ES8700323A1 - Procedimiento para la determincion fotometrica del tiempo de tromboplastina. - Google Patents

Procedimiento para la determincion fotometrica del tiempo de tromboplastina.

Info

Publication number
ES8700323A1
ES8700323A1 ES542020A ES542020A ES8700323A1 ES 8700323 A1 ES8700323 A1 ES 8700323A1 ES 542020 A ES542020 A ES 542020A ES 542020 A ES542020 A ES 542020A ES 8700323 A1 ES8700323 A1 ES 8700323A1
Authority
ES
Spain
Prior art keywords
reagent
determination
prothrombin
time
thromboplastin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542020A
Other languages
English (en)
Other versions
ES542020A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of ES542020A0 publication Critical patent/ES542020A0/es
Publication of ES8700323A1 publication Critical patent/ES8700323A1/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Eye Examination Apparatus (AREA)
  • Exposure Control For Cameras (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

PROCEDIMIENTO PARA LA DETERMINACION FOTOMETRICA DEL TIEMPO DE TROMBOPLASTINA. CONSISTE EN PREPARAR UN REACTIVO A BASE DE UNA SOLUCION TAMPON CON UN INTERVALO DE PH DE 7 A 8,5, CON UNA TROMBOPLASTINA PROTEOLITICAMENTE ACTIVA (OBTENIDA PREFERENTEMENTE DE PLACENTA HUMANA) Y UN SUSTRATO CROMOGENO PARA TROMBINA, QUE ES DISOCIADO POR LA TROMBOPLASTINA EN PRESENCIA DE IONES CALCIO, CON UNA PEQUEÑA VELOCIDAD DE REACCION. SE MEZCLA ESTA SOLUCION CON PLASMA Y SE DETERMINA EL TIEMPO EN QUE SE ALCANZA UN DETERMINADO AUMENTO DE LA EXTINCION. APLICABLE EN LA VIGILANCIA DE LA TERAPIA CON ANTICOAGULANTES.
ES542020A 1984-04-09 1985-04-08 Procedimiento para la determincion fotometrica del tiempo de tromboplastina. Expired ES8700323A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843413311 DE3413311A1 (de) 1984-04-09 1984-04-09 Reagenz zur bestimmung der thromboplastinzeit

Publications (2)

Publication Number Publication Date
ES542020A0 ES542020A0 (es) 1986-10-01
ES8700323A1 true ES8700323A1 (es) 1986-10-01

Family

ID=6233070

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542020A Expired ES8700323A1 (es) 1984-04-09 1985-04-08 Procedimiento para la determincion fotometrica del tiempo de tromboplastina.

Country Status (9)

