FI991477A - Menetelmä tolterodiinin valmistamiseksi - Google Patents

Menetelmä tolterodiinin valmistamiseksi Download PDF

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Publication number
FI991477A
FI991477A FI991477A FI991477A FI991477A FI 991477 A FI991477 A FI 991477A FI 991477 A FI991477 A FI 991477A FI 991477 A FI991477 A FI 991477A FI 991477 A FI991477 A FI 991477A
Authority
FI
Finland
Prior art keywords
tolterodine
preparation
benzopyran
dihydro
phenyl
Prior art date
Application number
FI991477A
Other languages
English (en)
Swedish (sv)
Other versions
FI991477A0 (fi
Inventor
James R Gage
John E Cabaj
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI991477A0 publication Critical patent/FI991477A0/fi
Publication of FI991477A publication Critical patent/FI991477A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
FI991477A 1996-12-31 1999-06-29 Menetelmä tolterodiinin valmistamiseksi FI991477A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3396196P 1996-12-31 1996-12-31
PCT/US1997/022521 WO1998029402A1 (en) 1996-12-31 1997-12-18 Process to prepare tolterodine

Publications (2)

Publication Number Publication Date
FI991477A0 FI991477A0 (fi) 1999-06-29
FI991477A true FI991477A (fi) 1999-06-29

Family

ID=21873473

Family Applications (1)

Application Number Title Priority Date Filing Date
FI991477A FI991477A (fi) 1996-12-31 1999-06-29 Menetelmä tolterodiinin valmistamiseksi

Country Status (23)

