FI59814C - Foerfarande foer framstaellning av terapeutiskt anvaendbar cyklosporin d - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbar cyklosporin d Download PDF

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Publication number
FI59814C
FI59814C FI781348A FI781348A FI59814C FI 59814 C FI59814 C FI 59814C FI 781348 A FI781348 A FI 781348A FI 781348 A FI781348 A FI 781348A FI 59814 C FI59814 C FI 59814C
Authority
FI
Finland
Prior art keywords
cyclosporin
chj
cyclosporine
framework
determination
Prior art date
Application number
FI781348A
Other languages
English (en)
Finnish (fi)
Other versions
FI781348A (fi
FI59814B (fi
Inventor
Rene P Traber
Max Kuhn
Hans Hofmann
Eugen Haerri
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH582277A external-priority patent/CH628022A5/de
Priority claimed from CH582377A external-priority patent/CH628023A5/de
Priority claimed from CH745777A external-priority patent/CH632010A5/de
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of FI781348A publication Critical patent/FI781348A/fi
Priority to FI801682A priority Critical patent/FI63562C/fi
Priority to FI801681A priority patent/FI63561C/fi
Application granted granted Critical
Publication of FI59814B publication Critical patent/FI59814B/fi
Publication of FI59814C publication Critical patent/FI59814C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/945—Trichoderma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI781348A 1977-05-10 1978-05-02 Foerfarande foer framstaellning av terapeutiskt anvaendbar cyklosporin d FI59814C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI801682A FI63562C (fi) 1977-05-10 1980-05-26 Foerfarande foer framstaellning av terapeutiskt anvaendbar isocyklosporin d
FI801681A FI63561C (fi) 1977-05-10 1980-05-26 Foerfarande foer framstaellning av terapeutiskt anvaendbar dihydrocyklosporin d

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH582277 1977-05-10
CH582277A CH628022A5 (en) 1977-05-10 1977-05-10 Process for the preparation of an antibiotic derivative
CH582377 1977-05-10
CH582377A CH628023A5 (en) 1977-05-10 1977-05-10 Process for the preparation of an antibiotic derivative
CH745777 1977-06-17
CH745777A CH632010A5 (en) 1977-06-17 1977-06-17 Process for the preparation of a novel antibiotic

Publications (3)

Publication Number Publication Date
FI781348A FI781348A (fi) 1978-11-11
FI59814B FI59814B (fi) 1981-06-30
FI59814C true FI59814C (fi) 1981-10-12

Family

ID=27175344

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781348A FI59814C (fi) 1977-05-10 1978-05-02 Foerfarande foer framstaellning av terapeutiskt anvaendbar cyklosporin d

Country Status (17)

Country Link
US (2) US4220641A (es)
JP (1) JPS53139789A (es)
AU (1) AU526582B2 (es)
CA (1) CA1117046A (es)
DE (1) DE2819094A1 (es)
DK (1) DK148751C (es)
ES (1) ES469567A1 (es)
FI (1) FI59814C (es)
FR (1) FR2390420A1 (es)
GB (1) GB1591934A (es)
IE (1) IE46883B1 (es)
IL (1) IL54666A (es)
IT (1) IT1104195B (es)
NL (1) NL7804846A (es)
PH (1) PH13973A (es)
PT (1) PT68013B (es)
SE (3) SE438860B (es)

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* Cited by examiner, † Cited by third party
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SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
IE54936B1 (en) * 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
DE3260468D1 (en) * 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
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GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
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US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
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US5239057A (en) * 1987-03-27 1993-08-24 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US5427960A (en) * 1987-03-27 1995-06-27 Abbott Laboratories Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
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US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
EP0391909B1 (en) * 1987-09-03 1994-08-17 The University Of Georgia Research Foundation, Inc. Ocular cyclosporin composition
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
US7081445B2 (en) * 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
EP0473961B1 (en) * 1990-08-15 1996-01-03 Abbott Laboratories Immunoassay reagents and method for determining cyclosporine
JP3099365B2 (ja) * 1991-01-25 2000-10-16 藤沢薬品工業株式会社 シクロスポリンａおよび／またはｃの製造法
ES2078374T3 (es) * 1991-04-06 1995-12-16 Dresden Arzneimittel Procedimiento para la produccion por fermentacion y aislamiento de ciclosporina a, y nuevas cepas formadoras de ciclosporina.
GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
CN1079837C (zh) * 1995-02-28 2002-02-27 国家研究发展公司 从分枝层壁菌制备环胞多肽a的方法
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
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SG115386A1 (en) 1997-01-30 2005-10-28 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions substantially free of any oil
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
IN188719B (es) * 1997-09-08 2002-11-02 Panacea Biotec Ltd
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ES2256959T3 (es) 1997-10-08 2006-07-16 Isotechnika,Inc. Analogos de ciclosporina deuterados y no deuterados y su uso como agentes inmunomoduladores.
DK1091975T3 (da) 1998-07-01 2006-04-18 Debiopharm Sa Ny cyclosporin med forbedret aktivitetsprofil
AU2002331509B2 (en) * 2001-10-19 2007-12-06 Aurinia Pharmaceuticals Inc. Synthesis of cyclosporin analogs
EP1435910B9 (en) * 2001-10-19 2010-02-03 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
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US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
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US8367618B2 (en) * 2009-01-30 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection
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Family Cites Families (3)

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JPS4838877B1 (es) * 1970-06-30 1973-11-20 Toyo Jozo Kk
CH614931A5 (es) * 1975-11-04 1979-12-28 Sandoz Ag
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production

Also Published As

Publication number Publication date
SE8401135D0 (sv) 1984-03-01
JPS6252760B2 (es) 1987-11-06
SE8401135L (sv) 1984-03-01
FR2390420A1 (fr) 1978-12-08
AU3594778A (en) 1979-11-15
GB1591934A (en) 1981-07-01
SE8401134L (sv) 1984-03-01
ES469567A1 (es) 1980-01-01
IE780932L (en) 1978-11-10
DE2819094A1 (de) 1978-11-23
DE2819094C2 (es) 1988-11-03
AU526582B2 (en) 1983-01-20
JPS53139789A (en) 1978-12-06
DK188778A (da) 1978-11-11
PT68013B (fr) 1980-03-05
NL7804846A (nl) 1978-11-14
SE438860B (sv) 1985-05-13
FI781348A (fi) 1978-11-11
IT7849208A0 (it) 1978-05-05
US4289851A (en) 1981-09-15
CA1117046A (en) 1982-01-26
DK148751C (da) 1986-02-24
IL54666A (en) 1980-12-31
PH13973A (en) 1980-11-20
SE7805055L (sv) 1978-11-11
DK148751B (da) 1985-09-16
IE46883B1 (en) 1983-10-19
FR2390420B1 (es) 1980-10-31
FI59814B (fi) 1981-06-30
US4220641A (en) 1980-09-02
PT68013A (fr) 1978-06-01
IL54666A0 (en) 1978-07-31
SE8401134D0 (sv) 1984-03-01
IT1104195B (it) 1985-10-21

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Owner name: SANDOZ AG