Country Link
US (1) US4784944A (es)
EP (1) EP0158254B1 (es)
JP (1) JPH0711524B2 (es)
AT (1) ATE35000T1 (es)
AU (1) AU582570B2 (es)
CA (1) CA1258221A (es)
DE (2) DE3413311A1 (es)
DK (1) DK163671C (es)
ES (1) ES8700323A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3616496A1 (de) * 1986-05-16 1987-11-19 Boehringer Mannheim Gmbh Analyseelement zur bestimmung von gerinnungsparametern
US5190862A (en) * 1987-04-01 1993-03-02 Boehringer Mannheim Gmbh Chromogenic compounds and the use thereof as enzyme substrates
SE8702556D0 (sv) * 1987-06-18 1987-06-18 Kabivitrum Ab Bestemning av vid proteolys aktiva komponenter
US5312745A (en) * 1987-06-18 1994-05-17 Chromogenix Ab Determination of components active in proteolysis
DE68912477T3 (de) * 1988-03-03 1999-12-23 Nippon Shoji K.K., Osaka Verfahren zum messen der biologischen wirkung von antithrombin iii und reagenzkit zu dessen messung
JPH0650999B2 (ja) * 1988-09-12 1994-07-06 日本商事株式会社 血液凝固因子安定化法
US5169786A (en) * 1989-12-19 1992-12-08 Ortho Diagnostic Systems, Inc. Method of determining levels of extrinsic and intrinsic clotting factors and protein c
DE4006634A1 (de) * 1990-03-03 1991-09-05 Behringwerke Ag Funktioneller test zur bestimmung der protein s-aktivitaet
US5254350A (en) * 1991-07-22 1993-10-19 Helena Laboratories Corporation Method of preparing a thromboplastin extract
JP3180824B2 (ja) * 1991-08-30 2001-06-25 シスメックス株式会社 血液凝固試薬
JP3524120B2 (ja) * 1992-05-08 2004-05-10 生化学工業株式会社 前処理剤、前処理方法、前処理された試料による測定法、測定用キット及び試料の判定方法
ATE202633T1 (de) * 1994-04-28 2001-07-15 Dade Behring Inc Kalibrator für prothrombin-zeit-assays
US5888826A (en) * 1994-06-30 1999-03-30 Dade Behring Inc. Combination reagent holding and test device
US5602037A (en) * 1994-06-30 1997-02-11 Dade International, Inc. Combination reagent holding and test device
ES2163519T3 (es) * 1994-06-30 2002-02-01 Dade Behring Inc Miembros separadores bioactivos porosos.
US5780255A (en) * 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
US5958716A (en) * 1996-06-06 1999-09-28 Dade Behring Inc. Blood factor assay
EP1243928A4 (en) * 1999-12-24 2007-12-19 Sysmex Corp MEANS FOR STABILIZING COMPOSITIONS AND REAGENTS
KR100710122B1 (ko) 2001-05-09 2007-04-20 엑시스-시일드 에이에스에이 분석 시스템
EP1367135A1 (en) 2002-05-29 2003-12-03 Pentapharm AG Improved method for the assessment of thrombin formation in blood or plasma
US20050202509A1 (en) * 2003-11-28 2005-09-15 Sysmex Corporation Reagent for measuring clotting time and method for measuring clotting time
US7148067B2 (en) 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
DE102005003145B4 (de) * 2005-01-21 2006-10-19 Dade Behring Marburg Gmbh Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
CA2600907C (en) * 2005-03-04 2016-06-28 The Board Of Trustees Of The University Of Illinois Coagulation and fibrinolytic cascades modulator
US8821861B2 (en) * 2007-10-05 2014-09-02 The Board Of Trustees Of The University Of Illinois Fibrin sealant
WO2009061697A1 (en) 2007-11-09 2009-05-14 The Board Of Trustees Of The University Of Illinois Anticoagulant antagonist and hemophilia procoagulant
GB2454672A (en) * 2007-11-13 2009-05-20 Mologic Ltd Chromogenic protease substrates
IS2809B (is) 2011-03-08 2012-10-15 Haskoli Islands Blóðstorkumæling
JP6116231B2 (ja) * 2012-12-25 2017-04-19 株式会社Ｌｓｉメディエンス 組織トロンボプラスチン含有血液凝固能測定試薬及び測定方法
HUP1300542A2 (hu) * 2013-09-19 2015-03-30 Diagon Kft Eljárás és mérõrendszer véralvadási jellemzõk meghatározására
SE540132C2 (sv) * 2014-05-22 2018-04-10 Zafena Ab Analysmetod för bestämning av antikoagulanter i blod eller blodplasma

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL123584C (es) * 1958-05-16
US3527569A (en) * 1967-10-06 1970-09-08 Haematronics Inc Prothrombin timer
US3520659A (en) * 1967-10-20 1970-07-14 Xerox Corp Method and apparatus for use in determining prothrombin time of a blood sample
ES431736A1 (es) * 1973-11-13 1977-05-16 Behringwerke Ag Procedimiento para la preparacion de un agente para diagnos-tico para el proposito de efectuar el control de la capaci- dad de coagulacion de la sangre.
CH622286A5 (es) * 1975-06-23 1981-03-31 Pentapharm Ag
US4169015A (en) * 1975-07-11 1979-09-25 Ab Kabi Novel chromogenic thrombin substrates
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
DE3019612A1 (de) * 1980-05-22 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisiertes thrombinpraeparat
DE3113350A1 (de) * 1981-04-02 1982-10-21 Boehringer Mannheim Gmbh, 6800 Mannheim Reagens zur optischen bestimmung des blutgerinnungsverhaltens
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
DE3563222D1 (en) 1988-07-14
CA1258221A (en) 1989-08-08
DK163671B (da) 1992-03-23
JPH0711524B2 (ja) 1995-02-08
ES542020A0 (es) 1986-10-01
JPS60230066A (ja) 1985-11-15
AU4089285A (en) 1985-10-17
AU582570B2 (en) 1989-04-06
US4784944A (en) 1988-11-15
DK163671C (da) 1992-08-17
EP0158254B1 (de) 1988-06-08
EP0158254A1 (de) 1985-10-16
DK154985A (da) 1985-10-10
DK154985D0 (da) 1985-04-03
ATE35000T1 (de) 1988-06-15
DE3413311A1 (de) 1985-10-17

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20040601