FI103884B - Menetelmä farmaseuttisesti tehokkaiden guanidinokarbonyylisubstituoitujen isokinoliinien valmistamiseksi - Google Patents

Menetelmä farmaseuttisesti tehokkaiden guanidinokarbonyylisubstituoitujen isokinoliinien valmistamiseksi Download PDF

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Publication number
FI103884B
FI103884B FI934185A FI934185A FI103884B FI 103884 B FI103884 B FI 103884B FI 934185 A FI934185 A FI 934185A FI 934185 A FI934185 A FI 934185A FI 103884 B FI103884 B FI 103884B
Authority
FI
Finland
Prior art keywords
alkyl
amino
guanidinocarbonyl
isoquinolinone
hydrochloride
Prior art date
Application number
FI934185A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI934185A (fi
FI934185A0 (fi
FI103884B1 (fi
Inventor
Hans-Jochen Lang
Wolfgang Scholz
Bansi Lal
Heinrich Englert
Ramesh Matioram Gidwani
Ramanujam Rajagopalan
Radha Panicker
Chinnakulandai Sankar
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI934185A0 publication Critical patent/FI934185A0/fi
Publication of FI934185A publication Critical patent/FI934185A/fi
Application granted granted Critical
Publication of FI103884B publication Critical patent/FI103884B/fi
Publication of FI103884B1 publication Critical patent/FI103884B1/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
FI934185A 1992-09-28 1993-09-24 Menetelmä farmaseuttisesti tehokkaiden guanidinokarbonyylisubstituoitujen isokinoliinien valmistamiseksi FI103884B1 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92116535 1992-09-28
EP92116535 1992-09-28

Publications (4)

Publication Number Publication Date
FI934185A0 FI934185A0 (fi) 1993-09-24
FI934185A FI934185A (fi) 1994-03-29
FI103884B true FI103884B (fi) 1999-10-15
FI103884B1 FI103884B1 (fi) 1999-10-15

Family

ID=8210063

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934185A FI103884B1 (fi) 1992-09-28 1993-09-24 Menetelmä farmaseuttisesti tehokkaiden guanidinokarbonyylisubstituoitujen isokinoliinien valmistamiseksi

Country Status (18)

