis Ag |
17α-hydroxylase/C17,20-lyase inhibitors
|
IT1402029B1
(en)
|
2010-10-14 |
2013-08-28 |
Italiana Sint Spa |
PROCEDURE FOR THE PREPARATION OF ERLOTINIB
|
US9309322B2
(en)
|
2010-11-12 |
2016-04-12 |
Scott & White Healthcare (Swh) |
Antibodies to tumor endothelial marker 8
|
WO2012066061A1
(en)
|
2010-11-19 |
2012-05-24 |
F. Hoffmann-La Roche Ag |
Pyrazolopyridines and pyrazolopyridines and their use as tyk2 inhibitors
|
EA024026B1
(en)
*
|
2010-11-25 |
2016-08-31 |
Рациофарм Гмбх |
Novel salts and polymorphic forms of afatinib
|
DE102010053124A1
(en)
|
2010-12-01 |
2012-06-06 |
Volkswagen Ag |
Clutch, particularly for transmission of motor vehicle, particularly dual clutch for automatic or automated dual clutch transmission, has friction clutch, which is connected with motor shaft on one side
|
AU2011346567A1
(en)
|
2010-12-21 |
2013-07-25 |
Novartis Ag |
Bi-heteroaryl compounds as Vps34 inhibitors
|
EP2468883A1
(en)
|
2010-12-22 |
2012-06-27 |
Pangaea Biotech S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
WO2012085176A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors
|
US9134297B2
(en)
|
2011-01-11 |
2015-09-15 |
Icahn School Of Medicine At Mount Sinai |
Method and compositions for treating cancer and related methods
|
PE20140293A1
(en)
|
2011-01-31 |
2014-03-19 |
Novartis Ag |
NEW HETERO CYCLIC DERIVATIVES
|
EP2673277A1
(en)
|
2011-02-10 |
2013-12-18 |
Novartis AG |
[1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
EP2492688A1
(en)
|
2011-02-23 |
2012-08-29 |
Pangaea Biotech, S.A. |
Molecular biomarkers for predicting response to antitumor treatment in lung cancer
|
JP5808826B2
(en)
|
2011-02-23 |
2015-11-10 |
インテリカイン, エルエルシー |
Heterocyclic compounds and uses thereof
|
KR20220031732A
(en)
|
2011-03-04 |
2022-03-11 |
뉴젠 세러퓨틱스 인코포레이티드 |
Alkyne substituted quinazoline compound and methods of use
|
US8609818B2
(en)
|
2011-03-10 |
2013-12-17 |
Omeros Corporation |
Generation of anti-FN14 monoclonal antibodies by ex-vivo accelerated antibody evolution
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
CA2828946C
(en)
|
2011-04-18 |
2016-06-21 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
GB201106870D0
(en)
|
2011-04-26 |
2011-06-01 |
Univ Belfast |
Marker
|
MX359399B
(en)
|
2011-04-28 |
2018-09-27 |
Novartis Ag |
17a-HYDROXYLASE/C17,20-LYASE INHIBITORS.
|
WO2012155339A1
(en)
*
|
2011-05-17 |
2012-11-22 |
江苏康缘药业股份有限公司 |
4-phenylamino-6-butenamide-7-alkyloxy quinazoline derivatives, preparative method and use thereof
|
US9945862B2
(en)
|
2011-06-03 |
2018-04-17 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
MX2013014398A
(en)
|
2011-06-09 |
2014-03-21 |
Novartis Ag |
Heterocyclic sulfonamide derivatives.
|
EP2721007B1
(en)
|
2011-06-20 |
2015-04-29 |
Novartis AG |
Cyclohexyl isoquinolinone compounds
|
EP2721008B1
(en)
|
2011-06-20 |
2015-04-29 |
Novartis AG |
Hydroxy substituted isoquinolinone derivatives as p53 (mdm2 or mdm4) inhibitors
|
CN102267952B
(en)
*
|
2011-06-21 |
2013-12-11 |
天津市汉康医药生物技术有限公司 |
Quinazoline compound and preparation method and application thereof
|
WO2013001445A1
(en)
|
2011-06-27 |
2013-01-03 |
Novartis Ag |
Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
|
US8575339B2
(en)
*
|
2011-07-05 |
2013-11-05 |
Xueheng Cheng |
Derivatives of erlotinib
|
WO2013007765A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Fused tricyclic compounds for use as inhibitors of janus kinases
|
WO2013007768A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
|
AU2012295394B2
(en)
|
2011-08-12 |
2016-04-14 |
Omeros Corporation |
Anti-FZD10 monoclonal antibodies and methods for their use
|
CN103889976A
(en)
|
2011-08-12 |
2014-06-25 |
弗·哈夫曼-拉罗切有限公司 |
Indazole compounds, compositions and methods of use
|
CN104024432B
(en)
|
2011-08-31 |
2017-02-22 |
基因泰克公司 |
Diagnostic Markers
|
ES2691650T3
(en)
|
2011-09-15 |
2018-11-28 |
Novartis Ag |
3- (quinolin-6-yl-thio) - [1,2,4] -triazolo- [4,3-a] -pyridines 6-substituted as inhibitors of tyrosine kinase c-Met
|
JP2014526538A
(en)
|
2011-09-20 |
2014-10-06 |
エフ.ホフマン−ラ ロシュ アーゲー |
Imidazopyridine compounds, compositions and methods of use
|
JP2014531213A
(en)
|
2011-09-30 |
2014-11-27 |
ジェネンテック, インコーポレイテッド |
Diagnostic methylation markers for epithelial or mesenchymal phenotype and response to EGFR kinase inhibitors in tumors or tumor cells
|
HU230483B1
(en)
|
2011-10-10 |
2016-07-28 |
Egis Gyógyszergyár Nyrt. |
Erlotinib salts
|
WO2013056069A1
(en)
|
2011-10-13 |
2013-04-18 |
Bristol-Myers Squibb Company |
Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors
|
EP2771342B1
(en)
|
2011-10-28 |
2016-05-18 |
Novartis AG |
Purine derivatives and their use in the treatment of disease
|
WO2013080141A1
(en)
|
2011-11-29 |
2013-06-06 |
Novartis Ag |
Pyrazolopyrrolidine compounds
|
US9408885B2
(en)
|
2011-12-01 |
2016-08-09 |
Vib Vzw |
Combinations of therapeutic agents for treating melanoma
|
EP2794594A1
(en)
|
2011-12-22 |
2014-10-29 |
Novartis AG |
Quinoline derivatives
|
PL2794600T3
(en)
|
2011-12-22 |
2018-06-29 |
Novartis Ag |
2,3-Dihydro-benzo[1,4]oxazine derivatives and related compounds as phosphoinositide-3 kinase (PI3K) inhibitors for the treatment of e.g. rheumatoid arthritis
|
MX2014007731A
(en)
|
2011-12-23 |
2015-01-12 |
Novartis Ag |
Compounds for inhibiting the interaction of bcl2 with binding partners.
