SU466233A1 - Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives - Google Patents

Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives

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Publication number
SU466233A1
SU466233A1 SU1932177A SU1932177A SU466233A1 SU 466233 A1 SU466233 A1 SU 466233A1 SU 1932177 A SU1932177 A SU 1932177A SU 1932177 A SU1932177 A SU 1932177A SU 466233 A1 SU466233 A1 SU 466233A1
Authority
SU
USSR - Soviet Union
Prior art keywords
methyl
producing
derivatives
dialkylaminoalkylaminoquinazoline
hydrogen
Prior art date
Application number
SU1932177A
Other languages
Russian (ru)
Inventor
Леонид Николаевич Яхонтов
Елена Васильевна Пронина
Галина Петровна Жихарева
Original Assignee
Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе filed Critical Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе
Priority to SU1932177A priority Critical patent/SU466233A1/en
Application granted granted Critical
Publication of SU466233A1 publication Critical patent/SU466233A1/en

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Description

(54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 2-МЕТИЛ-4ДИАЛКИЛАМИНОАЛКИЛАМИНОХИНАЗОЛИНА(54) METHOD FOR OBTAINING DERIVATIVES OF 2-METHYL-4 DIAHYL-ALINO ALKYLAMINOHINAZOLINE

1212

экстракт иро.мывают водой, сушат и упаривают . Остаток переКристаллизовьГВают из гептана . Получают 7,04 г целевого продукта (т. пл. 104-105° С) в виде бесцветных кристаллов, хорошо растворимых в эфи1ре, ххлороформе, ацетоне, энилацетате, спиртах, хуже растворимых IB гептане, нерастворимых ,в .В0,де. Выход 70%.extract iro.myvayut water, dried and evaporated. The residue is recrystallized from heptane. Obtain 7.04 g of the desired product (mp. 104-105 ° C) as colorless crystals, well soluble in ether, chloroform, acetone, enil acetate, alcohols, worse than soluble IB heptane, insoluble, in .B0, de. Yield 70%.

Найдено, %: С 72,23; Н 9,28; N 18,85.Found,%: C 72.23; H 9.28; N 18.85.

CisHas.CisHas.

18,65.18.65.

%: С 71,96; Н 9,39; N %: C, 71.96; H 9.39; N

Вычислено, могут быть получены сCalculated can be obtained with

АналогичноSimilarly

выходом 77-95%; наа1рпмер, 2-метал-4-д«эт,илай1ииоэтила-мнлохииазолин , 2,6-д.имет.ил-4-дн1метиламиноэтиламИ1нохиназол и н , 2-iMет1ил-4-дИметил ам1И1Н01П|рОП-ил аМИНО-6-.мето сихИназол1ИН.yield 77-95%; Naa1rpmer, 2-metal-4-d "et, illyiiioethyl-mnlohiazoline, 2,6-dimethyl-4-dnmethylaminoethylaminoquinazol and n, 2-iMet1yl-4-dImethyl sihInazol1IN.

Предмет изобретени  Способ получени  произ,водных 2-метил-4диалкила1 Ы ноал1К1Нла1М 1 НОХИ|назол:Ина оощеи формулыThe subject of the invention. Method for producing prod, aqueous 2-methyl-4-dialkyl 1 S Noal 1 C 1 N 1 1 M 1 NOHI | Design: Inoshe formulas

Л.L.

NH-A-ЯСNH-A-YAS

пдеR - ато-м водорода (Или галогена,pdeR - atoms of hydrogen (or halogen,

ал1какси;Г1руп1па ил1И алкил;al1acci; G1up1pa il1I alkyl;

RI 1Й Ra - алкил;RI 1Y Ra is alkyl;

А - нормальный или рааветвленный углаводоро дный р.адвкал, отличающийс  те.м, что производное 2-метил-4-хлор|Х|Иназоли .на (подвергают .взаИМОдействию с дйалкила .миноалюиламашом ,в среде /imepTiHoro растворител .A is a normal or branched hydrogen / hydrogen branch, characterized by the fact that 2-methyl-4-chloro | X | Inazoli is a derivative (subjected to interaction with dialkyl, aluminoylmash, in the medium / imepTiHoro solvent.

2. Cnocoi6 по п. 1, отличающийс  тем, что процесс провод т лри температуре ниже 100° С.2. Cnocoi6 according to claim 1, characterized in that the process is carried out at a temperature below 100 ° C.

SU1932177A 1973-06-08 1973-06-08 Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives SU466233A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU1932177A SU466233A1 (en) 1973-06-08 1973-06-08 Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1932177A SU466233A1 (en) 1973-06-08 1973-06-08 Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives

Publications (1)

Publication Number Publication Date
SU466233A1 true SU466233A1 (en) 1975-04-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
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Country Status (1)

Country Link
SU (1) SU466233A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019474A1 (en) * 1994-12-22 1996-06-27 Warner-Lambert Company Quinazolines as inhibitors of endothelin converting enzyme
USRE41065E1 (en) 1995-06-06 2009-12-29 Pfizer, Inc. Alkynl and azido-substituted 4-anilinoquinazolines
RU2694252C2 (en) * 1995-03-30 2019-07-10 Пфайзер Продактс Инк. Derivatives of 4-(substituted phenylamino)qyinazoline or pharmaceutically acceptable salts thereof, method of inhibiting receptor tyrosine kinase and pharmaceutical composition

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019474A1 (en) * 1994-12-22 1996-06-27 Warner-Lambert Company Quinazolines as inhibitors of endothelin converting enzyme
US5658902A (en) * 1994-12-22 1997-08-19 Warner-Lambert Company Quinazolines as inhibitors of endothelin converting enzyme
RU2694252C2 (en) * 1995-03-30 2019-07-10 Пфайзер Продактс Инк. Derivatives of 4-(substituted phenylamino)qyinazoline or pharmaceutically acceptable salts thereof, method of inhibiting receptor tyrosine kinase and pharmaceutical composition
USRE41065E1 (en) 1995-06-06 2009-12-29 Pfizer, Inc. Alkynl and azido-substituted 4-anilinoquinazolines

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