Country Link
US (1) US5922914A (fi)
EP (1) EP0960109B1 (fi)
JP (1) JP4199310B2 (fi)
KR (2) KR20000057548A (fi)
CN (1) CN1151141C (fi)
AT (1) ATE226949T1 (fi)
AU (1) AU717985B2 (fi)
CA (1) CA2273789C (fi)
CZ (1) CZ295477B6 (fi)
DE (1) DE69716767T2 (fi)
DK (1) DK0960109T3 (fi)
ES (1) ES2186018T3 (fi)
FI (1) FI991477A (fi)
HK (1) HK1023566A1 (fi)
HU (1) HUP0000527A3 (fi)
NO (1) NO317158B1 (fi)
NZ (1) NZ336533A (fi)
PL (1) PL191603B1 (fi)
PT (1) PT960109E (fi)
RU (1) RU2176246C2 (fi)
SI (1) SI0960109T1 (fi)
SK (1) SK283591B6 (fi)
WO (1) WO1998029402A1 (fi)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000515525A (ja) * 1996-07-19 2000-11-21 アベーグ，グンナー 尿と胃腸の疾患の治療におけるｓ（―）―トルテロジン
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
PT1196172E (pt) * 1999-07-01 2006-05-31 Pharmacia & Upjohn Co Llc (s,s)-reboxetina para tratar a dor cronica
SE9904850D0 (sv) * 1999-12-30 1999-12-30 Pharmacia & Upjohn Ab Novel process and intermediates
US6566537B2 (en) 1999-12-30 2003-05-20 Pharmacia Ab Process and intermediates
DE10028443C1 (de) * 2000-06-14 2002-05-29 Sanol Arznei Schwarz Gmbh Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
DE10033016A1 (de) * 2000-07-07 2002-01-24 Sanol Arznei Schwarz Gmbh Verfahren zur Herstellung von 3,3-Diarylpropylaminen
PE20020547A1 (es) 2000-10-24 2002-06-12 Upjohn Co Uso de la tolterodina en tratamientos del asma
US20030027856A1 (en) * 2001-06-29 2003-02-06 Aberg A.K. Gunnar Tolterodine metabolites
IN191835B (fi) * 2001-08-03 2004-01-10 Ranbaxy Lab Ltd
JP3981357B2 (ja) 2001-10-26 2007-09-26 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 第４級アンモニウム化合物および抗ムスカリン剤としてのそれらの使用
US7005449B2 (en) 2002-04-23 2006-02-28 Pharmacia & Upjohn Company Tolterodine salts
US7399779B2 (en) 2002-07-08 2008-07-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists
ATE396969T1 (de) 2002-07-31 2008-06-15 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignen
WO2004014363A1 (en) 2002-08-09 2004-02-19 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist
AU2002326072A1 (en) 2002-08-23 2004-03-11 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
US7101888B2 (en) * 2002-08-28 2006-09-05 Pharmacia & Upjohn Company Oral liquid tolterodine composition
EP1572648B1 (en) 2002-12-10 2008-07-09 Ranbaxy Laboratories, Ltd. 3,6-disubstituted azabicyclo (3.1.0)-hexane derivatives as muscarinic receptor antagonists
EP1583741A1 (en) 2002-12-23 2005-10-12 Ranbaxy Laboratories, Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
AU2002347553A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
CA2517824A1 (en) * 2003-03-06 2004-09-16 Neela Praveen Kumar 3,3-diarylpropylamine derivatives and processes for isolation thereof
WO2004089281A2 (en) * 2003-04-08 2004-10-21 Hetero Drugs Limited Novel polymorphs of tolterodine tartrate
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
EP1618091A1 (en) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP2006514978A (ja) 2003-04-10 2006-05-18 ランバクシー ラボラトリーズ リミテッド ムスカリン受容体アンタゴニストである置換アザビシクロヘキサン誘導体
US7560479B2 (en) 2003-04-10 2009-07-14 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
BRPI0409302A (pt) 2003-04-11 2006-04-11 Ranbaxy Lab Ltd derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
ITMI20031354A1 (it) * 2003-07-02 2005-01-03 Istituto Di Chimica Biomolecolare D El Cnr Sezione Sintesis enantioselettiva di composti enantiomericamente arricchiti.
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
JP5250205B2 (ja) * 2003-12-24 2013-07-31 シプラ・リミテッド トルテロジン、その組成物及び使用、及びその製造方法
EP1629834A1 (en) 2004-08-27 2006-03-01 KRKA, D.D., Novo Mesto Sustained release pharmaceutical composition of tolterodine
ITMI20041920A1 (it) * 2004-10-11 2005-01-11 Chemi Spa Processo per la preparazione di n, n-diisopropil-3-2-idrossi-5-metilfenil-3-fenil-propabammina
US7355077B2 (en) * 2004-10-28 2008-04-08 Dr. Reddy's Laboratories Limited Process for preparing tolterodine
JP4513535B2 (ja) * 2004-12-03 2010-07-28 住友化学株式会社 トルテロジンの製造方法
TW200637804A (en) * 2005-01-10 2006-11-01 Teva Pharma Substantially pure tolterodine tartrate and process for preparing thereof
US7528267B2 (en) 2005-08-01 2009-05-05 Girindus America, Inc. Method for enantioselective hydrogenation of chromenes
ES2268987B1 (es) * 2005-08-05 2008-02-01 Ragactives, S.L. Procedimiento para la obtencion de 3,3-difenilpropilaminas.
WO2007039918A1 (en) * 2005-10-06 2007-04-12 Natco Pharma Limited Novel process for the preparation of tolterodine
WO2007045979A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
KR100686351B1 (ko) * 2006-01-12 2007-02-22 주식회사 카이로제닉스 톨테로딘 라세미체의 제조방법
ITMI20060110A1 (it) * 2006-01-24 2007-07-25 Dipharma Spa Procedimento per la purificazione di tolterodina
BRPI0712037A2 (pt) 2006-05-24 2011-12-20 Pfizer Ltd processo para a produção de derivados benzopiran-2-ol
US7268257B1 (en) 2006-05-31 2007-09-11 Sumitomo Chemical Company, Limited Process for producing tolterodine
CZ302585B6 (cs) * 2007-02-26 2011-07-20 Zentiva, A. S. Krystalická sul 2-[(1R)-3-[bis(1-methylethyl)amino]-1-fenylpropyl]-4-methylfenolu s kyselinou (2R,3R)-2,3-dihydroxybutandiovou
US8486452B2 (en) 2007-07-20 2013-07-16 Mylan Pharmaceuticals Inc. Stabilized tolterodine tartrate formulations
WO2009019599A2 (en) 2007-08-08 2009-02-12 Themis Laboratories Private Limited Extended release compositions comprising tolterodine
KR101188333B1 (ko) 2008-02-20 2012-10-09 에스케이케미칼주식회사 안정성이 우수하고 경피제로 유용한 톨테로딘 결정성산부가염
US20090214665A1 (en) * 2008-02-26 2009-08-27 Lai Felix S Controlled Release Muscarinic Receptor Antagonist Formulation
ITMI20082055A1 (it) * 2008-11-19 2009-02-18 Dipharma Francis Srl Procedimento per la preparazione di (r)-tolterodina base libera
WO2010092500A2 (en) 2009-02-12 2010-08-19 Alembic Limited A process for the preparation of tolterodine tartrate
WO2010094292A1 (en) * 2009-02-17 2010-08-26 Pharmathen S.A. Improved process for the preparation of (r)-2-(3-diisopropylamino)-1-phenylpropyl)-4methylphenol and salts thereof
EP2554184B1 (en) 2010-03-31 2016-10-26 ONO Pharmaceutical Co., Ltd. Preventive and/or remedy for hand and foot syndrome
EP2476665A1 (en) 2011-01-17 2012-07-18 Cambrex Profarmaco Milano S.r.l. Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
WO2012098044A1 (en) 2011-01-17 2012-07-26 Cambrex Profarmaco Milano S.R.L. Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
CN102516098B (zh) * 2011-12-09 2014-06-18 北京联本医药化学技术有限公司 酒石酸托特罗定制备方法
CN103044274B (zh) * 2012-11-29 2014-10-22 珠海保税区丽珠合成制药有限公司 一种无溶剂合成酒石酸托特罗定的方法
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
CN110229072B (zh) * 2019-06-25 2022-04-08 中国药科大学 一种托特罗定及其对映体的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8800207D0 (sv) * 1988-01-22 1988-01-22 Kabivitrum Ab Nya aminer, deras anvendning och framstellning
US5382600A (en) * 1988-01-22 1995-01-17 Pharmacia Aktiebolag 3,3-diphenylpropylamines and pharmaceutical compositions thereof
DE69315920T2 (de) * 1992-09-04 1998-06-10 Takeda Chemical Industries Ltd Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung

Also Published As

Publication number Publication date
DE69716767D1 (de) 2002-12-05
KR100463614B1 (ko) 2004-12-29
SK283591B6 (sk) 2003-10-07
CZ227299A3 (cs) 1999-11-17
ES2186018T3 (es) 2003-05-01
CN1238768A (zh) 1999-12-15
PT960109E (pt) 2003-03-31
ATE226949T1 (de) 2002-11-15
EP0960109A1 (en) 1999-12-01
JP2001507691A (ja) 2001-06-12
PL191603B1 (pl) 2006-06-30
AU5956998A (en) 1998-07-31
HK1023566A1 (en) 2000-09-15
KR20000057548A (ko) 2000-09-25
JP4199310B2 (ja) 2008-12-17
SK81599A3 (en) 1999-12-10
US5922914A (en) 1999-07-13
NO993247L (no) 1999-08-09
RU2176246C2 (ru) 2001-11-27
WO1998029402A1 (en) 1998-07-09
NO993247D0 (no) 1999-06-29
DE69716767T2 (de) 2003-06-12
DK0960109T3 (da) 2002-11-25
HUP0000527A2 (hu) 2001-11-28
FI991477A0 (fi) 1999-06-29
NO317158B1 (no) 2004-08-30
NZ336533A (en) 2000-05-26
CA2273789C (en) 2006-06-06
PL334375A1 (en) 2000-02-28
CZ295477B6 (cs) 2005-08-17
EP0960109B1 (en) 2002-10-30
AU717985B2 (en) 2000-04-06
CA2273789A1 (en) 1998-07-09
SI0960109T1 (en) 2003-04-30
CN1151141C (zh) 2004-05-26
KR20000069771A (ko) 2000-11-25
HUP0000527A3 (en) 2001-12-28

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