|
BR112014015308A2
(en)
|
2011-12-23 |
2017-06-13 |
Novartis Ag |
compounds for inhibiting bcl2 interaction with binding counterparts
|
CA2859869A1
(en)
|
2011-12-23 |
2013-06-27 |
Novartis Ag |
Compounds for inhibiting the interaction of bcl2 with binding partners
|
EA201491259A1
(en)
|
2011-12-23 |
2014-11-28 |
Новартис Аг |
COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF BCL2 WITH BOND PARTNERS
|
US9126980B2
(en)
|
2011-12-23 |
2015-09-08 |
Novartis Ag |
Compounds for inhibiting the interaction of BCL2 with binding partners
|
JO3357B1
(en)
|
2012-01-26 |
2019-03-13 |
Novartis Ag |
Imidazopyrrolidinone compounds
|
AU2013229786B2
(en)
|
2012-03-08 |
2017-06-22 |
Halozyme, Inc. |
Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
|
JP2015514710A
(en)
|
2012-03-27 |
2015-05-21 |
ジェネンテック, インコーポレイテッド |
Diagnosis and treatment of HER3 inhibitors
|
RU2660354C2
(en)
|
2012-04-03 |
2018-07-05 |
Новартис Аг |
Combined products containing tyrosine kinase inhibitors and their use
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
AU2013263043B2
(en)
|
2012-05-16 |
2016-06-16 |
Novartis Ag |
Dosage regimen for a PI-3 kinase inhibitor
|
JP6171003B2
(en)
|
2012-05-24 |
2017-07-26 |
ノバルティス アーゲー |
Pyrrolopyrrolidinone compounds
|
JP6427097B2
(en)
|
2012-06-15 |
2018-11-21 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. |
Compositions for treating cancer and methods for producing said compositions
|
WO2013190089A1
(en)
|
2012-06-21 |
2013-12-27 |
Pangaea Biotech, S.L. |
Molecular biomarkers for predicting outcome in lung cancer
|
NZ630289A
(en)
|
2012-09-04 |
2016-08-26 |
Shilpa Medicare Ltd |
Crystalline erlotinib hydrochloride process
|
TW201422625A
(en)
|
2012-11-26 |
2014-06-16 |
Novartis Ag |
Solid form of dihydro-pyrido-oxazine derivative
|
WO2014098176A1
(en)
|
2012-12-21 |
2014-06-26 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
Amorphous form of quinoline derivative, and method for producing same
|
EP2948453B1
(en)
|
2013-01-22 |
2017-08-02 |
Novartis AG |
Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction
|
US9403827B2
(en)
|
2013-01-22 |
2016-08-02 |
Novartis Ag |
Substituted purinone compounds
|
WO2014118112A1
(en)
|
2013-01-29 |
2014-08-07 |
Synthon B.V. |
Pharmaceutical composition comprising erlotinib hydrochloride
|
WO2014128612A1
(en)
|
2013-02-20 |
2014-08-28 |
Novartis Ag |
Quinazolin-4-one derivatives
|
EP2961412A4
(en)
|
2013-02-26 |
2016-11-09 |
Triact Therapeutics Inc |
Cancer therapy
|
US20140275092A1
(en)
|
2013-03-13 |
2014-09-18 |
Constellation Pharmaceuticals, Inc. |
Pyrazolo compounds and uses thereof
|
WO2014151147A1
(en)
|
2013-03-15 |
2014-09-25 |
Intellikine, Llc |
Combination of kinase inhibitors and uses thereof
|
US20160051556A1
(en)
|
2013-03-21 |
2016-02-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method and Pharmaceutical Composition for use in the Treatment of Chronic Liver Diseases Associated with a Low Hepcidin Expression
|
WO2014155268A2
(en)
|
2013-03-25 |
2014-10-02 |
Novartis Ag |
Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
|
KR102204279B1
(en)
|
2013-05-14 |
2021-01-15 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
US20150018376A1
(en)
|
2013-05-17 |
2015-01-15 |
Novartis Ag |
Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
|
UY35675A
(en)
|
2013-07-24 |
2015-02-27 |
Novartis Ag |
SUBSTITUTED DERIVATIVES OF QUINAZOLIN-4-ONA
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
WO2015022663A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
WO2015022664A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
EP3041474B1
(en)
|
2013-09-05 |
2020-03-18 |
Genentech, Inc. |
Antiproliferative compounds
|
US9381246B2
(en)
|
2013-09-09 |
2016-07-05 |
Triact Therapeutics, Inc. |
Cancer therapy
|
MX2016003256A
(en)
|
2013-09-12 |
2016-06-07 |
Halozyme Inc |
Modified anti-epidermal growth factor receptor antibodies and methods of use thereof.
