ATE396969T1 - 3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignen - Google Patents
3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignenInfo
- Publication number
- ATE396969T1 ATE396969T1 AT02751482T AT02751482T ATE396969T1 AT E396969 T1 ATE396969 T1 AT E396969T1 AT 02751482 T AT02751482 T AT 02751482T AT 02751482 T AT02751482 T AT 02751482T AT E396969 T1 ATE396969 T1 AT E396969T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- compounds
- muscarine receptor
- hexane derivatives
- disubstituted azabicyclo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2002/002984 WO2004014853A1 (en) | 2002-07-31 | 2002-07-31 | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE396969T1 true ATE396969T1 (de) | 2008-06-15 |
Family
ID=31503897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02751482T ATE396969T1 (de) | 2002-07-31 | 2002-07-31 | 3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignen |
Country Status (7)
Country | Link |
---|---|
US (1) | US7265147B2 (de) |
EP (1) | EP1546098B1 (de) |
AT (1) | ATE396969T1 (de) |
AU (1) | AU2002368152A1 (de) |
DE (1) | DE60226906D1 (de) |
HK (1) | HK1079787A1 (de) |
WO (1) | WO2004014853A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ537584A (en) | 2002-07-08 | 2006-07-28 | Ranbaxy Lab Ltd | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
AU2003214520A1 (en) | 2003-04-09 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
CN100436414C (zh) | 2003-04-11 | 2008-11-26 | 兰贝克赛实验室有限公司 | 作为毒蕈碱受体拮抗剂的氮杂双环衍生物 |
EP1746998A1 (de) * | 2004-03-22 | 2007-01-31 | Ranbaxy Laboratories, Ltd. | Kombinationstherapie für symptome der unteren harnwege |
EP1934184A1 (de) | 2005-10-05 | 2008-06-25 | Ranbaxy Laboratories, Ltd. | 3 -azabicyclooctanderivate als antagonisten des muscarinrezeptors |
AU2006334107A1 (en) | 2005-12-30 | 2007-07-12 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
US20090137623A1 (en) | 2005-12-30 | 2009-05-28 | Naresh Kumar | Muscarinic receptor antagonists |
US20090326004A1 (en) | 2008-06-03 | 2009-12-31 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
JP5815542B2 (ja) * | 2009-10-29 | 2015-11-17 | ヤンセン ファーマシューティカ エヌ.ベー. | Dpp−1阻害剤として有用なアルキニル誘導体 |
CA2796877A1 (en) | 2010-04-30 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel beta 3 adrenergic receptor agonists |
ES2619829T3 (es) | 2011-11-18 | 2017-06-27 | Heptares Therapeutics Limited | Agonistas del receptor muscarínico M1 |
CN104177284B (zh) * | 2014-08-01 | 2016-08-24 | 常州大学 | 合成3-氮杂二环[3,1,0]己基-1-甲醛的方法 |
GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
GB201709652D0 (en) | 2017-06-16 | 2017-08-02 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL267508A (de) * | 1960-07-26 | |||
US4183857A (en) * | 1978-07-06 | 1980-01-15 | Shell Oil Company | 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione |
SE8800207D0 (sv) | 1988-01-22 | 1988-01-22 | Kabivitrum Ab | Nya aminer, deras anvendning och framstellning |
GB8906166D0 (en) | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
GB8928042D0 (en) | 1989-12-12 | 1990-02-14 | Pfizer Ltd | Muscarinic receptor antagonists |
US5281601A (en) * | 1989-12-12 | 1994-01-25 | Pfizer Inc. | Muscarinic receptor antagonists |
GB9202443D0 (en) | 1992-02-05 | 1992-03-18 | Fujisawa Pharmaceutical Co | A novel substituted-acetamide compound and a process for the preparation thereof |
FI100051B (fi) | 1992-02-18 | 1997-09-15 | Favorit Oy | Kompostori |
JP3429338B2 (ja) | 1992-07-27 | 2003-07-22 | 杏林製薬株式会社 | 新規なアリールグリシンアミド誘導体及びその製造法 |
