FI96956B - Förfarande för framställning av ett terapeutiskt användbart hirudinderivat - Google Patents

Förfarande för framställning av ett terapeutiskt användbart hirudinderivat Download PDF

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Publication number
FI96956B
FI96956B FI890127A FI890127A FI96956B FI 96956 B FI96956 B FI 96956B FI 890127 A FI890127 A FI 890127A FI 890127 A FI890127 A FI 890127A FI 96956 B FI96956 B FI 96956B
Authority
FI
Finland
Prior art keywords
gly
glu
thr
cys
leu
Prior art date
Application number
FI890127A
Other languages
English (en)
Finnish (fi)
Other versions
FI890127A0 (sv
FI96956C (sv
FI890127A (sv
Inventor
Paul Habermann
Dominique Tripier
Peter Crause
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25865106&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI96956(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from HU851341A external-priority patent/HU198085B/hu
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI890127A0 publication Critical patent/FI890127A0/sv
Publication of FI890127A publication Critical patent/FI890127A/sv
Application granted granted Critical
Publication of FI96956B publication Critical patent/FI96956B/sv
Publication of FI96956C publication Critical patent/FI96956C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI890127A 1985-04-11 1989-01-11 Förfarande för framställning av ett terapeutiskt användbart hirudinderivat FI96956C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU134185 1985-04-11
HU851341A HU198085B (en) 1984-04-18 1985-04-11 Process for producing new hirudine derivatives with anticoagulant effect and pharmaceutical compositions comprising same as active ingredient
DE3805540 1988-02-23
DE3805540 1988-02-23

Publications (4)

Publication Number Publication Date
FI890127A0 FI890127A0 (sv) 1989-01-11
FI890127A FI890127A (sv) 1989-07-14
FI96956B true FI96956B (sv) 1996-06-14
FI96956C FI96956C (sv) 1996-09-25

Family

ID=25865106

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890127A FI96956C (sv) 1985-04-11 1989-01-11 Förfarande för framställning av ett terapeutiskt användbart hirudinderivat

Country Status (9)

Country Link
EP (1) EP0324712B1 (sv)
AT (1) ATE87938T1 (sv)
DE (2) DE19775033I2 (sv)
DK (1) DK172350B1 (sv)
ES (1) ES2055149T3 (sv)
FI (1) FI96956C (sv)
IL (1) IL88925A (sv)
LU (1) LU90127I2 (sv)
NL (1) NL970027I2 (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
DE59010205D1 (de) * 1989-12-01 1996-04-18 Basf Ag Hirudin-Muteine und deren Polyalkylenglykolkonjugate
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19529997C1 (de) 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de) 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) * 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
EP0787569B1 (en) 1996-01-31 2002-10-02 Sumitomo Bakelite Company Limited Method of producing epoxy resin-encapsulated semiconductor device
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
DE19944870A1 (de) * 1999-09-18 2001-03-29 Aventis Pharma Gmbh Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium
DE10033195A1 (de) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunktionale Fusionsproteine aus Hirudin und TAP
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.

Also Published As

Publication number Publication date
FI890127A0 (sv) 1989-01-11
NL970027I2 (nl) 1998-04-01
EP0324712A2 (de) 1989-07-19
LU90127I2 (fr) 1997-10-06
DE19775033I2 (de) 2011-01-20
EP0324712B1 (de) 1993-04-07
DK172350B1 (da) 1998-04-06
ES2055149T3 (es) 1994-08-16
DK13189D0 (da) 1989-01-12
NL970027I1 (nl) 1997-10-01
ATE87938T1 (de) 1993-04-15
DE58903988D1 (de) 1993-05-13
FI96956C (sv) 1996-09-25
IL88925A (en) 1995-11-27
DK13189A (da) 1989-07-14
EP0324712A3 (en) 1990-07-04
FI890127A (sv) 1989-07-14

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Legal Events

Date Code Title Description
BB Publication of examined application
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L92

Extension date: 20120313

FG Patent granted

Owner name: SCHERING AKTIENGESELLSCHAFT

MA Patent expired