|
BR112016003229A8
(en)
|
2013-09-22 |
2020-02-04 |
Calitor Sciences Llc |
compound, pharmaceutical composition, and, use of a compound or pharmaceutical composition
|
AR097894A1
(en)
|
2013-10-03 |
2016-04-20 |
Hoffmann La Roche |
CDK8 THERAPEUTIC INHIBITORS OR USE OF THE SAME
|
WO2015084804A1
(en)
|
2013-12-03 |
2015-06-11 |
Novartis Ag |
Combination of mdm2 inhibitor and braf inhibitor and their use
|
TN2016000179A1
(en)
|
2013-12-06 |
2017-10-06 |
Novartis Ag |
Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor.
|
EP3527587A1
(en)
|
2013-12-17 |
2019-08-21 |
F. Hoffmann-La Roche AG |
Combination therapy comprising ox40 binding agonists and pd-l1 binding antagonists
|
CN112353943A
(en)
|
2013-12-17 |
2021-02-12 |
豪夫迈·罗氏有限公司 |
Methods of treating cancer with PD-1 axis binding antagonists and taxanes
|
US9242965B2
(en)
|
2013-12-31 |
2016-01-26 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
|
WO2015145388A2
(en)
|
2014-03-27 |
2015-10-01 |
Novartis Ag |
Methods of treating colorectal cancers harboring upstream wnt pathway mutations
|
WO2015148867A1
(en)
|
2014-03-28 |
2015-10-01 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
CA2943262A1
(en)
|
2014-03-31 |
2015-10-08 |
Genentech, Inc. |
Anti-ox40 antibodies and methods of use
|
BR112016022345A2
(en)
|
2014-03-31 |
2017-10-10 |
Genentech Inc |
combination therapy comprising antiangiogenesis agents and ox40 binding agonists
|
WO2015153345A1
(en)
|
2014-04-03 |
2015-10-08 |
Invictus Oncology Pvt. Ltd. |
Supramolecular combinatorial therapeutics
|
WO2015156674A2
(en)
|
2014-04-10 |
2015-10-15 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
CN107207510B
(en)
|
2014-07-31 |
2019-11-29 |
诺华股份有限公司 |
Conjoint therapy
|
MX2017001980A
(en)
|
2014-08-28 |
2017-05-04 |
Eisai R&D Man Co Ltd |
High-purity quinoline derivative and method for manufacturing same.
|
JP6814730B2
(en)
|
2014-09-05 |
2021-01-20 |
ジェネンテック, インコーポレイテッド |
Therapeutic compounds and their use
|
JP2017529358A
(en)
|
2014-09-19 |
2017-10-05 |
ジェネンテック, インコーポレイテッド |
Use of CBP / EP300 inhibitors and BET inhibitors for the treatment of cancer
|
JP6783230B2
(en)
|
2014-10-10 |
2020-11-11 |
ジェネンテック, インコーポレイテッド |
Pyrrolidone amide compounds as inhibitors of histone demethylase
|
ES2855075T3
(en)
|
2014-10-17 |
2021-09-23 |
Novartis Ag |
Combination of ceritinib with an EGFR inhibitor
|
CA2908441A1
(en)
|
2014-10-28 |
2016-04-28 |
Cerbios-Pharma Sa |
Process for the preparation of erlotinib
|
MX2017005751A
(en)
|
2014-11-03 |
2018-04-10 |
Genentech Inc |
Method and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment.
|
EP3215850B1
(en)
|
2014-11-03 |
2019-07-03 |
F. Hoffmann-La Roche AG |
Assays for detecting t cell immune subsets and methods of use thereof
|
WO2016073282A1
(en)
|
2014-11-06 |
2016-05-12 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
MA40943A
(en)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS
|
MA40940A
(en)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS
|
WO2016077375A1
(en)
|
2014-11-10 |
2016-05-19 |
Genentech, Inc. |
Bromodomain inhibitors and uses thereof
|
MX2017006320A
(en)
|
2014-11-17 |
2017-08-10 |
Genentech Inc |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists.