JPH06135958A (ja) | 1992-10-28 | 1994-05-17 | Tanabe Seiyaku Co Ltd | ベンゾシクロヘプテン誘導体及びその製法 |
NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
KR19990008109A (ko) | 1995-04-28 | 1999-01-25 | 나가사까 겐지로 | 1,4-이치환 피페리딘 유도체 |
CA2179574A1 (en) * | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
WO1997013766A1 (fr) * | 1995-10-13 | 1997-04-17 | Banyu Pharmaceutical Co., Ltd. | Derives heteroaromatiques substitues |
AU2793197A (en) | 1996-05-31 | 1998-01-05 | Banyu Pharmaceutical Co., Ltd. | 1,4-disubstituted piperidine derivatives |
PE92198A1 (es) | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
GB9620049D0 (en) * | 1996-09-26 | 1996-11-13 | Hayles J R | Repellent formulations |
KR20000057548A (ko) | 1996-12-13 | 2000-09-25 | 알프레드 엘. 미첼슨 | 광학적 전송물질 및 결합재 |
TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
-
2002
- 2002-07-31 AT AT02751482T patent/ATE396969T1/de not_active IP Right Cessation
- 2002-07-31 EP EP02751482A patent/EP1546098B1/de not_active Expired - Lifetime
- 2002-07-31 AU AU2002368152A patent/AU2002368152A1/en not_active Abandoned
- 2002-07-31 DE DE60226906T patent/DE60226906D1/de not_active Expired - Fee Related
- 2002-07-31 US US10/523,208 patent/US7265147B2/en not_active Expired - Fee Related
- 2002-07-31 WO PCT/IB2002/002984 patent/WO2004014853A1/en active IP Right Grant
-
2005
- 2005-12-29 HK HK05112123.0A patent/HK1079787A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2002368152A1 (en) | 2004-02-25 |
EP1546098B1 (de) | 2008-05-28 |
WO2004014853A1 (en) | 2004-02-19 |
HK1079787A1 (zh) | 2006-04-13 |
US7265147B2 (en) | 2007-09-04 |
EP1546098A1 (de) | 2005-06-29 |
DE60226906D1 (de) | 2008-07-10 |
EP1546098A4 (de) | 2006-08-23 |
US20060122253A1 (en) | 2006-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE423769T1 (de) | Fluor- und sulfonylaminohaltige, 3,6- disubstituierte azabicyclo 3.1.0 hexanderivate als muscarinrezeptorantagonisten | |
HK1079787A1 (zh) | 用作毒蕈碱受體拮抗劑的3,6-二取代的氮雜雙環[3.1.0]己烷衍生物 | |
WO2004004629A3 (en) | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists | |
EP1796678A4 (de) | Carboxamid-spirolactam-cgrp-rezeptor-antagonisten | |
IL182317A0 (en) | Cgrp receptor antagonists | |
WO2004091514A3 (en) | Cgrp receptor antagonists | |
GEP20084519B (en) | 3-(4-heteroarylcyclo-hexylamino) cyclopenta-necarboxamides as modulators of chemokine receptors | |
HK1085724A1 (en) | 3,6-disubstituted azabicyclo 3.1.0-hexane derivatives as muscarinic receptor antagonists | |
MXPA06003363A (es) | Derivados de fenil-piperazina como moduladores de receptores muscarinicos. | |
WO2006035282A3 (en) | Muscarinic receptor antagonists | |
EP1398029A8 (de) | 3-substituierte Pyrazol-Derivate,die an den NR3B1 Rezeptor binden | |
MXPA04003298A (es) | Compuestos de piperidina como antagonistas muscarinicos. | |
WO2004067510A8 (en) | 3,6-disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists | |
EA200501593A1 (ru) | Азабициклические производные в качестве антагонистов мускаринового рецептора | |
ATE386738T1 (de) | Flavaxat-derivate als muscarin-rezeptor antagonisten | |
ATE362364T1 (de) | Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten | |
WO2006018708A3 (en) | Pyrrolidine derivatives as muscarinic receptor antagonists | |
WO2006032994A3 (en) | Muscarinic receptor antagonists | |
ATE383343T1 (de) | Imidazolderivate verwendbar als histamin h3 rezeptorliganden | |
ATE419246T1 (de) | Als antagonisten des muscarinrezeptors geeignete xanthinderivate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |