FI105810B - Användning av (3S,4S)-3-[(1R)-1-trialkylsilyloxietyl]-4-[(1R)-(heterocyklyl-tiokarbonyl)-etyl]azetidin-2-on derivat vid framställningen av karbapenem antibiotika - Google Patents

Användning av (3S,4S)-3-[(1R)-1-trialkylsilyloxietyl]-4-[(1R)-(heterocyklyl-tiokarbonyl)-etyl]azetidin-2-on derivat vid framställningen av karbapenem antibiotika Download PDF

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Publication number
FI105810B
FI105810B FI981397A FI981397A FI105810B FI 105810 B FI105810 B FI 105810B FI 981397 A FI981397 A FI 981397A FI 981397 A FI981397 A FI 981397A FI 105810 B FI105810 B FI 105810B
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Finland
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singlet
multiplet
doublet
formula
ethyl
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FI981397A
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English (en)
Finnish (fi)
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FI981397A (sv
FI981397A0 (sv
Inventor
Akira Yoshida
Koichi Hirai
Yuji Iwano
Hiroo Koyama
Takahide Nishi
Kozo Oda
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Sankyo Co
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Publication of FI105810B publication Critical patent/FI105810B/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Earth Drilling (AREA)

Claims (7)

1. Användning av (3S,4S)-3-[(lR)-l-trialkyIsilyloxietyl]-4-[(lEMheterocyklyltiokar-bonyl)-etyI]azetidin-2-on derivat med farmein (Ia): 5 0R| ch3 HjC^N-p-^y---Z~R3 0») 10 ° o H där: 15 R1 avser en trialkylsilylgrupp, där var och en av nämnda alkylgrupper är likadan eller olik och gruppen avser 1-5 kolatomer; : '· R3 avser en pyridylgrupp, som valbart kan vara substituerad med en alkylgrupp med ' 20 1-6 kolatomer, eller med en kinolingrupp; och Z avser en svavelatom eller en syreatom; • · · • · · • · • · · • · · *·’ för framställning av karbapenem med farmein (XIX): 25 ··♦ !:::! 0R‘ ch3 i •s b'c rrV-»” ™ O'; * *· COiH 105810 96 där R1 och Z defmieras som ovan och R14 är en varierande organisk grupp som generelt används i nämnda positionen i karbapenemderivater.
2. Användning enligt patentkrav 1, kännetecknad därav, att R3 avser en 5 pyrid-2-ylgrupp, som valbart kan vara substituerad med en alkylgrupp med 1-6 kolatomer eller med en kinolin-2-ylgrupp.
3. Användning enligt patentkrav 1, kännetecknad därav, att derivatet med formeln (Ia) avser (3S,4S)-3-[(lR)-l-t-butyldimetylsilyloxietyl]-4-[(lR)-(2-pyridyltio- 10 karbony 1) -ety 1] atsetidin-2-on.
4. Användning enligt patentkrav 1, kännetecknad därav, att derivatet med formeln (Ia) avser (3S,4S)-3-[(lR)-l-t-butyldimetylsilyloxietyl]-4-[(lR)(2-kinolintio-karbony 1) -ety 1] atsetidin-2-on. 15
5. Användning enligt patentkrav 1, kännetecknad därav, att derivatet med formeln (Ia) avser (3S,4S)-3-[(lR)-l-t-butyldimetylsilyloxietyl]-4-{(lR)-[3-metyl-2-pyridyltiokarbonyl]etyl}atsetidin-2-on. « «· v ·' 20
6. Användning enligt patentkrav 1, kännetecknad därav, att derivatet med : ’.· formeln (Ia) avser (3S,4S)-3-[(lR)-l-t-butyldimetylsilyloxietyl]-4-{(lR)-[4-metyI-2- *:'': pyridyltiokarbonyl]etyl}atsetidin-2-on. • · • f
· • « « • · ··· • · · *·* * 7. Användning enligt patentkrav 1, kännetecknad därav, att derivatet med 25 formeln (Ia) avser (3S,4S)-3-[(lR)-l-t-butyldimetylsilyloxietyl]-4-{(lR)-[5-metyl-2- • V ’ ”; ’ pyridy Itiokarbony 1] ety l}atsetidin-2-on. • · • · • · • · · • · · * * * * I · « I * • · • · · * * • * · III fl · « · « « « · • ·
FI981397A 1991-05-31 1998-06-16 Användning av (3S,4S)-3-[(1R)-1-trialkylsilyloxietyl]-4-[(1R)-(heterocyklyl-tiokarbonyl)-etyl]azetidin-2-on derivat vid framställningen av karbapenem antibiotika FI105810B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP12957691 1991-05-31
JP12957691 1991-05-31
JP17222091 1991-07-12
JP17222091 1991-07-12

Publications (3)

Publication Number Publication Date
FI981397A0 FI981397A0 (sv) 1992-05-27
FI981397A FI981397A (sv) 1998-06-16
FI105810B true FI105810B (sv) 2000-10-13

Family

ID=26464925

Family Applications (2)