|
WO2016082879A1
(en)
*
|
2014-11-27 |
2016-06-02 |
Synthon B.V. |
Pharmaceutical composition comprising erlotinib hydrochloride
|
EP3632915A1
(en)
|
2014-11-27 |
2020-04-08 |
Genentech, Inc. |
4,5,6,7-tetrahydro-1 h-pyrazolo[4,3-c]pyridin-3-amine compounds as cbp and/or ep300 inhibitors
|
WO2016106340A2
(en)
|
2014-12-23 |
2016-06-30 |
Genentech, Inc. |
Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
|
SG11201704852SA
(en)
|
2014-12-24 |
2017-07-28 |
Genentech Inc |
Therapeutic, diagnostic and prognostic methods for cancer of the bladder
|
EP3240908A2
(en)
|
2014-12-30 |
2017-11-08 |
F. Hoffmann-La Roche AG |
Methods and compositions for prognosis and treatment of cancers
|
JP6659703B2
(en)
|
2015-01-09 |
2020-03-04 |
ジェネンテック, インコーポレイテッド |
Pyridazinone derivatives and their use in the treatment of cancer
|
WO2016112284A1
(en)
|
2015-01-09 |
2016-07-14 |
Genentech, Inc. |
(piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer
|
WO2016112251A1
(en)
|
2015-01-09 |
2016-07-14 |
Genentech, Inc. |
4,5-dihydroimidazole derivatives and their use as histone demethylase (kdm2b) inhibitors
|
EP3250571B1
(en)
|
2015-01-29 |
2022-11-30 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
EP3250552B1
(en)
|
2015-01-30 |
2019-03-27 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
BR112017017428A2
(en)
|
2015-02-25 |
2018-04-03 |
Eisai R&D Management Co., Ltd. |
" method for suppressing the bitterness of quinoline derivative "
|
MA41598A
(en)
|
2015-02-25 |
2018-01-02 |
Constellation Pharmaceuticals Inc |
PYRIDAZINE THERAPEUTIC COMPOUNDS AND THEIR USES
|
CN104725327B
(en)
*
|
2015-03-03 |
2017-08-25 |
山东大学 |
A kind of environment-friendly preparation method of erlotinib Hydrochloride
|
KR102662228B1
(en)
|
2015-03-04 |
2024-05-02 |
머크 샤프 앤드 돔 코포레이션 |
Combination of PD-1 antagonists and VEGFR/FGFR/RET tyrosine kinase inhibitors to treat cancer
|
MX2017012805A
(en)
|
2015-04-07 |
2018-04-11 |
Genentech Inc |
Antigen binding complex having agonistic activity and methods of use.
|
HRP20201900T4
(en)
|
2015-05-12 |
2024-06-07 |
F. Hoffmann - La Roche Ag |
Therapeutic and diagnostic methods for cancer
|
WO2016196298A1
(en)
|
2015-05-29 |
2016-12-08 |
Genentech, Inc. |
Therapeutic and diagnolstic methods for cancer
|
WO2016200836A1
(en)
|
2015-06-08 |
2016-12-15 |
Genentech, Inc. |
Methods of treating cancer using anti-ox40 antibodies
|
WO2016200835A1
(en)
|
2015-06-08 |
2016-12-15 |
Genentech, Inc. |
Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
|
JP6757959B2
(en)
|
2015-06-16 |
2020-09-23 |
株式会社 PRISM BioLab |
Anti-cancer agent
|
CA2986263A1
(en)
|
2015-06-17 |
2016-12-22 |
Genentech, Inc. |
Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes
|
CN105017162B
(en)
*
|
2015-06-26 |
2017-10-27 |
陕西师范大学 |
4 pairs of propenylbenzene amido quinazoline derivatives and its application in antineoplastic is prepared
|
JP6946270B2
(en)
|
2015-08-26 |
2021-10-06 |
ファンダシオン デル セクトル プーブリコ エスタタル セントロ ナショナル デ インベスティゲーショネス オンコロジカス カルロス 3(エフ エス ピー クニオ) |
Condensed tricyclic compound as a protein kinase inhibitor
|
JP2018526376A
(en)
|
2015-08-28 |
2018-09-13 |
ノバルティス アーゲー |
Includes (A) the cyclin-dependent kinase 4/6 (CDK4 / 6) inhibitor LEE011 (= ribocyclib) and (B) the epidermal growth factor receptor (EGFR) inhibitor erlotinib for the treatment or prevention of cancer Pharmaceutical combination
|
JP2018532990A
(en)
|
2015-09-04 |
2018-11-08 |
オービーアイ ファーマ,インコーポレイテッド |
Glycan arrays and methods of use
|
WO2017044434A1
(en)
|
2015-09-11 |
2017-03-16 |
Sunshine Lake Pharma Co., Ltd. |
Substituted heteroaryl compounds and methods of use
|
CA2994858C
(en)
|
2015-09-25 |
2024-01-23 |
Genentech, Inc. |
Anti-tigit antibodies and methods of use
|
RU2018119085A
(en)
|
2015-11-02 |
2019-12-04 |
Новартис Аг |
SCHEME OF INTRODUCTION OF THE PHOSPHATIDYLINOSITOL-3-KINASE INHIBITOR
|
ES2907574T3
(en)
|
2015-12-16 |
2022-04-25 |
Genentech Inc |
Process for the preparation of tricyclic pi3k inhibitor compounds and methods for their use for the treatment of cancer.
|
AU2017205089B2
(en)
|
2016-01-08 |
2023-10-05 |
F. Hoffmann-La Roche Ag |
Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies
|
MX2018010361A
(en)
|
2016-02-29 |
2019-07-08 |
Genentech Inc |
Therapeutic and diagnostic methods for cancer.
