FI106962B - Menetelmä (1R, 5S, 6S)-2-[1-(1,3-tiatsolin-2-yyli)atsetidin-3-yyli]-tio-6-[(R)-1-hydroksietyyli]-1-metyylikarbapen-2-eemi-3-karboksyylihappojohdannaisten valmistamiseksi - Google Patents
Menetelmä (1R, 5S, 6S)-2-[1-(1,3-tiatsolin-2-yyli)atsetidin-3-yyli]-tio-6-[(R)-1-hydroksietyyli]-1-metyylikarbapen-2-eemi-3-karboksyylihappojohdannaisten valmistamiseksi Download PDFInfo
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- FI106962B FI106962B FI943164A FI943164A FI106962B FI 106962 B FI106962 B FI 106962B FI 943164 A FI943164 A FI 943164A FI 943164 A FI943164 A FI 943164A FI 106962 B FI106962 B FI 106962B
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21330693 | 1993-07-01 | ||
JP21330693 | 1993-07-01 | ||
JP7932094 | 1994-03-28 | ||
JP7932094 | 1994-03-28 | ||
JP12204694 | 1994-05-12 | ||
JP12204694 | 1994-05-12 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI943164A0 FI943164A0 (fi) | 1994-07-01 |
FI943164A FI943164A (fi) | 1995-01-02 |
FI106962B true FI106962B (fi) | 2001-05-15 |
Family
ID=27302982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI943164A FI106962B (fi) | 1993-07-01 | 1994-07-01 | Menetelmä (1R, 5S, 6S)-2-[1-(1,3-tiatsolin-2-yyli)atsetidin-3-yyli]-tio-6-[(R)-1-hydroksietyyli]-1-metyylikarbapen-2-eemi-3-karboksyylihappojohdannaisten valmistamiseksi |
Country Status (16)
Country | Link |
---|---|
US (2) | US5534510A (pt) |
EP (2) | EP0632039B1 (pt) |
JP (1) | JP2666118B2 (pt) |
KR (1) | KR100331293B1 (pt) |
AT (2) | ATE212636T1 (pt) |
AU (1) | AU682510B2 (pt) |
CA (1) | CA2127193C (pt) |
DE (2) | DE69433955T2 (pt) |
DK (2) | DK0632039T3 (pt) |
ES (2) | ES2170080T3 (pt) |
FI (1) | FI106962B (pt) |
HU (1) | HU220609B1 (pt) |
IL (1) | IL110161A (pt) |
NO (2) | NO306780B1 (pt) |
PT (2) | PT924210E (pt) |
TW (1) | TW254943B (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5783703A (en) * | 1993-07-01 | 1998-07-21 | Lederle (Japan), Ltd. | Sulfur-containing compounds method for their use and prodction |
TW432061B (en) * | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
NO955007L (no) * | 1994-12-12 | 1996-06-13 | Lederle Japan Ltd | Tiolforbindelser |
TW420681B (en) * | 1995-12-08 | 2001-02-01 | Lederle Japan Ltd | Carbapenem-3-carboxylic acid ester derivatives |
NZ332687A (en) | 1996-05-09 | 2000-05-26 | Sankyo Co | use of 1-methyl-carbapenem derivatives as anti-helicobacter pylori agents |
KR20010079713A (ko) * | 1998-09-10 | 2001-08-22 | 마쓰자와 도로, 하야시 지로 | 카르바페넴 화합물 |
KR100325375B1 (ko) * | 2000-01-31 | 2002-03-06 | 박호군 | 이미다졸린 고리가 치환된 카바페넴 유도체 |
SK5982003A3 (en) * | 2000-11-16 | 2004-05-04 | Sankyo Co | 1-Methylcarbapenem derivatives |
KR100441406B1 (ko) * | 2001-09-05 | 2004-07-23 | 한국과학기술연구원 | 티아졸리딘 고리 치환체를 갖는 1-β-메틸 카바페넴유도체 및 그 제조 방법 |