Application Number Title Priority Date Filing Date
FI922449A FI103726B1 (sv) 1991-05-31 1992-05-27 S-2-karbamoyl- och tiokarbamoylfenyl-2(R)- (3S,4S -3[1(R)-trialkylsilyloxi)etyl]-2-oxo-4-azetidinyl propionat och -tiopropionat derivat användbara som intermediater vid framställningen av karbapenemantibiotika och förfarande för framställning av dessa
FI981397A FI105810B (sv) 1991-05-31 1998-06-16 Användning av (3S,4S)-3-[(1R)-1-trialkylsilyloxietyl]-4-[(1R)-(heterocyklyl-tiokarbonyl)-etyl]azetidin-2-on derivat vid framställningen av karbapenem antibiotika

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI922449A FI103726B1 (sv) 1991-05-31 1992-05-27 S-2-karbamoyl- och tiokarbamoylfenyl-2(R)- (3S,4S -3[1(R)-trialkylsilyloxi)etyl]-2-oxo-4-azetidinyl propionat och -tiopropionat derivat användbara som intermediater vid framställningen av karbapenemantibiotika och förfarande för framställning av dessa

Country Status (22)

Country Link
EP (2) EP0845459A1 (sv)
KR (2) KR0171425B1 (sv)
CN (1) CN1038930C (sv)
AT (1) ATE198194T1 (sv)
AU (1) AU646740B2 (sv)
CA (1) CA2070002A1 (sv)
CZ (1) CZ284627B6 (sv)
DE (1) DE69231602T2 (sv)
DK (1) DK0516486T3 (sv)
ES (1) ES2152927T3 (sv)
FI (2) FI103726B1 (sv)
GR (1) GR3035222T3 (sv)
HK (1) HK1011978A1 (sv)
HU (1) HU218677B (sv)
IE (1) IE921761A1 (sv)
IL (1) IL102050A (sv)
IS (1) IS3870A (sv)
NO (1) NO304231B1 (sv)
NZ (1) NZ242961A (sv)
PT (1) PT516486E (sv)
RU (1) RU2047602C1 (sv)
TW (1) TW203604B (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2590429B2 (ja) * 1994-03-08 1997-03-12 工業技術院長 β‐ラクタム誘導体及びその製造方法
CN106083582A (zh) * 2016-08-11 2016-11-09 北京神雾环境能源科技集团股份有限公司 一种乙炔羰基化制丙烯酸甲酯的***和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019764A (ja) 1983-07-13 1985-01-31 Sankyo Co Ltd アゼチジノン誘導体の製造法
EP0186057A1 (en) * 1984-12-13 1986-07-02 Merck & Co. Inc. Carbapenems having a 2-position substituent joined through an alkyleneheteroatom bridge
JPS6254427A (ja) 1985-07-31 1987-03-10 Nec Corp 半導体装置の製造方法
US4895939A (en) 1986-02-24 1990-01-23 Bristol-Myers Company High percentage β-yield synthesis of carbapenem intermediates
US4772683A (en) * 1986-02-24 1988-09-20 Bristol-Myers Company High percentage beta-yield synthesis of carbapenem intermediates
US5011832A (en) * 1990-06-26 1991-04-30 Merck & Co., Inc. 2-biphenyl-carbapenem antibacterial agents

Also Published As

Publication number Publication date
TW203604B (sv) 1993-04-11
AU1717592A (en) 1992-12-03
KR0171557B1 (ko) 1999-03-30
FI922449A0 (fi) 1992-05-27
EP0516486A2 (en) 1992-12-02
DE69231602T2 (de) 2001-08-02
DK0516486T3 (da) 2001-01-29
HU9201802D0 (en) 1992-08-28
RU2047602C1 (ru) 1995-11-10
NO922127D0 (no) 1992-05-29
CN1068108A (zh) 1993-01-20
HU218677B (hu) 2000-10-28
HK1011978A1 (en) 1999-07-23
CZ162692A3 (en) 1993-09-15
HUT64307A (en) 1993-12-28
ES2152927T3 (es) 2001-02-16
FI103726B (sv) 1999-08-31
DE69231602D1 (de) 2001-01-25
PT516486E (pt) 2001-03-30
NO922127L (no) 1992-12-01
FI922449A (fi) 1992-12-01
FI981397A (sv) 1998-06-16
KR0171425B1 (ko) 1999-03-30
NZ242961A (en) 1993-08-26
IL102050A0 (en) 1992-12-30
FI103726B1 (sv) 1999-08-31
CN1038930C (zh) 1998-07-01
KR920021564A (ko) 1992-12-18
NO304231B1 (no) 1998-11-16
CA2070002A1 (en) 1992-12-01
GR3035222T3 (en) 2001-04-30
IS3870A (is) 1992-12-02
AU646740B2 (en) 1994-03-03
FI981397A0 (sv) 1992-05-27
EP0516486B1 (en) 2000-12-20
CZ284627B6 (cs) 1999-01-13
EP0516486A3 (en) 1993-01-07
EP0845459A1 (en) 1998-06-03
ATE198194T1 (de) 2001-01-15
IE921761A1 (en) 1992-12-02
IL102050A (en) 1997-08-14

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