ES8602814A1 - A procedure for preparing a cephalosporine (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for preparing a cephalosporine (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES8602814A1
ES8602814A1 ES541520A ES541520A ES8602814A1 ES 8602814 A1 ES8602814 A1 ES 8602814A1 ES 541520 A ES541520 A ES 541520A ES 541520 A ES541520 A ES 541520A ES 8602814 A1 ES8602814 A1 ES 8602814A1
Authority
ES
Spain
Prior art keywords
formula
translation
preparing
procedure
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541520A
Other languages
Spanish (es)
Other versions
ES541520A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59054522A external-priority patent/JPS60199894A/en
Priority claimed from JP59062226A external-priority patent/JPS60208986A/en
Priority claimed from JP59066649A external-priority patent/JPS60214783A/en
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of ES541520A0 publication Critical patent/ES541520A0/en
Publication of ES8602814A1 publication Critical patent/ES8602814A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A PROCEDURE FOR PREPARING A FORMULA CEPHALOSPORIN (I). IT CONSISTS OF 1) REACTION A COMPOUND OF FORMULA (V) WHERE R IS OPTIONALLY SUBSTITUTED LOWER ALKYL, R4 IS ALKYL, ARALKYL OR ARYL, X IS HALOGEN WITH THIOUREA IN SOLVENT AS-ETHYL ACETATE OR OTHER V30 . 2) SUBMIT THE PRODUCT OBTAINED IN REACTION WITH A HALOGENANT OF -30 TO 30 C. 3) THE COMPOUND OBTAINED IN 2) OF FORMULA IV IS REACTIONED WITH ANOTHER FORMULA (VI) IN THE PRESENCE OF AN INORGANIC BASIS TO GIVE PLACE TO (II); 4) DEHYDRATE (II) IN THE PRESENCE OF ACID TO GIVE PLACE TO CEPHALOSPORIN (I) WHERE R2 IS HYDROGEN AND R3 IS HETERO-CYCLE REPLACED OR NOT. OF APPLICATION AS ANTIBACTERIAL OF WIDE SPECTRUM. (Machine-translation by Google Translate, not legally binding)
ES541520A 1984-03-23 1985-03-22 A procedure for preparing a cephalosporine (Machine-translation by Google Translate, not legally binding) Expired ES8602814A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP59054522A JPS60199894A (en) 1984-03-23 1984-03-23 Novel preparation of cephalosporin
JP59062226A JPS60208986A (en) 1984-03-31 1984-03-31 Novel cephalosporin
JP59066649A JPS60214783A (en) 1984-04-05 1984-04-05 2-amino-4-hydroxythiazoline derivative and its salt

Publications (2)

Publication Number Publication Date
ES541520A0 ES541520A0 (en) 1985-12-01
ES8602814A1 true ES8602814A1 (en) 1985-12-01

Family

ID=27295315

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541520A Expired ES8602814A1 (en) 1984-03-23 1985-03-22 A procedure for preparing a cephalosporine (Machine-translation by Google Translate, not legally binding)

Country Status (10)

Country Link
KR (1) KR870001796B1 (en)
AR (1) AR243192A1 (en)
AT (1) AT386207B (en)
CH (2) CH673460A5 (en)
DK (1) DK132585A (en)
ES (1) ES8602814A1 (en)
FI (1) FI86184C (en)
NO (1) NO167574C (en)
PL (1) PL145915B1 (en)
PT (1) PT80154B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1365A (en) * 1980-03-28 1987-08-07 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production

Also Published As

Publication number Publication date
PL252525A1 (en) 1985-12-17
CH673460A5 (en) 1990-03-15
NO167574B (en) 1991-08-12
CH669383A5 (en) 1989-03-15
NO167574C (en) 1991-11-20
PT80154B (en) 1987-06-17
PL145915B1 (en) 1988-11-30
KR850006420A (en) 1985-10-05
KR870001796B1 (en) 1987-10-12
AT386207B (en) 1988-07-25
AR243192A1 (en) 1993-07-30
FI86184C (en) 1992-07-27
ES541520A0 (en) 1985-12-01
ATA86985A (en) 1987-12-15
DK132585D0 (en) 1985-03-22
FI86184B (en) 1992-04-15
NO851166L (en) 1985-09-24
FI851173L (en) 1985-09-24
FI851173A0 (en) 1985-03-22
DK132585A (en) 1985-09-24
PT80154A (en) 1985-04-01

Similar Documents

Publication Publication Date Title
ES391299A1 (en) 2-(n-allyl-phenylamino)-imidazolines-(2)and salts thereof
ES8507484A1 (en) Beta-lactam compounds and production thereof.
ES8403131A1 (en) Process for preparing penicillanic acid 1,1-dioxide derivatives and certain intermediates useful therein.
ES448721A1 (en) A procedure for the production of antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding)
ES400824A1 (en) Amidinocarbamates
ES412207A1 (en) Alpha-amino-rho-hydroxyphenylacetamidocephalosporins
ES8602814A1 (en) A procedure for preparing a cephalosporine (Machine-translation by Google Translate, not legally binding)
ES404744A1 (en) Cephalosporin derivatives
ES8601910A1 (en) New amidine derivatives of 2-substituted 4-phenilimidazole.
ES419739A1 (en) 2-aryl-amino-imidazoline-2 compounds
ES432225A1 (en) Production of benzenesulphonamides
ES437842A1 (en) Process for preparing thiohydrozoazetidiones
ES448000A1 (en) 2,3-methylene prostaglandins and their preparation
ES435351A1 (en) 1-(3-phenylpropyl)-4-furoylpiperazine derivatives
ES465346A1 (en) 2h-imidazole-2-thione derivatives
GB1291696A (en) PROCESS FOR THE PRODUCTION OF alpha-SUBSTITUTED BENZOINS AND BENZOIN ETHERS
ES442988A1 (en) Preparation of salicylamide derivatives
GB1500826A (en) Spiro compounds and their use in pharmaceutical compositions
ES401342A1 (en) Pyridine derivatives
ES437041A1 (en) A procedure for preparing 1-ftalazone derivatives. (Machine-translation by Google Translate, not legally binding)
ES467734A1 (en) Procedure for the obtaining of derivatives of 5-nitroimidazol. (Machine-translation by Google Translate, not legally binding)
ES421810A1 (en) Pyrimidopyrimidines
ES444483A1 (en) A procedure for the preparation of new derivatives of acid2,3-alquilen (lower) penam-3-carboxylic. (Machine-translation by Google Translate, not legally binding)
ES427622A1 (en) Procedure for the preparation of 2-amino-bencil-amines. (Machine-translation by Google Translate, not legally binding)
ES421929A1 (en) Procedure for the preparation of substitute sulfonanilides. (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201