Country Link
US (1) US5416094A (fr)
EP (1) EP0590455B1 (fr)
JP (1) JP3645579B2 (fr)
AT (1) ATE198328T1 (fr)
AU (1) AU662079B2 (fr)
CA (1) CA2107008C (fr)
DE (1) DE69329787T2 (fr)
DK (1) DK0590455T3 (fr)
ES (1) ES2152938T3 (fr)
FI (1) FI103884B1 (fr)
GR (1) GR3035537T3 (fr)
HU (1) HU218208B (fr)
IL (1) IL107118A (fr)
NO (1) NO180374C (fr)
NZ (1) NZ248761A (fr)
PT (1) PT590455E (fr)
TW (1) TW272189B (fr)
ZA (1) ZA937141B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4344550A1 (de) * 1993-12-24 1995-06-29 Hoechst Ag Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4415873A1 (de) * 1994-05-05 1995-11-09 Hoechst Ag Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5627193A (en) * 1995-02-09 1997-05-06 Mitsui Toatsu Chemicals, Inc. Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
KR19990064338A (ko) * 1995-10-19 1999-07-26 페기 토츠케 이소퀴놀린 유도체 및 이소퀴놀린 조합 라이브러리
US5874443A (en) * 1995-10-19 1999-02-23 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19548708A1 (de) * 1995-12-23 1997-06-26 Merck Patent Gmbh Cyclische Sulfone
US20040122096A1 (en) * 1996-06-03 2004-06-24 Hoechst Aktiengesellschaft Use of inhibitors of the cellular Na+/H+ exchanger (NHE) for preparing a medicament for normalizing serum lipids
US5916899A (en) * 1996-10-18 1999-06-29 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
CA2271116A1 (fr) * 1996-11-13 1998-05-22 Gregory J. Wells Inhibiteurs benzothiazo, ou contenant des groupes heterocycliques apparentes, de la cysteine ou des proteases serines
US5952328A (en) * 1997-11-12 1999-09-14 Cephalon, Inc. Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
JP2002502414A (ja) * 1997-06-02 2002-01-22 藤沢薬品工業株式会社 細胞中のＮａ▲上＋▼／Ｈ▲上＋▼交換の阻害剤としてのグアニジン誘導体
US6534503B1 (en) 1998-04-28 2003-03-18 Lion Bioscience Ag Melanocortin receptor-3 ligands to treat sexual dysfunction
US6284735B1 (en) 1998-04-28 2001-09-04 Lion Bioscience Ag HP-3228 and related peptides to treat sexual dysfunction
EP1076649A4 (fr) 1998-04-28 2010-06-02 Trega Biosciences Inc Composes a base d'isoquinoline tenant lieu de ligands de recepteurs de melanocortine et procedes d'utilisation
DE19859727A1 (de) * 1998-12-23 2000-06-29 Aventis Pharma Gmbh Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung
MY140868A (en) * 2004-12-24 2010-01-29 Astrazeneca Ab Amide derivatives
WO2007053610A2 (fr) * 2005-11-01 2007-05-10 The Regents Of The University Of California Traitement de la fibrillation auriculaire a base de pirfenidone
TW200800908A (en) * 2006-02-15 2008-01-01 Sanofi Aventis Novel azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
CN101641013B (zh) 2007-01-22 2014-07-30 Gtx公司 核受体结合剂
WO2018058109A1 (fr) 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions et méthodes pour le traitement de troubles métaboliques
CN112367983A (zh) * 2018-04-06 2021-02-12 伊利诺伊大学评议会 Keap1/nrf2蛋白-蛋白相互作用的1,4取代的异喹啉抑制剂
KR102605163B1 (ko) * 2021-06-01 2023-11-23 연세대학교 산학협력단 뇌암의 예방 또는 치료용 조성물

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US3780027A (en) * 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung
DE3013906A1 (de) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3233424A1 (de) * 1982-09-09 1984-03-15 Hoechst Ag, 6230 Frankfurt Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
JP2930399B2 (ja) * 1990-10-18 1999-08-03 雪印乳業株式会社 新規イソキノリン誘導体またはその酸付加塩

Also Published As

Publication number Publication date
FI934185A (fi) 1994-03-29
AU4865993A (en) 1994-04-14
NZ248761A (en) 1995-04-27
JP3645579B2 (ja) 2005-05-11
ZA937141B (en) 1994-05-18
NO933450D0 (no) 1993-09-27
NO180374C (no) 1997-04-09
PT590455E (pt) 2001-04-30
TW272189B (fr) 1996-03-11
EP0590455B1 (fr) 2000-12-27
IL107118A (en) 1998-06-15
GR3035537T3 (en) 2001-06-29
FI934185A0 (fi) 1993-09-24
NO933450L (no) 1994-03-29
US5416094A (en) 1995-05-16
HU218208B (hu) 2000-06-28
HUT70149A (en) 1995-09-28
DK0590455T3 (da) 2001-01-22
HU9302725D0 (en) 1993-12-28
NO180374B (no) 1996-12-30
EP0590455A1 (fr) 1994-04-06
IL107118A0 (en) 1993-12-28
FI103884B1 (fi) 1999-10-15
JPH06211799A (ja) 1994-08-02
CA2107008C (fr) 2004-11-16
CA2107008A1 (fr) 1994-03-29
ATE198328T1 (de) 2001-01-15
ES2152938T3 (es) 2001-02-16
DE69329787D1 (de) 2001-02-01
DE69329787T2 (de) 2001-06-13
AU662079B2 (en) 1995-08-17

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