ES8700323A1 - Procedimiento para la determincion fotometrica del tiempo de tromboplastina. - Google Patents
Procedimiento para la determincion fotometrica del tiempo de tromboplastina.Info
- Publication number
- ES8700323A1 ES8700323A1 ES542020A ES542020A ES8700323A1 ES 8700323 A1 ES8700323 A1 ES 8700323A1 ES 542020 A ES542020 A ES 542020A ES 542020 A ES542020 A ES 542020A ES 8700323 A1 ES8700323 A1 ES 8700323A1
- Authority
- ES
- Spain
- Prior art keywords
- reagent
- determination
- prothrombin
- time
- thromboplastin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Eye Examination Apparatus (AREA)
- Exposure Control For Cameras (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
PROCEDIMIENTO PARA LA DETERMINACION FOTOMETRICA DEL TIEMPO DE TROMBOPLASTINA. CONSISTE EN PREPARAR UN REACTIVO A BASE DE UNA SOLUCION TAMPON CON UN INTERVALO DE PH DE 7 A 8,5, CON UNA TROMBOPLASTINA PROTEOLITICAMENTE ACTIVA (OBTENIDA PREFERENTEMENTE DE PLACENTA HUMANA) Y UN SUSTRATO CROMOGENO PARA TROMBINA, QUE ES DISOCIADO POR LA TROMBOPLASTINA EN PRESENCIA DE IONES CALCIO, CON UNA PEQUEÑA VELOCIDAD DE REACCION. SE MEZCLA ESTA SOLUCION CON PLASMA Y SE DETERMINA EL TIEMPO EN QUE SE ALCANZA UN DETERMINADO AUMENTO DE LA EXTINCION. APLICABLE EN LA VIGILANCIA DE LA TERAPIA CON ANTICOAGULANTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843413311 DE3413311A1 (de) | 1984-04-09 | 1984-04-09 | Reagenz zur bestimmung der thromboplastinzeit |
Publications (2)
Publication Number | Publication Date |
---|---|
ES542020A0 ES542020A0 (es) | 1986-10-01 |
ES8700323A1 true ES8700323A1 (es) | 1986-10-01 |
Family
ID=6233070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542020A Expired ES8700323A1 (es) | 1984-04-09 | 1985-04-08 | Procedimiento para la determincion fotometrica del tiempo de tromboplastina. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4784944A (es) |
EP (1) | EP0158254B1 (es) |
JP (1) | JPH0711524B2 (es) |
AT (1) | ATE35000T1 (es) |
AU (1) | AU582570B2 (es) |
CA (1) | CA1258221A (es) |
DE (2) | DE3413311A1 (es) |
DK (1) | DK163671C (es) |
ES (1) | ES8700323A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3616496A1 (de) * | 1986-05-16 | 1987-11-19 | Boehringer Mannheim Gmbh | Analyseelement zur bestimmung von gerinnungsparametern |
US5190862A (en) * | 1987-04-01 | 1993-03-02 | Boehringer Mannheim Gmbh | Chromogenic compounds and the use thereof as enzyme substrates |
SE8702556D0 (sv) * | 1987-06-18 | 1987-06-18 | Kabivitrum Ab | Bestemning av vid proteolys aktiva komponenter |
US5312745A (en) * | 1987-06-18 | 1994-05-17 | Chromogenix Ab | Determination of components active in proteolysis |
DE68912477T3 (de) * | 1988-03-03 | 1999-12-23 | Nippon Shoji K.K., Osaka | Verfahren zum messen der biologischen wirkung von antithrombin iii und reagenzkit zu dessen messung |
JPH0650999B2 (ja) * | 1988-09-12 | 1994-07-06 | 日本商事株式会社 | 血液凝固因子安定化法 |
US5169786A (en) * | 1989-12-19 | 1992-12-08 | Ortho Diagnostic Systems, Inc. | Method of determining levels of extrinsic and intrinsic clotting factors and protein c |
DE4006634A1 (de) * | 1990-03-03 | 1991-09-05 | Behringwerke Ag | Funktioneller test zur bestimmung der protein s-aktivitaet |
US5254350A (en) * | 1991-07-22 | 1993-10-19 | Helena Laboratories Corporation | Method of preparing a thromboplastin extract |
JP3180824B2 (ja) * | 1991-08-30 | 2001-06-25 | シスメックス株式会社 | 血液凝固試薬 |
JP3524120B2 (ja) * | 1992-05-08 | 2004-05-10 | 生化学工業株式会社 | 前処理剤、前処理方法、前処理された試料による測定法、測定用キット及び試料の判定方法 |
ATE202633T1 (de) * | 1994-04-28 | 2001-07-15 | Dade Behring Inc | Kalibrator für prothrombin-zeit-assays |
US5888826A (en) * | 1994-06-30 | 1999-03-30 | Dade Behring Inc. | Combination reagent holding and test device |
US5602037A (en) * | 1994-06-30 | 1997-02-11 | Dade International, Inc. | Combination reagent holding and test device |
ES2163519T3 (es) * | 1994-06-30 | 2002-02-01 | Dade Behring Inc | Miembros separadores bioactivos porosos. |
US5780255A (en) * | 1995-06-09 | 1998-07-14 | Instrumentation Laboratory, S.P.A. | Protein C pathway screening test |
US5958716A (en) * | 1996-06-06 | 1999-09-28 | Dade Behring Inc. | Blood factor assay |
EP1243928A4 (en) * | 1999-12-24 | 2007-12-19 | Sysmex Corp | MEANS FOR STABILIZING COMPOSITIONS AND REAGENTS |