KR100451670B1 (ko) * | 2001-09-14 | 2004-10-08 | 한국화학연구원 | 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법 |
EP1443047A4 (en) | 2001-11-05 | 2005-04-27 | Sumitomo Pharma | NEW CARBAPENE COMPOUNDS |
TW200403244A (en) * | 2002-05-14 | 2004-03-01 | Sankyo Co | 1β-Methylcarbapenem derivatives for oral use |
WO2004035540A1 (ja) | 2002-10-18 | 2004-04-29 | Meiji Seika Kaisha, Ltd. | マロン酸モノエステルおよびその製造方法 |
AU2003301425A1 (en) * | 2002-10-18 | 2004-05-04 | Meiji Seika Kaisha, Ltd. | Process for producing carbapenem derivative and intermediate for use in the production |
KR101059339B1 (ko) * | 2002-11-13 | 2011-08-24 | 가부시키가이샤 가네카 | 경구 투여용 카르바페넴 화합물의 제조 방법 |
JPWO2004089954A1 (ja) * | 2003-04-08 | 2006-07-06 | 大日本住友製薬株式会社 | 新規なカルバペネム化合物 |
KR101188930B1 (ko) * | 2003-12-30 | 2012-10-08 | 메디시스 테크놀로지스 코포레이션 | 가동 제어가 있는 초음파 치료 헤드 |
EP1627891A1 (en) * | 2004-08-11 | 2006-02-22 | Covion Organic Semiconductors GmbH | Polymers for use in organic electroluminescent devices |
KR100599876B1 (ko) * | 2004-08-31 | 2006-07-13 | 한국화학연구원 | 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법 |
EP1785426A4 (en) * | 2004-09-03 | 2008-02-20 | Dainippon Sumitomo Pharma Co | NEW CARBAPENEM DERIVATIVE |
JP2006176418A (ja) * | 2004-12-21 | 2006-07-06 | Kaneka Corp | 経口投与用カルバペネム化合物の製造方法と新規β−ラクタム化合物 |
EP1864985A4 (en) * | 2005-03-25 | 2010-01-06 | Dainippon Sumitomo Pharma Co | NEW CARBAPENEM COMPOUND |
KR100723889B1 (ko) | 2006-06-30 | 2007-05-31 | 주식회사 하이닉스반도체 | 직렬 입/출력 인터페이스를 가진 멀티 포트 메모리 소자 |
JP5013795B2 (ja) * | 2006-09-25 | 2012-08-29 | Meiji Seikaファルマ株式会社 | 経口投与用カルバペネム |
CN101848911A (zh) * | 2007-09-20 | 2010-09-29 | 国际药品工业株式会社 | 碳青霉烯类抗生素的合成中间体的酸加成盐及其制备方法 |
JP2011504495A (ja) * | 2007-11-23 | 2011-02-10 | クジェ ファーマシューティカル インダストリアル カンパニー リミテッド | 2−アリールメチルアゼチジン−カルバペネム−3−カルボン酸エステル誘導体またはその塩、その製造方法及びそれを含む医薬組成物 |
CN102558181B (zh) * | 2010-12-15 | 2015-04-22 | 石药集团中奇制药技术(石家庄)有限公司 | 一种碳青霉烯抗生素的制备方法 |
CN102731507B (zh) * | 2011-04-13 | 2015-04-01 | 石药集团中奇制药技术(石家庄)有限公司 | 泰比培南晶型、其制备方法及其在制备药物中的应用 |
CN103059026A (zh) * | 2011-10-20 | 2013-04-24 | 北京康健源科技有限公司 | 一种替比培南匹夫酯的制备方法 |
CN102584812B (zh) * | 2011-11-18 | 2014-03-12 | 深圳万乐药业有限公司 | 一种泰比培南酯杂质的制备方法 |
CN102503940B (zh) * | 2011-11-22 | 2013-12-25 | 深圳万乐药业有限公司 | 制备泰比培南酯开环杂质的方法 |
CN103059027A (zh) * | 2012-12-20 | 2013-04-24 | 安徽悦康凯悦制药有限公司 | 替比培南匹伏酯的制备方法 |
CN115192533A (zh) * | 2016-12-15 | 2022-10-18 | 斯派尔治疗有限公司 | 新型替比培南匹伏酯速释和调释口服剂型 |
CA3049690C (en) * | 2017-02-06 | 2023-03-21 | Spero Therapeutics, Inc. | Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use |
CN110698469A (zh) * | 2019-10-28 | 2020-01-17 | 南京红杉生物科技有限公司 | 泰比培南酯中间体及其合成方法、应用 |
AU2021378320A1 (en) | 2020-11-11 | 2023-06-22 | Spero Therapeutics, Inc. | High dosage tebipenem pivoxil tablet formulation |
