IT1293558B1 - Derivati chinolinici - Google Patents
Derivati chinoliniciInfo
- Publication number
- IT1293558B1 IT1293558B1 ITMI950494A IT1293558B1 IT 1293558 B1 IT1293558 B1 IT 1293558B1 IT MI950494 A ITMI950494 A IT MI950494A IT 1293558 B1 IT1293558 B1 IT 1293558B1
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- disorders
- substd
- opt
- alkoxy
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title abstract 4
- 206010065390 Inflammatory pain Diseases 0.000 title abstract 2
- 206010015037 epilepsy Diseases 0.000 title abstract 2
- 208000019693 Lung disease Diseases 0.000 title 1
- 208000007920 Neurogenic Inflammation Diseases 0.000 title 1
- 102000007124 Tachykinin Receptors Human genes 0.000 title 1
- 108010072901 Tachykinin Receptors Proteins 0.000 title 1
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 208000017520 skin disease Diseases 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 3
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000006413 ring segment Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- BUJGEMBLEXNUBK-MENZVKOBSA-N CC(C)C[C@@H](C(=O)NS(=O)(=O)OC[C@@H]1[C@H]([C@H]([C@@H](CO1)CCCN2C=C(N=N2)CNC(=O)NCC3=CC=CC=C3)O)O)N Chemical compound CC(C)C[C@@H](C(=O)NS(=O)(=O)OC[C@@H]1[C@H]([C@H]([C@@H](CO1)CCCN2C=C(N=N2)CNC(=O)NCC3=CC=CC=C3)O)O)N BUJGEMBLEXNUBK-MENZVKOBSA-N 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 101001125071 Homo sapiens Neuromedin-K receptor Proteins 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102100029409 Neuromedin-K receptor Human genes 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000001485 cycloalkadienyl group Chemical group 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 235000012631 food intake Nutrition 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002390 heteroarenes Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000005544 phthalimido group Chemical group 0.000 abstract 1
- 150000003248 quinolines Chemical class 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- -1 sulphonamido Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Priority Applications (67)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI950494 IT1293558B1 (it) | 1995-03-14 | 1995-03-14 | Derivati chinolinici |
NZ287442A NZ287442A (en) | 1994-05-27 | 1995-05-23 | 4-substituted quinoline derivatives; medicaments; use as an nk3 receptor antagonist |
NZ329979A NZ329979A (en) | 1994-05-27 | 1995-05-23 | Use of NK3 receptor antagonists |
DE69531458T DE69531458T2 (de) | 1994-05-27 | 1995-05-23 | Chinolinderivate als tachykinin nk3 rezeptor antagonisten |
PT98204483T PT940391E (pt) | 1994-05-27 | 1995-05-23 | Derivados de quinolina como antagonistas do receptor de taquicinina nk3 |
HU9900343A HU9900343D0 (en) | 1994-05-27 | 1995-05-23 | Use of quinoline derivatives having tachycinin nk3 receptor antagonist |
ES95920894T ES2204952T3 (es) | 1994-05-27 | 1995-05-23 | Derivados de la quinoleina utiles como antagonistas del receptor nk3 de la taquiquinina. |
PT95920894T PT804419E (pt) | 1994-05-27 | 1995-05-23 | Derivados de quinolina como antagonistas do receptor de taquiquinina nk3 |
CN95194338A CN1092642C (zh) | 1994-05-27 | 1995-05-23 | 用作速激肽nk3受体拮抗剂的喹啉衍生物 |
RO96-02234A RO114445B1 (ro) | 1994-05-27 | 1995-05-23 | Derivaţi de chinolină antagonişti ai receptorului nk3 tachichinină,procedeu de preparare,compoziţii farmaceutice pe baza acestora şi metodă de tratament |
PCT/EP1995/002000 WO1995032948A1 (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin nk3 receptor antagonists |
SK47-99A SK282722B6 (sk) | 1994-05-27 | 1995-05-23 | N-(alfa-Etylbenzyl)-3-hydroxy-2-fenylchinolín-4-karboxamid, farmaceutický prípravok s jeho obsahom a jeho použitie |
DE69533408T DE69533408T2 (de) | 1994-05-27 | 1995-05-23 | Chinolinderivate als Tachykinin NK3 Rezeptor Antagonisten |
