FI990268A - Ei-peptidi-NK-antagonistin käytt¦ ihosairauksien ja kutinan hoitoon tarkoitettujen lääkkeiden valmistukseen - Google Patents

Ei-peptidi-NK-antagonistin käytt¦ ihosairauksien ja kutinan hoitoon tarkoitettujen lääkkeiden valmistukseen Download PDF

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Publication number
FI990268A
FI990268A FI990268A FI990268A FI990268A FI 990268 A FI990268 A FI 990268A FI 990268 A FI990268 A FI 990268A FI 990268 A FI990268 A FI 990268A FI 990268 A FI990268 A FI 990268A
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FI
Finland
Prior art keywords
itching
antagonist
medicament
peptide
manufacture
Prior art date
Application number
FI990268A
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English (en)
Swedish (sv)
Other versions
FI990268A0 (fi
FI119721B (fi
Inventor
Carlo Farina
Giuseppe Arnaldo Mari Giardina
Mario Grugni
Luca Francesco Raveglia
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT94MI001099A external-priority patent/ITMI941099A1/it
Priority claimed from ITMI950494 external-priority patent/IT1293558B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of FI990268A publication Critical patent/FI990268A/fi
Publication of FI990268A0 publication Critical patent/FI990268A0/fi
Application granted granted Critical
Publication of FI119721B publication Critical patent/FI119721B/fi

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    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
FI990268A 1994-05-27 1999-02-10 Ei-peptidi-NK-antagonistin käyttö ihosairauksien ja kutinan hoitoon tarkoitettujen lääkkeiden valmistukseen FI119721B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IT94MI001099A ITMI941099A1 (it) 1994-05-27 1994-05-27 Derivati chinolinici
ITMI941099 1994-05-27
ITMI950494 IT1293558B1 (it) 1995-03-14 1995-03-14 Derivati chinolinici
ITMI950494 1995-03-14
EP9502000 1995-05-23
PCT/EP1995/002000 WO1995032948A1 (en) 1994-05-27 1995-05-23 Quinoline derivatives as tachykinin nk3 receptor antagonists

Publications (3)

Publication Number Publication Date
FI990268A true FI990268A (fi) 1999-02-10
FI990268A0 FI990268A0 (fi) 1999-02-10
FI119721B FI119721B (fi) 2009-02-27

Family

ID=26331143

Family Applications (2)

Application Number Title Priority Date Filing Date
FI964712A FI115052B (fi) 1994-05-27 1996-11-26 Kinoliinijohdannaisia takykiniini-NK3-reseptoriantagonisteina
FI990268A FI119721B (fi) 1994-05-27 1999-02-10 Ei-peptidi-NK-antagonistin käyttö ihosairauksien ja kutinan hoitoon tarkoitettujen lääkkeiden valmistukseen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI964712A FI115052B (fi) 1994-05-27 1996-11-26 Kinoliinijohdannaisia takykiniini-NK3-reseptoriantagonisteina

Country Status (35)

Country Link
US (5) US6608083B1 (fi)
EP (2) EP0804419B1 (fi)
JP (5) JP3664492B2 (fi)
KR (1) KR100316571B1 (fi)
CN (3) CN1092642C (fi)
AP (1) AP578A (fi)
AR (1) AR037069A2 (fi)
AT (2) ATE273959T1 (fi)
AU (1) AU699319B2 (fi)
BG (2) BG64004B1 (fi)
BR (1) BR9507788A (fi)
CA (1) CA2191352C (fi)
CZ (1) CZ291476B6 (fi)
DE (2) DE69533408T2 (fi)
DK (1) DK0804419T3 (fi)
DZ (1) DZ1889A1 (fi)
ES (2) ES2227769T3 (fi)
FI (2) FI115052B (fi)
HK (2) HK1003884A1 (fi)
HU (1) HU226535B1 (fi)
IL (1) IL113844A (fi)
MA (1) MA23560A1 (fi)
MX (1) MX9605903A (fi)
MY (1) MY129596A (fi)
NO (2) NO307783B1 (fi)
NZ (1) NZ287442A (fi)
OA (1) OA10592A (fi)
PL (2) PL186075B1 (fi)
PT (2) PT940391E (fi)
RO (1) RO114445B1 (fi)
SA (1) SA95160290B1 (fi)
SK (2) SK282721B6 (fi)
TW (2) TW427977B (fi)
UA (1) UA51623C2 (fi)
WO (1) WO1995032948A1 (fi)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
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NZ287442A (en) * 1994-05-27 1998-05-27 Smithkline Beecham Spa 4-substituted quinoline derivatives; medicaments; use as an nk3 receptor antagonist
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.
GB9524137D0 (en) * 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
GB9524104D0 (en) 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
AU757836B2 (en) * 1995-11-24 2003-03-06 Smithkline Beecham Spa Quinoline derivatives
US6277862B1 (en) * 1995-11-24 2001-08-21 Smithkline Beecham S.P.A. Quinoline derivatives
WO1998041506A1 (en) * 1997-03-14 1998-09-24 Smithkline Beecham Corporation Novel quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
CA2291111A1 (en) * 1997-05-23 1998-11-26 Giuseppe Arnaldo Maria Giardina Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists
US20010012846A1 (en) * 1997-05-23 2001-08-09 Glardina Giuseppe Arnaldo Maria Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.
EP1652840A3 (en) * 1997-09-17 2006-05-17 Smithkline Beecham Corporation (-)-(S)-N-(.alpha.-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide
US6083944A (en) * 1997-10-07 2000-07-04 Cephalon, Inc. Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
US6780875B2 (en) * 1998-11-20 2004-08-24 Smithkline Beecham S.P.A. Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
AR021354A1 (es) * 1998-11-20 2002-07-17 Smithkline Beecham Spa Procedimiento para la preparacion de un compuesto derivado de quinolina y un procedimiento para preparar una composicion farmaceutica
GB9825554D0 (en) 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
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