Family Cites Families (5)
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US3665001A (en) * | 1970-06-11 | 1972-05-23 | Exxon Research Engineering Co | Azinyl organophosphorus compounds |
JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | 1―置換カルバペネム―3―カルボン酸誘導体 |
US4696923A (en) * | 1984-04-23 | 1987-09-29 | Merck & Co., Inc. | 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids |
JPS63255280A (ja) * | 1987-04-11 | 1988-10-21 | Nippon Redarii Kk | (1r,5s,6s)−2−置換−6−〔(r)−1−ヒドロキシエチル〕−1−メチル−カルバペネム−3−カルボン酸誘導体 |
GB9210096D0 (en) * | 1992-05-11 | 1992-06-24 | Fujisawa Pharmaceutical Co | 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation |
-
1994
- 1994-06-28 AU AU65987/94A patent/AU682510B2/en not_active Expired
- 1994-06-29 US US08/267,397 patent/US5534510A/en not_active Expired - Lifetime
- 1994-06-29 IL IL11016194A patent/IL110161A/en not_active IP Right Cessation
- 1994-06-30 PT PT99104079T patent/PT924210E/pt unknown
- 1994-06-30 JP JP6170496A patent/JP2666118B2/ja not_active Expired - Lifetime
- 1994-06-30 DK DK94110186T patent/DK0632039T3/da active
- 1994-06-30 NO NO942483A patent/NO306780B1/no not_active IP Right Cessation
- 1994-06-30 ES ES94110186T patent/ES2170080T3/es not_active Expired - Lifetime
- 1994-06-30 AT AT94110186T patent/ATE212636T1/de active
- 1994-06-30 ES ES99104079T patent/ES2222630T3/es not_active Expired - Lifetime
- 1994-06-30 CA CA002127193A patent/CA2127193C/en not_active Expired - Lifetime
- 1994-06-30 HU HU9401957A patent/HU220609B1/hu unknown
- 1994-06-30 PT PT94110186T patent/PT632039E/pt unknown
- 1994-06-30 DE DE69433955T patent/DE69433955T2/de not_active Expired - Lifetime
- 1994-06-30 EP EP94110186A patent/EP0632039B1/en not_active Expired - Lifetime
- 1994-06-30 AT AT99104079T patent/ATE273975T1/de active
- 1994-06-30 DE DE69429742T patent/DE69429742T2/de not_active Expired - Lifetime
- 1994-06-30 EP EP99104079A patent/EP0924210B1/en not_active Expired - Lifetime
- 1994-06-30 DK DK99104079T patent/DK0924210T3/da active
- 1994-07-01 FI FI943164A patent/FI106962B/fi not_active IP Right Cessation
- 1994-07-01 KR KR1019940015809A patent/KR100331293B1/ko not_active IP Right Cessation
- 1994-07-01 TW TW083106001A patent/TW254943B/zh not_active IP Right Cessation
-
1996
- 1996-04-12 US US08/631,224 patent/US5679790A/en not_active Expired - Lifetime
-
1999
- 1999-03-02 NO NO991019A patent/NO307379B1/no not_active IP Right Cessation
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PC | Transfer of assignment of patent |
Owner name: PFIZER JAPAN INC. Free format text: PFIZER JAPAN INC. |
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MA | Patent expired |