PL95341889A PL186665B1 (pl) | 1994-05-27 | 1995-05-23 | Pochodne chinoliny jako antagoniści receptorów NKtachykininy, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca pochodne chinoliny oraz ich zastosowanie |
CA002191352A CA2191352C (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin nk3 receptor antagonists |
CZ19963470A CZ291476B6 (cs) | 1994-05-27 | 1995-05-23 | N-(alfa-Ethylbenzyl)-3-hydroxy-2-fenylchinolin-4-karboxamid, farmaceutický prostředek s jeho obsahem a použití |
AT95920894T ATE246677T1 (de) | 1994-05-27 | 1995-05-23 | Chinolinderivate als tachykinin nk3 rezeptor antagonisten |
SK1514-96A SK282721B6 (sk) | 1994-05-27 | 1995-05-23 | Nepeptidové NK3 antagonistické látky, spôsob ich výroby, farmaceutické prostriedky s ich obsahom a ich použitie |
HU9603262A HU226535B1 (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin nk3 receptor antagonists, pharmaceutical compositions containing them, and their use |
KR1019960706701A KR100316571B1 (ko) | 1994-05-27 | 1995-05-23 | 타키키닌nk3수용체길항제로서퀴놀린유도체 |
SI9530687T SI0804419T1 (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin nk 3 receptor antagonists |
CA002257662A CA2257662C (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin nk3 receptor antagonists |
AT98204483T ATE273959T1 (de) | 1994-05-27 | 1995-05-23 | Chinolinderivate als tachykinin nk3 rezeptor antagonisten |
ES98204483T ES2227769T3 (es) | 1994-05-27 | 1995-05-23 | Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina. |
JP50028796A JP3664492B2 (ja) | 1994-05-27 | 1995-05-23 | タチキニン nk▲下3▼ 受容体アンタゴニストとしてのキノリン誘導体 |
SI9530709T SI0940391T1 (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin NK3 receptor antagonists |
UA96124918A UA51623C2 (uk) | 1994-05-27 | 1995-05-23 | ПОХІДНІ ХІНОЛІНУ ЯК АНТАГОНІСТИ NK<sub>3</sub> РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА СПОСІБ ЛІКУВАННЯ ЗАХВОРЮВАНЬ |
AU26164/95A AU699319B2 (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin nk3 receptor antagonists |
EP95920894A EP0804419B1 (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin nk 3 receptor antagonists |
PL95317381A PL186075B1 (pl) | 1994-05-27 | 1995-05-23 | N-(-etylobenzylo)-3-hydroksy-2-fenylochinolino-4-karboksyamid oraz kompozycja farmaceutyczna zawierająca ten związek |
BR9507788A BR9507788A (pt) | 1994-05-27 | 1995-05-23 | Composto ou solvato ou sal do mesmo processo para a preparação do composto composição farmacêutica antagonista do receptor de NK3 uso do composto uso do antagonista do receptor de NG3 e processo para o tratamento e/ou profilaxia de distúrbios pulmonares e distúrbios convulsivos |
DK95920894T DK0804419T3 (da) | 1994-05-27 | 1995-05-23 | Quinolinderivater som tachykinin NK 3-receptor-antagonister |
EP98204483A EP0940391B1 (en) | 1994-05-27 | 1995-05-23 | Quinoline derivatives as tachykinin NK3 receptor antagonists |
APAP/P/1995/000745A AP578A (en) | 1994-05-27 | 1995-05-24 | Quinoline derivatives. |
DZ950061A DZ1889A1 (fr) | 1994-05-27 | 1995-05-24 | Dérivés de quinoléine nouveaux, procédé pour leur préparation et compositions pharmaceutiques les contenant. |
IL11384495A IL113844A (en) | 1994-05-27 | 1995-05-25 | N-(alpha-ETHYLBENZYL)-3-HYDROXY-2-PHENYLQUINOLINE-4-CARBOXAMIDE AND ITS USE IN THE PREPARATION OF MEDICAMENTS |
MYPI95001381A MY129596A (en) | 1994-05-27 | 1995-05-25 | Quinoline derivatives as tachykinin nk3 receptor antagonists |
US08/450,437 US6608083B1 (en) | 1994-05-27 | 1995-05-25 | Quinoline derivatives(2) |
MA23898A MA23560A1 (fr) | 1994-05-27 | 1995-05-25 | Procede de preparation de derives de quinoline et utilisation de ces derives dans la production des medicaments |
US08/450,438 US5811553A (en) | 1994-05-27 | 1995-05-25 | Quinoline derivatives(2) |