KR100710122B1 (ko) | 2001-05-09 | 2007-04-20 | 엑시스-시일드 에이에스에이 | 분석 시스템 |
EP1367135A1 (en) | 2002-05-29 | 2003-12-03 | Pentapharm AG | Improved method for the assessment of thrombin formation in blood or plasma |
US20050202509A1 (en) * | 2003-11-28 | 2005-09-15 | Sysmex Corporation | Reagent for measuring clotting time and method for measuring clotting time |
US7148067B2 (en) | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
DE102005003145B4 (de) * | 2005-01-21 | 2006-10-19 | Dade Behring Marburg Gmbh | Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests |
US20080260858A1 (en) * | 2005-02-16 | 2008-10-23 | The Board Of Trustees Of The University Of Illnois | Universal Procoagulant |
CA2600907C (en) * | 2005-03-04 | 2016-06-28 | The Board Of Trustees Of The University Of Illinois | Coagulation and fibrinolytic cascades modulator |
US8821861B2 (en) * | 2007-10-05 | 2014-09-02 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
WO2009061697A1 (en) | 2007-11-09 | 2009-05-14 | The Board Of Trustees Of The University Of Illinois | Anticoagulant antagonist and hemophilia procoagulant |
GB2454672A (en) * | 2007-11-13 | 2009-05-20 | Mologic Ltd | Chromogenic protease substrates |
IS2809B (is) | 2011-03-08 | 2012-10-15 | Haskoli Islands | Blóðstorkumæling |
JP6116231B2 (ja) * | 2012-12-25 | 2017-04-19 | 株式会社Lsiメディエンス | 組織トロンボプラスチン含有血液凝固能測定試薬及び測定方法 |
HUP1300542A2 (hu) * | 2013-09-19 | 2015-03-30 | Diagon Kft | Eljárás és mérõrendszer véralvadási jellemzõk meghatározására |
SE540132C2 (sv) * | 2014-05-22 | 2018-04-10 | Zafena Ab | Analysmetod för bestämning av antikoagulanter i blod eller blodplasma |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL123584C (es) * | 1958-05-16 | |||
US3527569A (en) * | 1967-10-06 | 1970-09-08 | Haematronics Inc | Prothrombin timer |
US3520659A (en) * | 1967-10-20 | 1970-07-14 | Xerox Corp | Method and apparatus for use in determining prothrombin time of a blood sample |
ES431736A1 (es) * | 1973-11-13 | 1977-05-16 | Behringwerke Ag | Procedimiento para la preparacion de un agente para diagnos-tico para el proposito de efectuar el control de la capaci- dad de coagulacion de la sangre. |
CH622286A5 (es) * | 1975-06-23 | 1981-03-31 | Pentapharm Ag | |
US4169015A (en) * | 1975-07-11 | 1979-09-25 | Ab Kabi | Novel chromogenic thrombin substrates |
DE2757992A1 (de) * | 1977-12-24 | 1979-06-28 | Boehringer Mannheim Gmbh | Verfahren zur prothrombin-bestimmung |
US4289498A (en) * | 1979-01-08 | 1981-09-15 | Ortho Diagnostics, Inc. | One-stage prothrombin assay and compositions useful therein |
DE3019612A1 (de) * | 1980-05-22 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabilisiertes thrombinpraeparat |
DE3113350A1 (de) * | 1981-04-02 | 1982-10-21 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur optischen bestimmung des blutgerinnungsverhaltens |
DE3244030A1 (de) * | 1982-11-27 | 1984-05-30 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
-
1984
- 1984-04-09 DE DE19843413311 patent/DE3413311A1/de not_active Withdrawn
-
1985
- 1985-04-01 DE DE8585103896T patent/DE3563222D1/de not_active Expired
- 1985-04-01 AT AT85103896T patent/ATE35000T1/de not_active IP Right Cessation
- 1985-04-01 EP EP85103896A patent/EP0158254B1/de not_active Expired
- 1985-04-03 DK DK154985A patent/DK163671C/da not_active IP Right Cessation
- 1985-04-04 CA CA000478427A patent/CA1258221A/en not_active Expired
- 1985-04-04 AU AU40892/85A patent/AU582570B2/en not_active Ceased
- 1985-04-05 US US06/720,348 patent/US4784944A/en not_active Expired - Lifetime
- 1985-04-08 ES ES542020A patent/ES8700323A1/es not_active Expired
- 1985-04-08 JP JP60072846A patent/JPH0711524B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3563222D1 (en) | 1988-07-14 |
CA1258221A (en) | 1989-08-08 |
DK163671B (da) | 1992-03-23 |
JPH0711524B2 (ja) | 1995-02-08 |
ES542020A0 (es) | 1986-10-01 |
JPS60230066A (ja) | 1985-11-15 |
AU4089285A (en) | 1985-10-17 |
AU582570B2 (en) | 1989-04-06 |
US4784944A (en) | 1988-11-15 |
DK163671C (da) | 1992-08-17 |
EP0158254B1 (de) | 1988-06-08 |
EP0158254A1 (de) | 1985-10-16 |
DK154985A (da) | 1985-10-10 |
DK154985D0 (da) | 1985-04-03 |
ATE35000T1 (de) | 1988-06-15 |
DE3413311A1 (de) | 1985-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20040601 |