FI70416C - Foerfarande foer framstaellning av en injektabel chondroitin polysulfat - Google Patents
Foerfarande foer framstaellning av en injektabel chondroitin polysulfat Download PDFInfo
- Publication number
- FI70416C FI70416C FI821651A FI821651A FI70416C FI 70416 C FI70416 C FI 70416C FI 821651 A FI821651 A FI 821651A FI 821651 A FI821651 A FI 821651A FI 70416 C FI70416 C FI 70416C
- Authority
- FI
- Finland
- Prior art keywords
- chondroitin
- methanol
- liters
- solution
- carried out
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (9)
1. Förfarande för framställning av ett injicerbart kondroitinpolysulfat, kännetecknat därav, att A) ratt kondroitinpolysulfat depolymeriseras oxldativt, B) det depolymeriserade kondroitinpolysulfatet blekes, om sa är nödvändigt, med perättiksyra, C) fran produkten, som erhallits fran steget A eller B, isoleras en bestämd fraktion med avseende a molekylvikt genom att avlägsna materialet med högre molekylvikt med metanolutfalining under användning av 25-45 % metanol av blandnings hela volym eller ultrafiltrering under användning av ett filt-reringsmembran med en uteslutningsgräns av minst 6000 och skilja det tili fraktionen hörande materialet fran materialet med lägre molekylvikt med en andra metanolutfällning under användning av 60-85 % metanol av blandningens hela volym, eller med en andra ultrafiltrering under användning av ett filt-reringsmembran med en uteslutningsgräns av högst 8000, D) produkten, som erhallits efter C, demineraliseras, om sa är nödvändigt, med katjonbytare, och E) produkten, som erhallits efter C och D avfärgas, om sa är nödvändigt, med aktivt träkol.
2. Förfarande enligt patentkrav 1, kännetecknat därav, att den oxidativa depolymerisationen A utföres med väteperoxid utan närvaro av tunga metaller.
3. Förfarande enligt patentkrav 2, kännetecknat därav, att det utföres i närvarande av ett komplexbildande medel.
4. Förfarande enligt patentkrav 1, kännetecknat därav, att den oxidativa polymerirationen A utföres med perättiksyra i närvaro av salter av jäm, kobolt, koppar, mangan och/eller vanadin.
5. Förfarande enligt patentkrav 1, känne tecknat därav, att den oxidativa polvmerisationen A utföres med perättiksyra i närvaro av salter av järn, kobolt och/eller mangan. Il
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3118588A DE3118588C2 (de) | 1981-05-11 | 1981-05-11 | Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung |
DE3118588 | 1981-05-11 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI821651A0 FI821651A0 (fi) | 1982-05-11 |
FI821651L FI821651L (fi) | 1982-11-12 |
FI70416B FI70416B (fi) | 1986-03-27 |
FI70416C true FI70416C (fi) | 1986-09-19 |
Family
ID=6131969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI821651A FI70416C (fi) | 1981-05-11 | 1982-05-11 | Foerfarande foer framstaellning av en injektabel chondroitin polysulfat |
Country Status (19)
Country | Link |
---|---|
US (1) | US4524066A (sv) |
JP (1) | JPS57192401A (sv) |
AT (1) | AT387225B (sv) |
AU (1) | AU552545B2 (sv) |
BE (1) | BE893097A (sv) |
CA (1) | CA1207758A (sv) |
CH (1) | CH650788A5 (sv) |
DE (1) | DE3118588C2 (sv) |
DK (1) | DK160317C (sv) |
FI (1) | FI70416C (sv) |
FR (1) | FR2505185B1 (sv) |
GB (1) | GB2098232B (sv) |
IE (1) | IE53633B1 (sv) |
IL (1) | IL65743A (sv) |
IT (1) | IT1157939B (sv) |
LU (1) | LU84143A1 (sv) |
NL (1) | NL186638C (sv) |
NO (1) | NO157147C (sv) |
SE (1) | SE458118B (sv) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3244214A1 (de) * | 1982-11-30 | 1984-05-30 | B. Braun Melsungen Ag, 3508 Melsungen | Verfahren zur reinigung und fraktionierung von heparin |
US4623539A (en) * | 1983-02-04 | 1986-11-18 | Tunc Deger C | Nutrient barrier polysaccharide compositions and method of use |
FR2572731B1 (fr) * | 1984-11-07 | 1987-03-06 | Sanofi Sa | Nouveaux sulfates de xylanes de bas poids moleculaires, leur procede de preparation et leur activite antithrombotique et hypolipemiante par voie orale |
IT1214609B (it) * | 1985-05-17 | 1990-01-18 | Opocrin Spa | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. |
AU604542B2 (en) * | 1987-03-19 | 1990-12-20 | Arthropharm Pty Ltd | Polysulphated polysaccharide complexes |
US5668116A (en) * | 1987-03-19 | 1997-09-16 | Anthropharm Pty. Limited | Anti-inflammatory compounds and compositions |
DK0408770T3 (da) * | 1989-02-06 | 1996-10-07 | Taiho Pharmaceutical Co Ltd | Sulfateret polysaccharid, farmaceutisk acceptable salte heraf, fremstilling heraf og lægemiddel indeholdende samme som aktiv bestanddel |