TW088121625A TW533199B (en) | 1994-05-27 | 1995-05-26 | Quinoline derivatives |
TW084105319A TW427977B (en) | 1994-05-27 | 1995-05-26 | Quinoline derivatives |
SA95160290A SA95160290B1 (ar) | 1994-05-27 | 1995-10-03 | مشتقات كينولين (2) |
BG101008A BG64004B1 (bg) | 1994-05-27 | 1996-11-25 | Производни на хинолина като тахикинин nк долу 3 рецепторни антагонисти |
NO965036A NO307783B1 (no) | 1994-05-27 | 1996-11-26 | Kinolinderivater som tachykinin NK3 reseptor-antagonister, farmasøytiske preparater inneholdende dem og anvendelse av slike derivater |
MX9605903A MX9605903A (es) | 1994-05-27 | 1996-11-26 | Derivados de quinolina como antagonistas del receptor nk3 de taquicinina. |
FI964712A FI115052B (fi) | 1994-05-27 | 1996-11-26 | Kinoliinijohdannaisia takykiniini-NK3-reseptoriantagonisteina |
OA60928A OA10592A (en) | 1994-05-27 | 1996-11-27 | Quinoline derivatives as tachykinin nk3 receptor antagonists |
HK98103021A HK1003884A1 (en) | 1994-05-27 | 1998-04-09 | Quinoline derivatives as tachykinin nk3 receptor and antagonists |
IL12680698A IL126806A0 (en) | 1994-05-27 | 1998-10-29 | Quinoline derivatives |
CN99100978A CN1276211A (zh) | 1994-05-27 | 1999-01-15 | 非肽类nk3-拮抗剂的制药用途 |
AU12162/99A AU1216299A (en) | 1994-05-27 | 1999-01-19 | Quinoline derivatives as tachykinin NK3 receptor antagonists |
IL12822099A IL128220A0 (en) | 1994-05-27 | 1999-01-25 | Quinoline derivatives and uses thereof |
FI990268A FI119721B (fi) | 1994-05-27 | 1999-02-10 | Ei-peptidi-NK-antagonistin käyttö ihosairauksien ja kutinan hoitoon tarkoitettujen lääkkeiden valmistukseen |
BG103181A BG103181A (bg) | 1994-05-27 | 1999-02-16 | Използване на непептидни nk3 антагонисти за лечение на кожни заболявания и сърбеж |
NO991813A NO326714B1 (no) | 1994-05-27 | 1999-04-16 | Anvendelse av kinolinderivater for fremstilling av farmasøytisk preparat for behandling av hudsykdommer og kløe. |
JP11172597A JP2000026314A (ja) | 1994-05-27 | 1999-06-18 | タチキニンnk3受容体アンタゴニストとしてのキノリン誘導体 |
HK00101401A HK1024469A1 (en) | 1994-05-27 | 2000-03-06 | Quinoline derivatives as tachykinin nk3 receptor antagonists. |
ARP000103117A AR037069A2 (es) | 1994-05-27 | 2000-06-22 | Un nuevo derivado de la quinolin-4-carboxamida, la n-(alfa-etilbencil)-3-hidroxi-2-fenilquinolin-4-carboxamida, una composicion farmaceutica que lo contiene y su uso para la fabricacion de medicamentos |
IL13930100A IL139301A0 (en) | 1994-05-27 | 2000-10-26 | Quinoline derivatives |
US09/867,133 US20030236281A1 (en) | 1994-05-27 | 2001-05-29 | Quinoline derivatives(2) |
JP2001326622A JP2002179594A (ja) | 1994-05-27 | 2001-10-24 | タチキニンnk3受容体アンタゴニストとしてのキノリン誘導体 |
CN02107941A CN1428145A (zh) | 1994-05-27 | 2002-03-18 | 用作速激肽nk3受体拮抗剂的喹啉衍生物 |
JP2004287629A JP2005068155A (ja) | 1994-05-27 | 2004-09-30 | タチキニンnk3受容体アンタゴニストとしてのキノリン誘導体 |
US10/999,180 US20050096316A1 (en) | 1994-05-27 | 2004-11-29 | Quinoline derivatives(2) |
US11/385,461 US7482458B2 (en) | 1994-05-27 | 2006-03-21 | Quinoline derivatives |
JP2006355694A JP2007126475A (ja) | 1994-05-27 | 2006-12-28 | タチキニンnk3受容体アンタゴニストとしてのキノリン誘導体 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI950494 IT1293558B1 (it) | 1995-03-14 | 1995-03-14 | Derivati chinolinici |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI950494A0 ITMI950494A0 (it) | 1995-03-14 |
ITMI950494A1 ITMI950494A1 (it) | 1996-09-14 |
IT1293558B1 true IT1293558B1 (it) | 1999-03-01 |
Family
ID=11370888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI950494 IT1293558B1 (it) | 1994-05-27 | 1995-03-14 | Derivati chinolinici |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1293558B1 (it) |
-
1995
- 1995-03-14 IT ITMI950494 patent/IT1293558B1/it active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI950494A1 (it) | 1996-09-14 |
ITMI950494A0 (it) | 1995-03-14 |
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