|
CA3019560A1
(en)
|
2016-03-29 |
2017-10-05 |
Obi Pharma, Inc. |
Antibodies, pharmaceutical compositions and methods
|
US10980894B2
(en)
|
2016-03-29 |
2021-04-20 |
Obi Pharma, Inc. |
Antibodies, pharmaceutical compositions and methods
|
JP2019515670A
(en)
|
2016-04-15 |
2019-06-13 |
ジェネンテック, インコーポレイテッド |
Methods for monitoring and treating cancer
|
EP3443350B1
(en)
|
2016-04-15 |
2020-12-09 |
H. Hoffnabb-La Roche Ag |
Methods for monitoring and treating cancer
|
CA3018406A1
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
EP3445395A4
(en)
|
2016-04-22 |
2019-12-25 |
OBI Pharma, Inc. |
Cancer immunotherapy by immune activation or immune modulation via globo series antigens
|
US20190151346A1
(en)
|
2016-05-10 |
2019-05-23 |
INSERM (Institute National de la Santé et de la Recherche Médicale) |
Combinations therapies for the treatment of cancer
|
EP4067347B1
(en)
|
2016-05-24 |
2024-06-19 |
Genentech, Inc. |
Heterocyclic inhibitors of cbp/ep300 for the treatment of cancer
|
EP3464286B1
(en)
|
2016-05-24 |
2021-08-18 |
Genentech, Inc. |
Pyrazolopyridine derivatives for the treatment of cancer
|
EP4371570A3
(en)
|
2016-06-08 |
2024-07-17 |
Xencor, Inc. |
Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b
|
US20200129519A1
(en)
|
2016-06-08 |
2020-04-30 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
KR20230117482A
(en)
|
2016-07-27 |
2023-08-08 |
오비아이 파머 인코퍼레이티드 |
Immunogenic/therapeutic glycan compositions and uses thereof
|
EP3491026A4
(en)
|
2016-07-29 |
2020-07-29 |
OBI Pharma, Inc. |
Human antibodies, pharmaceutical compositions and methods
|
WO2018027204A1
(en)
|
2016-08-05 |
2018-02-08 |
Genentech, Inc. |
Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
|
CN109476748B
(en)
|
2016-08-08 |
2023-05-23 |
豪夫迈·罗氏有限公司 |
Methods for treatment and diagnosis of cancer
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
AU2017339517B2
(en)
|
2016-10-06 |
2024-03-14 |
Foundation Medicine, Inc. |
Therapeutic and diagnostic methods for cancer
|
WO2018078143A1
(en)
|
2016-10-28 |
2018-05-03 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Means and methods for determining efficacy of anti-egfr inhibitors in colorectal cancer (crc) therapy
|
EP3532091A2
(en)
|
2016-10-29 |
2019-09-04 |
H. Hoffnabb-La Roche Ag |
Anti-mic antibidies and methods of use
|
BR112019010356A2
(en)
|
2016-11-21 |
2019-08-27 |
Obi Pharma Inc |
carbohydrate molecule, antibody-antibody conjugate (adc), composition, method for preparing the composition, method for treating cancer in an individual, method for inducing or ameliorating the immune reaction in an individual in need thereof, drug-antibody conjugate compound, use of an antibody-drug conjugate compound, method for determining therapeutic efficacy of adcc cancer cells, and method for imaging an individual
|
JOP20190154B1
(en)
|
2016-12-22 |
2022-09-15 |
Amgen Inc |
Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
|
KR20190134631A
(en)
|
2017-03-01 |
2019-12-04 |
제넨테크, 인크. |
How to diagnose and treat cancer
|
CN106928069B
(en)
*
|
2017-03-21 |
2019-03-19 |
上海玉函化工有限公司 |
A kind of preparation method of 4,5- bis- (2- methoxy ethoxy) -2- ethyl nitrobenzoate
|
WO2018189220A1
(en)
|
2017-04-13 |
2018-10-18 |
F. Hoffmann-La Roche Ag |
An interleukin-2 immunoconjugate, a cd40 agonist, and optionally a pd-1 axis binding antagonist for use in methods of treating cancer
|
JOP20190272A1
(en)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same
|
CN107200715B
(en)
*
|
2017-06-22 |
2020-05-29 |
陕西师范大学 |
Quinazoline derivative and application thereof in preparation of antitumor drugs
|
AU2018304458B2
(en)
|
2017-07-21 |
2021-12-09 |
Foundation Medicine, Inc. |
Therapeutic and diagnostic methods for cancer
|
KR20200037366A
(en)
|
2017-08-11 |
2020-04-08 |
제넨테크, 인크. |
Anti-CD8 antibodies and uses thereof
|
EP4141005B1
(en)
|
2017-09-08 |
2024-04-03 |
Amgen Inc. |
Inhibitors of kras g12c and methods of using the same
|
CN111373055A
(en)
|
2017-09-08 |
2020-07-03 |
豪夫迈·罗氏有限公司 |
Methods for diagnosis and treatment of cancer
|
US20200290978A1
(en)
*
|
2017-09-26 |
2020-09-17 |
The Regents Of The University Of California |
Compositions and methods for treating cancer
|
WO2019084395A1
(en)
|
2017-10-27 |
2019-05-02 |
University Of Virginia Patent Foundation |
Compounds and methods for regulating, limiting, or inhibiting avil expression
|
EP3707510B1
(en)
|
2017-11-06 |
2024-06-26 |
F. Hoffmann-La Roche AG |
Diagnostic and therapeutic methods for cancer
|
JP7254076B2
(en)
|
2017-11-19 |
2023-04-07 |
サンシャイン・レイク・ファーマ・カンパニー・リミテッド |
Substituted heteroaryl compounds and methods of use
|
WO2019143874A1
(en)
|
2018-01-20 |
2019-07-25 |
Sunshine Lake Pharma Co., Ltd. |
Substituted aminopyrimidine compounds and methods of use
|
JP7480048B2
(en)
|
2018-01-26 |
2024-05-09 |
エグゼリクシス, インコーポレイテッド |
Compounds for treating kinase-dependent disorders
|
CA3088127A1
(en)
|
2018-01-26 |
2019-08-01 |
Exelixis, Inc. |
Compounds for the treatment of kinase-dependent disorders
|
JP7321165B2
(en)
|
2018-01-26 |
2023-08-04 |
エグゼリクシス, インコーポレイテッド |
Compounds for treating kinase dependent disorders
|
TWI660728B
(en)
*
|
2018-02-09 |
2019-06-01 |
國立交通大學 |
Quinazolinamine derivatives and pharmaceutical compositions and uses thereof
|
CA3092108A1
(en)
|
2018-02-26 |
2019-08-29 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
WO2019213526A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
MX2020010836A
(en)
|
2018-05-04 |
2021-01-08 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same.