US5519010A (en) * | 1989-02-06 | 1996-05-21 | Taiho Pharmaceutical Co., Ltd. | Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component |
US5141928B1 (en) * | 1989-12-20 | 1995-11-14 | Brujo Inc | Ophthalmic medication |
JPH05279381A (ja) * | 1991-09-13 | 1993-10-26 | Dainippon Ink & Chem Inc | 硫酸化オリゴ糖芳香族配糖体 |
IT1256236B (it) * | 1992-12-23 | 1995-11-29 | Mediolanum Farmaceutici Srl | Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani |
US5880108A (en) * | 1995-02-14 | 1999-03-09 | Bioniche, Inc. | Method for treating the internal urinary bladder and associated structures using hyaluronic acid |
IN181358B (sv) * | 1995-02-14 | 1998-05-30 | Bioniche Inc | |
US5591724A (en) * | 1995-02-14 | 1997-01-07 | Bioniche Inc. | Method for treating the urinary bladder and associated structures using hyaluronic acid |
WO2000056298A2 (en) * | 1999-03-19 | 2000-09-28 | Luitpold Pharmaceuticals, Inc. | Treatment of lyme disease with polysulfated glycosaminoglycan formulations |
WO2004078105A2 (fr) * | 2003-02-27 | 2004-09-16 | Sanofi-Synthelabo | Composition de fondaparinux sodique de haute purete |
JP4679138B2 (ja) * | 2004-12-24 | 2011-04-27 | 株式会社日本バリアフリー | 高純度化されたムコ多糖類の製造方法 |
FR2969618B1 (fr) * | 2010-12-28 | 2014-05-16 | Pf Medicament | Procede de preparation de chondroitine sulfate de sodium |
RU2677330C2 (ru) * | 2015-11-20 | 2019-01-16 | Закрытое Акционерное Общество "Фармфирма "Сотекс" | Способ приготовления инъекционной формы препарата хондроитина сульфата |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE136572C (sv) * | 1902-12-05 | |||
DE870094C (de) * | 1950-10-17 | 1953-03-09 | Geigy Ag J R | Verfahren zur Herstellung von Polyschwefelsaeureestern des Chondroitins |
DE935843C (de) * | 1951-07-12 | 1955-12-01 | Hoffmann La Roche | Verfahren zur Herstellung eines blutgerinnungshemmenden Mittels |
US2767167A (en) * | 1953-07-06 | 1956-10-16 | Gen Mills Inc | Process of reducing the viscosity of gums |
DE968752C (de) * | 1954-01-29 | 1958-03-27 | Hoffmann La Roche | Verfahren zur Herstellung von Chondroitinpolyschwefelsaeureestern |
US2803558A (en) * | 1956-06-27 | 1957-08-20 | Commw Color & Chemical Co | Method of treating adhesive gums |
US2959583A (en) * | 1959-01-23 | 1960-11-08 | Warner Lambert Pharmaceutical | Method of purifying sulfated polysaccharides |
US3175942A (en) * | 1962-03-13 | 1965-03-30 | Evans Medical Ltd | Gastro-intestinal therapeutic |
US3174904A (en) * | 1963-03-25 | 1965-03-23 | Rexall Drug Chemical | Method of purifying sulfated carbohydrates |
US3405120A (en) * | 1966-01-27 | 1968-10-08 | Green Cross Corp | Low molecular chondroitin sulfate and method for manufacturing the same |
US3454560A (en) * | 1966-03-01 | 1969-07-08 | Seikagaku Kogyo Co Ltd | Process for the production of chondroitin polysulfate |
BE857389A (fr) * | 1977-08-02 | 1977-12-01 | Marbex Finance Ltd | Procede de preparation de chondroitines-sulfates de metaux alcalins et alcalino-terreux d'un poids moleculaire de 3000 a 6000 |
-
1981
- 1981-05-11 DE DE3118588A patent/DE3118588C2/de not_active Expired
-
1982
- 1982-04-29 US US06/373,226 patent/US4524066A/en not_active Expired - Lifetime
- 1982-05-06 BE BE0/208024A patent/BE893097A/fr not_active IP Right Cessation
- 1982-05-07 NL NLAANVRAGE8201873,A patent/NL186638C/xx not_active IP Right Cessation
- 1982-05-10 CA CA000402613A patent/CA1207758A/en not_active Expired
- 1982-05-10 JP JP57076774A patent/JPS57192401A/ja active Granted
- 1982-05-11 LU LU84143A patent/LU84143A1/fr unknown
- 1982-05-11 FR FR8208182A patent/FR2505185B1/fr not_active Expired
- 1982-05-11 IE IE1127/82A patent/IE53633B1/en not_active IP Right Cessation
- 1982-05-11 FI FI821651A patent/FI70416C/fi not_active IP Right Cessation
- 1982-05-11 AU AU83573/82A patent/AU552545B2/en not_active Expired
- 1982-05-11 GB GB8213536A patent/GB2098232B/en not_active Expired
- 1982-05-11 CH CH2919/82A patent/CH650788A5/de not_active IP Right Cessation
- 1982-05-11 DK DK211882A patent/DK160317C/da not_active IP Right Cessation
- 1982-05-11 IL IL65743A patent/IL65743A/xx not_active IP Right Cessation
- 1982-05-11 IT IT21189/82A patent/IT1157939B/it active Protection Beyond IP Right Term
- 1982-05-11 AT AT0184282A patent/AT387225B/de not_active IP Right Cessation
- 1982-05-11 NO NO821551A patent/NO157147C/no not_active IP Right Cessation
- 1982-05-11 SE SE8202947A patent/SE458118B/sv not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |
Owner name: LUITPOLD PHARMACEUTICALS, INC. |