|
MA52564A
(en)
|
2018-05-10 |
2021-03-17 |
Amgen Inc |
KRAS G12C INHIBITORS FOR CANCER TREATMENT
|
AU2019275404A1
(en)
|
2018-05-21 |
2020-12-03 |
Nanostring Technologies, Inc. |
Molecular gene signatures and methods of using same
|
MA52765A
(en)
|
2018-06-01 |
2021-04-14 |
Amgen Inc |
KRAS G12C INHIBITORS AND THEIR PROCEDURES FOR USE
|
MA52780A
(en)
|
2018-06-11 |
2021-04-14 |
Amgen Inc |
KRAS G12C INHIBITORS FOR CANCER TREATMENT
|
MA51848A
(en)
|
2018-06-12 |
2021-04-21 |
Amgen Inc |
KRAS G12C INHIBITORS AND THEIR PROCEDURES FOR USE
|
AU2019288728A1
(en)
|
2018-06-23 |
2021-01-14 |
Genentech, Inc. |
Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
|
US11203645B2
(en)
|
2018-06-27 |
2021-12-21 |
Obi Pharma, Inc. |
Glycosynthase variants for glycoprotein engineering and methods of use
|
CN110642796B
(en)
*
|
2018-06-27 |
2023-03-17 |
烟台药物研究所 |
Quinazoline derivative and application thereof
|
BR112021000673A2
(en)
|
2018-07-18 |
2021-04-20 |
Genentech, Inc. |
methods for treating an individual with lung cancer, kits, anti-pd-l1 antibody and compositions
|
JP2021535169A
(en)
|
2018-09-03 |
2021-12-16 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
Carboxamide and sulfonamide derivatives useful as TEAD modulators
|
MX2021003214A
(en)
|
2018-09-19 |
2021-05-12 |
Genentech Inc |
Therapeutic and diagnostic methods for bladder cancer.
|
EP4249917A3
(en)
|
2018-09-21 |
2023-11-08 |
F. Hoffmann-La Roche AG |
Diagnostic methods for triple-negative breast cancer
|
CN113382986A
(en)
|
2018-09-25 |
2021-09-10 |
黑钻治疗公司 |
Tyrosine kinase inhibitor compositions, methods of making and methods of using the same
|
US20210393632A1
(en)
|
2018-10-04 |
2021-12-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Egfr inhibitors for treating keratodermas
|
CN113196061A
(en)
|
2018-10-18 |
2021-07-30 |
豪夫迈·罗氏有限公司 |
Methods of diagnosis and treatment of sarcoma-like renal cancer
|
CA3117221A1
(en)
|
2018-11-16 |
2020-05-22 |
Amgen Inc. |
Improved synthesis of key intermediate of kras g12c inhibitor compound
|
JP7377679B2
(en)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
|
AU2019384118A1
(en)
|
2018-11-19 |
2021-05-27 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
WO2020132651A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Kif18a inhibitors
|
CN113226473A
(en)
|
2018-12-20 |
2021-08-06 |
美国安进公司 |
KIF18A inhibitors
|
CA3123044A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Heteroaryl amides useful as kif18a inhibitors
|
MA54546A
(en)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS
|
JPWO2020130125A1
(en)
|
2018-12-21 |
2021-11-04 |
第一三共株式会社 |
Combination of antibody-drug conjugate and kinase inhibitor
|
WO2020163589A1
(en)
|
2019-02-08 |
2020-08-13 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
KR20210133237A
(en)
|
2019-02-27 |
2021-11-05 |
제넨테크, 인크. |
Dosing for treatment with anti-TIGIT and anti-CD20 or anti-CD38 antibodies
|
EP3931565A4
(en)
|
2019-02-27 |
2023-04-12 |
Epiaxis Therapeutics Pty Ltd |
Methods and agents for assessing t-cell function and predicting response to therapy
|
KR20210146287A
(en)
|
2019-03-01 |
2021-12-03 |
레볼루션 메디슨즈, 인크. |
Bicyclic heteroaryl compounds and uses thereof
|
CN113727758A
(en)
|
2019-03-01 |
2021-11-30 |
锐新医药公司 |
Bicyclic heterocyclic compounds and use thereof
|
WO2020223233A1
(en)
|
2019-04-30 |
2020-11-05 |
Genentech, Inc. |
Prognostic and therapeutic methods for colorectal cancer
|
KR20220004744A
(en)
|
2019-05-03 |
2022-01-11 |
제넨테크, 인크. |
Methods of Treating Cancer Using Anti-PD-L1 Antibodies
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
CN114144414A
(en)
|
2019-05-21 |
2022-03-04 |
美国安进公司 |
Solid state form
|
CN112300279A
(en)
|
2019-07-26 |
2021-02-02 |
上海复宏汉霖生物技术股份有限公司 |
Methods and compositions directed to anti-CD 73 antibodies and variants
|
AU2020324963A1
(en)
|
2019-08-02 |
2022-02-24 |
Amgen Inc. |
KIF18A inhibitors
|
CN114401953A
(en)
|
2019-08-02 |
2022-04-26 |
美国安进公司 |
KIF18A inhibitors
|
JP2022542392A
(en)
|
2019-08-02 |
2022-10-03 |
アムジエン・インコーポレーテツド |
Pyridine derivatives as KIF18A inhibitors
|
AU2020326627A1
(en)
|
2019-08-02 |
2022-03-17 |
Amgen Inc. |
KIF18A inhibitors
|
US20230192853A1
(en)
|
2019-09-04 |
2023-06-22 |
Genentech, Inc. |
Cd8 binding agents and uses thereof
|
US20220315579A1
(en)
|
2019-09-26 |
2022-10-06 |
Exelixis, Inc. |
Pyridone compounds and methods of use
|
WO2021062085A1
(en)
|
2019-09-27 |
2021-04-01 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
WO2021081212A1
(en)
|
2019-10-24 |
2021-04-29 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
CN114728936A
(en)
|
2019-10-29 |
2022-07-08 |
豪夫迈·罗氏有限公司 |
Bifunctional compounds for the treatment of cancer
|
TW202132314A
(en)
|
2019-11-04 |
2021-09-01 |
美商銳新醫藥公司 |
Ras inhibitors
|
BR112022008565A2
(en)
|
2019-11-04 |
2022-08-09 |
Revolution Medicines Inc |
COMPOUND, PHARMACEUTICAL COMPOSITION, CONJUGATE, METHODS TO TREAT CANCER AND A RAS PROTEIN-RELATED DISORDER
|
CN115873020A
(en)
|
2019-11-04 |
2023-03-31 |
锐新医药公司 |
RAS inhibitors
|
CN115066613A
(en)
|
2019-11-06 |
2022-09-16 |
基因泰克公司 |
Diagnostic and therapeutic methods for treating hematologic cancers
|
KR20220100903A
(en)
|
2019-11-08 |
2022-07-18 |
레볼루션 메디슨즈, 인크. |
Bicyclic heteroaryl compounds and uses thereof
|
WO2021094379A1
(en)
|
2019-11-12 |
2021-05-20 |
Astrazeneca Ab |
Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
|
EP4058435A1
(en)
|
2019-11-13 |
2022-09-21 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
AR120456A1
(en)
|
2019-11-14 |
2022-02-16 |
Amgen Inc |
ENHANCED SYNTHESIS OF KRAS G12C INHIBITOR COMPOUND
|
MX2022005708A
(en)
|
2019-11-14 |
2022-06-08 |
Amgen Inc |
Improved synthesis of kras g12c inhibitor compound.
|
CN114980976A
(en)
|
2019-11-27 |
2022-08-30 |
锐新医药公司 |
Covalent RAS inhibitors and uses thereof
|
AU2020403145A1
(en)
|
2019-12-13 |
2022-07-07 |
Genentech, Inc. |
Anti-Ly6G6D antibodies and methods of use
|
WO2021127404A1
(en)
|
2019-12-20 |
2021-06-24 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
AU2021206217A1
(en)
|
2020-01-07 |
2022-09-01 |
Revolution Medicines, Inc. |
SHP2 inhibitor dosing and methods of treating cancer
|
US20230056604A1
(en)
|
2020-01-20 |
2023-02-23 |
Astrazeneca Ab |
Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
|
WO2021194481A1
(en)
|
2020-03-24 |
2021-09-30 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
EP4096646A1
(en)
|
2020-01-27 |
2022-12-07 |
Genentech, Inc. |
Methods for treatment of cancer with an anti-tigit antagonist antibody
|
WO2022050954A1
(en)
|
2020-09-04 |
2022-03-10 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
WO2021177980A1
(en)
|
2020-03-06 |
2021-09-10 |
Genentech, Inc. |
Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist
|
WO2021202959A1
(en)
|
2020-04-03 |
2021-10-07 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
WO2021222167A1
(en)
|
2020-04-28 |
2021-11-04 |
Genentech, Inc. |
Methods and compositions for non-small cell lung cancer immunotherapy
|
IL299039A
(en)
|
2020-06-16 |
2023-02-01 |
Genentech Inc |
Methods and compositions for treating triple-negative breast cancer
|
JP2023530351A
(en)
|
2020-06-18 |
2023-07-14 |
レヴォリューション・メディスンズ,インコーポレイテッド |
Methods of delaying, preventing and treating acquired resistance to RAS inhibitors
|
WO2021257124A1
(en)
|
2020-06-18 |
2021-12-23 |
Genentech, Inc. |
Treatment with anti-tigit antibodies and pd-1 axis binding antagonists
|
JP2023531290A
(en)
|
2020-06-30 |
2023-07-21 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
A method for predicting the risk of recurrence and/or death in patients with solid tumors after neoadjuvant therapy and definitive surgery
|
WO2022002873A1
(en)
|
2020-06-30 |
2022-01-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
|
US11787775B2
(en)
|
2020-07-24 |
2023-10-17 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
EP4189121A1
(en)
|
2020-08-03 |
2023-06-07 |
Genentech, Inc. |
Diagnostic and therapeutic methods for lymphoma
|
EP4196612A1
(en)
|
2020-08-12 |
2023-06-21 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
WO2022047243A1
(en)
|
2020-08-27 |
2022-03-03 |
Enosi Life Sciences Corp. |
Methods and compositions to treat autoimmune diseases and cancer
|
IL301062A
(en)
|
2020-09-03 |
2023-05-01 |
Revolution Medicines Inc |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
AU2021345111A1
(en)
|
2020-09-15 |
2023-04-06 |
Revolution Medicines, Inc. |
Indole derivatives as Ras inhibitors in the treatment of cancer
|
AU2021347232A1
(en)
|
2020-09-23 |
2023-04-27 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
CA3193952A1
(en)
|
2020-10-05 |
2022-04-14 |
Bernard Martin Fine |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
US20230107642A1
(en)
|
2020-12-18 |
2023-04-06 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
CN117396472A
(en)
|
2020-12-22 |
2024-01-12 |
上海齐鲁锐格医药研发有限公司 |
SOS1 inhibitors and uses thereof
|
PE20231505A1
(en)
|
2021-02-12 |
2023-09-26 |
Hoffmann La Roche |
BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER
|
US20240158393A1
(en)
|
2021-02-19 |
2024-05-16 |
Exelixis, Inc. |
Pyridone compounds and methods of use
|
MX2023013084A
(en)
|
2021-05-05 |
2023-11-17 |
Revolution Medicines Inc |
Ras inhibitors for the treatment of cancer.
|
JP2024516450A
(en)
|
2021-05-05 |
2024-04-15 |
レボリューション メディシンズ インコーポレイテッド |
Covalent RAS inhibitors and uses thereof
|
CA3217393A1
(en)
|
2021-05-05 |
2022-11-10 |
Elena S. Koltun |
Ras inhibitors
|
CA3221390A1
(en)
|
2021-05-25 |
2022-12-01 |
Erasca, Inc. |
Sulfur-containing heteroaromatic tricyclic kras inhibitors
|
WO2022266206A1
(en)
|
2021-06-16 |
2022-12-22 |
Erasca, Inc. |
Kras inhibitor conjugates
|
AU2022315530A1
(en)
|
2021-07-20 |
2024-01-18 |
Ags Therapeutics Sas |
Extracellular vesicles from microalgae, their preparation, and uses
|
EP4384522A1
(en)
|
2021-08-10 |
2024-06-19 |
Erasca, Inc. |
Selective kras inhibitors
|
AR127308A1
(en)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
RAS INHIBITORS
|
US20230202984A1
(en)
|
2021-11-24 |
2023-06-29 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
US20230203062A1
(en)
|
2021-11-24 |
2023-06-29 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
WO2023114954A1
(en)
|
2021-12-17 |
2023-06-22 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
WO2023144127A1
(en)
|
2022-01-31 |
2023-08-03 |
Ags Therapeutics Sas |
Extracellular vesicles from microalgae, their biodistribution upon administration, and uses
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
WO2023187037A1
(en)
|
2022-03-31 |
2023-10-05 |
Astrazeneca Ab |
Epidermal growth factor receptor (egfr) tyrosine kinase inhibitors in combination with an akt inhibitor for the treatment of cancer
|
WO2023191816A1
(en)
|
2022-04-01 |
2023-10-05 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
WO2023219613A1
(en)
|
2022-05-11 |
2023-11-16 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
WO2023240058A2
(en)
|
2022-06-07 |
2023-12-14 |
Genentech, Inc. |
Prognostic and therapeutic methods for cancer
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
WO2024002938A1
(en)
|
2022-06-27 |
2024-01-04 |
Astrazeneca Ab |
Combinations involving epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
|
WO2024015897A1
(en)
|
2022-07-13 |
2024-01-18 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
WO2024020432A1
(en)
|
2022-07-19 |
2024-01-25 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
WO2024033457A1
(en)
|
2022-08-11 |
2024-02-15 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydrothiazepine derivatives
|
WO2024033389A1
(en)
|
2022-08-11 |
2024-02-15 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydrothiazepine derivatives
|
WO2024033388A1
(en)
|
2022-08-11 |
2024-02-15 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydrothiazepine derivatives
|
WO2024033458A1
(en)
|
2022-08-11 |
2024-02-15 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydroazepine derivatives
|
WO2024081916A1
(en)
|
2022-10-14 |
2024-04-18 |
Black Diamond Therapeutics, Inc. |
Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
|
WO2024085242A2
(en)
|
2022-10-21 |
2024-04-25 |
Kawasaki Institute Of Industrial Promotion |
Non-fouling or super stealth vesicle
|
WO2024088808A1
(en)
|
2022-10-24 |
2024-05-02 |
Ags Therapeutics Sas |
Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof
|
WO2024091991A1
(en)
|
2022-10-25 |
2024-05-02 |
Genentech, Inc. |
Therapeutic and diagnostic methods for multiple myeloma
|